James Flory

James Flory

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James Flory

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Metformin for Type 2 Diabetes-Reply.

JAMA 2019 10;322(13):1313

Section of Endocrinology, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1001/jama.2019.11505DOI Listing
October 2019

Reports of Lactic Acidosis Attributed to Metformin, 2015-2018.

Diabetes Care 2019 Oct 9. Epub 2019 Oct 9.

Yale School of Medicine, New Haven, CT.

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http://dx.doi.org/10.2337/dc19-0923DOI Listing
October 2019

Metformin in 2019.

JAMA 2019 May;321(19):1926-1927

Section of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2019.3805DOI Listing
May 2019

Feature Selection in Predictive Modeling: A Systematic Study on Drug Response Heterogeneity for Type II Diabetic Patients.

AMIA Jt Summits Transl Sci Proc 2019 6;2019:295-304. Epub 2019 May 6.

Department of Healthcare Policy and Research. Weill Cornell Medicine.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568100PMC
May 2019

Ethical Acceptability of Postrandomization Consent in Pragmatic Clinical Trials.

JAMA Netw Open 2018 12 7;1(8):e186149. Epub 2018 Dec 7.

Public Health Section, School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom.

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2018.6149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324565PMC
December 2018

Diagnosis-based cohort augmentation using laboratory results data: The case of chronic kidney disease.

Pharmacoepidemiol Drug Saf 2018 08 22;27(8):872-877. Epub 2018 Jun 22.

Institute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA.

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http://doi.wiley.com/10.1002/pds.4583
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http://dx.doi.org/10.1002/pds.4583DOI Listing
August 2018

From Sour Grapes to Low-Hanging Fruit: A Case Study Demonstrating a Practical Strategy for Natural Language Processing Portability.

AMIA Jt Summits Transl Sci Proc 2018 18;2017:104-112. Epub 2018 May 18.

Center for Health Informatics and Bioinformatics, NYU Langone Medical Center, New York, New York.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961788PMC
May 2018

Comparative Safety of Sulfonylureas and the Risk of Sudden Cardiac Arrest and Ventricular Arrhythmia.

Diabetes Care 2018 04 2;41(4):713-722. Epub 2018 Feb 2.

Center for Pharmacoepidemiology Research and Training, Center for Clinical Epidemiology and Biostatistics, and Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.2337/dc17-0294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860838PMC
April 2018

Ethics and practice of Trials within Cohorts: An emerging pragmatic trial design.

Clin Trials 2018 02 11;15(1):9-16. Epub 2017 Dec 11.

4 University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1177/1740774517746620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006508PMC
February 2018

Rejoinder.

Clin Trials 2018 02;15(1):27-28

3 University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1177/1740774517746629DOI Listing
February 2018

Comparative risk of serious hypoglycemia with oral antidiabetic monotherapy: A retrospective cohort study.

Pharmacoepidemiol Drug Saf 2018 01 6;27(1):9-18. Epub 2017 Nov 6.

Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/pds.4337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770147PMC
January 2018

Comparative adherence to diabetes drugs: An analysis of electronic health records and claims data.

Diabetes Obes Metab 2017 08 10;19(8):1184-1187. Epub 2017 Apr 10.

COHRDATA, Santa Monica, California.

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http://dx.doi.org/10.1111/dom.12931DOI Listing
August 2017

Pro- and Antiarrhythmic Actions of Sulfonylureas: Mechanistic and Clinical Evidence.

Trends Endocrinol Metab 2017 08 22;28(8):561-586. Epub 2017 May 22.

Center for Pharmacoepidemiology Research and Training, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.tem.2017.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522643PMC
August 2017

Agreement and validity of electronic health record prescribing data relative to pharmacy claims data: A validation study from a US electronic health record database.

Pharmacoepidemiol Drug Saf 2017 Aug 12;26(8):963-972. Epub 2017 Jun 12.

Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/pds.4234DOI Listing
August 2017

What Is the Right Way to Respect Patient Perspectives?

Am J Bioeth 2015 ;15(9):32-3

a Weill Cornell Medical College.

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http://dx.doi.org/10.1080/15265161.2015.1062176DOI Listing
July 2017

Instrumental Variable Methods for Continuous Outcomes That Accommodate Nonignorable Missing Baseline Values.

Am J Epidemiol 2017 06;185(12):1233-1239

Department of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1093/aje/kww137DOI Listing
June 2017

A tutorial on the use of instrumental variables in pharmacoepidemiology.

Pharmacoepidemiol Drug Saf 2017 Apr 27;26(4):357-367. Epub 2017 Feb 27.

Center for Pharmacoepidemiology Research and Training, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/pds.4158DOI Listing
April 2017

Will Cardiovascular Outcomes Data on Newer Diabetes Drugs Bury the Older Agents?

Authors:
James Flory

JAMA Intern Med 2017 03;177(3):301-302

Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1001/jamainternmed.2016.8284DOI Listing
March 2017

Proposals to Conduct Randomized Controlled Trials Without Informed Consent: a Narrative Review.

