Publications by authors named "James L Mohler"

100Publications

Understanding the Relationship between Environmental Arsenic and Prostate Cancer Aggressiveness among African-American and European-American Men in North Carolina.

Int J Environ Res Public Health 2020 Nov 12;17(22). Epub 2020 Nov 12.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.

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http://dx.doi.org/10.3390/ijerph17228364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697081PMC
November 2020

High intratumoral CD8 T-cell infiltration is associated with improved survival in prostate cancer patients undergoing radical prostatectomy.

Prostate 2020 Oct 21. Epub 2020 Oct 21.

Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

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http://dx.doi.org/10.1002/pros.24068DOI Listing
October 2020

Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019.

J Clin Oncol 2020 Aug 9;38(24):2798-2811. Epub 2020 Jun 9.

Department of Urology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA.

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http://dx.doi.org/10.1200/JCO.20.00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430215PMC
August 2020

A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry.

Eur Urol 2020 Sep 12;78(3):316-320. Epub 2020 May 12.

Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2020.04.060DOI Listing
September 2020

A CD24-p53 axis contributes to African American prostate cancer disparities.

Prostate 2020 05 13;80(8):609-618. Epub 2020 Mar 13.

Department of Genetics and O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1002/pros.23973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176538PMC
May 2020

Current recommendations for prostate cancer genetic testing: NCCN prostate guideline.

Can J Urol 2019 Oct;26(5 Suppl 2):34-37

Departments of Urology and Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

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October 2019

NCCN Guidelines Updates: Management of Prostate Cancer.

J Natl Compr Canc Netw 2019 05;17(5.5):583-586

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http://dx.doi.org/10.6004/jnccn.2019.5011DOI Listing
May 2019

Potential impact of combined inhibition of 3α-oxidoreductases and 5α-reductases on prostate cancer.

Asian J Urol 2019 Jan 26;6(1):50-56. Epub 2018 Sep 26.

Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

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http://dx.doi.org/10.1016/j.ajur.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363635PMC
January 2019

In honor of Dr. Donald S. Coffey - Prostate cancer biology and therapy.

Asian J Urol 2019 Jan 3;6(1):1-2. Epub 2018 Nov 3.

Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

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http://dx.doi.org/10.1016/j.ajur.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363597PMC
January 2019

Dietary patterns based on the Mediterranean diet and DASH diet are inversely associated with high aggressive prostate cancer in PCaP.

Ann Epidemiol 2019 01 5;29:16-22.e1. Epub 2018 Sep 5.

Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC. Electronic address:

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http://dx.doi.org/10.1016/j.annepidem.2018.08.012DOI Listing
January 2019

The association of metformin use with prostate cancer aggressiveness among Black Americans and White Americans in a population-based study.

Cancer Causes Control 2018 Nov 28;29(11):1143-1150. Epub 2018 Sep 28.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, 135 Dauer Drive, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s10552-018-1087-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275149PMC
November 2018

Proteomic Analysis of Charcoal-Stripped Fetal Bovine Serum Reveals Changes in the Insulin-like Growth Factor Signaling Pathway.

J Proteome Res 2018 09 3;17(9):2963-2977. Epub 2018 Aug 3.

Department of Urology, Roswell Park Comprehensive Cancer Center , Elm and Carlton Streets , Buffalo , New York 14263 , United States.

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http://dx.doi.org/10.1021/acs.jproteome.8b00135DOI Listing
September 2018

Mathematical modeling of intracrine androgen metabolism in prostate cancer: Methodological aspects.

Prostate 2018 Jun 25. Epub 2018 Jun 25.

Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York.

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http://dx.doi.org/10.1002/pros.23665DOI Listing
June 2018

Modelling attrition and nonparticipation in a longitudinal study of prostate cancer.

BMC Med Res Methodol 2018 06 20;18(1):60. Epub 2018 Jun 20.

LSUHSC, School of Public Health, Health Policy and Systems Management Program, New Orleans, USA.

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http://dx.doi.org/10.1186/s12874-018-0518-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011525PMC
June 2018

NCCN Guidelines Updates: Prostate Cancer and Prostate Cancer Early Detection.

J Natl Compr Canc Netw 2018 05;16(5S):620-623

Presented by Peter H. Carroll, MD, MPH, Department of Urology, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, and James L. Mohler, MD, Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.

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http://dx.doi.org/10.6004/jnccn.2018.0036DOI Listing
May 2018

Statin use, high cholesterol and prostate cancer progression; results from HCaP-NC.

