Publications by authors named "James E Rothman"

100Publications

Synaptotagmin-1 membrane binding is driven by the C2B domain and assisted cooperatively by the C2A domain.

Sci Rep 2020 Oct 22;10(1):18011. Epub 2020 Oct 22.

Laboratoire de Physique de L'Ecole Normale Supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université de Paris, 75005, Paris, France.

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http://dx.doi.org/10.1038/s41598-020-74923-yDOI Listing
October 2020

The golgin family exhibits a propensity to form condensates in living cells.

FEBS Lett 2020 Oct 2;594(19):3086-3094. Epub 2020 Aug 2.

Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1002/1873-3468.13884DOI Listing
October 2020

TANGO1 membrane helices create a lipid diffusion barrier at curved membranes.

Elife 2020 May 26;9. Epub 2020 May 26.

Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.

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http://dx.doi.org/10.7554/eLife.57822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266638PMC
May 2020

A tribute to Paul A. Marks, MD, 1926-2020.

Authors:
James E Rothman

J Clin Invest 2020 Jun;130(6):2727-2728

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http://dx.doi.org/10.1172/JCI140020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260022PMC
June 2020

Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis.

Elife 2020 May 13;9. Epub 2020 May 13.

Department of Cell Biology, Yale University School of Medicine, New Haven, United States.

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http://dx.doi.org/10.7554/eLife.54506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220375PMC
May 2020

Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release.

Proc Natl Acad Sci U S A 2020 02 3;117(7):3819-3827. Epub 2020 Feb 3.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1920403117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035618PMC
February 2020

Munc13-1 MUN domain and Munc18-1 cooperatively chaperone SNARE assembly through a tetrameric complex.

Proc Natl Acad Sci U S A 2020 01 30;117(2):1036-1041. Epub 2019 Dec 30.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520;

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http://dx.doi.org/10.1073/pnas.1914361117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969487PMC
January 2020

Jim's View: Is the Golgi stack a phase-separated liquid crystal?

Authors:
James E Rothman

FEBS Lett 2019 10 27;593(19):2701-2705. Epub 2019 Sep 27.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1002/1873-3468.13609DOI Listing
October 2019

Golgin45-Syntaxin5 Interaction Contributes to Structural Integrity of the Golgi Stack.

Sci Rep 2019 08 28;9(1):12465. Epub 2019 Aug 28.

School of Life Science and Technology, ShanghaiTech University, Shanghai, China.

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http://dx.doi.org/10.1038/s41598-019-48875-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713708PMC
August 2019

Jim's view: Why basic science?

Authors:
James E Rothman

FEBS Lett 2019 07 12;593(14):1693-1697. Epub 2019 Jul 12.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1002/1873-3468.13510DOI Listing
July 2019

Jim's view: What makes transformative basic science possible?

Authors:
James E Rothman

FEBS Lett 2019 08 12;593(15):1877-1878. Epub 2019 Jul 12.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1002/1873-3468.13517DOI Listing
August 2019

Jim's view: Patience vs urgency.

Authors:
James E Rothman

FEBS Lett 2019 08 12;593(16):2081-2082. Epub 2019 Jul 12.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1002/1873-3468.13518DOI Listing
August 2019

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders.

Nat Commun 2019 07 12;10(1):3094. Epub 2019 Jul 12.

Department of Neuromuscular Disorders, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1038/s41467-019-10910-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626132PMC
July 2019

Structural basis for the clamping and Ca activation of SNARE-mediated fusion by synaptotagmin.

Nat Commun 2019 06 3;10(1):2413. Epub 2019 Jun 3.

Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520, USA.

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http://dx.doi.org/10.1038/s41467-019-10391-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546687PMC
June 2019

Highly Reproducible Physiological Asymmetric Membrane with Freely Diffusing Embedded Proteins in a 3D-Printed Microfluidic Setup.

Small 2019 05 12;15(21):e1900725. Epub 2019 Apr 12.

