James Naismith

James Naismith

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James Naismith

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Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria.

Nat Rev Microbiol 2020 Mar 2;18(3):164-176. Epub 2019 Dec 2.

UMR-MD1, U-1261, Aix-Marseille Université, INSERM, SSA, IRBA, MCT, Faculté de Pharmacie, Marseille, France.

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http://dx.doi.org/10.1038/s41579-019-0294-2DOI Listing
March 2020

The Biosynthesis of the Benzoxazole in Nataxazole Proceeds via an Unstable Ester and has Synthetic Utility.

Angew Chem Int Ed Engl 2020 Jan 5. Epub 2020 Jan 5.

Division of Structural Biology, Wellcome Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1002/anie.201915685DOI Listing
January 2020

Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations.

Nat Commun 2019 07 19;10(1):3214. Epub 2019 Jul 19.

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, 610064, Chengdu, China.

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http://dx.doi.org/10.1038/s41467-019-11154-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642264PMC
July 2019

Insights into the Mechanism of the Cyanobactin Heterocyclase Enzyme.

Biochemistry 2019 04 5;58(16):2125-2132. Epub 2019 Apr 5.

Research Complex at Harwell , Didcot, Oxon OX11 0FA , United Kingdom.

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http://dx.doi.org/10.1021/acs.biochem.9b00084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497369PMC
April 2019

Complexes formed by the siderophore-based monosulfactam antibiotic BAL30072 and their interaction with the outer membrane receptor PiuA of P. aeruginosa.

Biometals 2019 02 11;32(1):155-170. Epub 2019 Jan 11.

Department of Physics, University of Cagliari, Cittadella Universitaria di Monserrato, S.P. 8 km 0.700, 09042, Monserrato, CA, Italy.

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http://link.springer.com/10.1007/s10534-018-00166-0
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http://dx.doi.org/10.1007/s10534-018-00166-0DOI Listing
February 2019

Getting Drugs into Gram-Negative Bacteria: Rational Rules for Permeation through General Porins.

ACS Infect Dis 2018 10 17;4(10):1487-1498. Epub 2018 Aug 17.

Department of Physics , University of Cagliari, Cittadella Universitaria di Monserrato , SP Monserrato-Sestu Km 0.8 , Monserrato , 09042 , Italy.

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http://pubs.acs.org/doi/10.1021/acsinfecdis.8b00108
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http://dx.doi.org/10.1021/acsinfecdis.8b00108DOI Listing
October 2018

Oxidation of the Cyanobactin Precursor Peptide Is Independent of the Leader Peptide and Operates in a Defined Order.

Biochemistry 2018 10 28;57(41):5996-6002. Epub 2018 Sep 28.

Research Complex at Harwell , Didcot , Oxon OX11 0FA , U.K.

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http://pubs.acs.org/doi/10.1021/acs.biochem.8b00835
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http://dx.doi.org/10.1021/acs.biochem.8b00835DOI Listing
October 2018

A Key Role for the Periplasmic PfeE Esterase in Iron Acquisition via the Siderophore Enterobactin in Pseudomonas aeruginosa.

ACS Chem Biol 2018 09 22;13(9):2603-2614. Epub 2018 Aug 22.

Université de Strasbourg, UMR7242, ESBS , 300 Bld Sébastien Brant , F-67413 Illkirch, Strasbourg , France.

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http://dx.doi.org/10.1021/acschembio.8b00543DOI Listing
September 2018

TonB-Dependent Receptor Repertoire of Pseudomonas aeruginosa for Uptake of Siderophore-Drug Conjugates.

Antimicrob Agents Chemother 2018 06 25;62(6). Epub 2018 May 25.

Service of Infectious Diseases, University Hospital Geneva, Geneva, Switzerland

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http://dx.doi.org/10.1128/AAC.00097-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971595PMC
June 2018

Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC.

Philos Trans R Soc Lond B Biol Sci 2018 06;373(1748)

Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK

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http://dx.doi.org/10.1098/rstb.2017.0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915712PMC
June 2018

Periplasmic depolymerase provides insight into ABC transporter-dependent secretion of bacterial capsular polysaccharides.

