James M Rae

James M Rae

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James M Rae

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Implication of environmental estrogens on breast cancer treatment and progression.

Toxicology 2019 Jun 30;421:41-48. Epub 2019 Mar 30.

Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA; Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA; Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0300483X183040
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http://dx.doi.org/10.1016/j.tox.2019.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561091PMC
June 2019

Impact of CYP3A5 phenotype on tacrolimus concentrations after sublingual and oral administration in lung transplant.

Pharmacogenomics 2019 Apr 15;20(6):421-432. Epub 2019 Apr 15.

Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI 48109, USA.

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https://www.futuremedicine.com/doi/10.2217/pgs-2019-0002
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http://dx.doi.org/10.2217/pgs-2019-0002DOI Listing
April 2019

Metabolites of n-Butylparaben and iso-Butylparaben Exhibit Estrogenic Properties in MCF-7 and T47D Human Breast Cancer Cell Lines.

Toxicol Sci 2018 07;164(1):50-59

Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109.

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http://dx.doi.org/10.1093/toxsci/kfy063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016648PMC
July 2018

Attempted replication of SNPs in RANKL and OPG with musculoskeletal adverse events during aromatase inhibitor treatment for breast cancer.

Physiol Genomics 2018 02 8;50(2):98-99. Epub 2017 Dec 8.

Department of Clinical Pharmacy, University of Michigan College of Pharmacy , Ann Arbor, Michigan.

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http://dx.doi.org/10.1152/physiolgenomics.00085.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867615PMC
February 2018

Institutional profile of pharmacogenetics within University of Michigan College of Pharmacy.

Pharmacogenomics 2017 Jul 26. Epub 2017 Jul 26.

Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI 48109-41065, USA.

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http://dx.doi.org/10.2217/pgs-2017-0107DOI Listing
July 2017

Germline genetic predictors of aromatase inhibitor concentrations, estrogen suppression and drug efficacy and toxicity in breast cancer patients.

Pharmacogenomics 2017 Apr 27;18(5):481-499. Epub 2017 Mar 27.

Breast Oncology Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109-1065, USA.

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http://dx.doi.org/10.2217/pgs-2016-0205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219438PMC
April 2017

Comparative analysis of circulating tumor DNA stability In KEDTA, Streck, and CellSave blood collection tubes.

Clin Biochem 2016 Dec 27;49(18):1354-1360. Epub 2016 Apr 27.

Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2016.03.012DOI Listing
December 2016

Individualized Tamoxifen Dose Escalation-Response.

Clin Cancer Res 2016 12;22(24):6301

Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-2351DOI Listing
December 2016

ESR1 and PGR polymorphisms are associated with estrogen and progesterone receptor expression in breast tumors.

Physiol Genomics 2016 09 19;48(9):688-98. Epub 2016 Aug 19.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.

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http://dx.doi.org/10.1152/physiolgenomics.00065.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111879PMC
September 2016

Pharmacogenetic Predictors of Response.

Adv Exp Med Biol 2016 ;882:191-215

Division of Hematology, Oncology, Department of Internal Medicine, University of Michigan Medical School, 48109, Ann Arbor, 6310 Cancer Center, 1500 E. Medical Center Dr.MI, USA.

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http://dx.doi.org/10.1007/978-3-319-22909-6_8DOI Listing
August 2016

Individualized Tamoxifen Dose Escalation: Confirmation of Feasibility, Question of Utility.

Clin Cancer Res 2016 07 24;22(13):3121-3. Epub 2016 Mar 24.

Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930675PMC
July 2016

The Metabolism, Analysis, and Targeting of Steroid Hormones in Breast and Prostate Cancer.

Horm Cancer 2016 06 11;7(3):149-64. Epub 2016 Mar 11.

Division of Metabolism, Diabetes, and Endocrinology, Department of Internal Medicine and Department of Pharmacology, University of Michigan School of Medicine, Room 5560A, MSRBII, 1150 W. Medical Center Drive, Ann Arbor, MI, 48019, USA.

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http://dx.doi.org/10.1007/s12672-016-0259-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860032PMC
June 2016

One step at a time: CYP2D6 guided tamoxifen treatment awaits convincing evidence of clinical validity.

