James M Brophy

James M Brophy

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James M Brophy

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Oral Fluoroquinolones and Risk of Mitral and Aortic Regurgitation.

J Am Coll Cardiol 2019 Sep;74(11):1444-1450

Departments of Medicine, Epidemiology, and Biostatistics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.jacc.2019.07.035DOI Listing
September 2019

Statin Use and Risk of Vascular Events Among Cancer Patients After Radiotherapy to the Thorax, Head, and Neck.

J Am Heart Assoc 2019 Jul 19;8(13):e005996. Epub 2019 Jun 19.

4 Division of Clinical Epidemiology Department of Medicine McGill University Health Centre Montreal Quebec Canada.

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http://dx.doi.org/10.1161/JAHA.117.005996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662340PMC
July 2019

A Non-inferiority Framework for Cost-Effectiveness Analysis.

Int J Technol Assess Health Care 2019 24;35(4):291-297. Epub 2019 Jul 24.

Health Quality Ontario, Toronto, Canada.

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http://dx.doi.org/10.1017/S0266462319000576DOI Listing
July 2019

Heart failure risk predictions in adult patients with congenital heart disease: a systematic review.

Heart 2019 Jul 26. Epub 2019 Jul 26.

Division of Cardiology, McGill University Health Centre, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1136/heartjnl-2019-314977DOI Listing
July 2019

Challenges in Assessing the Incidence of Atrial Fibrillation Hospitalizations.

Can J Cardiol 2019 Jun 7. Epub 2019 Jun 7.

Division of Clinical Epidemiology, McGill University Health Centre Research Institute, Montreal, Quebec, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada; Division of Cardiology, McGill University Health Centre Research Institute, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2019.06.001DOI Listing
June 2019

Subsequent Event Risk in Individuals With Established Coronary Heart Disease.

Authors:
Riyaz S Patel Vinicius Tragante Amand F Schmidt Raymond O McCubrey Michael V Holmes Laurence J Howe Kenan Direk Axel Åkerblom Karin Leander Salim S Virani Karol A Kaminski Jochen D Muehlschlegel Hooman Allayee Peter Almgren Maris Alver Ekaterina V Baranova Hassan Behloui Bram Boeckx Peter S Braund Lutz P Breitling Graciela Delgado Nubia E Duarte Marie-Pierre Dubé Line Dufresne Niclas Eriksson Luisa Foco Markus Scholz Crystel M Gijsberts Charlotte Glinge Yan Gong Jaana Hartiala Mahyar Heydarpour Jaroslav A Hubacek Marcus Kleber Daniel Kofink Salma Kotti Pekka Kuukasjärvi Vei-Vei Lee Andreas Leiherer Petra A Lenzini Daniel Levin Leo-Pekka Lyytikäinen Nicola Martinelli Ute Mons Christopher P Nelson Kjell Nikus Anna P Pilbrow Rafal Ploski Yan V Sun Michael W T Tanck W H Wilson Tang Stella Trompet Sander W van der Laan Jessica Van Setten Ragnar O Vilmundarson Chiara Viviani Anselmi Efthymia Vlachopoulou Lawien Al Ali Eric Boerwinkle Carlo Briguori John F Carlquist Kathryn F Carruthers Gavino Casu John Deanfield Panos Deloukas Frank Dudbridge Thomas Engstrøm Natalie Fitzpatrick Kim Fox Bruna Gigante Stefan James Marja-Liisa Lokki Paulo A Lotufo Nicola Marziliano Ify R Mordi Joseph B Muhlestein Christopher Newton-Cheh Jan Pitha Christoph H Saely Ayman Samman-Tahhan Pratik B Sandesara Andrej Teren Adam Timmis Frans Van de Werf Els Wauters Arthur A M Wilde Ian Ford David J Stott Ale Algra Maria G Andreassi Diego Ardissino Benoit J Arsenault Christie M Ballantyne Thomas O Bergmeijer Connie R Bezzina Simon C Body Eric H Boersma Peter Bogaty Michiel L Bots Hermann Brenner Jasper J Brugts Ralph Burkhardt Clara Carpeggiani Gianluigi Condorelli Rhonda M Cooper-DeHoff Sharon Cresci Nicolas Danchin Ulf de Faire Robert N Doughty Heinz Drexel James C Engert Keith A A Fox Domenico Girelli Diederick E Grobbee Emil Hagström Stanley L Hazen Claes Held Harry Hemingway Imo E Hoefer G Kees Hovingh Reza Jabbari Julie A Johnson J Wouter Jukema Marcin P Kaczor Mika Kähönen Jiri Kettner Marek Kiliszek Olaf H Klungel Bo Lagerqvist Diether Lambrechts Jari O Laurikka Terho Lehtimäki Daniel Lindholm B K Mahmoodi Anke H Maitland-van der Zee Ruth McPherson Olle Melander Andres Metspalu Anna Niemcunowicz-Janica Oliviero Olivieri Grzegorz Opolski Colin N Palmer Gerard Pasterkamp Carl J Pepine Alexandre C Pereira Louise Pilote Arshed A Quyyumi A Mark Richards Marek Sanak Agneta Siegbahn Tabassome Simon Juha Sinisalo J Gustav Smith John A Spertus Steen Stender Alexandre F R Stewart Wojciech Szczeklik Anna Szpakowicz Jean-Claude Tardif Jurriën M Ten Berg Jacob Tfelt-Hansen George Thanassoulis Joachim Thiery Christian Torp-Pedersen Yolanda van der Graaf Frank L J Visseren Johannes Waltenberger Peter E Weeke Pim Van der Harst Chim C Lang Naveed Sattar Vicky A Cameron Jeffrey L Anderson James M Brophy Guillaume Pare Benjamin D Horne Winfried März Lars Wallentin Nilesh J Samani Aroon D Hingorani Folkert W Asselbergs

