James E Pease

James E Pease

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James E Pease

James E Pease

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A degradatory fate for CCR4 suggests a primary role in Th2 inflammation.

J Leukoc Biol 2020 Mar 13;107(3):455-466. Epub 2020 Feb 13.

National Heart & Lung Institute, Inflammation, Repair & Development Section, Imperial College London, London, UK.

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http://dx.doi.org/10.1002/JLB.2A0120-089RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155072PMC
March 2020

Chemokine Subversion by Human Herpesviruses.

J Innate Immun 2018 30;10(5-6):465-478. Epub 2018 Aug 30.

Inflammation, Repair and Development Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United

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http://dx.doi.org/10.1159/000492161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289880PMC
October 2019

Tipping the balance: A biased nanobody antagonist of CCR3 with potential for the treatment of eosinophilic inflammation.

J Allergy Clin Immunol 2019 02 17;143(2):552-553. Epub 2018 Nov 17.

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2018.10.052DOI Listing
February 2019

Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35.

J Immunol 2018 07 6;201(2):714-724. Epub 2018 Jun 6.

Inflammation, Repair and Development Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1700884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036231PMC
July 2018

CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration.

Sci Rep 2018 06 21;8(1):9466. Epub 2018 Jun 21.

Receptor Biology Group, Inflammation, Repair and Development Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1038/s41598-018-27710-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013489PMC
June 2018

Eosinophils on trial.

Clin Exp Allergy 2018 05;48(5):490-492

Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/cea.13147DOI Listing
May 2018

Designing small molecule CXCR3 antagonists.

Authors:
James E Pease

Expert Opin Drug Discov 2017 Feb 30;12(2):159-168. Epub 2016 Dec 30.

a Inflammation, Repair & Development Section, National Heart & Lung Institute, Faculty of Medicine , Imperial College London , London , UK.

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http://dx.doi.org/10.1080/17460441.2017.1268597DOI Listing
February 2017

Biased agonism at chemokine receptors: obstacles or opportunities for drug discovery?

J Leukoc Biol 2016 06 23;99(6):901-9. Epub 2015 Dec 23.

Receptor Biology Group, Inflammation, Resolution and Development Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, United Kingdom; and

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http://dx.doi.org/10.1189/jlb.2MR0815-392RDOI Listing
June 2016

Bisphenol A suppresses Th1-type immune response in human peripheral blood mononuclear cells in vitro.

Immunol Lett 2015 Dec 22;168(2):285-92. Epub 2015 Oct 22.

Division of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innrain 80, 6020 Innsbruck, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2015.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400269PMC
December 2015

Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function.

Immunity 2015 Nov;43(5):945-58

Inflammation, Repair & Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ UK. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658339PMC
November 2015

Targeting chemokine receptors in disease--a case study of CCR4.

Eur J Pharmacol 2015 Sep 14;763(Pt B):169-77. Epub 2015 May 14.

Leukocyte Biology Section, MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784718PMC
September 2015

IRF5 controls both acute and chronic inflammation.

Proc Natl Acad Sci U S A 2015 Sep 17;112(35):11001-6. Epub 2015 Aug 17.

Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1506254112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568217PMC
September 2015

CXCR3 antagonist VUF10085 binds to an intrahelical site distinct from that of the broad spectrum antagonist TAK-779.

Br J Pharmacol 2015 Apr 10;172(7):1822-33. Epub 2015 Feb 10.

Leukocyte Biology Section, NHLI Division, Faculty of Medicine, Imperial College, London, UK.

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http://dx.doi.org/10.1111/bph.13027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376459PMC
April 2015

"Chemokine receptors as therapeutic targets: Why aren't there more drugs?".

Eur J Pharmacol 2015 Jan 10;746:363-7. Epub 2014 Jul 10.

Refractory Respiratory Inflammation DPU, Respiratory Therapy Area Unit, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts SG1 2NY, UK.

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http://dx.doi.org/10.1016/j.ejphar.2014.06.060DOI Listing
January 2015

Distinct conformations of the chemokine receptor CCR4 with implications for its targeting in allergy.

J Immunol 2014 Apr 21;192(7):3419-27. Epub 2014 Feb 21.

Leukocyte Biology Section, Medical Research Council-Asthma UK Centre in Allergic Mechanisms of Asthma, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1300232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965571PMC
April 2014

CCL17/thymus and activation-regulated chemokine induces calcitonin gene-related peptide in human airway epithelial cells through CCR4.

J Allergy Clin Immunol 2013 Oct 2;132(4):942-50.e1-3. Epub 2013 Jun 2.

Leukocyte Biology Section, National Heart and Lung Institute, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2013.04.015DOI Listing
October 2013

Editorial: are all eotaxins created equal?

