James E Crowe

James E Crowe

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James E Crowe

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A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface.

Cell 2019 May;177(5):1136-1152.e18

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.04.011DOI Listing
May 2019

Antibody Determinants of Influenza Immunity.

Authors:
James E Crowe

J Infect Dis 2019 Apr;219(Supplement_1):S21-S29

Vanderbilt Vaccine Center, Nashville, Tennessee.

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452307PMC
April 2019

Early Human B Cell Response to Ebola Virus in Four U.S. Survivors of Infection.

J Virol 2019 Apr 3;93(8). Epub 2019 Apr 3.

Departments of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA

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http://dx.doi.org/10.1128/JVI.01439-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450119PMC
April 2019

Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains.

Front Immunol 2019 22;10:558. Epub 2019 Mar 22.

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440498PMC
March 2019

Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody.

Structure 2019 Feb 21;27(2):253-267.e8. Epub 2018 Nov 21.

Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365167PMC
February 2019

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains.

PLoS Biol 2019 Feb 4;17(2):e3000139. Epub 2019 Feb 4.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.3000139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375650PMC
February 2019

Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice.

Cell Rep 2019 Feb;26(6):1585-1597.e4

Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.01.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420780PMC
February 2019

High frequency of shared clonotypes in human B cell receptor repertoires.

Nature 2019 Feb 13;566(7744):398-402. Epub 2019 Feb 13.

The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1038/s41586-019-0934-8DOI Listing
February 2019

Influenza Virus-Specific Human Antibody Repertoire Studies.

Authors:
James E Crowe

J Immunol 2019 Jan;202(2):368-373

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1801459
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http://dx.doi.org/10.4049/jimmunol.1801459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327975PMC
January 2019

Human Monoclonal Antibodies That Neutralize Pandemic GII.4 Noroviruses.

Gastroenterology 2018 12 28;155(6):1898-1907. Epub 2018 Aug 28.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.08.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402321PMC
December 2018

Potent Neutralizing Human Monoclonal Antibodies Preferentially Target Mature Dengue Virus Particles: Implication for Novel Strategy for Dengue Vaccine.

J Virol 2018 Dec 12;92(23). Epub 2018 Nov 12.

Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA

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http://dx.doi.org/10.1128/JVI.00556-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232466PMC
December 2018

Current Understanding of Humoral Immunity to Enterovirus D68.

J Pediatric Infect Dis Soc 2018 Dec;7(suppl_2):S49-S53

Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.

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https://academic.oup.com/jpids/article/7/suppl_2/S49/5261307
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http://dx.doi.org/10.1093/jpids/piy124DOI Listing
December 2018

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein.

Immunity 2018 08 17;49(2):363-374.e10. Epub 2018 Jul 17.

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104738PMC
August 2018

Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors.

Cell Rep 2018 Aug;24(7):1802-1815.e5

Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.07.035DOI Listing
August 2018

Antibody Repertoires to the Same Ebola Vaccine Antigen Are Differentially Affected by Vaccine Vectors.

Cell Rep 2018 Aug;24(7):1816-1829

Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77555, USA; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.07.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145141PMC
August 2018

Is It Possible to Develop a "Universal" Influenza Virus Vaccine? Potential for a Universal Influenza Vaccine.

Authors:
James E Crowe

Cold Spring Harb Perspect Biol 2018 Jul 2;10(7). Epub 2018 Jul 2.

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232-0417.

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http://dx.doi.org/10.1101/cshperspect.a029496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829045PMC
July 2018

Multi-Donor Longitudinal Antibody Repertoire Sequencing Reveals the Existence of Public Antibody Clonotypes in HIV-1 Infection.

Cell Host Microbe 2018 06 31;23(6):845-854.e6. Epub 2018 May 31.

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002606PMC
June 2018

Integrating linear optimization with structural modeling to increase HIV neutralization breadth.

PLoS Comput Biol 2018 02 16;14(2):e1005999. Epub 2018 Feb 16.

Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833279PMC
February 2018

Human antibody recognition of antigenic site IV on Pneumovirus fusion proteins.

PLoS Pathog 2018 02 22;14(2):e1006837. Epub 2018 Feb 22.

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823459PMC
February 2018

Development of Human Monoclonal Antibodies Against Respiratory Syncytial Virus Using a High Efficiency Human Hybridoma Technique.

Methods Mol Biol 2016 ;1442:63-76

Department of Pathology, Microbiology and Immunology,, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1007/978-1-4939-3687-8_6DOI Listing
January 2018

Synergistic anti-HCV broadly neutralizing human monoclonal antibodies with independent mechanisms.

Proc Natl Acad Sci U S A 2018 01 18;115(1):E82-E91. Epub 2017 Dec 18.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;

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http://dx.doi.org/10.1073/pnas.1718441115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776832PMC
January 2018

The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.