Circ Genom Precis Med 2019 Apr 21;12(4):e002470. Epub 2019 Mar 21.

Institute of Health Informatics (N.F., A. Timmis, H.H., F.W.A.), Faculty of Population Health Science, University College London, United Kingdom.

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http://dx.doi.org/10.1161/CIRCGEN.119.002470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629546PMC
April 2019

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.

Authors:
Riyaz S Patel Amand F Schmidt Vinicius Tragante Raymond O McCubrey Michael V Holmes Laurence J Howe Kenan Direk Axel Åkerblom Karin Leander Salim S Virani Karol A Kaminski Jochen D Muehlschlegel Marie-Pierre Dubé Hooman Allayee Peter Almgren Maris Alver Ekaterina V Baranova Hassan Behlouli Bram Boeckx Peter S Braund Lutz P Breitling Graciela Delgado Nubia E Duarte Line Dufresne Niclas Eriksson Luisa Foco Crystel M Gijsberts Yan Gong Jaana Hartiala Mahyar Heydarpour Jaroslav A Hubacek Marcus Kleber Daniel Kofink Pekka Kuukasjärvi Vei-Vei Lee Andreas Leiherer Petra A Lenzini Daniel Levin Leo-Pekka Lyytikäinen Nicola Martinelli Ute Mons Christopher P Nelson Kjell Nikus Anna P Pilbrow Rafal Ploski Yan V Sun Michael W T Tanck W H Wilson Tang Stella Trompet Sander W van der Laan Jessica van Setten Ragnar O Vilmundarson Chiara Viviani Anselmi Efthymia Vlachopoulou Eric Boerwinkle Carlo Briguori John F Carlquist Kathryn F Carruthers Gavino Casu John Deanfield Panos Deloukas Frank Dudbridge Natalie Fitzpatrick Bruna Gigante Stefan James Marja-Liisa Lokki Paulo A Lotufo Nicola Marziliano Ify R Mordi Joseph B Muhlestein Chris Newton Cheh Jan Pitha Christoph H Saely Ayman Samman-Tahhan Pratik B Sandesara Andrej Teren Adam Timmis Frans Van de Werf Els Wauters Arthur A M Wilde Ian Ford David J Stott Ale Algra Maria G Andreassi Diego Ardissino Benoit J Arsenault Christie M Ballantyne Thomas O Bergmeijer Connie R Bezzina Simon C Body Peter Bogaty Gert J de Borst Hermann Brenner Ralph Burkhardt Clara Carpeggiani Gianluigi Condorelli Rhonda M Cooper-DeHoff Sharon Cresci Ulf de Faire Robert N Doughty Heinz Drexel James C Engert Keith A A Fox Domenico Girelli Emil Hagström Stanley L Hazen Claes Held Harry Hemingway Imo E Hoefer G Kees Hovingh Julie A Johnson Pim A de Jong J Wouter Jukema Marcin P Kaczor Mika Kähönen Jiri Kettner Marek Kiliszek Olaf H Klungel Bo Lagerqvist Diether Lambrechts Jari O Laurikka Terho Lehtimäki Daniel Lindholm Bakhtawar K Mahmoodi Anke H Maitland-van der Zee Ruth McPherson Olle Melander Andres Metspalu Witold Pepinski Oliviero Olivieri Grzegorz Opolski Colin N Palmer Gerard Pasterkamp Carl J Pepine Alexandre C Pereira Louise Pilote Arshed A Quyyumi A Mark Richards Marek Sanak Markus Scholz Agneta Siegbahn Juha Sinisalo J Gustav Smith John A Spertus Alexandre F R Stewart Wojciech Szczeklik Anna Szpakowicz Jurriën M Ten Berg George Thanassoulis Joachim Thiery Yolanda van der Graaf Frank L J Visseren Johannes Waltenberger Pim Van der Harst Jean-Claude Tardif Naveed Sattar Chim C Lang Guillaume Pare James M Brophy Jeffrey L Anderson Winfried März Lars Wallentin Vicky A Cameron Benjamin D Horne Nilesh J Samani Aroon D Hingorani Folkert W Asselbergs

Circ Genom Precis Med 2019 Apr 21;12(4):e002471. Epub 2019 Mar 21.

Institute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).