J Gen Intern Med 2016 12 6;31(12):1511-1518. Epub 2016 Jul 6.

Department of Healthcare Policy and Research, Weill Cornell Medical College, 425 East 61st Street, 301, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s11606-016-3780-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130947PMC
December 2016

Novel Anti-glycemic Drugs and Reduction of Cardiovascular Risk in Diabetes: Expectations Realized, Promises Unmet.

Curr Atheroscler Rep 2016 Dec;18(12):79

Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1007/s11883-016-0633-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509052PMC
December 2016

Citizen Petition to the US Food and Drug Administration to Change Prescribing Guidelines: The Metformin Experience.

Circulation 2016 11;134(18):1405-1408

From Section of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT (K.J.L., S.E.I.); Department of Healthcare Policy and Research, Weill Cornell Medical College and Memorial Sloan Kettering Cancer Center, New York, NY (J.H.F.); and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (S.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147418PMC
November 2016

Diabetes Management in Cancer Patients.

Oncology (Williston Park) 2016 Jun;30(6):565-70

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June 2016

Comparative risk of severe hypoglycemia among concomitant users of thiazolidinedione antidiabetic agents and antihyperlipidemics.

Diabetes Res Clin Pract 2016 May 14;115:60-7. Epub 2016 Mar 14.

Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, United States; Center for Pharmacoepidemiology Research and Training, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, United States; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine at the University of Pennsylvania, 34th Street & Civic Center Boulevard, Philadelphia, PA 19104, United States.

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http://dx.doi.org/10.1016/j.diabres.2016.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890073PMC
May 2016

A Sensitivity Analysis to Assess Bias Due to Selecting Subjects Based on Treatment Received.

Epidemiology 2016 Mar;27(2):e5-7

Department of Statistics, Center for Pharmacoepidemiology Research and Training, University of Pennsylvania, Philadelphia, PA, Department of Statistics, University of Pennsylvania, Philadelphia, PA Weill-Cornell School of Medicine, New York, NY Center for Pharmacoepidemiology, Research and Training, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1097/EDE.0000000000000430DOI Listing
March 2016

Methadone Use and the Risk of Hypoglycemia for Inpatients With Cancer Pain.

J Pain Symptom Manage 2016 Jan 3;51(1):79-87.e1. Epub 2015 Sep 3.

Palliative Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1016/j.jpainsymman.2015.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484401PMC
January 2016

Stage 2 hypertension: predictors of failure to achieve blood pressure control and the impact of adding one additional antihypertensive class.

Pharmacoepidemiol Drug Saf 2015 Nov 9;24(11):1170-9. Epub 2015 Sep 9.

DaVita Clinical Research, Minneapolis, MN, USA.

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http://dx.doi.org/10.1002/pds.3849DOI Listing
November 2015

Metformin use reduction in mild to moderate renal impairment: possible inappropriate curbing of use based on food and drug administration contraindications.

JAMA Intern Med 2015 Mar;175(3):458-9

Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

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http://archinte.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamainternmed.2014.6936DOI Listing
March 2015

Proton pump inhibitors do not impair the effectiveness of metformin in patients with diabetes.

Br J Clin Pharmacol 2015 Feb;79(2):330-6

Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Division of Endocrinology, Weill Cornell Medical College, New York, NY.

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http://dx.doi.org/10.1111/bcp.12506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309638PMC
February 2015

Observational and clinical trial findings on the comparative effectiveness of diabetes drugs showed agreement.

J Clin Epidemiol 2015 Feb 26;68(2):200-10. Epub 2014 Nov 26.

Department of Public Health, Weill Cornell Medical College, 425 E 61st Street, 3rd Floor, Suite 301, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.jclinepi.2014.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349393PMC
February 2015

Basal Insulin Use in the Non-Critical Care Setting: Is Fasting Hypoglycemia Inevitable or Preventable?

J Diabetes Sci Technol 2014 Mar 21;8(2):427-428. Epub 2014 Jan 21.

New York Presbyterian Hospital/Weill-Cornell Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1177/1932296813520367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455403PMC
March 2014

Comparative effectiveness of oral diabetes drug combinations in reducing glycosylated hemoglobin.

J Comp Eff Res 2014 Jan;3(1):29-39

Weill Cornell Medical College, 525 East 68th Street, Baker Pavilion 20th Floor, NY 10021, USA.

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http://dx.doi.org/10.2217/cer.13.87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996558PMC
January 2014

High prevalence of aquagenic wrinkling of the palms in patients with cystic fibrosis and association with measurable increases in transepidermal water loss.

Pediatr Dermatol 2012 Sep-Oct;29(5):560-6. Epub 2012 Apr 4.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1111/j.1525-1470.2011.01708.xDOI Listing
February 2013

The prompted optional randomization trial: a new design for comparative effectiveness research.

Am J Public Health 2012 Dec 18;102(12):e8-10. Epub 2012 Oct 18.

