James P Allison

James P Allison

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James P Allison

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Immunologic Correlates of Pathologic Complete Response to Preoperative Immunotherapy in Hepatocellular Carcinoma.

Cancer Immunol Res 2019 Sep 9;7(9):1390-1395. Epub 2019 Jul 9.

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0605DOI Listing
September 2019

Blockade of CTLA-4 and PD-1 Enhances Adoptive T-cell Therapy Efficacy in an ICOS-Mediated Manner.

Cancer Immunol Res 2019 Aug 29. Epub 2019 Aug 29.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0873DOI Listing
August 2019

TLR1/2 ligand enhances antitumor efficacy of CTLA-4 blockade by increasing intratumoral Treg depletion.

Proc Natl Acad Sci U S A 2019 May 10;116(21):10453-10462. Epub 2019 May 10.

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1819004116
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http://dx.doi.org/10.1073/pnas.1819004116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534983PMC
May 2019

Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States.

Immunity 2019 04 26;50(4):1084-1098.e10. Epub 2019 Mar 26.

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Parker Institute for Cancer Immunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193009
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http://dx.doi.org/10.1016/j.immuni.2019.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664799PMC
April 2019

Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3 Regulatory T Cells (Tregs) in Human Cancers.

Clin Cancer Res 2019 Feb 27;25(4):1233-1238. Epub 2018 Jul 27.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-0762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348141PMC
February 2019

Mechanisms of Resistance to Immune Checkpoint Blockade: Why Does Checkpoint Inhibitor Immunotherapy Not Work for All Patients?

Am Soc Clin Oncol Educ Book 2019 Jan 17;39:147-164. Epub 2019 May 17.

5 Division of Hematology and Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT.

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http://dx.doi.org/10.1200/EDBK_240837DOI Listing
January 2019

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy.

Cancer Discov 2018 09 16;8(9):1069-1086. Epub 2018 Aug 16.

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-18-0367DOI Listing
September 2018

Modulation of EZH2 expression in T cells improves efficacy of anti-CTLA-4 therapy.

J Clin Invest 2018 08 30;128(9):3813-3818. Epub 2018 Jul 30.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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https://www.jci.org/articles/view/99760
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http://dx.doi.org/10.1172/JCI99760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118570PMC
August 2018

Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade.

Cell 2017 Sep 10;170(6):1120-1133.e17. Epub 2017 Aug 10.

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Parker Institute for Cancer Immunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591072PMC
September 2017

Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer.

Nat Commun 2017 04 27;8:15095. Epub 2017 Apr 27.

Department of Cancer Biology, Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/ncomms15095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414182PMC
April 2017

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy.

Cell 2016 Oct 22;167(2):397-404.e9. Epub 2016 Sep 22.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088716PMC
http://dx.doi.org/10.1016/j.cell.2016.08.069DOI Listing
October 2016

Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities.

Proc Natl Acad Sci U S A 2016 10 3;113(42):11919-11924. Epub 2016 Oct 3.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030

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http://dx.doi.org/10.1073/pnas.1611421113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081579PMC
October 2016

Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner.

Cell Rep 2015 Oct 24;13(2):412-24. Epub 2015 Sep 24.

Swim Across America/Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Programs, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.08.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013825PMC
October 2015

Immune Checkpoint Blockade in Cancer Therapy: The 2015 Lasker-DeBakey Clinical Medical Research Award.

Authors:
James P Allison

JAMA 2015 Sep;314(11):1113-4

Department of Immunology and Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1001/jama.2015.11929DOI Listing
September 2015

Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine.

Proc Natl Acad Sci U S A 2015 Sep 8;112(38):E5290-9. Epub 2015 Sep 8.

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030

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http://dx.doi.org/10.1073/pnas.1514418112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586868PMC
September 2015

Checkpoints.

Authors:
James P Allison

Cell 2015 Sep;162(6):1202-5

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https://linkinghub.elsevier.com/retrieve/pii/S00928674150109
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http://dx.doi.org/10.1016/j.cell.2015.08.047DOI Listing
September 2015

Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer.

Cancer Immunol Res 2015 Aug 29;3(8):849-54. Epub 2015 Jun 29.

Program in Immunology, Howard Hughes Medical Institute, and Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939565PMC
August 2015

The future of immune checkpoint therapy.

Science 2015 Apr;348(6230):56-61

Department of Immunology, M.D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1126/science.aaa8172DOI Listing
April 2015

Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential.

Cell 2015 Apr;161(2):205-14

Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905674PMC
April 2015

Friends not foes: CTLA-4 blockade and mTOR inhibition cooperate during CD8+ T cell priming to promote memory formation and metabolic readiness.

J Immunol 2015 Mar 26;194(5):2089-98. Epub 2015 Jan 26.

Department of Immunology, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065;

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http://dx.doi.org/10.4049/jimmunol.1402390DOI Listing
March 2015

Cytotoxic T lymphocyte antigen-4 blockade enhances antitumor immunity by stimulating melanoma-specific T-cell motility.