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http://dx.doi.org/10.1161/CIRCGEN.119.002471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625876PMC
April 2019

Studying additive interaction in a healthcare database: Case study of NSAIDs, cardiovascular profiles, and acute myocardial infarction.

PLoS One 2018 10;13(8):e0201884. Epub 2018 Aug 10.

Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201884PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086415PMC
February 2019

The Reply.

Am J Med 2019 01;132(1):e24-e25

Department of Epidemiology Biostatistics and Occupational Health, McGill University; Division of Cardiology Department of Medicine, McGill University, Toronto Ontario, Canada.

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http://dx.doi.org/10.1016/j.amjmed.2018.09.017DOI Listing
January 2019

A Framework for Aiding the Translation of Scientific Evidence into Policy: The Experience of a Hospital-Based Technology Assessment Unit.

Int J Technol Assess Health Care 2019 Jan 24;35(3):204-211. Epub 2019 Apr 24.

Technology Assessment Unit,McGill University Health Centre,Montreal,Canada.

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http://dx.doi.org/10.1017/S0266462319000254DOI Listing
January 2019

Food for Thought: A "Low-Tech" Road to Improved Primary Cardiovascular Prevention: Adherence to Dietary Guidelines.

Authors:
James M Brophy

Can J Cardiol 2018 12 4;34(12):1551-1552. Epub 2018 Oct 4.

McGill University Health Center, Centre for Health Outcomes Research, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.09.014DOI Listing
December 2018

Diastolic Hypotension May Attenuate Benefits from Intensive Systolic Targets: Secondary Analysis of a Randomized Controlled Trial.

Am J Med 2018 10 12;131(10):1228-1233.e1. Epub 2018 Jun 12.

Department of Epidemiology, Biostatistics and Occupational Health; Division of Cardiology, Department of Medicine, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.amjmed.2018.05.022DOI Listing
October 2018

Statin medications and the risk of gynecomastia.

Clin Endocrinol (Oxf) 2018 10 15;89(4):470-473. Epub 2018 Jul 15.

Department of Ophthalmology and Visual Sciences and Pharmacology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://doi.wiley.com/10.1111/cen.13794
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http://dx.doi.org/10.1111/cen.13794DOI Listing
October 2018

Familial hypercholesterolemia in Canada: Initial results from the FH Canada national registry.

Atherosclerosis 2018 10;277:419-424

Research Institute of the McGill University Health Centre, Royal Victoria Hospital, Montreal, QC, Canada; Department of Medicine, McGill University, Royal Victoria Hospital, Montreal, QC, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00219150183028
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http://dx.doi.org/10.1016/j.atherosclerosis.2018.05.040DOI Listing
October 2018

Simplified Canadian Definition for Familial Hypercholesterolemia.

Can J Cardiol 2018 09 19;34(9):1210-1214. Epub 2018 May 19.

Research Institute of the McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada; Department of Medicine, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2018.05.015DOI Listing
September 2018

Sodium, Chloride, and Cardiovascular Mortality-Open Access Data Is Worth Its Salt.

Authors:
James M Brophy

Can J Cardiol 2018 08 11;34(8):968-969. Epub 2018 Apr 11.

McGill University Health Center, Centre for Health Outcomes Research (CORE), Montreal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.04.007DOI Listing
August 2018

Authors' reply to commentary: Renewed controversy over cardiovascular risk with non-steroidal anti-inflammatory drugs.

Int J Epidemiol 2018 04;47(2):674-675

University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada.

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http://dx.doi.org/10.1093/ije/dyy050DOI Listing
April 2018

Evaluation of the Pleiotropic Effects of Statins: A Reanalysis of the Randomized Trial Evidence Using Egger Regression-Brief Report.

Arterioscler Thromb Vasc Biol 2018 01 9;38(1):262-265. Epub 2017 Nov 9.

From the Preventive and Genomic Cardiology, Division of Cardiology, McGill University Health Centre and Research Institute, Montreal, QC, Canada (C.L., J.M.B., A.D.S., G.T.); Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada (J.M.B.); and MRC Integrative Epidemiology Unit, University of Bristol, United Kingdom (G.D.S.).

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http://dx.doi.org/10.1161/ATVBAHA.117.310052DOI Listing
January 2018

Risk of acute myocardial infarction with real-world NSAIDs depends on dose and timing of exposure.

Pharmacoepidemiol Drug Saf 2018 01 24;27(1):69-77. Epub 2017 Nov 24.

Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada.

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http://dx.doi.org/10.1002/pds.4358DOI Listing
January 2018

Big Data to Assess Potential Pregnancy-Related Cardiovascular Complications of Difficult Labour-Original Investigator-Driven Research Is Not Dead!

Authors:
James M Brophy

Can J Cardiol 2018 01;34(1):6-7

Departments of Medicine and Epidemiology (McGill), Royal Victoria Hospital, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2017.10.015DOI Listing
January 2018

Comparative effectiveness of novel oral anticoagulants in UK patients with non-valvular atrial fibrillation and chronic kidney disease: a matched cohort study.

BMJ Open 2018 01 24;8(1):e019638. Epub 2018 Jan 24.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1136/bmjopen-2017-019638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786093PMC
January 2018

Cardiac Resynchronization Therapy in Heart Failure: Do Evidence-Based Guidelines Follow the Evidence?

