Publications by authors named "James Fraser"

100Publications

qFit 3: Protein and ligand multiconformer modeling for X-ray crystallographic and single-particle cryo-EM density maps.

Protein Sci 2021 Jan 30;30(1):270-285. Epub 2020 Nov 30.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.

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January 2021

Discovery of allosteric binding sites by crystallographic fragment screening.

Curr Opin Struct Biol 2020 Dec 7;65:209-216. Epub 2020 Nov 7.

Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK; Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot OX11 0QX, UK; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK; Department of Biochemistry, University of Johannesburg, Auckland Park, 2006, South Africa. Electronic address:

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December 2020

Drivers of a habitat shift by critically endangered Siberian cranes: Evidence from long-term data.

Ecol Evol 2020 Oct 1;10(20):11055-11068. Epub 2020 Sep 1.

Jiangxi Province Key Laboratory of Watershed Ecosystem Change and Biodiversity Center for Watershed Ecology, Institute of Life Science and School of Life Science Nanchang University Nanchang China.

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October 2020

Are Posterior Crural Stitches Necessary in Pediatric Laparoscopic Fundoplication?

J Laparoendosc Adv Surg Tech A 2020 Dec 27;30(12):1272-1276. Epub 2020 Oct 27.

Department of Surgery, Children's Mercy Hospital, Kansas City, Missouri, USA.

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December 2020

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

Authors:
David E Gordon Joseph Hiatt Mehdi Bouhaddou Veronica V Rezelj Svenja Ulferts Hannes Braberg Alexander S Jureka Kirsten Obernier Jeffrey Z Guo Jyoti Batra Robyn M Kaake Andrew R Weckstein Tristan W Owens Meghna Gupta Sergei Pourmal Erron W Titus Merve Cakir Margaret Soucheray Michael McGregor Zeynep Cakir Gwendolyn Jang Matthew J O'Meara Tia A Tummino Ziyang Zhang Helene Foussard Ajda Rojc Yuan Zhou Dmitry Kuchenov Ruth Hüttenhain Jiewei Xu Manon Eckhardt Danielle L Swaney Jacqueline M Fabius Manisha Ummadi Beril Tutuncuoglu Ujjwal Rathore Maya Modak Paige Haas Kelsey M Haas Zun Zar Chi Naing Ernst H Pulido Ying Shi Inigo Barrio-Hernandez Danish Memon Eirini Petsalaki Alistair Dunham Miguel Correa Marrero David Burke Cassandra Koh Thomas Vallet Jesus A Silvas Caleigh M Azumaya Christian Billesbølle Axel F Brilot Melody G Campbell Amy Diallo Miles Sasha Dickinson Devan Diwanji Nadia Herrera Nick Hoppe Huong T Kratochvil Yanxin Liu Gregory E Merz Michelle Moritz Henry C Nguyen Carlos Nowotny Cristina Puchades Alexandrea N Rizo Ursula Schulze-Gahmen Amber M Smith Ming Sun Iris D Young Jianhua Zhao Daniel Asarnow Justin Biel Alisa Bowen Julian R Braxton Jen Chen Cynthia M Chio Un Seng Chio Ishan Deshpande Loan Doan Bryan Faust Sebastian Flores Mingliang Jin Kate Kim Victor L Lam Fei Li Junrui Li Yen-Li Li Yang Li Xi Liu Megan Lo Kyle E Lopez Arthur A Melo Frank R Moss Phuong Nguyen Joana Paulino Komal Ishwar Pawar Jessica K Peters Thomas H Pospiech Maliheh Safari Smriti Sangwan Kaitlin Schaefer Paul V Thomas Aye C Thwin Raphael Trenker Eric Tse Tsz Kin Martin Tsui Feng Wang Natalie Whitis Zanlin Yu Kaihua Zhang Yang Zhang Fengbo Zhou Daniel Saltzberg Anthony J Hodder Amber S Shun-Shion Daniel M Williams Kris M White Romel Rosales Thomas Kehrer Lisa Miorin Elena Moreno Arvind H Patel Suzannah Rihn Mir M Khalid Albert Vallejo-Gracia Parinaz Fozouni Camille R Simoneau Theodore L Roth David Wu Mohd Anisul Karim Maya Ghoussaini Ian Dunham Francesco Berardi Sebastian Weigang Maxime Chazal Jisoo Park James Logue Marisa McGrath Stuart Weston Robert Haupt C James Hastie Matthew Elliott Fiona Brown Kerry A Burness Elaine Reid Mark Dorward Clare Johnson Stuart G Wilkinson Anna Geyer Daniel M Giesel Carla Baillie Samantha Raggett Hannah Leech Rachel Toth Nicola Goodman Kathleen C Keough Abigail L Lind Reyna J Klesh Kafi R Hemphill Jared Carlson-Stevermer Jennifer Oki Kevin Holden Travis Maures Katherine S Pollard Andrej Sali David A Agard Yifan Cheng James S Fraser Adam Frost Natalia Jura Tanja Kortemme Aashish Manglik Daniel R Southworth Robert M Stroud Dario R Alessi Paul Davies Matthew B Frieman Trey Ideker Carmen Abate Nolwenn Jouvenet Georg Kochs Brian Shoichet Melanie Ott Massimo Palmarini Kevan M Shokat Adolfo García-Sastre Jeremy A Rassen Robert Grosse Oren S Rosenberg Kliment A Verba Christopher F Basler Marco Vignuzzi Andrew A Peden Pedro Beltrao Nevan J Krogan