Cancer Immunol Res 2014 Oct 18;2(10):970-80. Epub 2014 Jul 18.

Department of Immunology, MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0104DOI Listing
October 2014

Immune modulation in cancer with antibodies.

Annu Rev Med 2014 30;65:185-202. Epub 2013 Oct 30.

Ludwig Center for Cancer Immunotherapy, Memorial Sloan-Kettering Cancer Center, New York, New York 10065; email: , , ,

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http://dx.doi.org/10.1146/annurev-med-092012-112807DOI Listing
September 2014

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.

Cancer Cell 2014 Jun 22;25(6):719-34. Epub 2014 May 22.

Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA; Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180632PMC
June 2014

Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy.

J Exp Med 2014 Apr 31;211(4):715-25. Epub 2014 Mar 31.

Department of Immunology and 2 Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.

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http://dx.doi.org/10.1084/jem.20130590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978270PMC
April 2014

Prostate cancer progression correlates with increased humoral immune response to a human endogenous retrovirus GAG protein.

Clin Cancer Res 2013 Nov 30;19(22):6112-25. Epub 2013 Sep 30.

Authors' Affiliations: Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center; Departments of Surgery, Medicine, Pathology, Biostatistics, and Immunology, Memorial Sloan-Kettering Cancer Center; NYU Langone Medical Center, New York; Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; RIKEN Bioresource Center, Tsukuba, Ibaraki, Japan; and Klinik für Onkologie und Hämatologie, Krankenhaus Nordwest, Frankfurt, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3580DOI Listing
November 2013

Enhancement of tumor-reactive cytotoxic CD4+ T cell responses after ipilimumab treatment in four advanced melanoma patients.

Cancer Immunol Res 2013 Oct;1(4):235-44

Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Cancer Center, New York, NY 10065 ; Department of Medicine, Sloan-Kettering Cancer Center, New York, NY 10065 ; Swim Across America Laboratory and Ludwig Institute for Cancer Research, Memorial, Sloan-Kettering Cancer Center, New York, NY 10065 ; Weill Cornell Medical College of Cornell University, New York, NY 10065.

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880021PMC
October 2013

Increased frequency of ICOS+ CD4 T cells as a pharmacodynamic biomarker for anti-CTLA-4 therapy.

Cancer Immunol Res 2013 Oct 31;1(4):229-34. Epub 2013 Jul 31.

Authors' Affiliations: Ludwig Center for Cancer Immunotherapy, Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636341PMC
October 2013

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4.

J Exp Med 2013 Jul 10;210(7):1389-402. Epub 2013 Jun 10.

Howard Hughes Medical Institute, Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.

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http://dx.doi.org/10.1084/jem.20130066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698523PMC
July 2013

An open invitation to the cancer immunology community.

Cancer Immun 2012 1;12. Epub 2012 May 1.

Center for Immunotherapy of Cancer and Infectious Diseases, Department of Immunology, University of Connecticut School of Medicine, Farmington, CT, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380353PMC
May 2013

Monoclonal antibodies in cancer therapy.

Cancer Immun 2012 1;12:14. Epub 2012 May 1.

Ludwig Institute for Cancer Research, Melbourne, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380347PMC
May 2013

Cutting edge: chronic inflammatory liver disease in mice expressing a CD28-specific ligand.

J Immunol 2013 Jan 17;190(2):526-30. Epub 2012 Dec 17.

Program in Immunology, Howard Hughes Medical Institute, and Ludwig Center for Cancer Immunotherapy, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.4049/jimmunol.1202621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964790PMC
January 2013

B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells.

J Immunol 2012 Oct 12;189(8):4165-74. Epub 2012 Sep 12.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.4049/jimmunol.1201241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466330PMC
October 2012

Cutting edge: CTLA-4 on effector T cells inhibits in trans.

J Immunol 2012 Aug 2;189(3):1123-7. Epub 2012 Jul 2.

Department of Immunology, Howard Hughes Medical Institute, and Ludwig Center for Cancer Immunotherapy, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.4049/jimmunol.1200695DOI Listing
August 2012

CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection.

Oncoimmunology 2012 Jul;1(4):544-546

Department of Immunology; Memorial Sloan-Kettering Cancer Center; Howard Hughes Medical Institute; New York, NY USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382897PMC
http://dx.doi.org/10.4161/onci.19442DOI Listing
July 2012

Response to "Ipilimumab (Yervoy) and the TGN1412 catastrophe".

Immunobiology 2012 Jun 17;217(6):590-2. Epub 2011 Nov 17.

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http://dx.doi.org/10.1016/j.imbio.2011.11.001DOI Listing
June 2012

Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model.

Proc Natl Acad Sci U S A 2012 Apr 2;109(16):6187-92. Epub 2012 Apr 2.

Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1203479109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341063PMC
April 2012

Expression of Helios in peripherally induced Foxp3+ regulatory T cells.

J Immunol 2012 Feb 23;188(3):976-80. Epub 2011 Dec 23.