Circ Cardiovasc Qual Outcomes 2017 12;10(12)

From the Technology Assessment Unit, McGill University Health Centre, Montreal, Canada (N.D.A., E.S., N.D.); and Division of Cardiology, Department of Medicine, McGill University, Montreal, Canada (J.M.B.).

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http://dx.doi.org/10.1161/CIRCOUTCOMES.117.003554DOI Listing
December 2017

Impact of Selection Bias on Estimation of Subsequent Event Risk.

Circ Cardiovasc Genet 2017 10;10(5)

From the Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA (Y.-J.H., Z.L., P.L.); Groningen Research Institute of Pharmacy, University of Groningen, the Netherlands (A.F.S.); Institute of Cardiovascular Science and The Farr Institute, University College London, United Kingdom (A.F.S., A.D.H., F.W.A., R.P.); Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, United Kingdom (F.D.); Department of Health Sciences, University of Leicester, United Kingdom (F.D.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United Kingdom (M.V.H.); Medical Research Council Population Health Research Unit at the University of Oxford, United Kingdom (M.V.H.); Department of Medicine, McGill University, Montreal Quebec, Canada (J.M.B.); Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, The Netherlands (V.T., F.W.A.); Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA (A.A.Q.); Intermountain Heart Institute, Intermountain Medical Center, Murray, UT (R.O.M., B.D.H.); Department of Biomedical Informatics, University of Utah, Salt Lake City (B.D.H.); and Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia (Q.L.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659743PMC
October 2017

Sharing the Process of Diagnostic Decision Making.

JAMA Intern Med 2017 09;177(9):1245-1246

Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1001/jamainternmed.2017.1929DOI Listing
September 2017

Vioxx redux - or how I learned to worry about industry-sponsored clinical trials.

Authors:
James M Brophy

Indian J Med Ethics 2016 Oct-Dec;1(4):224-226. Epub 2016 Aug 30.

Department of Medicine; Professor of Medicine and Epidemiology (McGill), McGill University Health Centre, Royal Victoria Hospital, 1001 Decarie Blvd, Montreal, QC, CANADA H4A 3J1,.

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http://dx.doi.org/10.20529/IJME.2016.065DOI Listing
August 2017

What to Do Following Fibrinolysis for ST-Elevation Myocardial Infarction: Reappraising Routine Percutaneous Intervention.

JAMA Intern Med 2017 08;177(8):1073-1074

Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1001/jamainternmed.2017.1544DOI Listing
August 2017

Cost of Cardiac Surgery in Frail Compared With Nonfrail Older Adults.

Can J Cardiol 2017 08 30;33(8):1020-1026. Epub 2017 Mar 30.

Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Centre for Clinical Epidemiology, Lady Davis Institute, McGill University, Montreal, Quebec, Canada; Division of Cardiology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2017.03.019DOI Listing
August 2017

Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.

Authors:
Stephen Zewinger Marcus E Kleber Vinicius Tragante Raymond O McCubrey Amand F Schmidt Kenan Direk Ulrich Laufs Christian Werner Wolfgang Koenig Dietrich Rothenbacher Ute Mons Lutz P Breitling Herrmann Brenner Richard T Jennings Ioannis Petrakis Sarah Triem Mira Klug Alexandra Filips Stefan Blankenberg Christoph Waldeyer Christoph Sinning Renate B Schnabel Karl J Lackner Efthymia Vlachopoulou Ottar Nygård Gard Frodahl Tveitevåg Svingen Eva Ringdal Pedersen Grethe S Tell Juha Sinisalo Markku S Nieminen Reijo Laaksonen Stella Trompet Roelof A J Smit Naveed Sattar J Wouter Jukema Heinrich V Groesdonk Graciela Delgado Tatjana Stojakovic Anna P Pilbrow Vicky A Cameron A Mark Richards Robert N Doughty Yan Gong Rhonda Cooper-DeHoff Julie Johnson Markus Scholz Frank Beutner Joachim Thiery J Gustav Smith Ragnar O Vilmundarson Ruth McPherson Alexandre F R Stewart Sharon Cresci Petra A Lenzini John A Spertus Oliviero Olivieri Domenico Girelli Nicola I Martinelli Andreas Leiherer Christoph H Saely Heinz Drexel Axel Mündlein Peter S Braund Christopher P Nelson Nilesh J Samani Daniel Kofink Imo E Hoefer Gerard Pasterkamp Arshed A Quyyumi Yi-An Ko Jaana A Hartiala Hooman Allayee W H Wilson Tang Stanley L Hazen Niclas Eriksson Claes Held Emil Hagström Lars Wallentin Axel Åkerblom Agneta Siegbahn Igor Karp Christopher Labos Louise Pilote James C Engert James M Brophy George Thanassoulis Peter Bogaty Wojciech Szczeklik Marcin Kaczor Marek Sanak Salim S Virani Christie M Ballantyne Vei-Vei Lee Eric Boerwinkle Michael V Holmes Benjamin D Horne Aroon Hingorani Folkert W Asselbergs Riyaz S Patel Bernhard K Krämer Hubert Scharnagl Danilo Fliser Winfried März Thimoteus Speer

Lancet Diabetes Endocrinol 2017 07 26;5(7):534-543. Epub 2017 May 26.