Laboratoire de Physique de l'Ecole Normale Supérieure, PSL Research University, CNRS, Sorbonne Université, Université Sorbonne Paris Cité, Paris, 75005, France.

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http://dx.doi.org/10.1002/smll.201900725DOI Listing
May 2019

SNARE machinery is optimized for ultrafast fusion.

Proc Natl Acad Sci U S A 2019 02 30;116(7):2435-2442. Epub 2019 Jan 30.

Modélisation et Simulation Multi-Echelle, CNRS, Université Paris-Est Créteil, 94010 Créteil Cedex, France

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http://dx.doi.org/10.1073/pnas.1820394116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377469PMC
February 2019

Synaptotagmin oligomers are necessary and can be sufficient to form a Ca -sensitive fusion clamp.

FEBS Lett 2019 01 18;593(2):154-162. Epub 2019 Jan 18.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1002/1873-3468.13317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349546PMC
January 2019

Jim's view: analog to digital conversion in biology.

Authors:
James E Rothman

FEBS Lett 2018 12 15;592(24):4009-4010. Epub 2018 Dec 15.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1002/1873-3468.13308DOI Listing
December 2018

FEBS Letters Special Issue on Exocytosis and Endocytosis.

FEBS Lett 2018 11;592(21):3477-3479

Nanobiology Institute, Yale University, West Haven, CT, USA.

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http://dx.doi.org/10.1002/1873-3468.13274DOI Listing
November 2018

Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis.

Proc Natl Acad Sci U S A 2018 08 23;115(32):E7624-E7631. Epub 2018 Jul 23.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520;

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http://dx.doi.org/10.1073/pnas.1808792115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094142PMC
August 2018

Jim's View: "Playing Billiards with Science".

Authors:
James E Rothman

FEBS Lett 2018 07 19;592(14):2381-2382. Epub 2018 Jun 19.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1002/1873-3468.13125DOI Listing
July 2018

High-Throughput Monitoring of Single Vesicle Fusion Using Freestanding Membranes and Automated Analysis.

Langmuir 2018 05 9;34(20):5849-5859. Epub 2018 May 9.

Laboratoire de Physique Statistique, Ecole Normale Supérieure , PSL Research University, Université Paris Diderot Sorbonne Paris Cité, Sorbonne Universités UPMC Univ Paris 06, CNRS , Paris 75005 , France.

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http://dx.doi.org/10.1021/acs.langmuir.8b00116DOI Listing
May 2018

Rearrangements under confinement lead to increased binding energy of Synaptotagmin-1 with anionic membranes in Mg and Ca.

FEBS Lett 2018 05 10;592(9):1497-1506. Epub 2018 Apr 10.

Département de Physique, Ecole Normale Supérieure, PSL Research University, CNRS, Paris, France.

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http://dx.doi.org/10.1002/1873-3468.13040DOI Listing
May 2018

PRRT2 Regulates Synaptic Fusion by Directly Modulating SNARE Complex Assembly.

Cell Rep 2018 01;22(3):820-831

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Clinical and Experimental Epilepsy, University College London, London WC1N 3BG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.12.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792450PMC
January 2018

Jim's View: "Some Thoughts for Young Scientists".

Authors:
James E Rothman

FEBS Lett 2018 02 15;592(4):461-462. Epub 2018 Jan 15.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1002/1873-3468.12960DOI Listing
February 2018

Two Disease-Causing SNAP-25B Mutations Selectively Impair SNARE C-terminal Assembly.

J Mol Biol 2018 02 19;430(4):479-490. Epub 2017 Oct 19.

Department of Cell Biology, Yale School of Medicine, New Haven, CT 06511, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222836173049
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http://dx.doi.org/10.1016/j.jmb.2017.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805579PMC
February 2018

Hypothesis - buttressed rings assemble, clamp, and release SNAREpins for synaptic transmission.

FEBS Lett 2017 11 31;591(21):3459-3480. Epub 2017 Oct 31.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1002/1873-3468.12874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698743PMC
November 2017

Land-locked mammalian Golgi reveals cargo transport between stable cisternae.

