James S Wiley

James S Wiley

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James S Wiley

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P2X7 as a scavenger receptor for innate phagocytosis in the brain.

Br J Pharmacol 2018 11 5;175(22):4195-4208. Epub 2018 Oct 5.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/bph.14470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193880PMC
November 2018

The scavenger activity of the human P2X7 receptor differs from P2X7 pore function by insensitivity to antagonists, genetic variation and sodium concentration: Relevance to inflammatory brain diseases.

Biochim Biophys Acta Mol Basis Dis 2018 Apr 9;1864(4 Pt A):1051-1059. Epub 2018 Jan 9.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.01.012DOI Listing
April 2018

Loss of Function of P2X7 Receptor Scavenger Activity in Aging Mice: A Novel Model for Investigating the Early Pathogenesis of Age-Related Macular Degeneration.

Am J Pathol 2017 Aug 17;187(8):1670-1685. Epub 2017 Jun 17.

Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.04.016DOI Listing
August 2017

Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer's disease.

Acta Neuropathol 2016 09 13;132(3):377-89. Epub 2016 Jul 13.

The Florey Institute of Neuroscience & Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1007/s00401-016-1596-3DOI Listing
September 2016

Lack of a Functioning P2X7 Receptor Leads to Increased Susceptibility to Toxoplasmic Ileitis.

PLoS One 2015 8;10(6):e0129048. Epub 2015 Jun 8.

Queensland Tropical Health Alliance Research Laboratory, Australian Institute of Tropical Health and Medicine, James Cook University, McGregor Rd, Smithfield, Queensland, 4878, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129048PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460092PMC
March 2016

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model.

Blood 2015 Dec 8;126(26):2863-70. Epub 2015 Oct 8.

Australian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, Australia; The Alfred Hospital, Melbourne, Australia;

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http://dx.doi.org/10.1182/blood-2014-10-609362DOI Listing
December 2015

P2X7 receptors mediate innate phagocytosis by human neural precursor cells and neuroblasts.

Stem Cells 2015 Feb;33(2):526-41

Discipline of Anatomy and Histology, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia; Bosch Institute, The University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1002/stem.1864DOI Listing
February 2015

A quantitative method for measuring innate phagocytosis by human monocytes using real-time flow cytometry.

Cytometry A 2014 Apr 16;85(4):313-21. Epub 2013 Oct 16.

The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, 3010, Australia.

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http://dx.doi.org/10.1002/cyto.a.22400DOI Listing
April 2014

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Authors:
Ashley H Beecham Nikolaos A Patsopoulos Dionysia K Xifara Mary F Davis Anu Kemppinen Chris Cotsapas Tejas S Shah Chris Spencer David Booth An Goris Annette Oturai Janna Saarela Bertrand Fontaine Bernhard Hemmer Claes Martin Frauke Zipp Sandra D'Alfonso Filippo Martinelli-Boneschi Bruce Taylor Hanne F Harbo Ingrid Kockum Jan Hillert Tomas Olsson Maria Ban Jorge R Oksenberg Rogier Hintzen Lisa F Barcellos Cristina Agliardi Lars Alfredsson Mehdi Alizadeh Carl Anderson Robert Andrews Helle Bach Søndergaard Amie Baker Gavin Band Sergio E Baranzini Nadia Barizzone Jeffrey Barrett Céline Bellenguez Laura Bergamaschi Luisa Bernardinelli Achim Berthele Viola Biberacher Thomas M C Binder Hannah Blackburn Izaura L Bomfim Paola Brambilla Simon Broadley Bruno Brochet Lou Brundin Dorothea Buck Helmut Butzkueven Stacy J Caillier William Camu Wassila Carpentier Paola Cavalla Elisabeth G Celius Irène Coman Giancarlo Comi Lucia Corrado Leentje Cosemans Isabelle Cournu-Rebeix Bruce A C Cree Daniele Cusi Vincent Damotte Gilles Defer Silvia R Delgado Panos Deloukas Alessia di Sapio Alexander T Dilthey Peter Donnelly Bénédicte Dubois Martin Duddy Sarah Edkins Irina Elovaara Federica Esposito Nikos Evangelou Barnaby Fiddes Judith Field Andre Franke Colin Freeman Irene Y Frohlich Daniela Galimberti Christian Gieger Pierre-Antoine Gourraud Christiane Graetz Andrew Graham Verena Grummel Clara Guaschino Athena Hadjixenofontos Hakon Hakonarson Christopher Halfpenny Gillian Hall Per Hall Anders Hamsten James Harley Timothy Harrower Clive Hawkins Garrett Hellenthal Charles Hillier Jeremy Hobart Muni Hoshi Sarah E Hunt Maja Jagodic Ilijas Jelčić Angela Jochim Brian Kendall Allan Kermode Trevor Kilpatrick Keijo Koivisto Ioanna Konidari Thomas Korn Helena Kronsbein Cordelia Langford Malin Larsson Mark Lathrop Christine Lebrun-Frenay Jeannette Lechner-Scott Michelle H Lee Maurizio A Leone Virpi Leppä Giuseppe Liberatore Benedicte A Lie Christina M Lill Magdalena Lindén Jenny Link Felix Luessi Jan Lycke Fabio Macciardi Satu Männistö Clara P Manrique Roland Martin Vittorio Martinelli Deborah Mason Gordon Mazibrada Cristin McCabe Inger-Lise Mero Julia Mescheriakova Loukas Moutsianas Kjell-Morten Myhr Guy Nagels Richard Nicholas Petra Nilsson Fredrik Piehl Matti Pirinen Siân E Price Hong Quach Mauri Reunanen Wim Robberecht Neil P Robertson Mariaemma Rodegher David Rog Marco Salvetti Nathalie C Schnetz-Boutaud Finn Sellebjerg Rebecca C Selter Catherine Schaefer Sandip Shaunak Ling Shen Simon Shields Volker Siffrin Mark Slee Per Soelberg Sorensen Melissa Sorosina Mireia Sospedra Anne Spurkland Amy Strange Emilie Sundqvist Vincent Thijs John Thorpe Anna Ticca Pentti Tienari Cornelia van Duijn Elizabeth M Visser Steve Vucic Helga Westerlind James S Wiley Alastair Wilkins James F Wilson Juliane Winkelmann John Zajicek Eva Zindler Jonathan L Haines Margaret A Pericak-Vance Adrian J Ivinson Graeme Stewart David Hafler Stephen L Hauser Alastair Compston Gil McVean Philip De Jager Stephen J Sawcer Jacob L McCauley