Department of Internal Medicine IV, Saarland University Hospital, Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/S2213-8587(17)30096-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651679PMC
July 2017

Authors' reply to Evans.

BMJ 2017 07 3;358:j3185. Epub 2017 Jul 3.

McGill University, Montreal, Canada.

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http://dx.doi.org/10.1136/bmj.j3185DOI Listing
July 2017

Authors' reply to Wicks.

BMJ 2017 07 19;358:j3434. Epub 2017 Jul 19.

McGill University, Montreal, Canada.

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http://dx.doi.org/10.1136/bmj.j3434DOI Listing
July 2017

Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data.

BMJ 2017 May 9;357:j1909. Epub 2017 May 9.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423546PMC
http://dx.doi.org/10.1136/bmj.j1909DOI Listing
May 2017

Letter by Brophy Regarding Article, "ImPRECISION: Limitations to Interpretation of a Large Randomized Clinical Trial".

Authors:
James M Brophy

Circulation 2017 05;135(21):e1052-e1053

From Royal Victoria Hospital, Montreal, Canada.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.026414DOI Listing
May 2017

Outcomes of Patients With ST-Elevation Myocardial Infarction Receiving and Not Receiving Reperfusion Therapy: The Importance of Examining All Patients.

Can J Cardiol 2016 11 4;32(11):1325.e11-1325.e18. Epub 2016 Mar 4.

Unité d'évaluation cardiovasculaire, Institut national d'excellence en santé et en services sociaux (INESSS), Montreal, Québec, Canada; Service de cardiologie, Département multidisciplinaire de cardiologie, Institut universitaire de cardiologie et de pneumologie de Québec, Québec City, Québec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2016.02.073DOI Listing
November 2016

Reply to Letter From Kroll et al.-Risk of Death With Conducted Energy Weapons.

Can J Cardiol 2016 10 8;32(10):1261.e13. Epub 2016 Jan 8.

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http://dx.doi.org/10.1016/j.cjca.2016.01.001DOI Listing
October 2016

STEMI Treatment 2016: Is Outcome Improvement Stalling and If So, Why?

Can J Cardiol 2016 10 23;32(10):1193-1196. Epub 2016 Jan 23.

McGill University (Royal Victoria Hospital), Montreal, Québec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2016.01.022DOI Listing
October 2016

Mortality risk of sotalol and amiodarone for post-CABG atrial fibrillation.

Int J Cardiol 2016 Jul 9;214:502-7. Epub 2016 Apr 9.

Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, 1020 Pine Ave. West, Montreal, QC H3A 1A2, Canada; Department of Medicine, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Ave. West, Ross 4.12, Montreal, QC H3A 1A1, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01675273163072
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http://dx.doi.org/10.1016/j.ijcard.2016.04.032DOI Listing
July 2016

Multicenter trials, guidelines, and uncertainties - Do we know as much as we think we do?

Authors:
James M Brophy

Int J Cardiol 2015 1;187:600-3. Epub 2015 Apr 1.

Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada; Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2015.04.004DOI Listing
May 2016

Physiological and perceived health effects from daily changes in air pollution and weather among persons with heart failure: a panel study.

J Expo Sci Environ Epidemiol 2015 Mar-Apr;25(2):187-99. Epub 2014 Jun 18.

Department of Medicine, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/jes.2014.43DOI Listing
December 2015

Estimating the Risk of Cardiac Mortality After Exposure to Conducted Energy Weapons.

Can J Cardiol 2015 Dec 13;31(12):1439-46. Epub 2015 Feb 13.

Department of Medicine, McGill University Health Center, and Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2015.02.006DOI Listing
December 2015

Risks of Cardiac Valve Regurgitation and Heart Failure Associated with Ergot- and Non-Ergot-Derived Dopamine Agonist Use in Patients with Parkinson's Disease: A Systematic Review of Observational Studies.

CNS Drugs 2015 Dec;29(12):985-98

Department of Epidemiology and Biostatistics, and of Medicine, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1007/s40263-015-0293-4DOI Listing
December 2015

Stroke in Adults With Congenital Heart Disease: Incidence, Cumulative Risk, and Predictors.

Circulation 2015 Dec 23;132(25):2385-94. Epub 2015 Nov 23.

From the McGill Adult Unit for Congenital Heart Disease Excellence, Montreal, Québec, Canada (J.L., J.T., M.K., L.G., A.J.M.); Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada (J.M.B., A.J.M.); and Division of Cardiology, Jewish General Hospital, Montreal, Québec, Canada (J.T.).

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December 2015

Risperidone and Risk of Gynecomastia in Young Men.

J Child Adolesc Psychopharmacol 2015 Nov 19;25(9):671-3. Epub 2015 Aug 19.