Department of Medicine, Weill Cornell School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.2105/AJPH.2012.301036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519302PMC
December 2012

Observational cohort study of the safety of digoxin use in women with heart failure.

BMJ Open 2012 13;2(2):e000888. Epub 2012 Apr 13.

Division of Endocrinology, Diabetes, and Metabolism in the Department of Medicine at New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1136/bmjopen-2012-000888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332247PMC
October 2012

Charge variability for acute appendicitis: is the problem overstated?

Arch Intern Med 2012 Oct;172(19):1524

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http://dx.doi.org/10.1001/archinternmed.2012.4406DOI Listing
October 2012

Clinical importance of the drug interaction between statins and CYP3A4 inhibitors: a retrospective cohort study in The Health Improvement Network.

Pharmacoepidemiol Drug Saf 2012 May 16;21(5):494-506. Epub 2012 Mar 16.

Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/pds.3199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890414PMC
May 2012

Simulation study of instrumental variable approaches with an application to a study of the antidiabetic effect of bezafibrate.

Pharmacoepidemiol Drug Saf 2012 May;21 Suppl 2:114-20

Epidemiology Department of Pfizer Inc, 500 Arcola Road, Collegeville, PA, USA.

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http://dx.doi.org/10.1002/pds.3252DOI Listing
May 2012

Common variants at five new loci associated with early-onset inflammatory bowel disease.

Authors:
Marcin Imielinski Robert N Baldassano Anne Griffiths Richard K Russell Vito Annese Marla Dubinsky Subra Kugathasan Jonathan P Bradfield Thomas D Walters Patrick Sleiman Cecilia E Kim Aleixo Muise Kai Wang Joseph T Glessner Shehzad Saeed Haitao Zhang Edward C Frackelton Cuiping Hou James H Flory George Otieno Rosetta M Chiavacci Robert Grundmeier Massimo Castro Anna Latiano Bruno Dallapiccola Joanne Stempak Debra J Abrams Kent Taylor Dermot McGovern Gary Silber Iwona Wrobel Antonio Quiros Jeffrey C Barrett Sarah Hansoul Dan L Nicolae Judy H Cho Richard H Duerr John D Rioux Steven R Brant Mark S Silverberg Kent D Taylor M Michael Barmuda Alain Bitton Themistocles Dassopoulos Lisa Wu Datta Todd Green Anne M Griffiths Emily O Kistner Michael T Murtha Miguel D Regueiro Jerome I Rotter L Philip Schumm A Hillary Steinhart Stephen R Targan Ramnik J Xavier Cécile Libioulle Cynthia Sandor Mark Lathrop Jacques Belaiche Olivier Dewit Ivo Gut Simon Heath Debby Laukens Myriam Mni Paul Rutgeerts André Van Gossum Diana Zelenika Denis Franchimont J P Hugot Martine de Vos Severine Vermeire Edouard Louis Lon R Cardon Carl A Anderson Hazel Drummond Elaine Nimmo Tariq Ahmad Natalie J Prescott Clive M Onnie Sheila A Fisher Jonathan Marchini Jilur Ghori Suzannah Bumpstead Rhian Gwillam Mark Tremelling Panos Delukas John Mansfield Derek Jewell Jack Satsangi Christopher G Mathew Miles Parkes Michel Georges Mark J Daly Melvin B Heyman George D Ferry Barbara Kirschner Jessica Lee Jonah Essers Richard Grand Michael Stephens Arie Levine David Piccoli John Van Limbergen Salvatore Cucchiara Dimitri S Monos Stephen L Guthery Lee Denson David C Wilson Straun F A Grant Mark Daly Mark S Silverberg Jack Satsangi Hakon Hakonarson

Nat Genet 2009 Dec 15;41(12):1335-40. Epub 2009 Nov 15.

Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267927PMC
December 2009

Antidiabetic action of bezafibrate in a large observational database.

Diabetes Care 2009 Apr 8;32(4):547-51. Epub 2009 Jan 8.

1Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.2337/dc08-1809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660490PMC
April 2009

Effects of L-carnitine on dialysis-related hypotension and muscle cramps: a meta-analysis.

Am J Kidney Dis 2008 Nov 15;52(5):962-71. Epub 2008 Aug 15.

Renal-Electrolyte and Hypertension Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S027263860801007
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http://dx.doi.org/10.1053/j.ajkd.2008.05.031DOI Listing
November 2008

Global health and the scientific research agenda.

Philos Public Aff 2004 ;32(1):36-65

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February 2005

Interventions to improve research participants' understanding in informed consent for research: a systematic review.

JAMA 2004 Oct;292(13):1593-601

Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Md 20892, USA.

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http://dx.doi.org/10.1001/jama.292.13.1593DOI Listing
October 2004

Place of death: U.S. trends since 1980.

Health Aff (Millwood) 2004 May-Jun;23(3):194-200

Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1377/hlthaff.23.3.194DOI Listing
June 2004