Proc Natl Acad Sci U S A 2018 05 7;115(21):E4870-E4879. Epub 2018 May 7.

Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada;

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http://dx.doi.org/10.1073/pnas.1801336115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003464PMC
May 2018

Characterization of the Fast and Promiscuous Macrocyclase from Plant PCY1 Enables the Use of Simple Substrates.

ACS Chem Biol 2018 03 12;13(3):801-811. Epub 2018 Feb 12.

Biomedical Sciences Research Complex , University of St. Andrews , North Haugh , St. Andrews , KY16 9ST , United Kingdom.

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http://dx.doi.org/10.1021/acschembio.8b00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859912PMC
March 2018

Synthesis of the natural product descurainolide and cyclic peptides from lignin-derived aromatics.

Org Biomol Chem 2018 01;16(2):266-273

School of Chemistry and Biomedical Sciences Research Complex, University of St. Andrews and EaStCHEM, St Andrews, Fife, Scotland, KY16 9ST, UK.

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http://dx.doi.org/10.1039/c7ob02697hDOI Listing
January 2018

Sparse Labeling PELDOR Spectroscopy on Multimeric Mechanosensitive Membrane Channels.

Biophys J 2017 Nov;113(9):1968-1978

Centre of Magnetic Resonance, University of St Andrews, North Haugh, St Andrews, Fife, United Kingdom; Biomedical Sciences Research Complex and EaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2017.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685675PMC
November 2017

Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3'-Deoxy Nucleoside of Pacidamycins.

Angew Chem Int Ed Engl 2017 10 30;56(41):12492-12497. Epub 2017 Aug 30.

School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.

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http://dx.doi.org/10.1002/anie.201705639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656905PMC
October 2017

Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates.

Nat Commun 2017 10 19;8(1):1045. Epub 2017 Oct 19.

Biomedical Sciences Research Complex, The University of St Andrews, North Haugh, St Andrews, K16 9ST, UK.

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http://dx.doi.org/10.1038/s41467-017-00862-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648786PMC
October 2017

Spectator no more, the role of the membrane in regulating ion channel function.

Curr Opin Struct Biol 2017 08 7;45:59-66. Epub 2016 Dec 7.

Biomedical Sciences Research Complex, North Haugh, University of St Andrews, KY16 9ST, United Kingdom; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy and Cancer, Chengdu 610041, China. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2016.10.017DOI Listing
August 2017

The rhizoferrin biosynthetic gene in the fungal pathogen Rhizopus delemar is a novel member of the NIS gene family.

Int J Biochem Cell Biol 2017 08 10;89:136-146. Epub 2017 Jun 10.

Department of Biological Sciences, Simon Fraser University, Burnaby V5A 1S6, Canada.

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http://dx.doi.org/10.1016/j.biocel.2017.06.005DOI Listing
August 2017

Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters.

Nat Chem Biol 2017 06 17;13(6):660-667. Epub 2017 Apr 17.

EastChem School of Chemistry, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/nchembio.2361DOI Listing
June 2017

YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.

Chem Rev 2017 Apr 3;117(8):5389-5456. Epub 2017 Mar 3.

Biomedical Science Research Complex, University of St Andrews , BSRC North Haugh, St Andrews KY16 9ST, United Kingdom.

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http://dx.doi.org/10.1021/acs.chemrev.6b00623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406272PMC
April 2017

Kinetic Landscape of a Peptide Bond-Forming Prolyl Oligopeptidase.

Biochemistry 2017 04 7;56(15):2086-2095. Epub 2017 Apr 7.

School of Chemistry, Biomedical Sciences Research Complex, University of St Andrews , North Haugh, St Andrews K16 9ST, U.K.

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http://dx.doi.org/10.1021/acs.biochem.7b00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397884PMC
April 2017

Kinetics and Structure of a Cold-Adapted Hetero-Octameric ATP Phosphoribosyltransferase.

Biochemistry 2017 02 24;56(5):793-803. Epub 2017 Jan 24.