Nat Genet 2013 Nov 29;45(11):1353-60. Epub 2013 Sep 29.

1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].

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http://dx.doi.org/10.1038/ng.2770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832895PMC
November 2013

A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration.

FASEB J 2013 Apr 9;27(4):1479-87. Epub 2013 Jan 9.

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1096/fj.12-215368DOI Listing
April 2013

A new role for the P2X7 receptor: a scavenger receptor for bacteria and apoptotic cells in the absence of serum and extracellular ATP.

Purinergic Signal 2012 Sep 4;8(3):579-86. Epub 2012 Apr 4.

Florey Neuroscience Institutes, University of Melbourne, Parkville, VIC, 3010, Australia.

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http://dx.doi.org/10.1007/s11302-012-9308-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360097PMC
September 2012

Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women.

Eur J Hum Genet 2012 May 11;20(5):559-64. Epub 2012 Jan 11.

Mellanby Centre for Bone Research, Academic Unit of Bone Biology, Department of Human Metabolism, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1038/ejhg.2011.245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330223PMC
May 2012

A loss-of-function polymorphism in the human P2X4 receptor is associated with increased pulse pressure.

Hypertension 2011 Dec 7;58(6):1086-92. Epub 2011 Nov 7.

Sydney Medical School Nepean, University of Sydney, Nepean Hospital, Penrith, New South Wales, 2751, Australia.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.176180DOI Listing
December 2011

The role of the P2X₇ receptor in infectious diseases.

PLoS Pathog 2011 Nov 10;7(11):e1002212. Epub 2011 Nov 10.

Institute for the Biotechnology of Infectious Diseases, University of Technology, Sydney, Broadway, New South Wales, Australia.

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http://dx.doi.org/10.1371/journal.ppat.1002212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213081PMC
November 2011

P2X(7) is a scavenger receptor for apoptotic cells in the absence of its ligand, extracellular ATP.

J Immunol 2011 Sep 5;187(5):2365-75. Epub 2011 Aug 5.

Sydney Medical School Nepean, University of Sydney, Nepean Hospital, Penrith, New South Wales 2750, Australia.

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http://dx.doi.org/10.4049/jimmunol.1101178DOI Listing
September 2011

Dysregulation of the inflammatory response to the parasite, Toxoplasma gondii, in P2X7 receptor-deficient mice.

Int J Parasitol 2011 Mar 31;41(3-4):301-8. Epub 2010 Oct 31.

Institute for Biotechnology of Infectious Diseases, University of Technology, Sydney, Broadway, NSW 2007, Australia.

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http://dx.doi.org/10.1016/j.ijpara.2010.10.001DOI Listing
March 2011

TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes.

Biochim Biophys Acta 2010 Nov 27;1798(11):2058-66. Epub 2010 Jul 27.

School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.bbamem.2010.07.022DOI Listing
November 2010

Identification of the promoter region of the P2RX4 gene.

Mol Biol Rep 2010 Oct 2;37(7):3369-76. Epub 2009 Dec 2.

