Publications by authors named "James M Larner"

62Publications

A single-institutional experience with low dose stereotactic body radiation therapy for liver metastases.

Rep Pract Oncol Radiother 2020 Nov-Dec;25(6):987-993. Epub 2020 Oct 2.

University of Virginia / Riverside, Radiosurgery Center, Newport News, VA, USA.

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October 2020

Stereotactic body radiation therapy for spinal metastases: a novel local control stratification by spinal region.

J Neurosurg Spine 2020 Oct 23:1-10. Epub 2020 Oct 23.

1Radiosurgery Center, Riverside Regional Medical Center (in partnership with University of Virginia Health System), Newport News.

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October 2020

Genesis of Quality Measurements to Improve the Care Delivered to Patients With Brain Metastases.

JCO Oncol Pract 2020 Aug 11:OP2000233. Epub 2020 Aug 11.

Department of Neurology, Division of Neuro-Oncology, University of Virginia Health System, Charlottesville, VA.

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August 2020

Stereotactic Body Radiation Therapy for Salvage Treatment of Recurrent Non-Small Cell Lung Cancer.

Pract Radiat Oncol 2020 Nov - Dec;10(6):e475-e484. Epub 2020 May 23.

University of Virginia/Riverside, Radiosurgery Center, Newport News, Virginia.

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May 2020

Stereotactic radiosurgery for the treatment of bulky spine metastases.

J Neurooncol 2020 Jun 15;148(2):381-388. Epub 2020 May 15.

University of Virginia / Riverside, Radiosurgery Center, Newport News, VA, USA.

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June 2020

Stereotactic body radiation therapy in the treatment of ovarian cancer.

Radiat Oncol 2020 May 13;15(1):108. Epub 2020 May 13.

University of Virginia / Riverside, Radiosurgery Center, Newport News, VA, USA.

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May 2020

Protein kinase CK2 phosphorylation of SAPS3 subunit increases PP6 phosphatase activity with Aurora A kinase.

Biochem J 2020 01;477(2):431-444

Center for Cell Signaling, Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, U.S.A.

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January 2020

Aurora B Kinase Promotes CHIP-Dependent Degradation of HIF1α in Prostate Cancer Cells.

Mol Cancer Ther 2020 04 17;19(4):1008-1017. Epub 2019 Dec 17.

Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, Virginia.

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April 2020

Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response.

DNA Repair (Amst) 2020 01 9;85:102737. Epub 2019 Nov 9.

Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address:

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January 2020

Rapid Response to Pembrolizumab in a Critically Ill Mechanically Ventilated Patient with New Diagnosis of NSCLC.

J Thorac Oncol 2019 09;14(9):e193-e195

Division of Hematology/Oncology, University of Virginia School of Medicine, Charlottesville, Virginia. Electronic address:

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September 2019

Spatial shifts in frame-based Gamma Knife radiosurgery: A case for cone beam CT imaging as quality assurance using the Gamma Knife® Icon™.

J Radiosurg SBRT 2018 ;5(4):315-322

Department of Neurological Surgery, University of Virginia Medical Center, PO Box 800212, Charlottesville, VA 22908-0212, USA.

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January 2018

Stereotactic Shifts During Frame-Based Image-Guided Stereotactic Radiosurgery: Clinical Measurements.

Int J Radiat Oncol Biol Phys 2018 11 24;102(4):895-902. Epub 2018 May 24.

Department of Radiation Oncology, University of Virginia Health System, Charlottesville, Virginia; Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia.

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November 2018

Functions of protein phosphatase-6 in NF-κB signaling and in lymphocytes.

Biochem Soc Trans 2017 06;45(3):693-701

Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, VA 22908, U.S.A.

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June 2017

Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP.

Mol Cancer Res 2017 08 23;15(8):1063-1072. Epub 2017 May 23.

Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, Virginia.

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August 2017

The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance.

Mol Cancer Res 2017 06 23;15(6):651-659. Epub 2017 Feb 23.

Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia.

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June 2017

Choosing a Prescription Isodose in Stereotactic Radiosurgery for Brain Metastases: Implications for Local Control.

World Neurosurg 2017 Feb 17;98:761-767.e1. Epub 2016 Nov 17.

Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia, USA; Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA.

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February 2017

When should patients with brain metastases receive whole brain irradiation?

J Radiosurg SBRT 2016 ;4(1):1-3

Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.

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January 2016

Checkpoint Kinase 2 Negatively Regulates Androgen Sensitivity and Prostate Cancer Cell Growth.

Cancer Res 2015 Dec 16;75(23):5093-105. Epub 2015 Nov 16.

Departments of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia. Cancer Center Member, University of Virginia, Charlottesville, Virginia.

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December 2015

Leukoencephalopathy After Stereotactic Radiosurgery for Brain Metastases.

Int J Radiat Oncol Biol Phys 2015 Nov 29;93(4):870-8. Epub 2015 Jul 29.

Department of Radiation Oncology, University of Virginia Health System, Charlottesville, Virginia; Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia.

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November 2015

Brainstem metastases treated with stereotactic radiosurgery: safety, efficacy, and dose response.

J Neurooncol 2015 Nov 4;125(2):385-92. Epub 2015 Sep 4.

Department of Radiation Oncology, University of Virginia, 1240 Lee Street, Box 800383, Charlottesville, VA, 22908, USA.