J Leukoc Biol 2013 Aug;94(2):207-9

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http://dx.doi.org/10.1189/jlb.0413189DOI Listing
August 2013

Human labour is associated with a decline in myometrial chemokine receptor expression: the role of prostaglandins, oxytocin and cytokines.

Am J Reprod Immunol 2013 Jan 9;69(1):21-32. Epub 2012 Oct 9.

Imperial College Parturition Research Group, Academic Department of Obstetrics & Gynaecology, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, UK.

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http://doi.wiley.com/10.1111/aji.12025
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http://dx.doi.org/10.1111/aji.12025DOI Listing
January 2013

Stretch and inflammatory cytokines drive myometrial chemokine expression via NF-κB activation.

Endocrinology 2012 Jan 1;153(1):481-91. Epub 2011 Nov 1.

Imperial College Parturition Research Group, Academic Department of Obstetrics and Gynaecology, Imperial College School of Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom.

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http://dx.doi.org/10.1210/en.2011-1506DOI Listing
January 2012

A distinct subset of human NK cells expressing HLA-DR expand in response to IL-2 and can aid immune responses to BCG.

Eur J Immunol 2011 Jul 7;41(7):1924-33. Epub 2011 Jun 7.

Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London, UK.

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http://dx.doi.org/10.1002/eji.201041180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549558PMC
July 2011

The CXCL16 A181V mutation selectively inhibits monocyte adhesion to CXCR6 but is not associated with human coronary heart disease.

Arterioscler Thromb Vasc Biol 2011 Apr 13;31(4):914-20. Epub 2011 Jan 13.

Leukocyte Biology Section, Division, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, Exhibition Rd, SW7 2AZ London, United Kingdom.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.110.220558
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http://dx.doi.org/10.1161/ATVBAHA.110.220558DOI Listing
April 2011

Targeting chemokine receptors in allergic disease.

Authors:
James E Pease

Biochem J 2011 Feb;434(1):11-24

Leukocyte Biology, and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, NHLI Division, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1042/BJ20101132DOI Listing
February 2011

Small molecule antagonists of chemokine receptors--is promiscuity a virtue?

Curr Top Med Chem 2010 ;10(13):1351-8

Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology & Medicine, South Kensington Campus, London SW7 2AZ, UK.

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http://dx.doi.org/10.2174/156802610791561228DOI Listing
January 2011

A single nucleotide polymorphism in the CCR3 gene ablates receptor export to the plasma membrane.

J Allergy Clin Immunol 2010 Jul 11;126(1):150-7.e2. Epub 2010 Jun 11.

Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2010.04.015DOI Listing
July 2010

The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo.

J Immunol 2010 Jun 28;184(11):6114-23. Epub 2010 Apr 28.

Leukocyte Biology Section, Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, South Kensington, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.0904177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956277PMC
June 2010

Modeling small molecule-compound binding to G-protein-coupled receptors.

Methods Enzymol 2009 ;460:263-88

Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California, USA.

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http://dx.doi.org/10.1016/S0076-6879(09)05213-6DOI Listing
August 2009

Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5.

Mol Pharmacol 2009 Jun 18;75(6):1325-36. Epub 2009 Mar 18.

Department of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA.

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http://dx.doi.org/10.1124/mol.108.053470DOI Listing
June 2009

Chemokine receptor antagonists: part 2.

Expert Opin Ther Pat 2009 Feb;19(2):199-221

Faculty of Medicine National Heart and Lung Institute, Imperial College of Science, Technology & Medicine, Leukocyte Biology Section, London, UK.

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http://dx.doi.org/10.1517/13543770802641353DOI Listing
February 2009

Chemokine receptor antagonists: Part 1.

Expert Opin Ther Pat 2009 Jan;19(1):39-58

Faculty of Medicine National Heart and Lung Institute, Imperial College of Science, Technology & Medicine, Leukocyte Biology Section, South Kensington Campus, London SW7 2AZ, UK.

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http://dx.doi.org/10.1517/13543770802641346DOI Listing
January 2009

Site-directed mutagenesis of the chemokine receptor CXCR6 suggests a novel paradigm for interactions with the ligand CXCL16.

Eur J Immunol 2008 Aug;38(8):2337-50

NHLI Division, Leukocyte Biology Section, Faculty of Medicine, Imperial College London, London, UK.

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http://doi.wiley.com/10.1002/eji.200838269
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http://dx.doi.org/10.1002/eji.200838269DOI Listing
August 2008

CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3.

J Leukoc Biol 2008 Apr 3;83(4):875-82. Epub 2008 Jan 3.

Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. j

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http://dx.doi.org/10.1189/jlb.1006645DOI Listing
April 2008

Structure and function of A41, a vaccinia virus chemokine binding protein.