Department of Medicine, Nepean Clinical School, Nepean Hospital, Level 5, South Block, Penrith, NSW, 2750, Australia.

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http://link.springer.com/content/pdf/10.1007/s11033-009-9924
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http://link.springer.com/10.1007/s11033-009-9924-5
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http://dx.doi.org/10.1007/s11033-009-9924-5DOI Listing
October 2010

P2X7 receptor activation induces cell death and microparticle release in murine erythroleukemia cells.

Biochim Biophys Acta 2010 Sep 8;1798(9):1797-804. Epub 2010 Jun 8.

School of Biological Sciences, University of Wollongong, Wollongong, Australia.

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http://dx.doi.org/10.1016/j.bbamem.2010.06.002DOI Listing
September 2010

Murine epidermal Langerhans cells and keratinocytes express functional P2X7 receptors.

Exp Dermatol 2010 Aug;19(8):e151-7

Department of Medicine, Nepean Clinical School, University of Sydney, Penrith, NSW, Australia.

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http://dx.doi.org/10.1111/j.1600-0625.2009.01029.xDOI Listing
August 2010

Two haplotypes of the P2X(7) receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1beta secretion.

FASEB J 2010 Aug 1;24(8):2916-27. Epub 2010 Apr 1.

Department of Medicine, University of Sydney, Nepean Clinical School, Nepean Hospital, Penrith, New South Wales, Australia.

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http://dx.doi.org/10.1096/fj.09-150862DOI Listing
August 2010

The P2X7-nonmuscle myosin membrane complex regulates phagocytosis of nonopsonized particles and bacteria by a pathway attenuated by extracellular ATP.

Blood 2010 Feb 9;115(8):1621-31. Epub 2009 Dec 9.

Department of Medicine, Nepean Clinical School, Penrith, Australia.

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http://dx.doi.org/10.1182/blood-2009-11-251744DOI Listing
February 2010

The P2X(7) receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types.

Purinergic Signal 2009 Sep 16;5(3):385-94. Epub 2009 Jun 16.

Department of Medicine, Nepean Clinical School, University of Sydney, Penrith, NSW, Australia.

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http://dx.doi.org/10.1007/s11302-009-9163-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717320PMC
September 2009

Extracellular ATP dissociates nonmuscle myosin from P2X(7) complex: this dissociation regulates P2X(7) pore formation.

Am J Physiol Cell Physiol 2009 Aug 3;297(2):C430-9. Epub 2009 Jun 3.

Department of Medicine, Nepean Clinical School, Penrith, NSW, Australia.

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http://dx.doi.org/10.1152/ajpcell.00079.2009DOI Listing
August 2009

Genetics of the P2X7 receptor and human disease.

Purinergic Signal 2009 Jun 25;5(2):257-62. Epub 2009 Mar 25.

Nepean Clinical School, Nepean Hospital, University of Sydney, Penrith, NSW, 2750, Australia.

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http://dx.doi.org/10.1007/s11302-009-9136-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686826PMC
June 2009

Editorial.

Purinergic Signal 2009 Jun;5(2):127-8

Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara, Via Borsari 46, Ferrara, 44100, Italy,

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http://dx.doi.org/10.1007/s11302-009-9159-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686833PMC
June 2009

Inhibition of the human P2X7 receptor by a novel protein tyrosine kinase antagonist.

Biochem Biophys Res Commun 2008 Jan 20;365(3):515-20. Epub 2007 Nov 20.

Department of Medicine, Nepean Clinical School, University of Sydney, Penrith, NSW, Australia.

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http://dx.doi.org/10.1016/j.bbrc.2007.11.008DOI Listing
January 2008

Canine erythrocytes express the P2X7 receptor: greatly increased function compared with human erythrocytes.

Am J Physiol Regul Integr Comp Physiol 2007 Nov 29;293(5):R2090-8. Epub 2007 Aug 29.

Dept. of Medicine, University of Sydney, Nepean Clinical School, Penrith, New South Wales, Australia.

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http://dx.doi.org/10.1152/ajpregu.00166.2007DOI Listing
November 2007

A quantitative method for routine measurement of cell surface P2X7 receptor function in leucocyte subsets by two-colour time-resolved flow cytometry.

J Immunol Methods 2007 Aug 26;325(1-2):67-77. Epub 2007 Jun 26.

Department of Medicine, the University of Sydney, Nepean Hospital, Penrith, New South Wales 2750, Australia.

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http://dx.doi.org/10.1016/j.jim.2007.06.002DOI Listing
August 2007

P2X(7) receptor activation causes phosphatidylserine exposure in human erythrocytes.

Biochem Biophys Res Commun 2007 Mar 30;355(1):169-73. Epub 2007 Jan 30.

