Publications by authors named "James M Mathew"

45Publications

Immune and gene expression profiling during tacrolimus to everolimus conversion early after liver transplantation.

Hum Immunol 2020 Nov 17. Epub 2020 Nov 17.

Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States; Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States. Electronic address:

View Article and Find Full Text PDF
November 2020

Chimerism and tolerance: past, present and future strategies to prolong renal allograft survival.

Curr Opin Nephrol Hypertens 2021 Jan;30(1):63-74

Comprehensive Transplant Center, Department of Surgery.

View Article and Find Full Text PDF
January 2021

Cell therapy can enable minimization of immunosuppression.

Nat Rev Nephrol 2020 09;16(9):486-487

Department of Surgery, Division of Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

View Article and Find Full Text PDF
September 2020

Outstanding questions in transplantation: Tolerance.

Am J Transplant 2020 02 28;20(2):348-354. Epub 2019 Nov 28.

Department of Surgery, Comprehensive Transplant Center, Northwestern University, Chicago, Illinois, USA.

View Article and Find Full Text PDF
February 2020

A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants.

Sci Rep 2018 05 9;8(1):7428. Epub 2018 May 9.

Department of Surgery, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

View Article and Find Full Text PDF
May 2018

Clinical transplant tolerance: Coming of age.

Hum Immunol 2018 May 2;79(5):255-257. Epub 2018 Mar 2.

Comprehensive Transplant Center; Northwestern University, Chicago, IL 60611 United States.

View Article and Find Full Text PDF
May 2018

Transcriptomic studies in tolerance: Lessons learned and the path forward.

Hum Immunol 2018 May 2;79(5):395-401. Epub 2018 Mar 2.

Department of Surgery, Comprehensive Transplant Center, Northwestern University, Chicago, IL, USA.

View Article and Find Full Text PDF
May 2018

Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells.

Hum Immunol 2018 May 1;79(5):277-282. Epub 2018 Feb 1.

Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, USA; Department of Microbiology-Immunology, Northwestern University, Chicago, IL, USA.

View Article and Find Full Text PDF
May 2018

Cellular and functional biomarkers of clinical transplant tolerance.

Hum Immunol 2018 May 31;79(5):322-333. Epub 2018 Jan 31.

Department of Surgery - Comprehensive Transplant Center, Northwestern University, Chicago, IL, USA.

View Article and Find Full Text PDF
May 2018

Generation and Characterization of Alloantigen-Specific Regulatory T Cells For Clinical Transplant Tolerance.

Sci Rep 2018 01 18;8(1):1136. Epub 2018 Jan 18.

Department of Surgery - Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

View Article and Find Full Text PDF
January 2018

Intragraft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation.

J Am Soc Nephrol 2018 02 30;29(2):423-433. Epub 2017 Nov 30.

Translational Genomics Transplant Laboratory, Department of Surgery, University of Virginia, Charlottesville, Virginia.

View Article and Find Full Text PDF
February 2018

Immunoregulatory Effects of Everolimus on In Vitro Alloimmune Responses.

PLoS One 2016 8;11(6):e0156535. Epub 2016 Jun 8.

Comprehensive Transplant Center, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

View Article and Find Full Text PDF
July 2017

Low incidence of acute rejection in hepatitis B virus positive liver transplant recipients and the impact of hepatitis B immunoglobulin.

Hum Immunol 2016 Apr 23;77(4):367-74. Epub 2016 Feb 23.

Department of Medicine - Division of Gastroenterology and Hepatology, 251 East Huron Street Galter Suite 3-150, Chicago, IL 60611, United States; Northwestern University Transplant Outcomes Research Collaborative (NUTORC), 676 N. St. Clair 19th Floor, Chicago, IL 60611, United States; Department of Surgery, Comprehensive Transplant Center, 676 N. St. Clair 19th Floor, Chicago, IL 60611, United States. Electronic address:

View Article and Find Full Text PDF
April 2016

Differential Effects of Tacrolimus versus Sirolimus on the Proliferation, Activation and Differentiation of Human B Cells.

PLoS One 2015 18;10(6):e0129658. Epub 2015 Jun 18.

Department of Medicine-Nephrology, Northwestern University, Chicago, IL, United States of America; Comprehensive Transplant Center, Northwestern University, Chicago, IL, United States of America.

View Article and Find Full Text PDF
April 2016

Differential Effects of Calcineurin and Mammalian Target of Rapamycin Inhibitors on Alloreactive Th1, Th17, and Regulatory T Cells.

Transplantation 2015 Sep;99(9):1774-84

1 Department of Medicine-Nephrology, Northwestern University Feinberg School of Medicine, Chicago, IL. 2 Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL. 3 Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL. 4 Department of Medicine and Rheumatology Division, Northwestern University Feinberg School of Medicine, Chicago, IL. 5 Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL. 6 Department of Surgery, University of Virginia, Charlottesville, VA.

View Article and Find Full Text PDF
September 2015

Immune reconstitution/immunocompetence in recipients of kidney plus hematopoietic stem/facilitating cell transplants.

Transplantation 2015 Feb;99(2):288-98

1 Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, IL. 2 Institute for Cellular Therapeutics, University of Louisville, Louisville, KY. 3 Regenerex, LLC, Louisville, KY.