School of Engineering and Applied Science, Rotterdam University of Applied Science , G. J. de Jonghweg 4-6, 3015 GG Rotterdam, The Netherlands.

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http://dx.doi.org/10.1021/acs.biochem.6b01138DOI Listing
February 2017

Synthesis of Hybrid Cyclopeptides through Enzymatic Macrocyclization.

ChemistryOpen 2017 02 13;6(1):11-14. Epub 2016 Dec 13.

School of Chemsitry University of St Andrews BSRC, North Haugh St Andrews KY16 9ST UK; State Key Laboratory of Biotherapy Sichuan University P. R. China.

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http://doi.wiley.com/10.1002/open.201600134
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http://dx.doi.org/10.1002/open.201600134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288752PMC
February 2017

Mechanisms of cyanobactin biosynthesis.

Curr Opin Chem Biol 2016 12 14;35:80-88. Epub 2016 Sep 14.

Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST Scotland, UK.

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http://dx.doi.org/10.1016/j.cbpa.2016.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164927PMC
December 2016

MOMP from Campylobacter jejuni Is a Trimer of 18-Stranded β-Barrel Monomers with a Ca Ion Bound at the Constriction Zone.

J Mol Biol 2016 11 30;428(22):4528-4543. Epub 2016 Sep 30.

Biomedical Sciences Research Complex, University of St Andrews, 09042 St Andrews, UK; State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090048PMC
November 2016

Bacterial polysaccharide synthesis and export.

Curr Opin Struct Biol 2016 10 19;40:81-88. Epub 2016 Aug 19.

Biomedical Science Research Complex, North Haugh, The University of St Andrews, St Andrews, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2016.07.016DOI Listing
October 2016

The Catalytic Mechanism of the Marine-Derived Macrocyclase PatGmac.

Chemistry 2016 Sep 8;22(37):13089-97. Epub 2016 Jul 8.

UCIBIO, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal.

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http://dx.doi.org/10.1002/chem.201601670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108404PMC
September 2016

Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule.

Nat Commun 2016 06 30;7:12103. Epub 2016 Jun 30.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy and Cancer, Chengdu 610041, China.

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http://dx.doi.org/10.1038/ncomms12103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931326PMC
June 2016

Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics.

Angew Chem Int Ed Engl 2016 05 5;55(19):5842-5. Epub 2016 Apr 5.

Biomedical Science Research Complex, University of St Andrews, BSRC, North Haugh, St Andrews, KY16 9ST, UK.

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http://doi.wiley.com/10.1002/anie.201601564
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http://dx.doi.org/10.1002/anie.201601564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924597PMC
May 2016

Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics.

Angew Chem Weinheim Bergstr Ger 2016 05 5;128(19):5936-5939. Epub 2016 Apr 5.

Biomedical Science Research Complex University of St Andrews, BSRC North Haugh St Andrews KY 16 9 ST UK; State Key Laboratory of Biotherapy Sichuan University China.

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http://dx.doi.org/10.1002/ange.201601564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924595PMC
May 2016

Mechanism of DNA loading by the DNA repair helicase XPD.

Nucleic Acids Res 2016 Apr 20;44(6):2806-15. Epub 2016 Feb 20.

Biomedical Sciences Research Complex, University of St Andrews, Fife KY16 9ST, UK

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http://dx.doi.org/10.1093/nar/gkw102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824113PMC
April 2016

A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway.

Angew Chem Int Ed Engl 2016 Mar 5;55(11):3596-9. Epub 2016 Feb 5.

Microbiology and Biotechnology Division, Department of Food and Environmental Sciences, P.O.Box 56, Viikki Biocenter, Viikinkaari 9, 00014, University of Helsinki, Finland.

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http://dx.doi.org/10.1002/anie.201509920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108402PMC
March 2016

Accurate Extraction of Nanometer Distances in Multimers by Pulse EPR.

Chemistry 2016 Mar 25;22(14):4700-3. Epub 2016 Feb 25.

Centre of Magnetic Resonance, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK.

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http://dx.doi.org/10.1002/chem.201505143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848767PMC
March 2016

Exploration of a potential difluoromethyl-nucleoside substrate with the fluorinase enzyme.

