James R Eshleman

James R Eshleman

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James R Eshleman

Publications by authors named "James R Eshleman"

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Tetraploid Partial Hydatidiform Moles Molecular Genotyping and Determination of Parental Contributions.

J Mol Diagn 2019 Oct 24. Epub 2019 Oct 24.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.jmoldx.2019.09.006DOI Listing
October 2019

Gene Variants That Affect Levels of Circulating Tumor Markers Increase Identification of Patients with Pancreatic Cancer.

Clin Gastroenterol Hepatol 2019 Oct 29. Epub 2019 Oct 29.

Department of Pathology The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD; Department of Medicine The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD; Department of Oncology The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.10.036DOI Listing
October 2019

Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice.

Gastroenterology 2019 09 1;157(3):838-850.e6. Epub 2019 Jun 1.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Skip Viragh Center for Pancreatic Cancer, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.05.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707836PMC
September 2019

Clinical mutational profiling and categorization of BRAF mutations in melanomas using next generation sequencing.

BMC Cancer 2019 Jul 5;19(1):665. Epub 2019 Jul 5.

Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins University School of Medicine, 1812 Ashland Ave, Suite 200, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1186/s12885-019-5864-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612071PMC
July 2019

No BRAF V600E Mutation Identified in 28 Periocular Pyogenic Granuloma.

Ophthalmic Plast Reconstr Surg 2018 Nov/Dec;34(6):525-527

Department of Pathology, First Affiliated Hospital, Dalian Medical University, Dalian, China.

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http://Insights.ovid.com/crossref?an=00002341-201811000-0000
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http://dx.doi.org/10.1097/IOP.0000000000001075DOI Listing
May 2019

A New Fast Phasing Method Based On Haplotype Subtraction.

J Mol Diagn 2019 May 11;21(3):427-436. Epub 2019 Mar 11.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504677PMC
May 2019

Protein-Programmed Accumulation of Yeast Cytosine Deaminase in Cancer Cells in Response to Mock-Hypoxia.

ACS Synth Biol 2019 May 23;8(5):948-954. Epub 2019 Apr 23.

Department of Chemical and Biomolecular Engineering , Johns Hopkins University , 3400 N. Charles Street , Baltimore , Maryland 21218 , United States.

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http://dx.doi.org/10.1021/acssynbio.9b00036DOI Listing
May 2019

Clinical Validation of Coexisting Activating Mutations Within EGFR, Mitogen-Activated Protein Kinase, and Phosphatidylinositol 3-Kinase Pathways in Lung Cancers.

Arch Pathol Lab Med 2019 Feb 7;143(2):174-182. Epub 2018 Sep 7.

From the Departments of Pathology (Drs De Marchi, Ibrahim, Zheng, Gocke, Eshleman, Belchis, Illei, and Lin, Ms Haley, Mr Fryer, and Ms Beierl) and Oncology (Drs Gocke and Eshleman), Johns Hopkins University School of Medicine, Baltimore, Maryland; and the Division of Hematology and Bone Marrow Transplantation, Hospital-University of Udine, Udine, Italy (Dr De Marchi).

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http://www.archivesofpathology.org/doi/10.5858/arpa.2017-049
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http://dx.doi.org/10.5858/arpa.2017-0495-OADOI Listing
February 2019

Validation Strategy for Ultrasensitive Mutation Detection.

Mol Diagn Ther 2018 10;22(5):603-611

Department of Pathology, Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s40291-018-0350-zDOI Listing
October 2018

Clinical Validation of Coexisting Activating Mutations Within EGFR, Mitogen-Activated Protein Kinase, and Phosphatidylinositol 3-Kinase Pathways in Lung Cancers.

Arch Pathol Lab Med 2018 Sep 7. Epub 2018 Sep 7.

From the Departments of Pathology (Drs De Marchi, Ibrahim, Zheng, Gocke, Eshleman, Belchis, Illei, and Lin, Ms Haley, Mr Fryer, and Ms Beierl) and Oncology (Drs Gocke and Eshleman), Johns Hopkins University School of Medicine, Baltimore, Maryland; and the Division of Hematology and Bone Marrow Transplantation, Hospital-University of Udine, Udine, Italy (Dr De Marchi).

