Publications by authors named "James Palacino"

19Publications

Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators.

Authors:
Daniel Aird Teng Teng Chia-Ling Huang Ermira Pazolli Deepti Banka Kahlin Cheung-Ong Cheryl Eifert Craig Furman Zhenhua Jeremy Wu Michael Seiler Silvia Buonamici Peter Fekkes Craig Karr James Palacino Eunice Park Peter G Smith Lihua Yu Yoshiharu Mizui Markus Warmuth Agustin Chicas Laura Corson Ping Zhu

Nat Commun 2019 01 11;10(1):137. Epub 2019 Jan 11.

H3 Biomedicine, Inc., 300 Technology Square, Cambridge, MA, 02139, USA.

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January 2019

The splice is right.

Authors:
James Palacino

Nat Chem Biol 2018 12;14(12):1068-1069

Target Discovery, H3 Biomedicine, Cambridge, MA, USA.

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December 2018

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.

Authors:
Stanley Chun-Wei Lee Khrystyna North Eunhee Kim Eunjung Jang Esther Obeng Sydney X Lu Bo Liu Daichi Inoue Akihide Yoshimi Michelle Ki Mirae Yeo Xiao Jing Zhang Min Kyung Kim Hana Cho Young Rock Chung Justin Taylor Benjamin H Durham Young Joon Kim Alessandro Pastore Sebastien Monette James Palacino Michael Seiler Silvia Buonamici Peter G Smith Benjamin L Ebert Robert K Bradley Omar Abdel-Wahab

Cancer Cell 2018 08;34(2):225-241.e8

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, Zuckerman 701, 408 East 69(th) Street, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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August 2018

High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration.

Authors:
Ismael Al-Ramahi Boxun Lu Simone Di Paola Kaifang Pang Maria de Haro Ivana Peluso Tatiana Gallego-Flores Nazish T Malik Kelly Erikson Benjamin A Bleiberg Matthew Avalos George Fan Laura Elizabeth Rivers Andrew M Laitman Javier R Diaz-García Marc Hild James Palacino Zhandong Liu Diego L Medina Juan Botas

Cell Syst 2018 07 20;7(1):28-40.e4. Epub 2018 Jun 20.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:

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July 2018

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types.

Authors:
Michael Seiler Shouyong Peng Anant A Agrawal James Palacino Teng Teng Ping Zhu Peter G Smith Silvia Buonamici Lihua Yu

Cell Rep 2018 04;23(1):282-296.e4

H3 Biomedicine, Inc., 300 Technology Square, Cambridge, MA 02139, USA. Electronic address:

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April 2018

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.

Authors:
Teng Teng Jennifer Hc Tsai Xiaoling Puyang Michael Seiler Shouyong Peng Sudeep Prajapati Daniel Aird Silvia Buonamici Benjamin Caleb Betty Chan Laura Corson Jacob Feala Peter Fekkes Baudouin Gerard Craig Karr Manav Korpal Xiang Liu Jason T Lowe Yoshiharu Mizui James Palacino Eunice Park Peter G Smith Vanitha Subramanian Zhenhua Jeremy Wu Jian Zou Lihua Yu Agustin Chicas Markus Warmuth Nicholas Larsen Ping Zhu

Nat Commun 2017 05 25;8:15522. Epub 2017 May 25.

H3 Biomedicine Inc., 300 Technology Sq, 5th Floor, Cambridge, Massachusetts 02139, USA.

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May 2017

Erratum: Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.

Authors:
Stanley Chun-Wei Lee Heidi Dvinge Eunhee Kim Hana Cho Jean-Baptiste Micol Young Rock Chung Benjamin H Durham Akihide Yoshimi Young Joon Kim Michael Thomas Camille Lobry Chun-Wei Chen Alessandro Pastore Justin Taylor Xujun Wang Andrei Krivtsov Scott A Armstrong James Palacino Silvia Buonamici Peter G Smith Robert K Bradley Omar Abdel-Wahab

Nat Med 2016 06;22(6):692

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June 2016

Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.

Authors:
Stanley Chun-Wei Lee Heidi Dvinge Eunhee Kim Hana Cho Jean-Baptiste Micol Young Rock Chung Benjamin H Durham Akihide Yoshimi Young Joon Kim Michael Thomas Camille Lobry Chun-Wei Chen Alessandro Pastore Justin Taylor Xujun Wang Andrei Krivtsov Scott A Armstrong James Palacino Silvia Buonamici Peter G Smith Robert K Bradley Omar Abdel-Wahab

Nat Med 2016 06 2;22(6):672-8. Epub 2016 May 2.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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June 2016

Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.

Authors:
James Palacino Susanne E Swalley Cheng Song Atwood K Cheung Lei Shu Xiaolu Zhang Mailin Van Hoosear Youngah Shin Donovan N Chin Caroline Gubser Keller Martin Beibel Nicole A Renaud Thomas M Smith Michael Salcius Xiaoying Shi Marc Hild Rebecca Servais Monish Jain Lin Deng Caroline Bullock Michael McLellan Sven Schuierer Leo Murphy Marcel J J Blommers Cecile Blaustein Frada Berenshteyn Arnaud Lacoste Jason R Thomas Guglielmo Roma Gregory A Michaud Brian S Tseng Jeffery A Porter Vic E Myer John A Tallarico Lawrence G Hamann Daniel Curtis Mark C Fishman William F Dietrich Natalie A Dales Rajeev Sivasankaran

Nat Chem Biol 2016 Apr;12(4):304

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April 2016

Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.