Pharmacogenomics 2016 06 1;17(8):823-6. Epub 2016 Jun 1.

Division of Hematology/Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA.

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http://dx.doi.org/10.2217/pgs-2016-0059DOI Listing
June 2016

The CYP17A1 inhibitor abiraterone exhibits estrogen receptor agonist activity in breast cancer.

Breast Cancer Res Treat 2016 05 15;157(1):23-30. Epub 2016 Apr 15.

Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1007/s10549-016-3774-3DOI Listing
May 2016

ESR1 Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients.

Clin Cancer Res 2016 Feb 10;22(4):993-9. Epub 2015 Aug 10.

The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland. The Whiting School of Engineering, Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993201PMC
February 2016

Genotyping concordance in DNA extracted from formalin-fixed paraffin embedded (FFPE) breast tumor and whole blood for pharmacogenetic analyses.

Mol Oncol 2015 Nov 29;9(9):1868-76. Epub 2015 Jul 29.

Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Health System, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624024PMC
November 2015

Development of circulating tumor cell-endocrine therapy index in patients with hormone receptor-positive breast cancer.

Clin Cancer Res 2015 Jun 7;21(11):2487-98. Epub 2014 Nov 7.

Breast Oncology Program of the Comprehensive Cancer Center and the Department of Internal Medicine, University of Michigan Health and Hospital System, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516625PMC
June 2015

Re: Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.

J Natl Cancer Inst 2015 May 26;107(5). Epub 2015 Mar 26.

Internal Medicine and Pharmacology, University of Michigan Medical School, Ann Arbor, MI (JMR); Edith Sanford Breast Cancer Research, Sanford Health and Research, Sioux Falls, SD (BLJ); Department of Medicine, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (MR); Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX (AMT).

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https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnc
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http://dx.doi.org/10.1093/jnci/djv065DOI Listing
May 2015

Infiltrating S100A8+ myeloid cells promote metastatic spread of human breast cancer and predict poor clinical outcome.

Breast Cancer Res Treat 2014 Nov 1;148(1):41-59. Epub 2014 Oct 1.

Department of Medicine, University of Miami Miller School of Medicine, 1120 N.W. 14th Street, CRB 620, Miami, FL, 33136, USA,

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http://dx.doi.org/10.1007/s10549-014-3122-4DOI Listing
November 2014

Response.

J Natl Cancer Inst 2014 Apr 3;106(5). Epub 2014 Apr 3.

NotesAffiliations of authors: Department of Internal Medicine and Department of Pharmacology, Michigan Medical School, Ann Arbor, MI (JMR); Edith Sanford Breast Cancer Research, Sanford Health and Research, Sioux Falls, SD (BL-J); Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA (MR).

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http://dx.doi.org/10.1093/jnci/dju064DOI Listing
April 2014

Concordance between CYP2D6 genotypes obtained from tumor-derived and germline DNA.

J Natl Cancer Inst 2013 Sep 19;105(17):1332-4. Epub 2013 Aug 19.

Breast Oncology Program, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109-5942, USA.

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http://dx.doi.org/10.1093/jnci/djt204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888280PMC
September 2013

Genetic associations with toxicity-related discontinuation of aromatase inhibitor therapy for breast cancer.

Breast Cancer Res Treat 2013 Apr 2;138(3):807-16. Epub 2013 Apr 2.

Breast Oncology Program, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Med Inn Bldg C450, Ann Arbor, MI 48109-5843, USA.

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http://dx.doi.org/10.1007/s10549-013-2504-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646626PMC
April 2013

Whole genome amplification of DNA for genotyping pharmacogenetics candidate genes.

Front Pharmacol 2012 30;3:54. Epub 2012 Mar 30.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine Indianapolis, IN, USA.

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http://journal.frontiersin.org/article/10.3389/fphar.2012.00
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http://dx.doi.org/10.3389/fphar.2012.00054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315790PMC
October 2012

Mechanisms of estrogen-independent breast cancer growth driven by low estrogen concentrations are unique versus complete estrogen deprivation.

Breast Cancer Res Treat 2012 Aug 29;134(3):1027-39. Epub 2012 Mar 29.

Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1007/s10549-012-2032-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951731PMC
August 2012

Functional characterization of a genetic polymorphism in the promoter of the ESR2 gene.

Horm Cancer 2012 Apr;3(1-2):37-43

Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, 46202, USA.

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http://link.springer.com/10.1007/s12672-011-0086-2
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http://dx.doi.org/10.1007/s12672-011-0086-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402208PMC
April 2012

Personalized tamoxifen: what is the best way forward?

Authors:
James M Rae

J Clin Oncol 2011 Aug 18;29(24):3206-8. Epub 2011 Jul 18.

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http://dx.doi.org/10.1200/JCO.2011.36.3895DOI Listing
August 2011

Reliable gene expression measurements from fine needle aspirates of pancreatic tumors: effect of amplicon length and quality assessment.

J Mol Diagn 2010 Sep 13;12(5):566-75. Epub 2010 Aug 13.

Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan 48109-0362, USA.

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http://dx.doi.org/10.2353/jmoldx.2010.090107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928420PMC
September 2010

Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients.

J Clin Pharmacol 2010 Apr 15;50(4):450-8. Epub 2010 Jan 15.

Division of Biostatistics/Clinical Pharmacology, Indiana University, School of Medicine, 410 W. 10th St., HITS 3000, Indianapolis, IN 46202; e-mail:

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http://dx.doi.org/10.1177/0091270009359182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816977PMC
April 2010

CYP2D6 testing for breast cancer patients: is there more to the story?

Oncology (Williston Park) 2009 Dec;23(14):1236, 1243, 1249

Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan Medical School, USA.

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December 2009

Pharmacogenetics of tamoxifen: who should undergo CYP2D6 genetic testing?

J Natl Compr Canc Netw 2009 Feb;7(2):203-13

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21231-1000, USA.

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http://dx.doi.org/10.6004/jnccn.2009.0014DOI Listing
February 2009

An expression signature of estrogen-regulated genes predicts disease-free survival in tamoxifen-treated patients better than progesterone receptor status.

Trans Am Clin Climatol Assoc 2008 ;119:77-90; discussion 90-2

Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442700PMC
November 2008

The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6.

J Pharmacol Exp Ther 2008 Nov 12;327(2):538-45. Epub 2008 Aug 12.

Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-5632, USA.

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http://dx.doi.org/10.1124/jpet.108.141796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704579PMC
November 2008

Pharmacogenetics and breast cancer endocrine therapy: CYP2D6 as a predictive factor for tamoxifen metabolism and drug response?

Expert Rev Mol Med 2008 Nov 20;10:e34. Epub 2008 Nov 20.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231-1000, USA.

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http://dx.doi.org/10.1017/S1462399408000896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133663PMC
November 2008

Monitoring serial changes in circulating human breast cancer cells in murine xenograft models.

Cancer Res 2008 Jul;68(14):5529-32

Breast Oncology Program, Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-0942, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789403PMC
July 2008

The role of single nucleotide polymorphisms in breast cancer metastasis.

Breast Cancer Res 2008 18;10(1):301. Epub 2008 Jan 18.

Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1186/bcr1842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374952PMC
June 2008

MDA-MB-435 cells are derived from M14 melanoma cells--a loss for breast cancer, but a boon for melanoma research.

Breast Cancer Res Treat 2007 Jul 27;104(1):13-9. Epub 2006 Sep 27.

Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, Med Sci I, Room 5323, Ann Arbor, MI 48109-0612, USA.

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http://dx.doi.org/10.1007/s10549-006-9392-8DOI Listing
July 2007

When will tumor gene expression profiling be incorporated into clinical breast cancer decision making?

Breast Cancer Res 2006 ;8(4):302

Bioinformatics Program, University of Michigan Medical Center, Ann Arbor, Michigan, USA.

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http://breast-cancer-research.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/bcr1519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779476PMC
January 2007

Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells.

J Pharmacol Exp Ther 2006 Aug 11;318(2):503-12. Epub 2006 May 11.

Division of Clinical Pharmacology, Indiana University School of Medicine, 1001 West 10th Street, WD Myers Bldg., W7123, Indianapolis, IN 46202, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.105.10051
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http://dx.doi.org/10.1124/jpet.105.100511DOI Listing
August 2006

Combination vinorelbine and capecitabine for metastatic breast cancer using a non-body surface area dosing scheme.