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http://dx.doi.org/10.5858/arpa.2018-0495-OADOI Listing
September 2018

Simple Detection of Telomere Fusions in Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm, and Pancreatic Cyst Fluid.

J Mol Diagn 2018 01 8;20(1):46-55. Epub 2017 Dec 8.

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medicine, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2017.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745545PMC
January 2018

Clinical mutational profiling of 1006 lung cancers by next generation sequencing.

Oncotarget 2017 Nov 20;8(57):96684-96696. Epub 2017 May 20.

Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA.

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http://dx.doi.org/10.18632/oncotarget.18042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722514PMC
November 2017

Haplotype Counting for Sensitive Chimerism Testing: Potential for Early Leukemia Relapse Detection.

J Mol Diagn 2017 05;19(3):427-436

Department of Pathology, Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, Maryland; Department of Oncology, Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15251578173010
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http://dx.doi.org/10.1016/j.jmoldx.2017.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707182PMC
May 2017

Nanopore sequencing detects structural variants in cancer.

Cancer Biol Ther 2016 19;17(3):246-53. Epub 2016 Jan 19.

b Department of Biomedical Engineering , Johns Hopkins University , Baltimore , MD , USA.

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http://dx.doi.org/10.1080/15384047.2016.1139236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848001PMC
January 2017

Molecular Diagnostics for Precision Medicine in Colorectal Cancer: Current Status and Future Perspective.

Biomed Res Int 2016 6;2016:9850690. Epub 2016 Sep 6.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1155/2016/9850690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028795PMC
January 2017

Hypermutation In Pancreatic Cancer.

Gastroenterology 2017 01 15;152(1):68-74.e2. Epub 2016 Nov 15.

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom; Department of Surgery, Bankstown Hospital, Bankstown, Sydney, New South Wales, Australia; South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales Australia, Liverpool, New South Wales, Australia; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085163518
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http://dx.doi.org/10.1053/j.gastro.2016.09.060DOI Listing
January 2017

Analytical Validation of Androgen Receptor Splice Variant 7 Detection in a Clinical Laboratory Improvement Amendments (CLIA) Laboratory Setting.

J Mol Diagn 2017 01 1;19(1):115-125. Epub 2016 Dec 1.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2016.08.003DOI Listing
January 2017

Cost-Savings Analysis of AR-V7 Testing in Patients With Metastatic Castration-Resistant Prostate Cancer Eligible for Treatment With Abiraterone or Enzalutamide.

Prostate 2016 12 12;76(16):1484-1490. Epub 2016 Jul 12.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pros.23232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735831PMC
December 2016

Clinical mutational profiling of bone metastases of lung and colon carcinoma and malignant melanoma using next-generation sequencing.

Cancer Cytopathol 2016 Oct 10;124(10):744-753. Epub 2016 Jun 10.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/cncy.21743DOI Listing
October 2016

Software-Based Pyrogram® Evaluation.

Methods Mol Biol 2015 ;1315:29-38

Department of Pathology, Penn State Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, USA,

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http://dx.doi.org/10.1007/978-1-4939-2715-9_3DOI Listing
March 2016

Genomic analyses identify molecular subtypes of pancreatic cancer.

