James J Foley

Pharmacological properties of revefenacin (TD-4208), a novel, nebulized long-acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat, guinea pig, and human isolated airway tissues.

Authors:

Sharath S Hegde M Teresa Pulido-Rios Mark A Luttmann James J Foley Gerald E Hunsberger Tod Steinfeld TaeWeon Lee Yuhua Ji Mathai M Mammen Jeffrey R Jasper

Pharmacol Res Perspect 2018 06 30;6(3):e00400. Epub 2018 Apr 30.

Theravance Biopharma U.S, Inc South San Francisco CA USA.

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June 2018

TLR2 agonism reverses chemotherapy-induced neutropenia in .

Authors:

Nicholas J Laping Michael P DeMartino Joshua E Cottom Jeffrey M Axten John G Emery Jeffrey H Guss Miriam Burman James J Foley Mui Cheung Allen Oliff Sanjay Kumar

Blood Adv 2017 Dec 8;1(26):2553-2562. Epub 2017 Dec 8.

New Targets Incubator and.

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December 2017

Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases.

Authors:

Michael Salmon Mark A Luttmann James J Foley Peter T Buckley Dulcie B Schmidt Miriam Burman Edward F Webb Christopher J DeHaas Charles J Kotzer Victoria J Barrett Robert J Slack Henry M Sarau Michael R Palovich Dramane I Lainé Douglas W P Hay William L Rumsey

J Pharmacol Exp Ther 2013 May 22;345(2):260-70. Epub 2013 Feb 22.

GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania, USA.

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May 2013

Tyrosine urea muscarinic acetylcholine receptor antagonists: achiral quaternary ammonium groups.

Authors:

Qi Jin Roderick S Davis Ann M Bullion Jian Jin Yonghui Wang Katherine L Widdowson Michael R Palovich James J Foley Dulcie B Schmidt Peter T Buckley Edward F Webb Michael Salmon Kristen E Belmonte Henry M Sarau Jakob Busch-Petersen

Bioorg Med Chem Lett 2012 Dec 2;22(23):7087-91. Epub 2012 Oct 2.

GlaxoSmithKline, 709 Swedeland Road, PO Box 1539, King of Prussia, PA 19406-0939, USA.

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December 2012

Design, synthesis and structure-activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists.

Bioorg Med Chem Lett 2012 May 15;22(9):3366-9. Epub 2012 Feb 15.

GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.

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May 2012

2' biaryl amides as novel and subtype selective M1 agonists. Part I: Identification, synthesis, and initial SAR.

Authors:

Brian Budzik Vincenzo Garzya Dongchuan Shi James J Foley Ralph A Rivero Christopher J Langmead Jeannette Watson Zining Wu Ian T Forbes Jian Jin

Bioorg Med Chem Lett 2010 Jun 17;20(12):3540-4. Epub 2010 May 17.

Discovery Research and Centers of Excellence for Drug Discovery, GlaxoSmithKline, Collegeville, PA 19426, USA.

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June 2010

Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD.

Authors:

Zehong Wan Dramane I Laine Hongxing Yan Chongjie Zhu Katherine L Widdowson Peter T Buckley Miriam Burman James J Foley Henry M Sarau Dulcie B Schmidt Edward F Webb Kristen E Belmonte Michael Palovich

Bioorg Med Chem Lett 2009 Aug 8;19(16):4560-2. Epub 2009 Jul 8.

Respiratory Centre of Excellence for Drug Discovery, Research and Development, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA 19406, USA.

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August 2009

Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists.

Authors:

Dramane I Lainé Brent McCleland Sonia Thomas Christopher Neipp Brian Underwood Jeremy Dufour Katherine L Widdowson Michael R Palovich Frank E Blaney James J Foley Edward F Webb Mark A Luttmann Miriam Burman Kristen Belmonte Michael Salmon

J Med Chem 2009 Apr;52(8):2493-505

GlaxoSmithKline, Respiratory CEDD, 709 Swedeland Road, P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939, USA.

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April 2009

Optimized procedures for producing biologically active chemokines.

Authors:

Quinn Lu Matthew C Burns Patrick J McDevitt Taylor L Graham Abby J Sukman James A Fornwald Xiaoyan Tang Kathleen T Gallagher Gerald E Hunsberger James J Foley Dulcie B Schmidt John J Kerrigan Tia S Lewis Robert S Ames Kyung O Johanson

Protein Expr Purif 2009 Jun;65(2):251-60

GlaxoSmithKline, Biological Reagents & Assay Development, Mail Code: UE0548, 709 Swedeland Road, King of Prussia, PA 19406, USA.

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June 2009

M3 muscarinic acetylcholine receptor antagonists: SAR and optimization of bi-aryl amines.