Nat Commun 2017 09 5;8(1):432. Epub 2017 Sep 5.

Department of Cell Biology, Yale School of Medicine, New Haven, CT, 06511, USA.

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http://www.nature.com/articles/s41467-017-00570-z
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http://dx.doi.org/10.1038/s41467-017-00570-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585379PMC
September 2017

Circular oligomerization is an intrinsic property of synaptotagmin.

Elife 2017 08 29;6. Epub 2017 Aug 29.

Departments of Cell Biology, Yale University School of Medicine, New Haven, United States.

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http://dx.doi.org/10.7554/eLife.27441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576491PMC
August 2017

ACBD3 functions as a scaffold to organize the Golgi stacking proteins and a Rab33b-GAP.

FEBS Lett 2017 09 21;591(18):2793-2802. Epub 2017 Aug 21.

Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, China.

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http://dx.doi.org/10.1002/1873-3468.12780DOI Listing
September 2017

Mutations in NKX6-2 Cause Progressive Spastic Ataxia and Hypomyelination.

Am J Hum Genet 2017 Jun;100(6):969-977

Department of Molecular Neuroscience, University College London, London WC1N 3BG, UK; Neurogenetics Laboratory, The National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK.

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http://dx.doi.org/10.1016/j.ajhg.2017.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473715PMC
June 2017

Entropic forces drive self-organization and membrane fusion by SNARE proteins.

Proc Natl Acad Sci U S A 2017 05 10;114(21):5455-5460. Epub 2017 May 10.

Department of Chemical Engineering, Columbia University, New York, NY 10027;

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http://dx.doi.org/10.1073/pnas.1611506114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448213PMC
May 2017

Low energy cost for optimal speed and control of membrane fusion.

Proc Natl Acad Sci U S A 2017 02 23;114(6):1238-1241. Epub 2017 Jan 23.

Laboratoire de Physique Statistique, Ecole Normale Supérieure, Paris Sciences et Lettres Research University, 75005 Paris, France;

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http://dx.doi.org/10.1073/pnas.1621309114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307435PMC
February 2017

Stability, folding dynamics, and long-range conformational transition of the synaptic t-SNARE complex.

Proc Natl Acad Sci U S A 2016 12 28;113(50):E8031-E8040. Epub 2016 Nov 28.

Department of Cell Biology, Yale School of Medicine, New Haven, CT 06520;

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http://dx.doi.org/10.1073/pnas.1605748113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167175PMC
December 2016

Kinetic barriers to SNAREpin assembly in the regulation of membrane docking/priming and fusion.

Proc Natl Acad Sci U S A 2016 09 6;113(38):10536-41. Epub 2016 Sep 6.

Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520; Nanobiology Institute, School of Medicine, Yale University, New Haven, CT 06520; Laboratoire de Physique Statistique, Ecole Normale Supérieure, Paris Sciences et Lettres Research University, 75005 Paris, France; Laboratoire de Physique Statistique, Université Paris Diderot Sorbonne Paris Cité, 75005 Paris, France; Laboratoire de Physique Statistique, Sorbonne Universités, Université Pierre et Marie Curie, Univ Paris 06, CNRS, 75005 Paris, France

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035884PMC
http://dx.doi.org/10.1073/pnas.1604000113DOI Listing
September 2016

Ultra-High Resolution 3D Imaging of Whole Cells.

Cell 2016 Aug 7;166(4):1028-1040. Epub 2016 Jul 7.

Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA; Department of Biomedical Engineering, Yale University, CT 06520, USA; Nanobiology Institute, Yale University, West Haven, CT 06516, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(16)30745-0.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S009286741630745
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http://dx.doi.org/10.1016/j.cell.2016.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005454PMC
August 2016

FRAP to Characterize Molecular Diffusion and Interaction in Various Membrane Environments.

PLoS One 2016 7;11(7):e0158457. Epub 2016 Jul 7.

Membrane Traffic in Health & Disease, INSERM ERL U950, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158457PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936743PMC
July 2017

Small cargoes pass through synthetically glued Golgi stacks.