Department of Medicine, Nepean Clinical School, University of Sydney, Penrith, NSW, Australia.

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http://dx.doi.org/10.1016/j.bbrc.2007.01.124DOI Listing
March 2007

A polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosis.

Am J Respir Crit Care Med 2007 Feb 9;175(4):360-6. Epub 2006 Nov 9.

Mycobacterial Research Programme, Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW, Australia.

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http://dx.doi.org/10.1164/rccm.200607-970OCDOI Listing
February 2007

Rottlerin inhibits P2X(7) receptor-stimulated phospholipase D activity in chronic lymphocytic leukaemia B-lymphocytes.

Immunol Cell Biol 2007 Jan 28;85(1):68-72. Epub 2006 Nov 28.

Department of Medicine, University of Sydney at Nepean Hospital, Penrith, New South Wales, Australia.

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http://doi.wiley.com/10.1038/sj.icb.7100005
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http://dx.doi.org/10.1038/sj.icb.7100005DOI Listing
January 2007

Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor.

Blood 2006 Jun 2;107(12):4946-53. Epub 2006 Mar 2.

Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW 2750, Australia.

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http://dx.doi.org/10.1182/blood-2005-07-2994DOI Listing
June 2006

Human epidermal and monocyte-derived langerhans cells express functional P2X receptors.

J Invest Dermatol 2005 Sep;125(3):482-90

Department of Medicine, University of Sydney at Nepean Hospital, Penrith, NSW, Australia.

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http://dx.doi.org/10.1111/j.0022-202X.2005.23835.xDOI Listing
September 2005

A 5' intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1-2% of the Caucasian population.

FEBS Lett 2005 May 14;579(12):2675-8. Epub 2005 Apr 14.

Department of Medicine, University of Sydney at Nepean Hospital, Penrith, NSW, Australia.

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http://dx.doi.org/10.1016/j.febslet.2005.03.091DOI Listing
May 2005

Extracellular ATP increases cation fluxes in human erythrocytes by activation of the P2X7 receptor.

J Biol Chem 2004 Oct 10;279(43):44749-55. Epub 2004 Aug 10.

Department of Medicine, University of Sydney at Nepean Hospital, Penrith, New South Wales 2750, Australia.

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http://dx.doi.org/10.1074/jbc.M405631200DOI Listing
October 2004

An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor.

J Biol Chem 2004 Jul 27;279(30):31287-95. Epub 2004 Apr 27.

Department of Medicine, University of Sydney at Nepean Hospital, Penrith, New South Wales 2750, Australia.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M313902200
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http://dx.doi.org/10.1074/jbc.M313902200DOI Listing
July 2004

Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor.

Br J Pharmacol 2004 Jul 21;142(6):1015-9. Epub 2004 Jun 21.

Department of Medicine, The University of Sydney at Nepean Hospital, Penrith, NSW, 2751, Australia.

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http://dx.doi.org/10.1038/sj.bjp.0705868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575114PMC
July 2004

CXCR4 but not CXCR3 expression correlates with lymphocyte counts in B-cell chronic lymphocytic leukemia.

Ann Hematol 2004 May 18;83(5):326-7. Epub 2004 Feb 18.

Department of Medicine, University of Sydney at Nepean Hospital, Penrith, NSW 2750, Australia.

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http://dx.doi.org/10.1007/s00277-004-0846-yDOI Listing
May 2004

Glu496 to Ala polymorphism in the P2X7 receptor impairs ATP-induced IL-1 beta release from human monocytes.

J Immunol 2004 Mar;172(6):3399-405

Department of Medicine, University of Sydney at Nepean Hospital, Penrith, New South Wales, Australia.

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http://dx.doi.org/10.4049/jimmunol.172.6.3399DOI Listing
March 2004

A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria.

J Immunol 2003 Nov;171(10):5442-6

Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW Australia.

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http://dx.doi.org/10.4049/jimmunol.171.10.5442DOI Listing
November 2003

An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor.

J Biol Chem 2003 May 13;278(19):17108-13. Epub 2003 Feb 13.

Department of Medicine, University of Sydney at Nepean Hospital, Penrith, New South Wales 2750, Australia.

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http://dx.doi.org/10.1074/jbc.M212759200DOI Listing
May 2003

Extracellular adenosine 5'-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors.

Int Immunol 2002 Dec;14(12):1415-21

Department of Medicine, University of Sydney, Level 5 South Block, Nepean Hospital, Penrith, NSW 2750, Australia.

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http://dx.doi.org/10.1093/intimm/dxf111DOI Listing
December 2002

The P2X7 receptor of CLL lymphocytes-a molecule with a split personality.

Lancet 2002 Dec;360(9349):1898-9

Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1016/S0140-6736(02)11933-7DOI Listing
December 2002