Bioorg Chem 2016 Feb 18;64:37-41. Epub 2015 Nov 18.

School of Chemistry and Biomedical Sciences Research Centre, University of St Andrews, North Haugh, St Andrews KY16 9ST, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2015.11.003DOI Listing
February 2016

Molecular Basis of Filtering Carbapenems by Porins from β-Lactam-resistant Clinical Strains of Escherichia coli.

J Biol Chem 2016 Feb 8;291(6):2837-47. Epub 2015 Dec 8.

From the School of Engineering and Sciences, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany,

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http://dx.doi.org/10.1074/jbc.M115.690156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742748PMC
February 2016

A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA.

J Mol Biol 2016 Jan 10;428(1):108-120. Epub 2015 Nov 10.

Biomedical Sciences Research Complex and EaStCHEM, School of Chemistry, University of St. Andrews, North Haugh, St. Andrews, Fife KY16 9ST, United Kingdom; State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan, China 610065. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2015.10.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840175PMC
January 2016

Taking a molecular motor for a spin: helicase mechanism studied by spin labeling and PELDOR.

Nucleic Acids Res 2016 Jan 10;44(2):954-68. Epub 2015 Dec 10.

Biomedical Sciences Research Complex, University of St Andrews, Fife KY16 9ST, UK

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http://dx.doi.org/10.1093/nar/gkv1373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737156PMC
January 2016

Derivatisable Cyanobactin Analogues: A Semisynthetic Approach.

Chembiochem 2015 Dec 10;16(18):2646-50. Epub 2015 Nov 10.

Biomedical Sciences Research Complex, University of St. Andrews, North Haugh, St. Andrews, KY16 9ST, UK.

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http://dx.doi.org/10.1002/cbic.201500494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736454PMC
December 2015

Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.

Nat Struct Mol Biol 2015 Aug 6;22(8):597-602. Epub 2015 Jul 6.

Centre for Gene Regulation and Expression, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/nsmb.3052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529489PMC
August 2015

Unraveling the specific regulation of the central pathway for anaerobic degradation of 3-methylbenzoate.

J Biol Chem 2015 May 20;290(19):12165-83. Epub 2015 Mar 20.

From the Department of Environmental Biology, Centro de Investigaciones Biológicas-Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain,

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http://www.jbc.org/content/290/19/12165.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.637074
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http://dx.doi.org/10.1074/jbc.M115.637074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424350PMC
May 2015

A coiled-coil domain acts as a molecular ruler to regulate O-antigen chain length in lipopolysaccharide.

Nat Struct Mol Biol 2015 Jan 15;22(1):50-56. Epub 2014 Dec 15.

Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Fife, KY16 9ST, UK.

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http://dx.doi.org/10.1038/nsmb.2935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650267PMC
January 2015

An efficient method for the in vitro production of azol(in)e-based cyclic peptides.

Angew Chem Int Ed Engl 2014 Dec 21;53(51):14171-4. Epub 2014 Oct 21.

Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE (UK); Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD (UK); Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516 (Egypt).

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http://doi.wiley.com/10.1002/anie.201408082
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http://dx.doi.org/10.1002/anie.201408082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282754PMC
December 2014

The structural biology of patellamide biosynthesis.

Curr Opin Struct Biol 2014 Dec 25;29:112-121. Epub 2014 Nov 25.

BSRC, North Haugh, The University, St Andrews, KY16 9ST.

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http://dx.doi.org/10.1016/j.sbi.2014.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268494PMC
December 2014

Editorial overview: Catalysis and regulation: enzyme catalysis, biosynthetic pathways and regulation.

Curr Opin Struct Biol 2014 Dec 2;29:iv-v. Epub 2014 Dec 2.

Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2014.11.004DOI Listing
December 2014

The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster.

Acta Crystallogr F Struct Biol Commun 2014 Dec 14;70(Pt 12):1597-603. Epub 2014 Nov 14.

Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife KY16 8ST, Scotland.

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http://dx.doi.org/10.1107/S2053230X1402425XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259220PMC
December 2014

Trapped translocation intermediates establish the route for export of capsular polysaccharides across Escherichia coli outer membranes.