Science 2020 12 15;370(6521). Epub 2020 Oct 15.

Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.

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December 2020

Air transportation over-utilization in pediatric trauma patients.

J Pediatr Surg 2020 Sep 8. Epub 2020 Sep 8.

Department of Pediatric Surgery, Children's Mercy Hospital, Kansas City, MO 64108. Electronic address:

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September 2020

Application of a 2D Molybdenum Telluride in SERS Detection of Biorelevant Molecules.

ACS Appl Mater Interfaces 2020 Oct 12;12(42):47774-47783. Epub 2020 Oct 12.

Department of Solid State Engineering, University of Chemistry and Technology, 166 28 Prague, Czech Republic.

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October 2020

Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico.

Nat Commun 2020 09 23;11(1):4808. Epub 2020 Sep 23.

Department of Chemistry and Biomolecular Sciences, University of Ottawa, 10 Marie Curie, Ottawa, ON, K1N 6N5, Canada.

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September 2020

Expanding the space of protein geometries by computational design of de novo fold families.

Science 2020 08;369(6507):1132-1136

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.

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August 2020

Surveying purine biosynthesis across the domains of life unveils promising drug targets in pathogens.

Immunol Cell Biol 2020 Nov 16;98(10):819-831. Epub 2020 Sep 16.

Australian Infectious Diseases Research Centre, School of Chemistry & Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia.

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November 2020

Structures of fungal and plant acetohydroxyacid synthases.

Nature 2020 10 8;586(7828):317-321. Epub 2020 Jul 8.

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.

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October 2020

Transforming Dementia Care Through Pragmatic Clinical Trials Embedded in Learning Healthcare Systems.

J Am Geriatr Soc 2020 Jul;68 Suppl 2:S43-S48

Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, Washington, USA.

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July 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.

bioRxiv 2020 Mar 22. Epub 2020 Mar 22.

QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.