Authors:
Peter Bailey David K Chang Katia Nones Amber L Johns Ann-Marie Patch Marie-Claude Gingras David K Miller Angelika N Christ Tim J C Bruxner Michael C Quinn Craig Nourse L Charles Murtaugh Ivon Harliwong Senel Idrisoglu Suzanne Manning Ehsan Nourbakhsh Shivangi Wani Lynn Fink Oliver Holmes Venessa Chin Matthew J Anderson Stephen Kazakoff Conrad Leonard Felicity Newell Nick Waddell Scott Wood Qinying Xu Peter J Wilson Nicole Cloonan Karin S Kassahn Darrin Taylor Kelly Quek Alan Robertson Lorena Pantano Laura Mincarelli Luis N Sanchez Lisa Evers Jianmin Wu Mark Pinese Mark J Cowley Marc D Jones Emily K Colvin Adnan M Nagrial Emily S Humphrey Lorraine A Chantrill Amanda Mawson Jeremy Humphris Angela Chou Marina Pajic Christopher J Scarlett Andreia V Pinho Marc Giry-Laterriere Ilse Rooman Jaswinder S Samra James G Kench Jessica A Lovell Neil D Merrett Christopher W Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Kim Moran-Jones Nigel B Jamieson Janet S Graham Fraser Duthie Karin Oien Jane Hair Robert Grützmann Anirban Maitra Christine A Iacobuzio-Donahue Christopher L Wolfgang Richard A Morgan Rita T Lawlor Vincenzo Corbo Claudio Bassi Borislav Rusev Paola Capelli Roberto Salvia Giampaolo Tortora Debabrata Mukhopadhyay Gloria M Petersen Donna M Munzy William E Fisher Saadia A Karim James R Eshleman Ralph H Hruban Christian Pilarsky Jennifer P Morton Owen J Sansom Aldo Scarpa Elizabeth A Musgrove Ulla-Maja Hagbo Bailey Oliver Hofmann Robert L Sutherland David A Wheeler Anthony J Gill Richard A Gibbs John V Pearson Nicola Waddell Andrew V Biankin Sean M Grimmond

Nature 2016 Mar 24;531(7592):47-52. Epub 2016 Feb 24.

Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.

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http://dx.doi.org/10.1038/nature16965DOI Listing
March 2016

Microsatellite Instability as a Biomarker for PD-1 Blockade.

Clin Cancer Res 2016 Feb;22(4):813-20

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1678DOI Listing
February 2016

Advancements in the development of HIF-1α-activated protein switches for use in enzyme prodrug therapy.

PLoS One 2014 26;9(11):e114032. Epub 2014 Nov 26.

Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114032PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245239PMC
December 2015

Mutational profiling of colorectal cancers with microsatellite instability.

Oncotarget 2015 Dec;6(39):42334-44

Department of Pathology and The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.18632/oncotarget.5997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747229PMC
December 2015

A combination of molecular markers and clinical features improve the classification of pancreatic cysts.

Gastroenterology 2015 Nov 4;149(6):1501-10. Epub 2015 Aug 4.

The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, Maryland; Department of Surgery, The Johns Hopkins University, Baltimore, Maryland; Department of Medicine, The Johns Hopkins University, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.07.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782782PMC
November 2015

Performance characteristics of next-generation sequencing in clinical mutation detection of colorectal cancers.

Mod Pathol 2015 Oct 31;28(10):1390-9. Epub 2015 Jul 31.

Departments of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/modpathol.2015.86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618462PMC
October 2015

Clinical detection and categorization of uncommon and concomitant mutations involving BRAF.

BMC Cancer 2015 Oct 24;15:779. Epub 2015 Oct 24.

Departments of Pathology, Johns Hopkins University School of Medicine, Baltimore, USA.

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http://dx.doi.org/10.1186/s12885-015-1811-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619530PMC
October 2015

Transflip mutations produce deletions in pancreatic cancer.

Genes Chromosomes Cancer 2015 Aug 29;54(8):472-481. Epub 2015 May 29.

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, 21231.

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http://dx.doi.org/10.1002/gcc.22258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833645PMC
August 2015

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.

N Engl J Med 2015 Jun 30;372(26):2509-20. Epub 2015 May 30.