3 Departments of Epidemiology, Biostatistics, and Medicine, McGill University , Montreal, Canada .

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http://dx.doi.org/10.1089/cap.2015.0024DOI Listing
November 2015

Placing HPS2-THRIVE in context using Bayesian analysis.

Int J Cardiol 2015 Sep 29;195:203-4. Epub 2015 May 29.

McGill University Health Center, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.ijcard.2015.05.156DOI Listing
September 2015

Improving the evidence base for better comparative effectiveness research.

Authors:
James M Brophy

J Comp Eff Res 2015 Sep 21;4(5):525-35. Epub 2015 Sep 21.

Department of Medicine, McGill University Health Center, Royal Victoria Hospital, 687 Pine avenue West, Ross 4.12, Montreal, Quebec, H3A 1A1, Canada.

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http://dx.doi.org/10.2217/cer.15.36DOI Listing
September 2015

Screening Strategies and Primary Prevention Interventions in Relatives of People With Coronary Artery Disease: A Systematic Review and Meta-analysis.

Can J Cardiol 2015 May 20;31(5):649-57. Epub 2015 Feb 20.

Department of Medicine, Division of Cardiology, McGill University Health Centre, Montreal, Québec, Canada; Preventive and Genomic Cardiology, McGill University Health Centre, Montreal, Québec, Canada; The Research Institute of the McGill University Health Centre, McGill University Health Centre, Montreal, Québec, Canada. Electronic address:

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May 2015

Testosterone therapy and risk of myocardial infarction: a pharmacoepidemiologic study.

Pharmacotherapy 2015 Jan 13;35(1):72-8. Epub 2015 Jan 13.

Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Therapeutic Evaluation Unit, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/phar.1534DOI Listing
January 2015

Risperidone use and risk for gynecomastia in men.

J Clin Psychopharmacol 2014 Oct;34(5):656-7

Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada and Therapeutic Evaluation Unit, Child and Family Research Institute University of British Columbia, Vancouver, Canada Department of Family Medicine, Faculty of Medicine, University of British Columbia and Vancouver Coastal Health - Richmond, Vancouver, Canada Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada and Therapeutic Evaluation Unit, Child and Family Research Institute, University of British Columbia, Vancouver, Canada Department of Medicine, McGill University, Royal Victoria Hospital, Montreal, Canada.

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http://dx.doi.org/10.1097/JCP.0000000000000182DOI Listing
October 2014

Fish oil for the reduction of atrial fibrillation recurrence, inflammation, and oxidative stress.

J Am Coll Cardiol 2014 Oct;64(14):1441-8

Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal Heart Institute Research Center, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.jacc.2014.07.956DOI Listing
October 2014

Antibiotics and sudden death in adults taking renin-angiotensin system blockers.

BMJ 2014 Oct 30;349:g6242. Epub 2014 Oct 30.

Department of Medicine, Epidemiology and Biostatistics, McGill University, Montreal, Canada.

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October 2014

Oral fluoroquinolone use and risk of peripheral neuropathy: a pharmacoepidemiologic study.

Neurology 2014 Sep 22;83(14):1261-3. Epub 2014 Aug 22.

From the Department of Pediatrics (M.E.), Faculty of Medicine, University of British Columbia, Vancouver; Therapeutic Evaluation Unit (M.E.), Child & Family Research Institute of British Columbia, Vancouver; Department of Medicine, Epidemiology and Biostatistics (J.M.B.), McGill University, Montreal, Canada; and Department of Neurology (A.S.), University of Washington, Seattle.

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http://dx.doi.org/10.1212/WNL.0000000000000846DOI Listing
September 2014

Long-term cost-effectiveness of transcatheter versus surgical closure of secundum atrial septal defect in adults.

Int J Cardiol 2014 Mar 8;172(1):109-14. Epub 2014 Jan 8.

McGill Adult Unit for Congenital Heart Disease Excellence (MAUDE Unit), McGill University Health Centre, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2013.12.144DOI Listing
March 2014

Door-to-balloon time and mortality.

N Engl J Med 2014 01;370(2):178

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http://dx.doi.org/10.1056/NEJMc1313113DOI Listing
January 2014

Male breast cancer and 5α-reductase inhibitors finasteride and dutasteride.

J Urol 2013 Nov 9;190(5):1811-4. Epub 2013 May 9.

U.S. Department of Health and Human Services/U.S. Food and Drug Administration/Center for Drug Evaluation and Research/Office of Pharmacovigilance and Epidemiology, Office of Surveillance and Epidemiology/Department of Epidemiology, Silver Spring, Maryland; Department of Pharmaceutical Outcomes & Policy, College of Pharmacy, University of Florida, Gainesville, Florida.

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http://dx.doi.org/10.1016/j.juro.2013.04.132DOI Listing
November 2013

Tamsulosin treatment for benign prostatic hyperplasia and risk of severe hypotension in men aged 40-85 years in the United States: risk window analyses using between and within patient methodology.

BMJ 2013 Nov 5;347:f6320. Epub 2013 Nov 5.

Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology, Department of Epidemiology, Silver Spring, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817852PMC
http://dx.doi.org/10.1136/bmj.f6320DOI Listing
November 2013

Associations between ambient air pollution and daily mortality among elderly persons in Montreal, Quebec.

