James R Downing

James R Downing

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James R Downing

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A six-gene leukemic stem cell score identifies high risk pediatric acute myeloid leukemia.

Leukemia 2019 Oct 23. Epub 2019 Oct 23.

Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.1038/s41375-019-0604-8DOI Listing
October 2019

Structure and evolution of double minutes in diagnosis and relapse brain tumors.

Acta Neuropathol 2019 01 28;137(1):123-137. Epub 2018 Sep 28.

Department of Computational Biology, St. Jude Children's Research Hospital, MS1135, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s00401-018-1912-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338707PMC
January 2019

Genome-wide association analysis identifies SNPs predictive of leukemic cell sensitivity to cytarabine in pediatric AML.

Oncotarget 2018 Oct 9;9(79):34859-34875. Epub 2018 Oct 9.

Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.18632/oncotarget.26163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201857PMC
October 2018

Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses.

Cancer Cell 2018 09 23;34(3):411-426.e19. Epub 2018 Aug 23.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 323, Memphis, TN 38105-3678, USA; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38105, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158019PMC
September 2018

POST: A framework for set-based association analysis in high-dimensional data.

Methods 2018 08 17;145:76-81. Epub 2018 May 17.

Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2018.05.011DOI Listing
August 2018

Genetic Risk for Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer.

J Clin Oncol 2018 07 30;36(20):2078-2087. Epub 2018 May 30.

Zhaoming Wang, Carmen L. Wilson, John Easton, Andrew Thrasher, Heather Mulder, Dale J. Hedges, Shuoguo Wang, Michael C. Rusch, Michael N. Edmonson, Jennifer Q. Lanctot, Eric Caron, Kyla Shelton, Kelsey Currie, Matthew Lear, Aman Patel, Celeste Rosencrance, Ying Shao, Bhavin Vadodaria, Donald Yergeau, Yadav Sapkota, Russell J. Brooke, Wonjong Moon, Evadnie Rampersaud, Xiaotu Ma, Ti-Cheng Chang, Stephen V. Rice, Cynthia Pepper, Xin Zhou, Xiang Chen, Wenan Chen, Matthew J. Ehrhardt, Matthew J. Krasin, Rebecca M. Howell, Nicholas S. Phillips, Courtney Lewis, Deokumar Srivastava, Ching-Hon Pui, Chimene A. Kesserwan, Gang Wu, Kim E. Nichols, James R. Downing, Melissa M. Hudson, Yutaka Yasui, Leslie L. Robison, and Jinghui Zhang, St Jude Children's Research Hospital, Memphis, TN; Qi Liu, University of Alberta, Edmonton, Alberta, Canada; Shawn Levy, Angela Jones, and Braden Boone, HudsonAlpha Institute for Biotechnology, Huntsville, AL; and Rebecca M. Howell, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://ascopubs.org/doi/10.1200/JCO.2018.77.8589
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http://dx.doi.org/10.1200/JCO.2018.77.8589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036620PMC
July 2018

Clear cell sarcoma of kidney involving a horseshoe kidney and harboring EGFR internal tandem duplication.

Pediatr Blood Cancer 2017 Nov 25;64(11). Epub 2017 Apr 25.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.26602DOI Listing
November 2017

The neoepitope landscape in pediatric cancers.

Genome Med 2017 08 31;9(1):78. Epub 2017 Aug 31.

Department of Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee, 38105, USA.

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http://dx.doi.org/10.1186/s13073-017-0468-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577668PMC
August 2017

The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis.

Neuron 2017 May;94(3):550-568.e10

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508517PMC
May 2017

Redefining "rare" in paediatric cancers.

Lancet Oncol 2016 Feb;17(2):138-139

Departments of Pathology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/S1470-2045(15)00538-0DOI Listing
February 2016

Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms.

Blood 2015 Dec 13;126(26):2899-901. Epub 2015 Nov 13.

Department of Medicine, Comprehensive Cancer Center, University of Chicago, Chicago, IL.

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http://dx.doi.org/10.1182/blood-2015-10-673228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692148PMC
December 2015

Germline Mutations in Predisposition Genes in Pediatric Cancer.

N Engl J Med 2015 Dec 18;373(24):2336-2346. Epub 2015 Nov 18.

Departments of Computational Biology (J.Z., G.W., M.N.E., D.H., X.M., X.Z., M.R.W., X.C., M.R., A.P., J.B.B., S.W.), Oncology (M.F.W., T.A.G., R.B.M., S.H.-D., R.N., E.Q., A.G., A.S.P., C.-H.P., K.E.N.), and Pathology (T.A.G., M.R.W., S.A.S., D.W.E., C.-H.P., J.R.D.) and the Pediatric Cancer Genome Project (J.Z., M.F.W., G.W., M.N.E., T.A.G., J.E., X.M., D.A.Y., B.V., X.C., R.B.M., S.H.-D., R.N., E.Q., S.A.S., M.R., A.P., J.B.B., S.W., M.S.W., A.G., D.W.E., A.S.P., C.-H.P., K.E.N., J.R.D.), St. Jude Children's Research Hospital, Memphis, TN; and the Department of Genetics and McDonnell Genome Institute, Washington University School of Medicine in St. Louis, St. Louis (L.D., E.R.M., R.K.W.).

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http://dx.doi.org/10.1056/NEJMoa1508054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734119PMC
December 2015

Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.

J Clin Oncol 2015 Sep 24;33(27):2938-48. Epub 2015 Aug 24.

Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig-Holstein, Christian-Albrechts-University, Kiel; Gabriele Escherich, Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany; Andrea Biondi, Clinica Pediatrica and Centro Ricerca Tettamanti, Università di Milano-Bicocca, Monza, Italy; Ajay Vora, Children's Cancer Group, School of Cancer, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom; André Baruchel, Hôpital Robert Debré and University of Paris Diderot, Paris, France; Lewis B. Silverman, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA; Kjeld Schmiegelow, Institute of Clinical Medicine, University of Copenhagen and Juliane Marie Centre, the University Hospital Rigshospitalet, Copenhagen, Denmark; Keizo Horibe, Nagoya Medical Center, Clinical Research Center, Nagoya, Japan; Yves C.M. Benoit, Universiteit Gent, Gent, Belgium; Shai Izraeli, Chaim Sheba Medical Center and Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; Allen Eng Juh Yeoh, Yong Loo Lin School of Medicine and Cancer Science Institute, National University of Singapore, and Viva-University Children's Cancer Centre, National University Hospital, Singapore; and Der-Cherng Liang, Mackay Memorial Hospital, Taipei, Taiwan.

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http://jco.ascopubs.org/content/early/2015/08/21/JCO.2014.59
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http://200.40.135.66:90/toc/0873/2015/0873-20150920-27-01.pd
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.59.1636
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http://dx.doi.org/10.1200/JCO.2014.59.1636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567699PMC
September 2015

The biology of pediatric acute megakaryoblastic leukemia.

Blood 2015 Aug 17;126(8):943-9. Epub 2015 Jul 17.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1182/blood-2015-05-567859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551356PMC
August 2015

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis.

Cell 2015 Jul 18;162(1):184-97. Epub 2015 Jun 18.

Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.05.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508757PMC
July 2015

CONSERTING: integrating copy-number analysis with structural-variation detection.

Nat Methods 2015 Jun 4;12(6):527-30. Epub 2015 May 4.

1] Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. [2] Pediatric Cancer Genome Project, St. Jude Children's Research Hospital and Washington University School of Medicine, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nmeth.3394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591043PMC
June 2015

Genome-wide single-nucleotide polymorphism analysis revealed SUFU suppression of acute graft-versus-host disease through downregulation of HLA-DR expression in recipient dendritic cells.

Sci Rep 2015 Jun 11;5:11098. Epub 2015 Jun 11.

1] Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN [2] Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/srep11098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464079PMC
June 2015

Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia.

PLoS Genet 2015 Jun 23;11(6):e1005262. Epub 2015 Jun 23.

Department of Medicine, Memorial Sloan Kettering Cancer Center (MSKCC), New York, New York, United States of America; Cancer Biology and Genetics Program, Sloan Kettering Institute, New York, New York, United States of America; Weill Cornell Medical College, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477877PMC
June 2015

Utility of early screening magnetic resonance imaging for extensive hip osteonecrosis in pediatric patients treated with glucocorticoids.

J Clin Oncol 2015 Feb 20;33(6):610-5. Epub 2015 Jan 20.

Sue C. Kaste, Deqing Pei, Cheng Cheng, Michael D. Neel, Raul C. Ribeiro, Monika L. Metzger, Deepa Bhojwani, Hiroto Inaba, Patrick Campbell, Jeffrey E. Rubnitz, Sima Jeha, John T. Sandlund, James R. Downing, Mary V. Relling, Ching-Hon Pui, and Scott C. Howard, St Jude Children's Research Hospital; Sue C. Kaste, University of Tennessee Health Sciences Center, Memphis, TN; and W. Paul Bowman, Cook Children's Medical Center, Fort Worth, TX.

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http://dx.doi.org/10.1200/JCO.2014.57.5480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322260PMC
February 2015

Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.

Nature 2014 Sep 20;513(7519):512-6. Epub 2014 Jul 20.

Department of Pediatrics and Benniof Children's Hospital, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nature13495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213126PMC
September 2014

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

N Engl J Med 2014 Sep;371(11):1005-15

From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children's Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) - all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children's Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) - all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) - all in Texas; Maine Children's Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein

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http://dx.doi.org/10.1056/NEJMoa1403088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900PMC
September 2014

Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice.

Blood 2014 Jun 25;123(24):3760-9. Epub 2014 Apr 25.

Moores University California San Diego Cancer Center, Biomedical Science Graduate Program, and Division of Biological Sciences, University of California San Diego, La Jolla, CA; Department of Pathology, University of California San Diego, La Jolla, CA.

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http://dx.doi.org/10.1182/blood-2013-08-521252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055923PMC
June 2014

PTEN action in leukaemia dictated by the tissue microenvironment.

Nature 2014 Jun 4;510(7505):402-6. Epub 2014 May 4.

1] Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA [2] Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA [3] Howard Hughes Medical Institute, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature13239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165899PMC
June 2014

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

N Engl J Med 2013 05 1;368(22):2059-74. Epub 2013 May 1.

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http://dx.doi.org/10.1056/NEJMoa1301689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767041PMC
May 2013

The Pediatric Cancer Genome Project.

Nat Genet 2012 May 29;44(6):619-22. Epub 2012 May 29.

St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/ng.2287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619412PMC
May 2012

A new FOXO pathway required for leukemogenesis.

Authors:
James R Downing

Cell 2011 Sep;146(5):669-70

Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.cell.2011.08.019DOI Listing
September 2011

Genomics and the continuum of cancer care.

N Engl J Med 2011 Jan;364(4):340-50

Wellcome Trust Sanger Institute,Hinxton, Cambridge, United Kingdom.

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http://www.nejm.org/doi/10.1056/NEJMra0907178
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http://dx.doi.org/10.1056/NEJMra0907178DOI Listing
January 2011