James R Gosset

James R Gosset

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James R Gosset

James R Gosset

Publications by authors named "James R Gosset"

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A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF-05105679.

Eur J Pharm Sci 2017 Nov 7;109S:S161-S167. Epub 2017 Jun 7.

Certara QSP, Canterbury Innovation Centre, Canterbury CT2 7FG, UK; Systems Pharmacology Cluster, Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.ejps.2017.06.009DOI Listing
November 2017

Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome.

Drug Metab Dispos 2017 05 2;45(5):501-511. Epub 2017 Mar 2.

Clinical Pharmacology (J.Q.D.), Pharmacokinetics, Pharmacodynamics, and Metabolism (J.R.G., J.R.C., A.S.K.), Statistics (V.L.), Early Clinical Development (K.C., A.K.), and Cardiovascular and Metabolic Disease Research Unit (L.B.), Pfizer Inc., Cambridge, Massachusetts; and Pharmacokinetics, Pharmacodynamics, and Metabolism (O.A.F., Z.L.), Clinical Development (S.G.T.), and Clinical Assay Group (P.N.), Pfizer Inc., Groton, Connecticut

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http://dx.doi.org/10.1124/dmd.116.074476DOI Listing
May 2017

Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.

J Med Chem 2016 Feb 27;59(3):1165-75. Epub 2016 Jan 27.

Worldwide Medicinal Chemistry, ‡Cardiovascular, Metabolic and Endocrine Diseases Research Unit, and §Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01752DOI Listing
February 2016

Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.

J Med Chem 2015 Sep 8;58(18):7164-72. Epub 2015 Sep 8.

Worldwide Medicinal Chemistry, ‡Cardiovascular, Metabolic and Endocrine Diseases Research Unit, and §Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01008DOI Listing
September 2015

Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans.

J Pharmacol Exp Ther 2014 11 14;351(2):259-69. Epub 2014 Aug 14.

Pfizer Limited, Neusentis Research Unit, Granta Park, Cambridge, United Kingdom (W.J.W., K.G., S.G., D.S.R.); Genito-Urinary Research Unit (W.J.W., J.C.G., K.C., M.P., P.-P.S., D.S.R.), Research Statistics (K.G., S.C.), Drug Safety, Research and Development (S.R.), Pharmacokinetics, Dynamics and Metabolism (J.R.G., T.M., K.B.), and Worldwide Medicinal Chemistry (M.D.A., P.A.G., M.J.P.), Pfizer Global Research and Development, Sandwich, Kent, United Kingdom; Pfizer Clinical Research Unit, Lenniksebaan, Brussels, Belgium (W.P.); and PharmaTherapeutics Pharmaceutical Sciences, Pfizer Limited, Sandwich, United Kingdom (N.C.).

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http://dx.doi.org/10.1124/jpet.114.216010DOI Listing
November 2014

Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond.

Expert Opin Drug Metab Toxicol 2013 Apr 21;9(4):459-72. Epub 2013 Jan 21.

Pfizer Worldwide Research and Development, Department of Pharmacokinetics, Dynamics and Metabolism, Eastern Point Road, Groton, CT 06340, USA.

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http://dx.doi.org/10.1517/17425255.2013.759210DOI Listing
April 2013

Application of PBPK modelling in drug discovery and development at Pfizer.

Xenobiotica 2012 Jan 30;42(1):94-106. Epub 2011 Oct 30.

Pfizer Worldwide R&D, Department of Pharmacokinetics, Dynamics and Metabolism, Sandwich, Kent, UK.

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http://dx.doi.org/10.3109/00498254.2011.627477DOI Listing
January 2012