James E Huettner

James E Huettner

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James E Huettner

James E Huettner

Publications by authors named "James E Huettner"

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33Publications

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Cadmium opens GluK2 kainate receptors with cysteine substitutions at the M3 helix bundle crossing.

J Gen Physiol 2019 Apr 29;151(4):435-451. Epub 2018 Nov 29.

Department of Cell Biology and Physiology, Washington University Medical School, St. Louis, MO

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http://www.jgp.org/lookup/doi/10.1085/jgp.201812234
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http://dx.doi.org/10.1085/jgp.201812234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445585PMC
April 2019

Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization.

Neuropharmacology 2019 01 15;144:91-103. Epub 2018 Oct 15.

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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https://academic.oup.com/ajcn/article-abstract/70/5/896/4729
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https://linkinghub.elsevier.com/retrieve/pii/S00283908183079
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http://dx.doi.org/10.1016/j.neuropharm.2018.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286210PMC
January 2019

Intracellular water preexchange lifetime in neurons and astrocytes.

Magn Reson Med 2018 03 4;79(3):1616-1627. Epub 2017 Jul 4.

Department of Chemistry, Washington University, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1002/mrm.26781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754269PMC
March 2018

Regulatory networks specifying cortical interneurons from human embryonic stem cells reveal roles for CHD2 in interneuron development.

Proc Natl Acad Sci U S A 2017 12 11;114(52):E11180-E11189. Epub 2017 Dec 11.

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110;

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http://dx.doi.org/10.1073/pnas.1712365115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748186PMC
December 2017

TARPs and AMPA Receptors: Function Follows Form.

Authors:
James E Huettner

Neuron 2017 Mar;93(5):989-991

Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.02.040DOI Listing
March 2017

Generation of highly enriched V2a interneurons from mouse embryonic stem cells.

Exp Neurol 2016 Mar 16;277:305-316. Epub 2016 Jan 16.

Department of Biomedical Engineering, Washington University, Campus Box 1097, One Brookings Drive, St. Louis, MO 63130, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2016.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761286PMC
March 2016

Radial symmetry in a chimeric glutamate receptor pore.

Nat Commun 2014 ;5:3349

Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/ncomms4349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962659PMC
November 2015

A puromycin selectable cell line for the enrichment of mouse embryonic stem cell-derived V3 interneurons.

Stem Cell Res Ther 2015 Nov 10;6:220. Epub 2015 Nov 10.

Department of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Drive, Box 1097, St. Louis, MO, 63130, USA.

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http://stemcellres.com/content/6/1/220
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http://dx.doi.org/10.1186/s13287-015-0213-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641415PMC
November 2015

Glutamate receptor pores.

Authors:
James E Huettner

J Physiol 2015 Jan 6;593(1):49-59. Epub 2014 May 6.

Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO, 63110, USA.

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http://dx.doi.org/10.1113/jphysiol.2014.272724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293053PMC
January 2015

A new method for generating high purity motoneurons from mouse embryonic stem cells.

Biotechnol Bioeng 2014 Oct 4;111(10):2041-55. Epub 2014 Jun 4.

Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, 63130.

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http://dx.doi.org/10.1002/bit.25260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146753PMC
October 2014

Vertebrate galectins: endogenous regulators of ionotropic glutamate receptors?

Authors:
James E Huettner

J Physiol 2014 May;592(10):2035-6

Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA

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http://dx.doi.org/10.1113/jphysiol.2014.273920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227891PMC
May 2014

Myosin II regulates activity dependent compensatory endocytosis at central synapses.

J Neurosci 2013 Oct;33(41):16131-45

Departments of Anatomy and Neurobiology and Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, and Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.

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http://dx.doi.org/10.1523/JNEUROSCI.2229-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792455PMC
October 2013

Q/R site interactions with the M3 helix in GluK2 kainate receptor channels revealed by thermodynamic mutant cycles.

J Gen Physiol 2013 Sep 12;142(3):225-39. Epub 2013 Aug 12.

Department of Cell Biology and Physiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1085/jgp.201311000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753602PMC
September 2013

An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity.

J Biol Chem 2011 Apr 8;286(16):14724-36. Epub 2011 Mar 8.

Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1074/jbc.M110.214973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077669PMC
April 2011

Fatty acid modulation and polyamine block of GluK2 kainate receptors analyzed by scanning mutagenesis.