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March 2020

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

Authors:
David E Gordon Gwendolyn M Jang Mehdi Bouhaddou Jiewei Xu Kirsten Obernier Kris M White Matthew J O'Meara Veronica V Rezelj Jeffrey Z Guo Danielle L Swaney Tia A Tummino Ruth Hüttenhain Robyn M Kaake Alicia L Richards Beril Tutuncuoglu Helene Foussard Jyoti Batra Kelsey Haas Maya Modak Minkyu Kim Paige Haas Benjamin J Polacco Hannes Braberg Jacqueline M Fabius Manon Eckhardt Margaret Soucheray Melanie J Bennett Merve Cakir Michael J McGregor Qiongyu Li Bjoern Meyer Ferdinand Roesch Thomas Vallet Alice Mac Kain Lisa Miorin Elena Moreno Zun Zar Chi Naing Yuan Zhou Shiming Peng Ying Shi Ziyang Zhang Wenqi Shen Ilsa T Kirby James E Melnyk John S Chorba Kevin Lou Shizhong A Dai Inigo Barrio-Hernandez Danish Memon Claudia Hernandez-Armenta Jiankun Lyu Christopher J P Mathy Tina Perica Kala Bharath Pilla Sai J Ganesan Daniel J Saltzberg Ramachandran Rakesh Xi Liu Sara B Rosenthal Lorenzo Calviello Srivats Venkataramanan Jose Liboy-Lugo Yizhu Lin Xi-Ping Huang YongFeng Liu Stephanie A Wankowicz Markus Bohn Maliheh Safari Fatima S Ugur Cassandra Koh Nastaran Sadat Savar Quang Dinh Tran Djoshkun Shengjuler Sabrina J Fletcher Michael C O'Neal Yiming Cai Jason C J Chang David J Broadhurst Saker Klippsten Phillip P Sharp Nicole A Wenzell Duygu Kuzuoglu-Ozturk Hao-Yuan Wang Raphael Trenker Janet M Young Devin A Cavero Joseph Hiatt Theodore L Roth Ujjwal Rathore Advait Subramanian Julia Noack Mathieu Hubert Robert M Stroud Alan D Frankel Oren S Rosenberg Kliment A Verba David A Agard Melanie Ott Michael Emerman Natalia Jura Mark von Zastrow Eric Verdin Alan Ashworth Olivier Schwartz Christophe d'Enfert Shaeri Mukherjee Matt Jacobson Harmit S Malik Danica G Fujimori Trey Ideker Charles S Craik Stephen N Floor James S Fraser John D Gross Andrej Sali Bryan L Roth Davide Ruggero Jack Taunton Tanja Kortemme Pedro Beltrao Marco Vignuzzi Adolfo García-Sastre Kevan M Shokat Brian K Shoichet Nevan J Krogan

Nature 2020 07 30;583(7816):459-468. Epub 2020 Apr 30.

QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.

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July 2020

Broadening the spectrum of fluorescent protein tools for use in the encapsulated human fungal pathogen Cryptococcus neoformans.

Fungal Genet Biol 2020 05 4;138:103365. Epub 2020 Mar 4.

Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia; School of Chemistry & Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia. Electronic address:

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May 2020

What Will Computational Modeling Approaches Have to Say in the Era of Atomistic Cryo-EM Data?

J Chem Inf Model 2020 May 24;60(5):2410-2412. Epub 2020 Feb 24.

Structural Bioinformatics Unit, Department of Structural Biology and Chemistry; CNRS UMR 3528; C3BI, CNRS USR 3756; Institut Pasteur, 75015 Paris, France.

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May 2020

Assessment of the nucleotide modifications in the high-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit.

Nucleic Acids Res 2020 03;48(5):2723-2732

Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA.

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March 2020

Migrated fractured sternal wire in proximity to the main pulmonary artery: Case report and review.

J Card Surg 2020 Mar 16;35(3):692-695. Epub 2020 Jan 16.

Division of Cardiology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

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March 2020

Habitat selection and potential fitness consequences of two early-successional species with differing life-history strategies.

Ecol Evol 2019 Dec 19;9(24):13966-13978. Epub 2019 Nov 19.

Department of Fish and Wildlife Conservation Virginia Tech Blacksburg Virginia.

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December 2019

Differences in the chitinolytic activity of mammalian chitinases on soluble and insoluble substrates.

Protein Sci 2020 04 21;29(4):966-977. Epub 2020 Jan 21.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California.

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April 2020

Liquid-like and rigid-body motions in molecular-dynamics simulations of a crystalline protein.

Struct Dyn 2019 Nov 18;6(6):064704. Epub 2019 Dec 18.

Computer, Computational, and Statistical Sciences Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.

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November 2019

Psychological impact of working in paediatric intensive care. A UK-wide prevalence study.

Arch Dis Child 2020 05 21;105(5):470-475. Epub 2019 Nov 21.

Paediatric Intensive Care Unit, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK

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May 2020

Regulatory Mechanism of the Atypical AP-1-Like Transcription Factor Yap1 in Cryptococcus neoformans.

mSphere 2019 11 20;4(6). Epub 2019 Nov 20.