FEBS Lett 2016 06 31;590(12):1675-86. Epub 2016 May 31.

Department of Cell Biology, School of Medicine, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1002/1873-3468.12210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925213PMC
June 2016

Self-assembly of size-controlled liposomes on DNA nanotemplates.

Nat Chem 2016 05 21;8(5):476-83. Epub 2016 Mar 21.

Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://www.nature.com/nchem/journal/v8/n5/pdf/nchem.2472.pdf
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http://dx.doi.org/10.1038/nchem.2472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021307PMC
May 2016

Using ApoE Nanolipoprotein Particles To Analyze SNARE-Induced Fusion Pores.

Langmuir 2016 Mar 18;32(12):3015-23. Epub 2016 Mar 18.

Department of Cell Biology, Yale University School of Medicine , New Haven, Connecticut 06510, United States.

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http://dx.doi.org/10.1021/acs.langmuir.6b00245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946868PMC
March 2016

A Programmable DNA Origami Platform to Organize SNAREs for Membrane Fusion.

J Am Chem Soc 2016 Apr 23;138(13):4439-47. Epub 2016 Mar 23.

Wyss Institute for Biologically Inspired Engineering and Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Department of Cancer Biology, Dana Farber Cancer Institute , Boston, Massachusetts 02115, United States.

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http://pubs.acs.org/doi/10.1021/jacs.5b13107
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http://dx.doi.org/10.1021/jacs.5b13107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950518PMC
April 2016

Accelerating SNARE-Mediated Membrane Fusion by DNA-Lipid Tethers.

Angew Chem Int Ed Engl 2015 Nov 6;54(48):14388-92. Epub 2015 Oct 6.

Nanobiology Institute, Yale University, West Haven, CT 06516 (USA).

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http://dx.doi.org/10.1002/anie.201506844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888371PMC
November 2015

Formation of Giant Unilamellar Proteo-Liposomes by Osmotic Shock.

Langmuir 2015 Jun 15;31(25):7091-9. Epub 2015 Jun 15.

†Laboratoire de Physique Statistique, Ecole Normale Supérieure de Paris, Université Pierre et Marie Curie, Université Paris Diderot, Centre National de la Recherche Scientifique, UMR 8550, 24 rue Lhomond, 75005 Paris, France.

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http://dx.doi.org/10.1021/acs.langmuir.5b01173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950989PMC
June 2015

Re-visiting the trans insertion model for complexin clamping.

Elife 2015 Apr 2;4. Epub 2015 Apr 2.

Department of Cell Biology, Yale University School of Medicine, New Haven, United States.

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http://dx.doi.org/10.7554/eLife.04463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384536PMC
April 2015

Calcium sensitive ring-like oligomers formed by synaptotagmin.

Proc Natl Acad Sci U S A 2014 Sep 8;111(38):13966-71. Epub 2014 Sep 8.

Departments of Cell Biology, Chemistry, and

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http://dx.doi.org/10.1073/pnas.1415849111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183308PMC
September 2014

Common intermediates and kinetics, but different energetics, in the assembly of SNARE proteins.

Elife 2014 Sep 1;3:e03348. Epub 2014 Sep 1.

Department of Cell Biology, Yale University School of Medicine, New Haven, United States.

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http://dx.doi.org/10.7554/eLife.03348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166003PMC
September 2014

Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo.

Proc Natl Acad Sci U S A 2014 Jul 30;111(28):10317-22. Epub 2014 Jun 30.

Departments of Biology and Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1409311111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104896PMC
July 2014

A half-zippered SNARE complex represents a functional intermediate in membrane fusion.

J Am Chem Soc 2014 Mar 18;136(9):3456-64. Epub 2014 Feb 18.

Department of Cell Biology, School of Medicine, Yale University , 333 Cedar Street, New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/ja410690mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985920PMC
March 2014

Membrane adhesion dictates Golgi stacking and cisternal morphology.