J Gen Physiol 2010 Sep;136(3):339-52

Department of Cell Biology and Physiology, Washington University Medical School, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1085/jgp.201010442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931155PMC
September 2010

Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells.

J Biol Chem 2010 Aug 23;285(34):26719-26. Epub 2010 Jun 23.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M110.134619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924115PMC
August 2010

Intrinsic, nondeterministic circadian rhythm generation in identified mammalian neurons.

Proc Natl Acad Sci U S A 2009 Sep 9;106(38):16493-8. Epub 2009 Sep 9.

Department of Biology, Washington University, St. Louis, MO 63130, USA.

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http://dx.doi.org/10.1073/pnas.0902768106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752526PMC
September 2009

Regulation of mouse embryonic stem cell neural differentiation by retinoic acid.

Dev Biol 2009 Apr 13;328(2):456-71. Epub 2009 Feb 13.

Department of Cell Biology and Physiology, Washington University Medical School, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ydbio.2009.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666105PMC
April 2009

The BTB/kelch protein, KRIP6, modulates the interaction of PICK1 with GluR6 kainate receptors.

Neuropharmacology 2008 Dec 23;55(7):1131-9. Epub 2008 Jul 23.

Department of Cell Biology and Physiology, Washington University, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2008.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685165PMC
December 2008

Amino acid substitutions in the pore helix of GluR6 control inhibition by membrane fatty acids.

J Gen Physiol 2008 Jul 18;132(1):85-99. Epub 2008 Jun 18.

Department of Cell Biology and Physiology, Washington University Medical School, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1085/jgp.200810009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442176PMC
July 2008

KRIP6: a novel BTB/kelch protein regulating function of kainate receptors.

Mol Cell Neurosci 2007 Apr 24;34(4):539-50. Epub 2007 Jan 24.

Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.mcn.2006.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939939PMC
April 2007

GABA and Gi/o differentially control circadian rhythms and synchrony in clock neurons.

Proc Natl Acad Sci U S A 2006 Dec 30;103(50):19188-93. Epub 2006 Nov 30.

Department of Biology, Washington University, St. Louis, MO 63130, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0607466103
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http://dx.doi.org/10.1073/pnas.0607466103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1748197PMC
December 2006

R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism.

J Biol Chem 2006 Sep 25;281(38):28222-31. Epub 2006 Jul 25.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M604428200DOI Listing
September 2006

Gap junctions and connexon hemichannels in human embryonic stem cells.

Stem Cells 2006 Jul 30;24(7):1654-67. Epub 2006 Mar 30.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA .

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http://dx.doi.org/10.1634/stemcells.2005-0003DOI Listing
July 2006

Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells.

Org Biomol Chem 2005 Oct 26;3(19):3544-50. Epub 2005 Aug 26.

Department of Molecular Biology & Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1039/b508157bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2617747PMC
October 2005

Q/R site editing controls kainate receptor inhibition by membrane fatty acids.

J Neurosci 2005 Oct;25(41):9470-8

Department of Cell Biology and Physiology, Washington University Medical School, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.2826-05.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725705PMC
October 2005

Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family.

J Cell Biol 2005 May 16;169(4):623-33. Epub 2005 May 16.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1083/jcb.200502007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171691PMC
May 2005

Synthetic ion channel activity documented by electrophysiological methods in living cells.

J Am Chem Soc 2004 Dec;126(48):15747-53

Department of Chemistry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1021/ja046626xDOI Listing
December 2004

Spine-tingling excitement from glutamate receptors.

Authors:
James E Huettner

Sci STKE 2003 Nov 25;2003(210):pe53. Epub 2003 Nov 25.

Department of Cell Biology and Physiology, Washington University Medical School, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/stke.2102003pe53DOI Listing
November 2003

Kainate receptors and synaptic transmission.

Authors:
James E Huettner

Prog Neurobiol 2003 Aug;70(5):387-407

Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/s0301-0082(03)00122-9DOI Listing
August 2003

Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn.

J Neurosci 2002 Sep;22(18):8010-7

Washington University Pain Center and Departments of Anesthesiology, Anatomy and Neurobiology, and Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758074PMC
September 2002

Glutamate and the presynaptic control of spinal sensory transmission.

Neuroscientist 2002 Apr;8(2):89-92

Department of Cell Biology & Physiology, Washington University Pain Center, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1177/107385840200800204DOI Listing
April 2002