Sci Total Environ 2013 Oct 19;463-464:931-42. Epub 2013 Jul 19.

Department of Medicine, McGill University, Montreal, Quebec, Canada; Division of Clinical Epidemiology, McGill University Health Centre, 687 Pine Ave. W., R4.29, Montreal, Quebec H3A 1A1, Canada. Electronic address:

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October 2013

Risk of acute kidney injury associated with the use of fluoroquinolones.

CMAJ 2013 Jul 3;185(10):E475-82. Epub 2013 Jun 3.

Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmacovigilance and Epidemiology, Silver Spring, MD, USA.

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http://dx.doi.org/10.1503/cmaj.121730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708027PMC
July 2013

Fibrinolysis or primary PCI in myocardial infarction.

N Engl J Med 2013 07;369(3):279; discussion page 281

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http://dx.doi.org/10.1056/NEJMc1305999DOI Listing
July 2013

Polycystic ovary syndrome and combined oral contraceptive use: a comparison of clinical practice in the United States to treatment guidelines.

Gynecol Endocrinol 2013 Apr 11;29(4):365-9. Epub 2013 Jan 11.

College of Pharmacy and Epidemiology, Pharmaceutical Outcomes & Policy, University of Florida, Newell Drive (HPNP), Gainesville, FL, USA.

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http://dx.doi.org/10.3109/09513590.2012.743007DOI Listing
April 2013

Risk of venous thromboembolism in women with polycystic ovary syndrome: a population-based matched cohort analysis.

CMAJ 2013 Feb 3;185(2):E115-20. Epub 2012 Dec 3.

Department of Pharmaceutical Outcome and Policy, University of Florida College of Pharmacy, Gainesville, FL, USA.

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http://dx.doi.org/10.1503/cmaj.120677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563911PMC
February 2013

Response.

Chest 2013 Feb;143(2):580

Department of Medicine, Montreal, QC, Canada; Department of Epidemiology, Biostatistics and Occupational Health, Montreal, QC, Canada; Centre for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1378/chest.12-2495DOI Listing
February 2013

Isotretinoin and risk for inflammatory bowel disease: a nested case-control study and meta-analysis of published and unpublished data.

JAMA Dermatol 2013 Feb;149(2):216-20

Therapeutic Evaluation Unit, Child and Family Research Institute of British Columbia, University of British Columbia, 950W28th Ave, Room A4-195, Vancouver, BC V5Z 4H4, Canada.

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February 2013

Bronchodilator use and the risk of arrhythmia in COPD: part 1: Saskatchewan cohort study.

Chest 2012 Aug;142(2):298-304

Department of Medicine, McGill University, QC, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Canada; Centre for Clinical Epidemiology, Jewish General Hospital-Lady Davis Research Institute, Montreal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1378/chest.10-2499DOI Listing
August 2012

Bronchodilator use and the risk of arrhythmia in COPD: part 2: reassessment in the larger Quebec cohort.

Chest 2012 Aug;142(2):305-311

Department of Medicine, McGill University, QC, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Canada; Centre for Clinical Epidemiology, Jewish General Hospital-Lady Davis Research Institute, Montreal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1378/chest.11-1597DOI Listing
August 2012

Oral fluoroquinolones and the risk of retinal detachment.

JAMA 2012 Apr;307(13):1414-9

Therapeutic Evaluation Unit, Child and Family Research Institute of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1001/jama.2012.383DOI Listing
April 2012

Irritable bowel syndrome and drospirenone-containing oral contraceptives; a comparative-safety study.

Curr Drug Saf 2012 Feb;7(1):8-15

LT United States Public Health Service, DHHS/FDA/CDER/OM/CACP, BLDG 22 Rm 3425, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.

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February 2012

Dopamine agonist use and the risk of heart failure.

Pharmacoepidemiol Drug Saf 2012 Jan 23;21(1):34-41. Epub 2011 Nov 23.

Center for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, Montreal, Québec, Canada.

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http://dx.doi.org/10.1002/pds.2267DOI Listing
January 2012

The association between drospirenone and hyperkalemia: a comparative-safety study.

BMC Clin Pharmacol 2011 Dec 30;11:23. Epub 2011 Dec 30.

University of Florida, College of Pharmacy, Pharmaceutical Outcomes & Policy, 101 S. Newell Drive (HPNP), PO Box 100496, Gainesville FL, USA 32611.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265420PMC
December 2011

ACP Journal Club. Review: Varenicline increases risk for serious adverse cardiovascular events in tobacco users.

Authors:
James M Brophy

Ann Intern Med 2011 Oct;155(8):JC4-5

McGill University, Montreal, Ontario, Canada.

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http://dx.doi.org/10.7326/0003-4819-155-8-201110180-02005DOI Listing
October 2011

Thiazolidinediones and the risk of incident congestive heart failure among patients with type 2 diabetes mellitus.

Pharmacoepidemiol Drug Saf 2011 Aug 13;20(8):785-96. Epub 2011 Jun 13.

Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada.