From the Swim Across America Laboratory (D.T.L., J.N.U., B.R.B., L.A.D.), Sidney Kimmel Comprehensive Cancer Center (D.T.L., J.N.U., H.W., H.K., A.D.E., A.D.S., B.S.L., N.S.A., D.L., B.B., R.C.D., D.M.P., N.P., K.W.K., S.Z., B.V., L.A.D.), Ludwig Center and Howard Hughes Medical Institute (B.R.B., A.D.S., N.P., K.W.K., S.Z., B.V., L.A.D.), and the Departments of Radiology (A.Z.) and Pathology (F.B., T.H., R.H.H., L.D.W., N.C., T.C.C., J.M.T., R.A.A., J.R.E.), Johns Hopkins University School of Medicine, Baltimore; Department of Medicine, Stanford University School of Medicine, Stanford, CA (G.A.F.); Providence Cancer Center at Providence Health and Services, Portland, OR (T.S.C.); Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh (J.J.L.); Bon Secours Cancer Institute, Richmond, VA (S.M.D.); Division of Medical Oncology, Ohio State University Comprehensive Cancer Center-James Cancer Center and Solove Research Institute, and Human Cancer Genetics Program, Ohio State University Comprehensive Cancer Center, Columbus (R.M.G., A.C.); and Merck, Kenilworth, NJ, and North Wales, PA (M.K.).

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http://dx.doi.org/10.1056/NEJMoa1500596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481136PMC
June 2015

KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound.

Clin Gastroenterol Hepatol 2015 May 4;13(5):963-9.e4. Epub 2014 Dec 4.

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland; Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland; Department of Medicine, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2014.11.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404180PMC
May 2015

Familial and sporadic pancreatic cancer share the same molecular pathogenesis.

Fam Cancer 2015 Mar;14(1):95-103

Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, Johns Hopkins University School of Medicine, Room 344, Cancer Research Building-II, 1550 Orleans Street, Baltimore, MD, 21231, USA.

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http://link.springer.com/content/pdf/10.1007/s10689-014-9755
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http://link.springer.com/10.1007/s10689-014-9755-y
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http://dx.doi.org/10.1007/s10689-014-9755-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357548PMC
March 2015

PD-L1 expression in melanocytic lesions does not correlate with the BRAF V600E mutation.

Cancer Immunol Res 2015 Feb 4;3(2):110-5. Epub 2014 Nov 4.

Department of Pathology, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland. Department of Dermatology, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, Baltimore, Maryland. Department of Oncology, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, Baltimore, Maryland.

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324161PMC
February 2015

Challenges posed to pathologists in the detection of KRAS mutations in colorectal cancers.

Arch Pathol Lab Med 2015 Feb;139(2):211-8

From the Departments of Pathology (Drs Dudley, Tseng, Rooper, Chen, Gocke, Eshleman and Lin, Mr Harris, and Ms Haley) and Oncology (Drs Gocke and Eshleman), Johns Hopkins University School of Medicine, Baltimore, Maryland; the Department of Pathology, Massachusetts General Hospital, Boston (Dr Dudley); and the Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan (Dr Tseng).

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http://dx.doi.org/10.5858/arpa.2013-0649-OADOI Listing
February 2015

Whole genomes redefine the mutational landscape of pancreatic cancer.

Nature 2015 Feb;518(7540):495-501

1] Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia [2] Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/nature14169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523082PMC
February 2015

Lymph node metastases of melanoma: challenges for BRAF mutation detection.

Hum Pathol 2015 Jan 7;46(1):113-9. Epub 2014 Oct 7.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287 USA. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2014.09.014DOI Listing
January 2015

Improved FLT3 internal tandem duplication PCR assay predicts outcome after allogeneic transplant for acute myeloid leukemia.

Biol Blood Marrow Transplant 2014 Dec 23;20(12):1989-95. Epub 2014 Aug 23.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10838791140053
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http://dx.doi.org/10.1016/j.bbmt.2014.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253693PMC
December 2014

Cytosine deamination is a major cause of baseline noise in next-generation sequencing.

Mol Diagn Ther 2014 Oct;18(5):587-93

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Suite 344, CRB-II, 1550 Orleans Street, Baltimore, MD, 21231, USA.

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http://dx.doi.org/10.1007/s40291-014-0115-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175022PMC
October 2014

False positives in multiplex PCR-based next-generation sequencing have unique signatures.

J Mol Diagn 2014 Sep 11;16(5):541-549. Epub 2014 Jul 11.

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2014.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188281PMC
September 2014

Haplotype counting by next-generation sequencing for ultrasensitive human DNA detection.