Authors:

Brian Budzik Yonghui Wang Dongchuan Shi Feng Wang Haibo Xie Zehong Wan Chongye Zhu James J Foley Parvathi Nuthulaganti Lorena A Kallal Henry M Sarau Dwight M Morrow Michael L Moore Ralph A Rivero Michael Palovich Michael Salmon Kristen E Belmonte Dramane I Laine Jian Jin

Bioorg Med Chem Lett 2009 Mar 4;19(6):1686-90. Epub 2009 Feb 4.

Centers of Excellence for Drug Discovery, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.

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March 2009

Camphor sulfonamide derivatives as novel, potent and selective CXCR3 antagonists.

Authors:

Yonghui Wang Jakob Busch-Petersen Feng Wang Terence J Kiesow Todd L Graybill Jian Jin Zheng Yang James J Foley Gerald E Hunsberger Dulcie B Schmidt Henry M Sarau Elizabeth A Capper-Spudich Zining Wu Laura S Fisher Michael S McQueney Ralph A Rivero Katherine L Widdowson

Bioorg Med Chem Lett 2009 Jan 6;19(1):114-8. Epub 2008 Nov 6.

Center of Excellence for Drug Discovery, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.

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January 2009

Muscarinic acetylcholine receptor antagonists: SAR and optimization of tyrosine ureas.

Authors:

Jian Jin Yonghui Wang Dongchuan Shi Feng Wang Wei Fu Roderick S Davis Qi Jin James J Foley Henry M Sarau Dwight M Morrow Michael L Moore Ralph A Rivero Michael Palovich Michael Salmon Kristen E Belmonte Jakob Busch-Petersen

Bioorg Med Chem Lett 2008 Oct 10;18(20):5481-6. Epub 2008 Sep 10.

Centers of Excellence for Drug Discovery and Molecular Discovery Research, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.

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October 2008

Discovery of biphenyl piperazines as novel and long acting muscarinic acetylcholine receptor antagonists.

J Med Chem 2008 Oct 18;51(19):5915-8. Epub 2008 Sep 18.

GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, USA.

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October 2008

Discovery of novel and long acting muscarinic acetylcholine receptor antagonists.

J Med Chem 2008 Aug 5;51(16):4866-9. Epub 2008 Aug 5.

GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, USA.

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August 2008

Urotensin-II receptor antagonists: synthesis and SAR of N-cyclic azaalkyl benzamides.

Authors:

Jian Jin Ming An Anthony Sapienza Nambi Aiyar Diane Naselsky Henry M Sarau James J Foley Kevin L Salyers Steven D Knight Richard M Keenan Ralph A Rivero Dashyant Dhanak Stephen A Douglas

Bioorg Med Chem Lett 2008 Jul 10;18(14):3950-4. Epub 2008 Jun 10.

Centers of Excellence for Drug Discovery, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.

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July 2008

Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists.

Authors:

Dramane I Lainé Haibo Xie Noémie Buffet James J Foley Peter Buckley Edward F Webb Katherine L Widdowson Michael R Palovich Kristen E Belmonte

Bioorg Med Chem Lett 2007 Nov 25;17(22):6066-9. Epub 2007 Sep 25.

GlaxoSmithkline, 709 Swedeland Road, King of Prussia, PA 19406, USA.

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November 2007

3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists.

Authors:

Yonghui Wang Jakob Busch-Petersen Feng Wang Lanping Ma Wei Fu Jeffrey K Kerns Jian Jin Michael R Palovich Jing-Kang Shen Miriam Burman James J Foley Dulcie B Schmidt Gerald E Hunsberger Henry M Sarau Katherine L Widdowson

Bioorg Med Chem Lett 2007 Jul 10;17(14):3864-7. Epub 2007 May 10.

Discovery Medicinal Chemistry, Molecular Discovery Research, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.

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July 2007

Oxazolidinones as novel human CCR8 antagonists.

Bioorg Med Chem Lett 2007 Mar 24;17(6):1722-5. Epub 2006 Dec 24.

Discovery Medicinal Chemistry, Molecular Discovery Research, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.

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March 2007

Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor.

Authors:

Brent W McCleland Roderick S Davis Michael R Palovich Katherine L Widdowson Michelle L Werner Miriam Burman James J Foley Dulcie B Schmidt Henry M Sarau Martin Rogers Kevin L Salyers Peter D Gorycki Theresa J Roethke Gary J Stelman Leonard M Azzarano Keith W Ward Jakob Busch-Petersen

Bioorg Med Chem Lett 2007 Mar 23;17(6):1713-7. Epub 2006 Dec 23.

GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.

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March 2007

N,N'-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors.

Authors:

Hong Nie Katherine L Widdowson Michael R Palovich Wei Fu John D Elliott Deborah L Bryan Miriam Burman Dulcie B Schmidt James J Foley Henry M Sarau Jakob Busch-Petersen

Bioorg Med Chem Lett 2006 Nov 24;16(21):5513-6. Epub 2006 Aug 24.

GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.

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November 2006

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