Department of Immunology, Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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http://www.jimmunol.org/content/188/3/976.full.pdf
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1102964
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http://dx.doi.org/10.4049/jimmunol.1102964DOI Listing
February 2012

Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy.

Cancer Res 2012 Jan 22;72(2):430-9. Epub 2011 Nov 22.

Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526218PMC
January 2012

Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses.

Proc Natl Acad Sci U S A 2012 Jan 5;109(3):881-6. Epub 2012 Jan 5.

Department of Immunology, Howard Hughes Medical Institute, and Ludwig Center for Cancer Immunotherapy, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1119763109
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http://dx.doi.org/10.1073/pnas.1119763109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271915PMC
January 2012

Retrospective. Lloyd J. Old (1933-2011).

Science 2012 Jan;335(6064):49

Department of Genitourinary Medical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1126/science.1217940DOI Listing
January 2012

Defining the critical hurdles in cancer immunotherapy.

Authors:
Bernard A Fox Dolores J Schendel Lisa H Butterfield Steinar Aamdal James P Allison Paolo Antonio Ascierto Michael B Atkins Jirina Bartunkova Lothar Bergmann Neil Berinstein Cristina C Bonorino Ernest Borden Jonathan L Bramson Cedrik M Britten Xuetao Cao William E Carson Alfred E Chang Dainius Characiejus A Raja Choudhury George Coukos Tanja de Gruijl Robert O Dillman Harry Dolstra Glenn Dranoff Lindy G Durrant James H Finke Jerome Galon Jared A Gollob Cécile Gouttefangeas Fabio Grizzi Michele Guida Leif Håkansson Kristen Hege Ronald B Herberman F Stephen Hodi Axel Hoos Christoph Huber Patrick Hwu Kohzoh Imai Elizabeth M Jaffee Sylvia Janetzki Carl H June Pawel Kalinski Howard L Kaufman Koji Kawakami Yutaka Kawakami Ulrich Keilholtz Samir N Khleif Rolf Kiessling Beatrix Kotlan Guido Kroemer Rejean Lapointe Hyam I Levitsky Michael T Lotze Cristina Maccalli Michele Maio Jens-Peter Marschner Michael J Mastrangelo Giuseppe Masucci Ignacio Melero Cornelius Melief William J Murphy Brad Nelson Andrea Nicolini Michael I Nishimura Kunle Odunsi Pamela S Ohashi Jill O'Donnell-Tormey Lloyd J Old Christian Ottensmeier Michael Papamichail Giorgio Parmiani Graham Pawelec Enrico Proietti Shukui Qin Robert Rees Antoni Ribas Ruggero Ridolfi Gerd Ritter Licia Rivoltini Pedro J Romero Mohamed L Salem Rik J Scheper Barbara Seliger Padmanee Sharma Hiroshi Shiku Harpreet Singh-Jasuja Wenru Song Per Thor Straten Hideaki Tahara Zhigang Tian Sjoerd H van Der Burg Paul von Hoegen Ena Wang Marij Jp Welters Hauke Winter Tara Withington Jedd D Wolchok Weihua Xiao Laurence Zitvogel Heinz Zwierzina Francesco M Marincola Thomas F Gajewski Jon M Wigginton Mary L Disis

J Transl Med 2011 Dec 14;9:214. Epub 2011 Dec 14.

Earle A, Chiles Research Institute, Robert W, Franz Research Center, Providence Cancer Center, Providence Portland Medical Center, Portland, OR, USA.

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http://dx.doi.org/10.1186/1479-5876-9-214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338100PMC
December 2011

Nobels: Toll pioneers deserve recognition.

Nature 2011 Nov 9;479(7372):178. Epub 2011 Nov 9.

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http://dx.doi.org/10.1038/479178aDOI Listing
November 2011

Novel cancer immunotherapy agents with survival benefit: recent successes and next steps.

Nat Rev Cancer 2011 Oct 24;11(11):805-12. Epub 2011 Oct 24.

Department of Genitourinary Medical Oncology, University of Texas M D Anderson Cancer Center, Box 0018-7, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

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http://www.nature.com/articles/nrc3153
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http://dx.doi.org/10.1038/nrc3153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426440PMC
October 2011

Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity.

J Exp Med 2011 Aug 4;208(8):1683-94. Epub 2011 Jul 4.

Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1084/jem.20100639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149222PMC
August 2011

Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.

Immunol Rev 2011 May;241(1):104-18

Ludwig Center for Cancer Immunotherapy, Howard Hughes Medical Institute, Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2011.01007.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727276PMC
May 2011

Strength of TCR-peptide/MHC interactions and in vivo T cell responses.

J Immunol 2011 May;186(9):5039-45

Department of Immunology, Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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http://dx.doi.org/10.4049/jimmunol.1003650DOI Listing
May 2011

Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production.

PLoS One 2011 Apr 29;6(4):e19499. Epub 2011 Apr 29.

Howard Hughes Medical Institute, Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019499PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085474PMC
April 2011