Cancer Chemother Pharmacol 2006 Jul 8;58(1):129-35. Epub 2005 Nov 8.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA.

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http://dx.doi.org/10.1007/s00280-005-0132-2DOI Listing
July 2006

GREB1 is a novel androgen-regulated gene required for prostate cancer growth.

Prostate 2006 Jun;66(8):886-94

Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1002/pros.20403DOI Listing
June 2006

What does an orphan G-protein-coupled receptor have to do with estrogen?

Breast Cancer Res 2005 29;7(6):243-4. Epub 2005 Sep 29.

Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA.

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http://breast-cancer-research.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/bcr1330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1410759PMC
February 2006

GREB 1 is a critical regulator of hormone dependent breast cancer growth.

Breast Cancer Res Treat 2005 Jul;92(2):141-9

Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical Center, 1150 W .Medical Center Drive, Ann Arbor, MI 48109-0612, USA.

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http://dx.doi.org/10.1007/s10549-005-1483-4DOI Listing
July 2005

LCC15-MB cells are MDA-MB-435: a review of misidentified breast and prostate cell lines.

Clin Exp Metastasis 2004 ;21(6):535-41

Invasion and Metastasis Unit, University of Melbourne, Department of Surgery, St. Vincent's Hospital, 29 Regent St., Fitzroy, 3065, Australia.

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http://dx.doi.org/10.1007/s10585-004-4117-zDOI Listing
March 2005

Common origins of MDA-MB-435 cells from various sources with those shown to have melanoma properties.

Clin Exp Metastasis 2004 ;21(6):543-52

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1007/s10585-004-3759-1DOI Listing
March 2005

(-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer.

Mol Cancer Ther 2005 Feb;4(2):197-205

Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, 5301B Medical Science Research Building III, 1500 West Medical Center Drive, Ann Arbor, MI 48109-0640, USA.

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February 2005

Metabolism of N,N',N"-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms.

J Pharmacol Exp Ther 2004 Sep 30;310(3):1011-9. Epub 2004 Apr 30.

Department of Pharmacology, Medical Science Research Building III, 1150 West Medical Center Dr., Ann Arbor, MI 48109-0632, USA.

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http://dx.doi.org/10.1124/jpet.104.069112DOI Listing
September 2004

EGFR and EGFRvIII expression in primary breast cancer and cell lines.

Breast Cancer Res Treat 2004 Sep;87(1):87-95

Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Medical Center, Ann Arbor, MI 48109-0612, USA.

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http://link.springer.com/content/pdf/10.1023/B:BREA.00000415
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http://link.springer.com/10.1023/B:BREA.0000041585.26734.f9
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http://dx.doi.org/10.1023/B:BREA.0000041585.26734.f9DOI Listing
September 2004

Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors.

Breast Cancer Res Treat 2004 Jan;83(2):99-107

Department of Oncology, Georgetown University Medical Center, Washington, DC, USA.

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http://dx.doi.org/10.1023/B:BREA.0000010702.10130.29DOI Listing
January 2004

Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.

J Natl Cancer Inst 2003 Dec;95(23):1758-64

The Breast Cancer Program, Department of Medicine, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC, USA.

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http://dx.doi.org/10.1093/jnci/djg108DOI Listing
December 2003

Genotyping for polymorphic drug metabolizing enzymes from paraffin-embedded and immunohistochemically stained tumor samples.

Pharmacogenetics 2003 Aug;13(8):501-7

Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan Medical Center, 5323 Med Sci 1, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1097/00008571-200308000-00008DOI Listing
August 2003

Sequence diversity and functional characterization of the 5'-regulatory region of human CYP2C19.

Pharmacogenetics 2003 Apr;13(4):199-206

Department of Medicine Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1097/00008571-200304000-00004DOI Listing
April 2003

Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism.

Drug Metab Dispos 2002 May;30(5):525-30

Division of Clinical Pharmacology, Department of Medicine, Georgetown University Medical Center, Washington, DC, USA.

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http://dx.doi.org/10.1124/dmd.30.5.525DOI Listing
May 2002