Prostate 2018 08 1;78(11):857-864. Epub 2018 May 1.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1002/pros.23644DOI Listing
August 2018

A brief history of intracrine androgen metabolism by castration-recurrent prostate cancer.

Authors:
James L Mohler

Am J Clin Exp Urol 2018 1;6(2):101-106. Epub 2018 Apr 1.

Department of Urology, Roswell Park Comprehensive Cancer CenterBuffalo, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902728PMC
April 2018

Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry.

J Natl Cancer Inst 2017 08;109(8)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.

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http://dx.doi.org/10.1093/jnci/djx084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448553PMC
August 2017

The Association of Diabetes and Obesity With Prostate Cancer Progression: HCaP-NC.

Prostate 2017 Jun 6;77(8):878-887. Epub 2017 Mar 6.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1002/pros.23342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695861PMC
June 2017

Unit Nonresponse in a Population-Based Study of Prostate Cancer.

PLoS One 2016 16;11(12):e0168364. Epub 2016 Dec 16.

Epidemiology Program, LSUHSC School of Public Health, New Orleans, Louisiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168364PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161356PMC
July 2017

Up-Regulation of Follistatin-Like 1 By the Androgen Receptor and Melanoma Antigen-A11 in Prostate Cancer.

Prostate 2017 04 14;77(5):505-516. Epub 2016 Dec 14.

Laboratories for Reproductive Biology, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1002/pros.23288DOI Listing
April 2017

A four gene signature predictive of recurrent prostate cancer.

Oncotarget 2017 Jan;8(2):3430-3440

Departments of Biomedical Genetics, University of Rochester Medical Center, Rochester NY, 14642, USA.

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http://dx.doi.org/10.18632/oncotarget.13837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356893PMC
January 2017

The association of diabetes and obesity with prostate cancer aggressiveness among Black Americans and White Americans in a population-based study.

Cancer Causes Control 2016 Dec 9;27(12):1475-1485. Epub 2016 Nov 9.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, 135 Dauer Drive, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s10552-016-0828-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139913PMC
December 2016

Validation of the Kattan Nomogram for Prostate Cancer Recurrence After Radical Prostatectomy.

J Natl Compr Canc Netw 2016 11;14(11):1395-1401

From the Department of Cancer Prevention, Roswell Park Cancer Institute, Buffalo, New York; Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio; Department of Urology, Center for Immunotherapy, and Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York; and Department of Urology, State University of New York at Buffalo, Buffalo, New York.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874800PMC
http://dx.doi.org/10.6004/jnccn.2016.0149DOI Listing
November 2016

Quality of care received and patient-reported regret in prostate cancer: Analysis of a population-based prospective cohort.

Cancer 2017 Jan 13;123(1):138-143. Epub 2016 Sep 13.

Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1002/cncr.30315DOI Listing
January 2017

Characterization of Prostate Cancer in a Functional Eunuch.

J Natl Compr Canc Netw 2016 09;14(9):1054-60

From the Departments of Urology, Pharmacology and Therapeutics, and Pathology, Roswell Park Cancer Institute, Buffalo, New York.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749417PMC
http://dx.doi.org/10.6004/jnccn.2016.0116DOI Listing
September 2016

Development and Validation of a Quality Assurance Score for Robot-assisted Radical Cystectomy: A 10-year Analysis.

Urology 2016 11 1;97:124-129. Epub 2016 Aug 1.

Department of Urology, Roswell Park Cancer Institute, Buffalo, NY. Electronic address:

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http://dx.doi.org/10.1016/j.urology.2016.06.063DOI Listing
November 2016

Intratumoral and Intertumoral Genomic Heterogeneity of Multifocal Localized Prostate Cancer Impacts Molecular Classifications and Genomic Prognosticators.

Eur Urol 2017 02 21;71(2):183-192. Epub 2016 Jul 21.

Department of Cancer Biology, Cleveland Clinic, Cleveland, OH, USA; Department of Urology, Cleveland Clinic, Cleveland, OH, USA; Department of Hematology/Medical Oncology, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906059PMC
February 2017

Androgen Deprivation Therapy for Advanced Prostate Cancer: Can Evolution Be Accelerated?

Authors:
James L Mohler

J Natl Compr Canc Netw 2016 06;14(6):701-3

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http://dx.doi.org/10.6004/jnccn.2016.0071DOI Listing
June 2016

Characterization of fibroblast-free CWR-R1ca castration-recurrent prostate cancer cell line.