J Mol Diagn 2014 Sep;16(5):495-503

Department of Pathology, Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, Maryland; Department of Oncology, Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15251578140009
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http://dx.doi.org/10.1016/j.jmoldx.2014.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691345PMC
September 2014

Tumor cellularity as a quality assurance measure for accurate clinical detection of BRAF mutations in melanoma.

Mol Diagn Ther 2014 Aug;18(4):409-18

Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Park SB202, 600 North Wolfe St., Baltimore, MD, 21287, USA.

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http://dx.doi.org/10.1007/s40291-014-0091-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643460PMC
August 2014

Microsatellite instability confounds engraftment analysis of hematopoietic stem-cell transplantation.

Appl Immunohistochem Mol Morphol 2014 Jul;22(6):416-20

Departments of *Pathology ‡Oncology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD †Department of Medical Genetics and Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1097/PDM.0000000000000029DOI Listing
July 2014

BRAF pyrosequencing analysis aided by a lookup table.

Am J Clin Pathol 2014 May;141(5):639-47

The Sol Goldman Pancreatic Cancer Research Center, Professor of Pathology and Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231;

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http://dx.doi.org/10.1309/AJCPVWH1K2ZIHHTVDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643461PMC
May 2014

DNA mismatch repair defects and microsatellite instability status in periocular sebaceous carcinoma.

Am J Ophthalmol 2014 Mar 7;157(3):640-7.e1-2. Epub 2013 Dec 7.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Ophthalmology, Johns Hopkins University School of Medicine Wilmer Eye Institute, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.ajo.2013.12.002DOI Listing
March 2014

Fundamentals of pyrosequencing.

Arch Pathol Lab Med 2013 Sep;137(9):1296-303

Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.5858/arpa.2012-0463-RADOI Listing
September 2013

Detection of minor clones with internal tandem duplication mutations of FLT3 gene in acute myeloid leukemia using delta-PCR.

Diagn Mol Pathol 2013 Mar;22(1):1-9

Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1097/PDM.0b013e31825d81f4DOI Listing
March 2013

Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity.

Clin Cancer Res 2012 Dec 2;18(23):6519-30. Epub 2012 Jul 2.

Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513499PMC
December 2012

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.

Authors:
Andrew V Biankin Nicola Waddell Karin S Kassahn Marie-Claude Gingras Lakshmi B Muthuswamy Amber L Johns David K Miller Peter J Wilson Ann-Marie Patch Jianmin Wu David K Chang Mark J Cowley Brooke B Gardiner Sarah Song Ivon Harliwong Senel Idrisoglu Craig Nourse Ehsan Nourbakhsh Suzanne Manning Shivangi Wani Milena Gongora Marina Pajic Christopher J Scarlett Anthony J Gill Andreia V Pinho Ilse Rooman Matthew Anderson Oliver Holmes Conrad Leonard Darrin Taylor Scott Wood Qinying Xu Katia Nones J Lynn Fink Angelika Christ Tim Bruxner Nicole Cloonan Gabriel Kolle Felicity Newell Mark Pinese R Scott Mead Jeremy L Humphris Warren Kaplan Marc D Jones Emily K Colvin Adnan M Nagrial Emily S Humphrey Angela Chou Venessa T Chin Lorraine A Chantrill Amanda Mawson Jaswinder S Samra James G Kench Jessica A Lovell Roger J Daly Neil D Merrett Christopher Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Nipun Kakkar Fengmei Zhao Yuan Qing Wu Min Wang Donna M Muzny William E Fisher F Charles Brunicardi Sally E Hodges Jeffrey G Reid Jennifer Drummond Kyle Chang Yi Han Lora R Lewis Huyen Dinh Christian J Buhay Timothy Beck Lee Timms Michelle Sam Kimberly Begley Andrew Brown Deepa Pai Ami Panchal Nicholas Buchner Richard De Borja Robert E Denroche Christina K Yung Stefano Serra Nicole Onetto Debabrata Mukhopadhyay Ming-Sound Tsao Patricia A Shaw Gloria M Petersen Steven Gallinger Ralph H Hruban Anirban Maitra Christine A Iacobuzio-Donahue Richard D Schulick Christopher L Wolfgang Richard A Morgan Rita T Lawlor Paola Capelli Vincenzo Corbo Maria Scardoni Giampaolo Tortora Margaret A Tempero Karen M Mann Nancy A Jenkins Pedro A Perez-Mancera David J Adams David A Largaespada Lodewyk F A Wessels Alistair G Rust Lincoln D Stein David A Tuveson Neal G Copeland Elizabeth A Musgrove Aldo Scarpa James R Eshleman Thomas J Hudson Robert L Sutherland David A Wheeler John V Pearson John D McPherson Richard A Gibbs Sean M Grimmond