PLoS Pathog 2008 Jan;4(1):e5

The Division of Structural Biology and The Oxford Protein Production Facility, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.0040005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211551PMC
January 2008

Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation.

J Biol Chem 2007 Sep 16;282(38):27935-43. Epub 2007 Jul 16.

Leukocyte Biology Section, National Heart and Lung Institute Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M703255200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151197PMC
September 2007

The CXC chemokine MIG/CXCL9 is important in innate immunity against Streptococcus pyogenes.

J Infect Dis 2007 Mar 18;195(5):684-93. Epub 2007 Jan 18.

Section for Respiratory Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1086/510857DOI Listing
March 2007

Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function.

J Leukoc Biol 2007 Feb 17;81(2):372-82. Epub 2006 Oct 17.

Department of Asthma, Allergy and Respiratory Science, King's College London, 5th Floor Thomas Guy House, Guy's Hospital, London, UK.

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http://dx.doi.org/10.1189/jlb.0706424DOI Listing
February 2007

Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist.

J Biol Chem 2006 Dec 5;281(48):36652-61. Epub 2006 Oct 5.

National Heart and Lung Institute Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M605584200DOI Listing
December 2006

Alanine scanning mutagenesis of the chemokine receptor CCR3 reveals distinct extracellular residues involved in recognition of the eotaxin family of chemokines.

Mol Immunol 2006 Mar 15;43(8):1221-31. Epub 2005 Aug 15.

Leukocyte Biology and Section, Biomedical Sciences Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.molimm.2005.07.015DOI Listing
March 2006

The attraction of chemokines as a target for specific anti-inflammatory therapy.

Br J Pharmacol 2006 Jan;147 Suppl 1:S212-21

Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ.

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http://dx.doi.org/10.1038/sj.bjp.0706475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1760746PMC
January 2006

Asthma, allergy and chemokines.

Authors:
James E Pease

Curr Drug Targets 2006 Jan;7(1):3-12

Leukocyte Biology Section, Biomedical Sciences Division, Sir Alexander Fleming Building, Imperial College London, Exhibition Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.2174/138945006775270204DOI Listing
January 2006

CCR1 antagonists in clinical development.

Expert Opin Investig Drugs 2005 Jul;14(7):785-96

Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, South Kensington Campus, London SW7 2AZ, UK.

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http://dx.doi.org/10.1517/13543784.14.7.785DOI Listing
July 2005

The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy.

Am J Respir Med 2002 ;1(1):19-25

Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology & Medicine, South Kensington, London SW7 2AZ, UK.

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http://dx.doi.org/10.1007/BF03257159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102088PMC
May 2005

Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist.

J Biol Chem 2005 Feb 17;280(6):4808-16. Epub 2004 Nov 17.

Leukocyte Biology, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M412267200DOI Listing
February 2005

CCR4 blockade does not inhibit allergic airways inflammation.

J Leukoc Biol 2003 Oct 15;74(4):558-63. Epub 2003 Jul 15.

Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1189/jlb.0103030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428841PMC
October 2003

Molecular characterization of the chemokine receptor CXCR3: evidence for the involvement of distinct extracellular domains in a multi-step model of ligand binding and receptor activation.

Eur J Immunol 2003 Oct;33(10):2927-36

Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London, GB.

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http://dx.doi.org/10.1002/eji.200324235DOI Listing
October 2003

Variations in eosinophil chemokine responses: an investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter.

J Immunol 2003 Jun;170(12):6190-201

Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.170.12.6190DOI Listing
June 2003

Proteoglycans are potent modulators of the biological responses of eosinophils to chemokines.

Eur J Immunol 2003 May;33(5):1302-10

Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, London, GB.

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http://dx.doi.org/10.1002/eji.200323509DOI Listing
May 2003

CCR4 in human allergen-induced late responses in the skin and lung.

Eur J Immunol 2002 Jul;32(7):1933-8

Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, GB.

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http://dx.doi.org/10.1002/1521-4141(200207)32:7<1933::AID-IMMU1933>3.0.CO;2-RDOI Listing
July 2002

Alanine scanning mutagenesis of CCR3 reveals that the three intracellular loops are essential for functional receptor expression.

Eur J Immunol 2002 04;32(4):1052-8

Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, GB.

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http://dx.doi.org/10.1002/1521-4141(200204)32:4<1052::AID-IMMU1052>3.0.CO;2-LDOI Listing
April 2002

The identification, characterization, and distribution of guinea pig CCR4 and epitope mapping of a blocking antibody.

J Biol Chem 2002 Mar 27;277(9):6864-73. Epub 2001 Nov 27.

Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Exhibition Road, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109974200DOI Listing
March 2002