Prostate 2016 09 8;76(12):1067-77. Epub 2016 Jun 8.

Department of Cancer Genetics, Center for Genetics and Pharmacology, Roswell Park Cancer Institute, Buffalo, New York.

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http://dx.doi.org/10.1002/pros.23190DOI Listing
September 2016

Evolving Use of Androgen Deprivation Therapy in Prostate Cancer Management.

Authors:
James L Mohler

J Natl Compr Canc Netw 2016 05;14(5 Suppl):663-5

Presented by James L. Mohler, MD, Department of Urology, Roswell Park Cancer Institute, Buffalo, New York.

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http://dx.doi.org/10.6004/jnccn.2016.0186DOI Listing
May 2016

Outcomes of Scheduled vs For-Cause Biopsy Regimens for Prostate Cancer Active Surveillance.

J Urol 2016 Oct 6;196(4):1061-8. Epub 2016 May 6.

Department of Urology, Roswell Park Cancer Institute, Buffalo, New York; Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York; Department of Urology, State University of New York at Buffalo, Buffalo, New York. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2016.05.003DOI Listing
October 2016

Regulators of Androgen Action Resource: a one-stop shop for the comprehensive study of androgen receptor action.

Database (Oxford) 2016 13;2016. Epub 2016 Feb 13.

Department of Cancer Biology, Cleveland Clinic, Cleveland, OH, USA Department of Urology Department of Hematology/Medical Oncology, Cleveland Clinic, Cleveland, OH, USA

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http://dx.doi.org/10.1093/database/bav125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752970PMC
October 2016

Statin Use and Prostate Cancer Aggressiveness: Results from the Population-Based North Carolina-Louisiana Prostate Cancer Project.

Cancer Epidemiol Biomarkers Prev 2016 04 27;25(4):670-7. Epub 2016 Jan 27.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-0631DOI Listing
April 2016

Application of Mannich bases to the synthesis of hydroxymethylated isoflavonoids as potential antineoplastic agents.

Org Biomol Chem 2015 Dec 29;13(46):11292-301. Epub 2015 Sep 29.

Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, Kyiv 02094, Ukraine.

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http://xlink.rsc.org/?DOI=C5OB01828E
Publisher Site
http://dx.doi.org/10.1039/c5ob01828eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651832PMC
December 2015

Simulation-based training in robot-assisted surgery: current evidence of value and potential trends for the future.

Curr Urol Rep 2015 Jun;16(6):41

A.T.L.A.S (Applied Technology Laboratory for Advanced Surgery) Program, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://dx.doi.org/10.1007/s11934-015-0508-8DOI Listing
June 2015

Revisiting nomenclature for the description of prostate cancer androgen-responsiveness.

Am J Clin Exp Urol 2014 12;2(2):121-6. Epub 2014 Jul 12.

Department of Urology, Roswell Park Cancer Institute Elm and Carlton Streets, Buffalo, NY 14263, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219297PMC
November 2014

The Thoc1 ribonucleoprotein and prostate cancer progression.

J Natl Cancer Inst 2014 Nov 8;106(11). Epub 2014 Oct 8.

Department of Pharmacology & Therapeutics (MC, YW, XZ, BAF, DWG), Department of Biostatistics (DLG), Department of Pathology (TK, WB, CDM), Department of Cancer Prevention and Population Science (RDPO), Department of Urology (JLM), Roswell Park Cancer Institute, Buffalo, NY; Department of Biomedical Sciences, Cornell University, Ithaca, NY (AYN); Department of Pathology, Virginia Commonwealth University, Richmond, VA (YL). Current affiliation: MedImmune LLC, Gaitherburg, MD.

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http://dx.doi.org/10.1093/jnci/dju306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271031PMC
November 2014

Roles for the backdoor pathway of androgen metabolism in prostate cancer response to castration and drug treatment.

Int J Biol Sci 2014 3;10(6):596-601. Epub 2014 Jun 3.

Department of Urology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.7150/ijbs.8780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062952PMC
February 2015

Low detectable prostate specific antigen after radical prostatectomy--treat or watch?

J Urol 2014 Nov 21;192(5):1390-6. Epub 2014 May 21.

Department of Urology, Roswell Park Cancer Institute, Buffalo, New York. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2014.05.088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586061PMC
November 2014

Concept and viability of androgen annihilation for advanced prostate cancer.