Proc Natl Acad Sci U S A 2014 Jun 19;111(22):8203-8. Epub 2014 May 19.

Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada N1G 2W1; and

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http://dx.doi.org/10.1073/pnas.1400341111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050593PMC
June 2014

Identification of fluorinases from Streptomyces sp MA37, Norcardia brasiliensis, and Actinoplanes sp N902-109 by genome mining.

Chembiochem 2014 Feb 21;15(3):364-8. Epub 2014 Jan 21.

UK Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE (UK).

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http://dx.doi.org/10.1002/cbic.201300732DOI Listing
February 2014

Probing the structure of the mechanosensitive channel of small conductance in lipid bilayers with pulsed electron-electron double resonance.

Biophys J 2014 Feb;106(4):834-42

Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany; Centre for Biomolecular Sciences, University of St. Andrews, St. Andrews, Scotland. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944623PMC
February 2014

PELDOR in rotationally symmetric homo-oligomers.

Mol Phys 2013 Oct 30;111(18-19):2845-2854. Epub 2013 May 30.

EaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, Scotland, UK ; Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, Scotland, UK ; Centre of Magnetic Resonance, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, Scotland, UK.

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http://dx.doi.org/10.1080/00268976.2013.798697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056887PMC
October 2013

The chemical basis of serine palmitoyltransferase inhibition by myriocin.

J Am Chem Soc 2013 Sep 11;135(38):14276-85. Epub 2013 Sep 11.

School of Chemistry, The University of Edinburgh , Edinburgh, Scotland, EH9 3JJ, United Kingdom.

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http://dx.doi.org/10.1021/ja4059876DOI Listing
September 2013

CRISPR interference: a structural perspective.

Biochem J 2013 Jul;453(2):155-66

Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Fife KY16 9ST, UK.

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http://dx.doi.org/10.1042/BJ20130316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727216PMC
July 2013

Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing.

Biochem J 2013 Jun;452(2):223-30

Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK.

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http://dx.doi.org/10.1042/BJ20130269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652601PMC
June 2013

Structure of PatF from Prochloron didemni.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 Jun 23;69(Pt 6):618-23. Epub 2013 May 23.

Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, Scotland.

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http://dx.doi.org/10.1107/S1744309113012931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668578PMC
June 2013

Wzi is an outer membrane lectin that underpins group 1 capsule assembly in Escherichia coli.

Structure 2013 May 25;21(5):844-53. Epub 2013 Apr 25.

Biomedical Sciences Research Complex, University of St Andrews, St Andrews KY16 9ST, UK.

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http://dx.doi.org/10.1016/j.str.2013.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791409PMC
May 2013

Structure of the archaeal Cascade subunit Csa5: relating the small subunits of CRISPR effector complexes.

RNA Biol 2013 May 22;10(5):762-9. Epub 2013 Apr 22.

Biomedical Sciences Research Complex, University of St. Andrews, North Haugh, St. Andrews, Fife, UK.

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http://dx.doi.org/10.4161/rna.23854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737334PMC
May 2013

Bacterial mechanosensitive channels--MscS: evolution's solution to creating sensitivity in function.

Annu Rev Biophys 2012 23;41:157-77. Epub 2012 Feb 23.

Biomedical Sciences Research Complex, The North Haugh, The University of St Andrews, Fife KY16 9ST, United Kingdom.

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http://dx.doi.org/10.1146/annurev-biophys-101211-113227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378650PMC
March 2013

An enzymatic route to selenazolines.

Chembiochem 2013 Mar 18;14(5):564-7. Epub 2013 Feb 18.

Biomedical Science Research Complex, University of St Andrews, North Haugh, St. Andrews, KY16 9ST, UK.

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http://dx.doi.org/10.1002/cbic.201300037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625746PMC
March 2013

The discovery of new cyanobactins from Cyanothece PCC 7425 defines a new signature for processing of patellamides.

Chembiochem 2012 Dec 21;13(18):2683-9. Epub 2012 Nov 21.

Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, UK.