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November 2015

Magnetic resonance-guided focused ultrasound for patients with painful bone metastases: phase III trial results.

J Natl Cancer Inst 2014 Apr 23;106(5). Epub 2014 Apr 23.

Affiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).

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April 2014

T-type Ca2+ channel inhibition induces p53-dependent cell growth arrest and apoptosis through activation of p38-MAPK in colon cancer cells.

Mol Cancer Res 2014 Mar 20;12(3):348-58. Epub 2013 Dec 20.

Department of Radiation Oncology, University of Virginia School of Medicine, P.O. Box 800383, Charlottesville, VA 22908.

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March 2014

PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase.

J Biol Chem 2012 Mar 1;287(12):9230-9. Epub 2012 Feb 1.

Department of Radiation Oncology, University of Virginia Health System, Charlottesville, Virginia 22908, USA.

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March 2012

Helical tomotherapy planning for lung cancer based on ventilation magnetic resonance imaging.

Med Dosim 2011 5;36(4):389-96. Epub 2011 Mar 5.

Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.

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April 2012

Size matters: a comparison of T1 and T2 peripheral non-small-cell lung cancers treated with stereotactic body radiation therapy (SBRT).

J Thorac Cardiovasc Surg 2010 Sep 15;140(3):583-9. Epub 2010 May 15.

Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.

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September 2010

Dynamic MRI of grid-tagged hyperpolarized helium-3 for the assessment of lung motion during breathing.

Int J Radiat Oncol Biol Phys 2009 Sep 18;75(1):276-84. Epub 2009 Jun 18.

Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.

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September 2009

A rabbit irradiation platform for outcome assessment of lung stereotactic radiosurgery.

Int J Radiat Oncol Biol Phys 2009 Apr;73(5):1588-95

Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.

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April 2009

Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6.

PLoS One 2009 9;4(2):e4395. Epub 2009 Feb 9.

Department of Radiation Oncology, University of Virginia Health System, Charlottesville, Virginia, United States of America.

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April 2009

PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53.

Mol Cancer Ther 2009 Jan;8(1):135-40

Department of Radiation Oncology, Center for Cell Signaling, University of Virginia Health System, Box 800383 Charlottesville, VA, USA.

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January 2009

Semiconductor nanoparticles as energy mediators for photosensitizer-enhanced radiotherapy.

Int J Radiat Oncol Biol Phys 2008 Nov;72(3):633-5

Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA.

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November 2008

Reproducibility of interfraction lung motion probability distribution function using dynamic MRI: statistical analysis.

Int J Radiat Oncol Biol Phys 2008 Nov;72(4):1228-35

Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.

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November 2008

Special treatment issues in lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition).

Chest 2007 Sep;132(3 Suppl):290S-305S

Division of Thoracic Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA.

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September 2007

Evaluation of thoracic spinal cord motion using dynamic MRI.

Radiother Oncol 2007 Sep 10;84(3):279-82. Epub 2007 Aug 10.

Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.

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September 2007

Helical TomoTherapy in the treatment of central nervous system metastasis.

Neurosurg Focus 2007 Mar 15;22(3):E8. Epub 2007 Mar 15.

Department of Radiation Oncology, University of Virginia Health System, Charlottesville, Virginia 22908, USA.

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March 2007

Protein phosphatase-1alpha regulates centrosome splitting through Nek2.

Cancer Res 2007 Feb;67(3):1082-9

Department of Radiation Oncology, University of Virginia Health System, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

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February 2007

A dosimetric comparison of non-coplanar IMRT versus Helical Tomotherapy for nasal cavity and paranasal sinus cancer.

Radiother Oncol 2007 Feb 31;82(2):174-8. Epub 2007 Jan 31.

Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.

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February 2007

A motion phantom study on helical tomotherapy: the dosimetric impacts of delivery technique and motion.

Phys Med Biol 2007 Jan 18;52(1):243-55. Epub 2006 Dec 18.

Department of Engineering Physics, University of Virginia, Charlottesville, VA 22908, USA.

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January 2007

ATM regulates ionizing radiation-induced disruption of HDAC1:PP1:Rb complexes.

Cell Signal 2007 Mar 23;19(3):504-10. Epub 2006 Aug 23.

Department of Radiation Oncology, University of Virginia Health System, Charlottesville, VA 22908, United States.

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March 2007

Dose as a function of liver volume and planning target volume in helical tomotherapy, intensity-modulated radiation therapy-based stereotactic body radiation therapy for hepatic metastasis.

Int J Radiat Oncol Biol Phys 2006 Oct 14;66(2):620-5. Epub 2006 Aug 14.

Department of Radiation Oncology, Medical School, University of Virginia Health System, Charlottesville, VA 22908, USA.

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October 2006

The Ki-67 labeling index as a prognostic factor in Grade II oligoastrocytomas.

J Neurosurg 2005 Jun;102(6):1033-9

Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA.

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June 2005

Ionizing radiation activates nuclear protein phosphatase-1 by ATM-dependent dephosphorylation.

J Biol Chem 2002 Nov 28;277(44):41756-61. Epub 2002 Aug 28.

Department of Radiation Oncology, University of Virginia Health System, Charlottesville 22908, USA.

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November 2002

ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation.

J Biol Chem 2002 Feb 26;277(7):4839-44. Epub 2001 Nov 26.

Department of Radiation Oncology University of Virginia Health Science System, Charlottesville, Virginia 22908, USA.

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February 2002