Department of Biotechnology, Center for Fungal Pathogenesis, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea

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November 2019

A simple, web-based repository for the management, access and analysis of micrographic images.

J Mol Histol 2019 Dec 30;50(6):573-580. Epub 2019 Oct 30.

School of Biomedical Sciences, The University of Queensland, Brisbane, 4072, Australia.

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December 2019

National child death review statutory and operational guidance: Key concepts for practising paediatricians.

Arch Dis Child Educ Pract Ed 2020 08 26;105(4):244-250. Epub 2019 Sep 26.

Health Sciences Research Institute, University of Warwick, Coventry, UK.

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August 2020

Temperature-jump solution X-ray scattering reveals distinct motions in a dynamic enzyme.

Nat Chem 2019 11 16;11(11):1058-1066. Epub 2019 Sep 16.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.

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November 2019

Child death review statutory and operational guidance: maximising learning from child deaths.

Arch Dis Child 2020 04 6;105(4):315-318. Epub 2019 Sep 6.

Health Sciences Research Institute, University of Warwick, Coventry, UK.

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April 2020

Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.

Cell Rep 2019 08;28(9):2317-2330.e8

Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; QB3, California Institute for Quantitative Biosciences, San Francisco, CA 94158, USA. Electronic address:

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August 2019

amdS as a dominant recyclable marker in Cryptococcus neoformans.

Fungal Genet Biol 2019 10 17;131:103241. Epub 2019 Jun 17.

Australian Infectious Diseases Research Centre, School of Chemistry & Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia. Electronic address:

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October 2019

Biomaterials in non-integer dimensions.

Nat Chem 2019 07;11(7):599-600

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, USA.

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July 2019

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.

Nat Chem Biol 2019 06 13;15(6):556-559. Epub 2019 May 13.

Institute for Molecular Bioscience and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, Queensland, Australia.

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June 2019

Effects of α-tubulin acetylation on microtubule structure and stability.

Proc Natl Acad Sci U S A 2019 05 9;116(21):10366-10371. Epub 2019 May 9.

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;

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May 2019

Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse.

J Cell Sci 2019 05 21;132(10). Epub 2019 May 21.

Eccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University, 131 Garran Road, Acton ACT 2601, Australia

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May 2019

The application of Lempel-Ziv and Titchener complexity analysis for equine telemetric electrocardiographic recordings.

Sci Rep 2019 02 22;9(1):2619. Epub 2019 Feb 22.

Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7AL, United Kingdom.

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February 2019

Quantitation of Purines from Pigeon Guano and Implications for Cryptococcus neoformans Survival During Infection.

Mycopathologia 2019 Apr 1;184(2):273-281. Epub 2019 Feb 1.

Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, 4072, Australia.

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April 2019

Parallel planning and the paediatric critical care patient.

Arch Dis Child 2019 10 31;104(10):994-997. Epub 2019 Jan 31.

Louis Dundas Centre for Children's Palliative Care, Great Ormond Street Hospital, London, UK.

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October 2019

A Multi-model Approach to Assessing Local and Global Cryo-EM Map Quality.

Structure 2019 02 15;27(2):344-358.e3. Epub 2018 Nov 15.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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February 2019

Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.

Bioorg Med Chem 2018 11 5;26(20):5408-5419. Epub 2018 Sep 5.

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address:

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November 2018

Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.

Proc Natl Acad Sci U S A 2018 10 24;115(41):E9649-E9658. Epub 2018 Sep 24.

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia;

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October 2018

Identifying Reasons for Failed Same-Day Discharge Following Primary Total Hip Arthroplasty.

J Arthroplasty 2018 12 9;33(12):3624-3628. Epub 2018 Aug 9.

The Rothman Institute, Thomas Jefferson University Hospital Department of Orthopedics, Philadelphia, PA.

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December 2018

One-Step Approach to Identifying Gestational Diabetes Mellitus: Association With Perinatal Outcomes.

Obstet Gynecol 2018 10;132(4):859-867

Kaiser Permanente Washington Health Research Institute, the Department of Epidemiology, University of Washington, Kaiser Permanente Washington, and Swedish Medical Center, Seattle, Washington.

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October 2018

Microsecond Valley Lifetime of Defect-Bound Excitons in Monolayer WSe_{2}.