Authors:
James L Mohler

Cancer 2014 Sep 25;120(17):2628-37. Epub 2014 Apr 25.

Department of Urology, Roswell Park Cancer Institute, Buffalo, New York; Department of Urology, State University of New York at Buffalo School of Medicine and Biotechnology, Buffalo, New York.

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http://doi.wiley.com/10.1002/cncr.28675
Publisher Site
http://dx.doi.org/10.1002/cncr.28675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140964PMC
September 2014

Prostate cancer, version 1.2014.

J Natl Compr Canc Netw 2013 Dec;11(12):1471-9

From 1Roswell Park Cancer Institute; 2Dana-Farber/Brigham and Women's Cancer Center; 3Duke Cancer Institute; 4The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; 5Huntsman Cancer Institute at the University of Utah; 6Memorial Sloan-Kettering Cancer Center; 7Fred & Pamela Buffett Cancer Center at The Nebraska Medical Center; 8Prostate Health Education Network; 9University of Washington/Seattle Cancer Care Alliance; 10Fox Chase Cancer Center; 11City of Hope Comprehensive Cancer Center; 12Massachusetts General Hospital Cancer Center; 13Robert H. Lurie Comprehensive Cancer Center of Northwestern University; 14Vanderbilt-Ingram Cancer Center; 15University of Michigan Comprehensive Cancer Center; 16Moffitt Cancer Center; 17St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; 18UCSF Helen Diller Family Comprehensive Cancer Center; 19The University of Texas MD Anderson Cancer Center; 20Patient Advocate; 21Stanford Cancer Institute; 22Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; 23The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; and 24National Comprehensive Cancer Network.

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http://dx.doi.org/10.6004/jnccn.2013.0174DOI Listing
December 2013

5α-reductase type 3 enzyme in benign and malignant prostate.

Prostate 2014 Feb 22;74(3):235-49. Epub 2013 Oct 22.

Department of Urology, Roswell Park Cancer Institute, Buffalo, New York.

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http://dx.doi.org/10.1002/pros.22745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992828PMC
February 2014

Mechanism of androgen receptor corepression by CKβBP2/CRIF1, a multifunctional transcription factor coregulator expressed in prostate cancer.

Mol Cell Endocrinol 2014 Jan 5;382(1):302-313. Epub 2013 Oct 5.

Laboratories for Reproductive Biology, Department of Pediatrics, University of North Carolina, School of Medicine, Chapel Hill, NC, United States; Lineberger Comprehensive Cancer Center, University of North Carolina, School of Medicine, Chapel Hill, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2013.09.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880566PMC
January 2014

Admixture mapping of prostate cancer in African Americans participating in the North Carolina-Louisiana Prostate Cancer Project (PCaP).

Prostate 2014 Jan 4;74(1):1-9. Epub 2013 Sep 4.

Department of Epidemiology, Division of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, Division of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1002/pros.22722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934014PMC
January 2014

Proto-oncogene activity of melanoma antigen-A11 (MAGE-A11) regulates retinoblastoma-related p107 and E2F1 proteins.

J Biol Chem 2013 Aug 12;288(34):24809-24. Epub 2013 Jul 12.

Laboratories for Reproductive Biology, Department of Pediatrics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M113.468579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750176PMC
August 2013

DNA methylation and nucleosome occupancy regulate the cancer germline antigen gene MAGEA11.

Epigenetics 2013 Aug 9;8(8):849-63. Epub 2013 Jul 9.

Department of Pharmacology and Therapeutics; Roswell Park Cancer Institute; Buffalo, NY USA.

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http://dx.doi.org/10.4161/epi.25500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883788PMC
August 2013

The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific.

Prostate 2013 Oct 28;73(14):1483-94. Epub 2013 Jun 28.

Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.

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http://dx.doi.org/10.1002/pros.22696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992475PMC
October 2013

Prostate cancer cells differ in testosterone accumulation, dihydrotestosterone conversion, and androgen receptor signaling response to steroid 5α-reductase inhibitors.

Prostate 2013 Sep 27;73(13):1470-82. Epub 2013 Jun 27.

Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

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http://dx.doi.org/10.1002/pros.22694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999702PMC
September 2013

New developments in the management of prostate cancer.

J Natl Compr Canc Netw 2013 May;11(5 Suppl):653-7

The Lank Center for Genitourinary Oncology and Solid Tumor Oncology at Dana-Farber Cancer Institute/Brigham & Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.6004/jnccn.2013.0194DOI Listing
May 2013