Proc Natl Acad Sci U S A 2014 Feb 21;111(5):1849-54. Epub 2014 Jan 21.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.

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http://dx.doi.org/10.1073/pnas.1323895111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918774PMC
February 2014

Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin.

Biophys J 2013 Dec;105(11):2507-16

Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2013.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853086PMC
December 2013

Inter-Golgi transport mediated by COPI-containing vesicles carrying small cargoes.

Elife 2013 Oct 1;2:e01296. Epub 2013 Oct 1.

Department of Cell Biology , Yale University School of Medicine , New Haven , United States ; Department of Chemistry , Yale University , New Haven , United States.

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http://dx.doi.org/10.7554/eLife.01296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787390PMC
October 2013

Stapled Golgi cisternae remain in place as cargo passes through the stack.

Elife 2013 Jun 4;2:e00558. Epub 2013 Jun 4.

Department of Cell Biology , Yale University School of Medicine , New Haven , United States.

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http://dx.doi.org/10.7554/eLife.00558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673335PMC
June 2013

Preparation and characterization of SNARE-containing nanodiscs and direct study of cargo release through fusion pores.

Nat Protoc 2013 May 18;8(5):935-48. Epub 2013 Apr 18.

Department of Cell Biology, School of Medicine, Yale University, New Haven, Connecticut, USA.

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http://www.nature.com/articles/nprot.2013.048
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http://dx.doi.org/10.1038/nprot.2013.048DOI Listing
May 2013

Single reconstituted neuronal SNARE complexes zipper in three distinct stages.

Science 2012 Sep 16;337(6100):1340-3. Epub 2012 Aug 16.

Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1224492
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http://dx.doi.org/10.1126/science.1224492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677750PMC
September 2012

Fusion of single proteoliposomes with planar, cushioned bilayers in microfluidic flow cells.

Nat Protoc 2012 Apr 19;7(5):903-20. Epub 2012 Apr 19.

Department of Cell Biology, School of Medicine, Yale University, New Haven, Connecticut, USA.

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http://www.nature.com/articles/nprot.2012.019
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http://dx.doi.org/10.1038/nprot.2012.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747733PMC
April 2012

Molecular mechanism of protein folding in the cell.

Cell 2011 Sep 9;146(6):851-4. Epub 2011 Sep 9.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520-8002, USA.

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http://dx.doi.org/10.1016/j.cell.2011.08.041DOI Listing
September 2011

Complexin cross-links prefusion SNAREs into a zigzag array.

Nat Struct Mol Biol 2011 Jul 24;18(8):927-33. Epub 2011 Jul 24.

Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/nsmb.2101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410656PMC
July 2011

Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state.

Nat Struct Mol Biol 2011 Jul 24;18(8):941-6. Epub 2011 Jul 24.

Department of Cell Biology, School of Medicine, Yale University, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/nsmb.2102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736826PMC
July 2011

The future of Golgi research.

Authors:
James E Rothman

Mol Biol Cell 2010 Nov;21(22):3776-80

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982129PMC
November 2010

Protein determinants of SNARE-mediated lipid mixing.

Biophys J 2010 Jul;99(2):553-60

Department of Cell Biology, School of Medicine, Yale University, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1016/j.bpj.2010.04.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905075PMC
July 2010

SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion.

J Cell Biol 2010 Jul 5;190(1):55-63. Epub 2010 Jul 5.

Department of Molecular, University of Colorado at Boulder, Boulder, CO 80309, USA.

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http://dx.doi.org/10.1083/jcb.201003148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911676PMC
July 2010

Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes.

Proc Natl Acad Sci U S A 2010 Apr 29;107(15):6876-81. Epub 2010 Mar 29.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1073/pnas.1002536107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872465PMC
April 2010

A fast, single-vesicle fusion assay mimics physiological SNARE requirements.

Proc Natl Acad Sci U S A 2010 Feb 2;107(8):3517-21. Epub 2010 Feb 2.