View Article and Find Full Text PDF
February 2015

Role of innate and acquired immune mechanisms in clinical intestinal transplant rejection.

Transplantation 2015 Jun;99(6):1273-81

1 Department of Surgery, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL. 2 Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL. 3 Jesse Brown VA Medical Center, Chicago, IL. 4 Department of Surgery, University of Miami Miller School of Medicine, Miami, FL. 5 Department of Microbiology-Immunology, University of Miami Miller School of Medicine, Miami, FL. 6 Miami VA Medical Center, Miami, FL. 7 Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, IL.

View Article and Find Full Text PDF
June 2015

Defining the alloreactive T cell repertoire using high-throughput sequencing of mixed lymphocyte reaction culture.

PLoS One 2014 3;9(11):e111943. Epub 2014 Nov 3.

Department of Surgery, Comprehensive Transplant center, Northwestern University, Chicago, Illinois, United States of America.

View Article and Find Full Text PDF
November 2015

Inhibitory effects of belatacept on allospecific regulatory T-cell generation in humans.

Transplantation 2013 Oct;96(8):689-96

1 Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL. 2 Department of Surgery, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL. 3 Jesse Brown VA Medical Center, Chicago, IL. 4 Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL.

View Article and Find Full Text PDF
October 2013

Genomic biomarkers correlate with HLA-identical renal transplant tolerance.

J Am Soc Nephrol 2013 Sep 20;24(9):1376-85. Epub 2013 Jun 20.

Comprehensive Transplant Center, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

View Article and Find Full Text PDF
September 2013

Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.

PLoS One 2011 14;6(12):e28948. Epub 2011 Dec 14.

Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

View Article and Find Full Text PDF
August 2012

Favorable effects of alemtuzumab on allospecific regulatory T-cell generation.

Hum Immunol 2012 Feb 23;73(2):141-9. Epub 2011 Nov 23.

Division of Gastroenterology, Hepatology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.

View Article and Find Full Text PDF
February 2012

Requirement of cognate CD4+ T-cell recognition for the regulation of allospecific CTL by human CD4+ CD127- CD25+ FOXP3+ cells generated in MLR.

PLoS One 2011 22;6(7):e22450. Epub 2011 Jul 22.

Department of Surgery, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

View Article and Find Full Text PDF
December 2011

Microchimerism in promoting graft acceptance in clinical transplantation.

Curr Opin Organ Transplant 2011 Aug;16(4):345-52

Department of Surgery, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

View Article and Find Full Text PDF
August 2011

Allospecific regulatory effects of sirolimus and tacrolimus in the human mixed lymphocyte reaction.

Transplantation 2011 Jan;91(2):199-206

Division of Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

View Article and Find Full Text PDF
January 2011

The human "Treg MLR": immune monitoring for FOXP3+ T regulatory cell generation.

Transplantation 2009 Dec;88(11):1303-11

Division of Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

View Article and Find Full Text PDF
December 2009

Evaluation of the tolerogenic effects of donor bone marrow cells using a severe combined immunodeficient mouse-human islet transplant model.

Hum Immunol 2008 Oct 12;69(10):605-13. Epub 2008 Aug 12.

Department of Surgery, Transplant Laboratories, Northwestern University, Chicago, IL, USA.

View Article and Find Full Text PDF
October 2008

FoxP3 mRNA transcripts and regulatory cells in renal transplant recipients 10 years after donor marrow infusion.

Transplantation 2007 Jun;83(12):1611-9

Department of Surgery, The Lillian Jean Kaplan Renal Transplant Center of the Division of Transplantation, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33101, USA.

View Article and Find Full Text PDF
June 2007

A randomized trial of three renal transplant induction antibodies: early comparison of tacrolimus, mycophenolate mofetil, and steroid dosing, and newer immune-monitoring.

Transplantation 2005 Aug;80(4):457-65

Dept. of Surgery, The Lillian Jean Kaplan Renal Transplant Center of the Division of Transplantation, University of Miami Leonard M. Miller School of Medicine, and the Miami Veterans Affairs Medical Center, Miami, Florida 33101, USA.

View Article and Find Full Text PDF
August 2005

Toward tolerance to human organ transplants: a few additional corollaries and questions.

Transplantation 2004 Mar;77(6):940-2

Department of Surgery, Division of Transplantation, University of Miami, and the Miami Veterans Affairs Medical Center, FL 33101, USA.

View Article and Find Full Text PDF
March 2004

Immune responses and their regulation by donor bone marrow cells in clinical organ transplantation.

Transpl Immunol 2003 Jul-Sep;11(3-4):307-21

Department of Surgery, Division of Transplantation (R-440), University of Miami School of Medicine, 1600 N.W. 10th Ave., Miami, FL 33136, USA.

View Article and Find Full Text PDF
April 2004

A novel micro-cell-mediated lympholytic assay for the evaluation of regulatory cells in human alloreactive CTL responses.

J Immunol Methods 2003 Jan;272(1-2):67-80

Division of Transplantation, Department of Surgery, University of Miami School of Medicine, R-440, 1600 N.W. 10th Ave., FL 33136, USA.

View Article and Find Full Text PDF
January 2003