Nature 2012 Nov 24;491(7424):399-405. Epub 2012 Oct 24.

The Kinghorn Cancer Centre, 370 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.

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http://dx.doi.org/10.1038/nature11547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530898PMC
November 2012

GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct.

HPB (Oxford) 2012 Oct 18;14(10):677-83. Epub 2012 Jun 18.

Departments of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1111/j.1477-2574.2012.00504.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461374PMC
October 2012

A protein therapeutic modality founded on molecular regulation.

Proc Natl Acad Sci U S A 2011 Sep 19;108(39):16206-11. Epub 2011 Sep 19.

Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1073/pnas.1102803108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182702PMC
September 2011

Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias.

Mod Pathol 2011 Feb 24;24(2):256-66. Epub 2010 Sep 24.

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1038/modpathol.2010.181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166222PMC
February 2011

Mutant proteins as cancer-specific biomarkers.

Proc Natl Acad Sci U S A 2011 Feb 19;108(6):2444-9. Epub 2011 Jan 19.

Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD21231, USA.

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http://dx.doi.org/10.1073/pnas.1019203108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038743PMC
February 2011

Δ-PCR, A Simple Method to Detect Translocations and Insertion/Deletion Mutations.

J Mol Diagn 2011 Jan 23;13(1):85-92. Epub 2010 Dec 23.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/j.jmoldx.2010.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069866PMC
January 2011

Comparison of Sanger sequencing, pyrosequencing, and melting curve analysis for the detection of KRAS mutations: diagnostic and clinical implications.

J Mol Diagn 2010 Jul 29;12(4):425-32. Epub 2010 Apr 29.

The Johns Hopkins Medical Institutions, Department of Pathology, 600 N. Wolfe Street, Park SB202, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.2353/jmoldx.2010.090188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893626PMC
July 2010

International network of cancer genome projects.

Authors:
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Tatsuhiro Shibata Marc van de Vijver P Andrew Futreal Hiroyuki Aburatani Mónica Bayés David D L Botwell Peter J Campbell Xavier Estivill Daniela S Gerhard Sean M Grimmond Ivo Gut Martin Hirst Carlos López-Otín Partha Majumder Marco Marra John D McPherson Hidewaki Nakagawa Zemin Ning Xose S Puente Yijun Ruan Tatsuhiro Shibata Michael R Stratton Hendrik G Stunnenberg Harold Swerdlow Victor E Velculescu Richard K Wilson Hong H Xue Liu Yang Paul T Spellman Gary D Bader Paul C Boutros Peter J Campbell Paul Flicek Gad Getz Roderic Guigó Guangwu Guo David Haussler Simon Heath Tim J Hubbard Tao Jiang Steven M Jones Qibin Li Nuria López-Bigas Ruibang Luo Lakshmi Muthuswamy B F Francis Ouellette John V Pearson Xose S Puente Victor Quesada Benjamin J Raphael Chris Sander Tatsuhiro Shibata Terence P Speed Lincoln D Stein Joshua M Stuart Jon W Teague Yasushi Totoki Tatsuhiko Tsunoda Alfonso Valencia David A Wheeler Honglong Wu Shancen Zhao Guangyu Zhou Lincoln D Stein Roderic Guigó Tim J Hubbard 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Nature 2010 Apr;464(7291):993-8

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http://dx.doi.org/10.1038/nature08987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902243PMC
April 2010