Centre National de la Recherche Scientifique and Université Paris Descartes, Unité Mixte de Recherche 8192, Institut de Biologie Physico-Chimique, 75005 Paris, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840481PMC
February 2010

Journeys through the Golgi--taking stock in a new era.

J Cell Biol 2009 Nov 9;187(4):449-53. Epub 2009 Nov 9.

Department of Cell and Developmental Biology, CRG-Centre de Regulació Genòmica, Institutcio Catalana de Recerca I Estudis Avancats, 88 08003 Barcelona, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779233PMC
November 2009

Intracellular bacteria encode inhibitory SNARE-like proteins.

PLoS One 2009 Oct 12;4(10):e7375. Epub 2009 Oct 12.

Thomas Jefferson University, Department of Microbiology and Immunology, Philadelphia, Pennsylvania, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756591PMC
October 2009

Alternative zippering as an on-off switch for SNARE-mediated fusion.

Science 2009 Jan;323(5913):512-6

Department of Physiology and Cellular Biophysics, Columbia University, College of Physicians and Surgeons, 1150 Saint Nicholas Avenue, Russ Berrie Building, Room 520, New York, NY 10032, USA.

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http://dx.doi.org/10.1126/science.1166500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736854PMC
January 2009

Membrane fusion: grappling with SNARE and SM proteins.

Science 2009 Jan;323(5913):474-7

Department of Cellular and Molecular Physiology, Stanford University, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1126/science.1161748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736821PMC
January 2009

Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro.

J Biol Chem 2008 Jul 22;283(30):21211-9. Epub 2008 May 22.

Department of Physiology and Cellular Biophysics, Columbia University, College of Physicians and Surgeons, 1150 St. Nicholas Avenue, New York, NY 10032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475712PMC
July 2008

SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes.

Proc Natl Acad Sci U S A 2008 Feb 11;105(7):2380-5. Epub 2008 Feb 11.

Department of Physiology and Cellular Biophysics, Columbia University, 1150 St. Nicholas Avenue, New York, NY 10032, USA.

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February 2008

Energetics and dynamics of SNAREpin folding across lipid bilayers.

Nat Struct Mol Biol 2007 Oct 30;14(10):890-6. Epub 2007 Sep 30.

Laboratoire de Physique Statistique, Unité Mixte de Recherche 8550, Centre National de la Recherche Scientifique associée aux Universités Paris VI et Paris VII, Ecole Normale Supérieure, 24 rue Lhomond, 75005 Paris, France.

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October 2007

Selective activation of cognate SNAREpins by Sec1/Munc18 proteins.

Cell 2007 Jan;128(1):183-95

Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA.

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January 2007

Cell-based assays using primary endothelial cells to study multiple steps in inflammation.

Methods Enzymol 2006 ;414:266-83

The Judith P. Sulzberger, MD, Columbia Genome Center, Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.

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December 2006

Lipidic antagonists to SNARE-mediated fusion.

J Biol Chem 2006 Oct 3;281(40):29597-605. Epub 2006 Aug 3.

Department of Physiology and Cellular Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA.

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October 2006

A clamping mechanism involved in SNARE-dependent exocytosis.

Science 2006 Aug 22;313(5787):676-80. Epub 2006 Jun 22.

Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA.

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August 2006

Functional mapping of disease susceptibility loci using cell biology.

Proc Natl Acad Sci U S A 2006 Mar 28;103(10):3698-703. Epub 2006 Feb 28.

The Judith P. Sulzberger, M.D., Columbia Genome Center and Department of Physiology and Cellular Biophysics, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1073/pnas.0510521103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533777PMC
March 2006

Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway.

J Cell Biol 2006 Feb;172(5):719-31

The Judith P. Sulzberger Columbia Genome Center, Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200510065
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063704PMC
February 2006

Dynamic transport of SNARE proteins in the Golgi apparatus.

Proc Natl Acad Sci U S A 2005 Oct 30;102(41):14647-52. Epub 2005 Sep 30.

Department of Cell Physiology and Metabolism, University of Geneva Medical School, 1211 Geneva 4, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253604PMC
October 2005