Authors:
James Palacino Susanne E Swalley Cheng Song Atwood K Cheung Lei Shu Xiaolu Zhang Mailin Van Hoosear Youngah Shin Donovan N Chin Caroline Gubser Keller Martin Beibel Nicole A Renaud Thomas M Smith Michael Salcius Xiaoying Shi Marc Hild Rebecca Servais Monish Jain Lin Deng Caroline Bullock Michael McLellan Sven Schuierer Leo Murphy Marcel J J Blommers Cecile Blaustein Frada Berenshteyn Arnaud Lacoste Jason R Thomas Guglielmo Roma Gregory A Michaud Brian S Tseng Jeffery A Porter Vic E Myer John A Tallarico Lawrence G Hamann Daniel Curtis Mark C Fishman William F Dietrich Natalie A Dales Rajeev Sivasankaran

Nat Chem Biol 2015 Sep;11(9):741

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September 2015

SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.

Authors:
James Palacino Susanne E Swalley Cheng Song Atwood K Cheung Lei Shu Xiaolu Zhang Mailin Van Hoosear Youngah Shin Donovan N Chin Caroline Gubser Keller Martin Beibel Nicole A Renaud Thomas M Smith Michael Salcius Xiaoying Shi Marc Hild Rebecca Servais Monish Jain Lin Deng Caroline Bullock Michael McLellan Sven Schuierer Leo Murphy Marcel J J Blommers Cecile Blaustein Frada Berenshteyn Arnaud Lacoste Jason R Thomas Guglielmo Roma Gregory A Michaud Brian S Tseng Jeffery A Porter Vic E Myer John A Tallarico Lawrence G Hamann Daniel Curtis Mark C Fishman William F Dietrich Natalie A Dales Rajeev Sivasankaran

Nat Chem Biol 2015 Jul 1;11(7):511-7. Epub 2015 Jun 1.

Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.

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July 2015

A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.

Authors:
Yuwei Yao Xiaotian Cui Ismael Al-Ramahi Xiaoli Sun Bo Li Jiapeng Hou Marian Difiglia James Palacino Zhi-Ying Wu Lixiang Ma Juan Botas Boxun Lu

Elife 2015 Mar 4;4. Epub 2015 Mar 4.

State Key Laboratory of Genetic Engineering, Department of Biophysics, School of Life Sciences, Fudan University, Shanghai, China.

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March 2015

Drugging unconventional targets: insights from Huntington's disease.

Authors:
Shenliang Yu Yijian Liang James Palacino Marian Difiglia Boxun Lu

Trends Pharmacol Sci 2014 Feb 2;35(2):53-62. Epub 2014 Jan 2.

State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China; Mass General Institute for Neurodegenerative Disease, Charlestown, MA, USA. Electronic address:

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February 2014

Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance.

Authors:
Boxun Lu Ismael Al-Ramahi Antonio Valencia Qiong Wang Frada Berenshteyn Haidi Yang Tatiana Gallego-Flores Salah Ichcho Arnaud Lacoste Marc Hild Marian Difiglia Juan Botas James Palacino

Nat Neurosci 2013 May 24;16(5):562-70. Epub 2013 Mar 24.

School of Life Sciences, Fudan University, Shanghai, China.

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May 2013

A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration.

Authors:
Boxun Lu James Palacino

FASEB J 2013 May 16;27(5):1820-9. Epub 2013 Jan 16.

School of Life Sciences, Fudan University, Shanghai, China.

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May 2013

Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors.

Authors:
Kimberly B Kegel Ellen Sapp Jonathan Alexander Patrick Reeves Dorothee Bleckmann Linsday Sobin Nicholas Masso Antonio Valencia Hyunkyung Jeong Dimitri Krainc James Palacino Daniel Curtis Rainer Kuhn Claudia Betschart Miguel Sena-Esteves Neil Aronin Paolo Paganetti Marian Difiglia

Mol Neurodegener 2010 Dec 14;5:58. Epub 2010 Dec 14.

Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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December 2010

Intrinsic resistance of neural stem cells to toxic metabolites may make them well suited for cell non-autonomous disorders: evidence from a mouse model of Krabbe leukodystrophy.

Authors:
Roseanne M Taylor Jean Pyo Lee James J Palacino Kate A Bower Jianxue Li Marie T Vanier David A Wenger Richard L Sidman Evan Y Snyder

J Neurochem 2006 Jun;97(6):1585-99

Department of Animal Science, Faculty of Veterinary Science, University of Sydney and New South Wales, Australia.

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June 2006

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice.

Authors:
James J Palacino Dijana Sagi Matthew S Goldberg Stefan Krauss Claudia Motz Maik Wacker Joachim Klose Jie Shen

J Biol Chem 2004 Apr 24;279(18):18614-22. Epub 2004 Feb 24.

Center for Neurologic Diseases, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA.

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April 2004

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons.

Authors:
Matthew S Goldberg Sheila M Fleming James J Palacino Carlos Cepeda Hoa A Lam Anushree Bhatnagar Edward G Meloni Nanping Wu Larry C Ackerson Gloria J Klapstein Mahadevan Gajendiran Bryan L Roth Marie-Francoise Chesselet Nigel T Maidment Michael S Levine Jie Shen

J Biol Chem 2003 Oct 20;278(44):43628-35. Epub 2003 Aug 20.

Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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October 2003