Phys Rev Lett 2018 Aug;121(5):057403

National Institute of Standards and Technology, Boulder, Colorado 80305, USA.

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August 2018

Towards developing an ethical framework for decision making in long-term ventilation in children.

Arch Dis Child 2018 11 5;103(11):1080-1084. Epub 2018 Jun 5.

Children's Long-term Ventilation Service, Royal Brompton Hospital and Harefields NHS Trust, London, UK.

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November 2018

Standard setting in Australian medical schools.

BMC Med Educ 2018 Apr 23;18(1):80. Epub 2018 Apr 23.

Education Office, Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.

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April 2018

Neuroprotective Role of the Ron Receptor Tyrosine Kinase Underlying Central Nervous System Inflammation in Health and Disease.

Front Immunol 2018 19;9:513. Epub 2018 Mar 19.

Center for Molecular Immunology and Infectious Diseases, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States.

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April 2019

Rescue of conformational dynamics in enzyme catalysis by directed evolution.

Nat Commun 2018 04 3;9(1):1314. Epub 2018 Apr 3.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA.

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April 2018

Periarticular Ropivacaine Cocktail Is Equivalent to Liposomal Bupivacaine Cocktail in Bilateral Total Knee Arthroplasty.

J Arthroplasty 2018 08 6;33(8):2455-2459. Epub 2018 Mar 6.

Rothman Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.

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August 2018

Response to: Open book examinations: Not a panacea.

Med Teach 2018 08 19;40(8):869-870. Epub 2018 Mar 19.

a School of Medicine , Griffith University , Gold Coast Campus , Southport , Queensland , Australia.

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August 2018

The Long History of the Diverse Roles of Short ORFs: sPEPs in Fungi.

Proteomics 2018 05 4;18(10):e1700219. Epub 2018 May 4.

Australian Infectious Diseases Research Centre, St Lucia, Queensland, Australia.

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May 2018

Bringing diffuse X-ray scattering into focus.

Curr Opin Struct Biol 2018 06 16;50:109-116. Epub 2018 Feb 16.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA. Electronic address:

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June 2018

The beer and biofuels laboratory: A report on implementing and supporting a large, interdisciplinary, yeast-focused course-based undergraduate research experience.

Biochem Mol Biol Educ 2018 05 31;46(3):213-222. Epub 2018 Jan 31.

School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.

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May 2018

Open book exams: A potential solution to the "full curriculum"?

Med Teach 2018 05 7;40(5):529-530. Epub 2017 Dec 7.

a School of Medicine , Griffith University , Gold Coast , QLD , Australia.

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May 2018

Antimicrobial Octapeptin C4 Analogues Active against Cryptococcus Species.

Antimicrob Agents Chemother 2018 02 25;62(2). Epub 2018 Jan 25.

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia

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February 2018

Pro-arrhythmic atrial phenotypes in incrementally paced murine Pgc1β hearts: effects of age.

Exp Physiol 2017 12 29;102(12):1619-1634. Epub 2017 Oct 29.

Physiological Laboratory, University of Cambridge, Cambridge, UK.

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December 2017

A fluorogenic C. neoformans reporter strain with a robust expression of m-cherry expressed from a safe haven site in the genome.

Fungal Genet Biol 2017 11 12;108:13-25. Epub 2017 Sep 12.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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November 2017

Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases.

J Am Chem Soc 2017 08 17;139(34):11650-11653. Epub 2017 Aug 17.

Department of Pharmaceutical Chemistry, University of California , San Francisco, California 94158, United States.

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August 2017

Purine Acquisition and Synthesis by Human Fungal Pathogens.

Microorganisms 2017 Jun 8;5(2). Epub 2017 Jun 8.

Australian Infectious Diseases Research Centre, School of Chemistry & Molecular Biosciences, the University of Queensland, St Lucia, Queensland 4072, Australia.

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June 2017

Clinical Decision Support in Computerized Providers' Order Entry for Imaging Tests in Canada.

Can Assoc Radiol J 2017 Nov 31;68(4):357-358. Epub 2017 May 31.

Division of Neuroradiology, Department of Medical Imaging, University of Ottawa, Ottawa, Ontario, Canada.

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November 2017