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http://doi.wiley.com/10.1002/pds.2165
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August 2011

Routine invasive management after fibrinolysis in patients with ST-elevation myocardial infarction: a systematic review of randomized clinical trials.

BMC Cardiovasc Disord 2011 Jun 20;11:34. Epub 2011 Jun 20.

Institut universitaire de cardiologie et pneumologie de Québec, Quebec, Canada.

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http://dx.doi.org/10.1186/1471-2261-11-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145591PMC
June 2011

Oral contraceptives and the risk of gallbladder disease: a comparative safety study.

CMAJ 2011 May 18;183(8):899-904. Epub 2011 Apr 18.

Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC.

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http://www.cmaj.ca/cgi/doi/10.1503/cmaj.110161
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091897PMC
May 2011

Analysis of willingness to pay for implantable cardioverter-defibrillator therapy.

Am J Cardiol 2011 Feb;107(3):423-7

Centre Hospitalier de l'Université de Montréal Research Centre, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.amjcard.2010.09.041DOI Listing
February 2011

Willingness to pay to eliminate the risk of restenosis following percutaneous coronary intervention: a contingent valuation.

Circ Cardiovasc Qual Outcomes 2011 Jan 14;4(1):46-52. Epub 2010 Dec 14.

Centre Hospitalier de Université de Montréal Research Centre, Université de Montréal, Quebec, Canada.

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http://dx.doi.org/10.1161/CIRCOUTCOMES.109.915421DOI Listing
January 2011

The potential interaction between clopidogrel and proton pump inhibitors: a systematic review.

BMC Med 2010 Dec 6;8:81. Epub 2010 Dec 6.

Federal University of Ceará School of Medicine, Fortaleza, Brazil.

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http://dx.doi.org/10.1186/1741-7015-8-81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016262PMC
December 2010

Statin use and risk of epilepsy: a nested case-control study.

Neurology 2010 Oct;75(17):1496-500

Center for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Canada.

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http://dx.doi.org/10.1212/WNL.0b013e3181f96253DOI Listing
October 2010

Contemporary cost analysis of single instillation of mitomycin after transurethral resection of bladder tumor in a universal health care system.

Urology 2010 Sep 15;76(3):652-6. Epub 2010 Apr 15.

Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.urology.2009.12.070DOI Listing
September 2010

Conflicting evidence: what's a clinician to do?

Ann Intern Med 2010 Sep;153(6):413-5

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http://dx.doi.org/10.7326/0003-4819-153-6-201009210-00011DOI Listing
September 2010

Gout, allopurinol use, and heart failure outcomes.

Arch Intern Med 2010 Aug;170(15):1358-64

Department of Medicine, McGill University Health Center, 687 Pine Ave W, Room A4.23, Montreal, QC H3A 1A1, Canada.

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http://dx.doi.org/10.1001/archinternmed.2010.198DOI Listing
August 2010

The disutility of restenosis--the impact of repeat percutaneous coronary intervention on quality of life.

Can J Cardiol 2010 Jun-Jul;26(6):197-200

Department of Epidemiology, Biostatistics and Health Technology Assessment, University Medical Centre Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/s0828-282x(10)70399-8DOI Listing
July 2010

Selective serotonin reuptake inhibitors and the risk of cataracts: a nested case-control study.

Ophthalmology 2010 Jun 7;117(6):1251-5. Epub 2010 Mar 7.

Center for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Vancouver, Canada.

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http://dx.doi.org/10.1016/j.ophtha.2009.11.042DOI Listing
June 2010

Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugs.

Am J Cardiol 2010 Jun;105(12):1740-5

Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.amjcard.2010.01.352DOI Listing
June 2010

ACP Journal Club. Ticagrelor was more effective than clopidogrel in acute coronary syndromes with planned invasive treatment.

Authors:
James M Brophy

Ann Intern Med 2010 May;152(10):JC5-4

McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.7326/0003-4819-152-10-201005180-02004DOI Listing
May 2010

Usefulness of soluble fas levels for improving diagnostic accuracy and prognosis for acute coronary syndromes.

Am J Cardiol 2010 Mar;105(6):797-803

Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.amjcard.2009.10.061DOI Listing
March 2010

Therapeutic management in patients with renal failure who experience an acute coronary syndrome.

Clin J Am Soc Nephrol 2010 Jan 29;5(1):87-94. Epub 2009 Oct 29.

Centre Hospitalier de l'Université de Montréal, 1058 Saint-Denis, Montreal, Quebec, Canada, H2X 3J4.

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http://dx.doi.org/10.2215/CJN.04290609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801654PMC
January 2010

The cost-effectiveness of Maze procedures using ablation techniques at the time of mitral valve surgery.

Int J Technol Assess Health Care 2009 Oct 12;25(4):485-96. Epub 2009 Oct 12.

Department of Cardiology, Royal Victoria Hospital, McGill University Health Centre, Quebec, Canada.

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http://dx.doi.org/10.1017/S0266462309990511DOI Listing
October 2009

Routine early angioplasty after fibrinolysis.

N Engl J Med 2009 Oct;361(15):1508; author reply 1509-10

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October 2009