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http://dx.doi.org/10.1002/cbic.201200661DOI Listing
December 2012

Structure of WbdD: a bifunctional kinase and methyltransferase that regulates the chain length of the O antigen in Escherichia coli O9a.

Mol Microbiol 2012 Nov 27;86(3):730-42. Epub 2012 Sep 27.

Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.

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http://dx.doi.org/10.1111/mmi.12014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482155PMC
November 2012

Crystallization, dehydration and experimental phasing of WbdD, a bifunctional kinase and methyltransferase from Escherichia coli O9a.

Acta Crystallogr D Biol Crystallogr 2012 Oct 18;68(Pt 10):1371-9. Epub 2012 Sep 18.

Biomedical Sciences Research Complex, The University of St Andrews, North Haugh, St Andrews KY16 9ST, Scotland.

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http://dx.doi.org/10.1107/S0907444912029599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447403PMC
October 2012

Conformational state of the MscS mechanosensitive channel in solution revealed by pulsed electron-electron double resonance (PELDOR) spectroscopy.

Proc Natl Acad Sci U S A 2012 Oct 10;109(40):E2675-82. Epub 2012 Sep 10.

Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews KY16 9ST, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1202286109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479538PMC
October 2012

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis.

Nature 2012 Sep;489(7414):115-20

Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1038/nature11376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442243PMC
September 2012

Tryptophan oxygenation: mechanistic considerations.

Authors:
James H Naismith

Biochem Soc Trans 2012 Jun;40(3):509-14

Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Scotland, U.K.

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http://dx.doi.org/10.1042/BST20120073DOI Listing
June 2012

Structural, mechanistic and regulatory studies of serine palmitoyltransferase.

Biochem Soc Trans 2012 Jun;40(3):547-54

EaStCHEM, School of Chemistry, University of Edinburgh, Edinburgh, Scotland, U.K.

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http://biochemsoctrans.org/lookup/doi/10.1042/BST20110769
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http://dx.doi.org/10.1042/BST20110769DOI Listing
June 2012

A model for 3-methyladenine recognition by 3-methyladenine DNA glycosylase I (TAG) from Staphylococcus aureus.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 Jun 22;68(Pt 6):610-5. Epub 2012 May 22.

The BSRC, University of St Andrews, North Haugh, St Andrews KY16 9ST, Scotland.

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http://dx.doi.org/10.1107/S1744309112016363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370894PMC
June 2012

MtsslWizard: In Silico Spin-Labeling and Generation of Distance Distributions in PyMOL.

Appl Magn Reson 2012 Apr 3;42(3):377-391. Epub 2012 Feb 3.

Biomedical Sciences Research Complex, The University of St. Andrews, Fife, KY16 9ST UK.

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http://dx.doi.org/10.1007/s00723-012-0314-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296949PMC
April 2012

Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales.

Proc Natl Acad Sci U S A 2012 Feb 21;109(7):E398-405. Epub 2011 Nov 21.

Biomedical Sciences Research Complex, University of St Andrews, Fife KY16 9ST, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1113277108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289382PMC
February 2012

Salt bridges regulate both dimer formation and monomeric flexibility in HdeB and may have a role in periplasmic chaperone function.

J Mol Biol 2012 Jan 25;415(3):538-46. Epub 2011 Nov 25.

Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Fife KY16 9ST, UK.

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http://dx.doi.org/10.1016/j.jmb.2011.11.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299563PMC
January 2012

Structural basis for acyl acceptor specificity in the achromobactin biosynthetic enzyme AcsD.

J Mol Biol 2011 Sep 1;412(3):495-504. Epub 2011 Aug 1.

Scottish Structural Proteomics Facility and Centre for Biomolecular Sciences, The University of St Andrews, Scotland KY16 9ST, UK.

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http://dx.doi.org/10.1016/j.jmb.2011.07.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323832PMC
September 2011

Mechanism of ubiquitylation by dimeric RING ligase RNF4.

Nat Struct Mol Biol 2011 Aug 21;18(9):1052-9. Epub 2011 Aug 21.

Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/nsmb.2108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326525PMC
August 2011