Cell Host Microbe 2018 Jan;23(1):101-109.e4

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772738PMC
January 2018

Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.

Structure 2017 12 16;25(12):1820-1828.e2. Epub 2017 Nov 16.

Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA; Center for Structural Biology, Vanderbilt University, Nashville, TN 37235, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2017.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718948PMC
December 2017

Epitope and Paratope Mapping Reveals Temperature-Dependent Alterations in the Dengue-Antibody Interface.

Structure 2017 09 17;25(9):1391-1402.e3. Epub 2017 Aug 17.

Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.str.2017.07.007DOI Listing
September 2017

Principles of Broad and Potent Antiviral Human Antibodies: Insights for Vaccine Design.

Authors:
James E Crowe

Cell Host Microbe 2017 Aug;22(2):193-206

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700460PMC
August 2017

A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV.

PLoS One 2016 25;11(5):e0155917. Epub 2016 May 25.

Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155917PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880302PMC
July 2017

Treating Flu with Skin of Frog.

Authors:
James E Crowe

Immunity 2017 04;46(4):517-518

Departments of Pediatrics, Pathology, Microbiology, and Immunology, and the Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.04.007DOI Listing
April 2017

Performance of computed tomography of the head to evaluate for skull fractures in infants with suspected non-accidental trauma.

Pediatr Radiol 2017 Jan 15;47(1):74-81. Epub 2016 Oct 15.

Emergency Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.

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http://dx.doi.org/10.1007/s00247-016-3707-7DOI Listing
January 2017

Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus.

Nat Microbiol 2017 Jan 30;2:16272. Epub 2017 Jan 30.

Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nmicrobiol.2016.272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308794PMC
January 2017

A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein.

Nat Microbiol 2017 Jan 30;2:16271. Epub 2017 Jan 30.

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

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http://www.nature.com/articles/nmicrobiol2016271
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http://dx.doi.org/10.1038/nmicrobiol.2016.271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463187PMC
January 2017

Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody.

Proc Natl Acad Sci U S A 2016 10 19;113(40):E5830-E5837. Epub 2016 Sep 19.

The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030;

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http://dx.doi.org/10.1073/pnas.1609990113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056091PMC
October 2016

Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections.

Cell 2016 Oct;167(3):684-694.e9

The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.09.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093772PMC
October 2016

Teaching a Clone to Walk, One Step at a Time.

Authors:
James E Crowe

Cell 2016 Sep;166(6):1360-1361

Departments of Pediatrics, Pathology, Microbiology, and Immunology and Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.08.039DOI Listing
September 2016

Pathogenic Chikungunya Virus Evades B Cell Responses to Establish Persistence.

Cell Rep 2016 08 21;16(5):1326-1338. Epub 2016 Jul 21.

Department of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO 80045, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003573PMC
August 2016

Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.

Nat Microbiol 2016 Aug 8;1(9):16128. Epub 2016 Aug 8.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nmicrobiol.2016.128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003320PMC
August 2016

Deciphering the human immunome.

Expert Rev Vaccines 2015 24;14(11):1421-5. Epub 2015 Aug 24.

b 2 International AIDS Vaccine Initiative, New York, NY, USA.

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http://dx.doi.org/10.1586/14760584.2015.1082427DOI Listing
July 2016

Recognition of influenza H3N2 variant virus by human neutralizing antibodies.

JCI Insight 2016 Jul;1(10)

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1172/jci.insight.86673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962875PMC
July 2016

Characterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells.

Virology 2016 06 6;493:162-72. Epub 2016 Apr 6.

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA.

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http://dx.doi.org/10.1016/j.virol.2016.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538722PMC
June 2016

Deep sequencing and human antibody repertoire analysis.

Curr Opin Immunol 2016 06 8;40:103-9. Epub 2016 Apr 8.

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232-0417, United States. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203765PMC
June 2016

Engineering Recombinant Reoviruses To Display gp41 Membrane-Proximal External-Region Epitopes from HIV-1.

mSphere 2016 May-Jun;1(3). Epub 2016 May 18.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1128/mSphere.00086-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888892PMC
June 2016

Association of VH4-59 Antibody Variable Gene Usage with Recognition of an Immunodominant Epitope on the HIV-1 Gag Protein.

PLoS One 2015 30;10(7):e0133509. Epub 2015 Jul 30.

Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America; Vanderbilt Vaccine Center, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133509PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520566PMC
May 2016

Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model.

PLoS One 2015 24;10(8):e0136708. Epub 2015 Aug 24.

Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; The Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136708PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547738PMC
May 2016

Early Th1 immunity promotes immune tolerance and may impair graft-versus-leukemia effect after allogeneic hematopoietic cell transplantation.

Haematologica 2016 05 27;101(5):e204-8. Epub 2016 Jan 27.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA

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http://dx.doi.org/10.3324/haematol.2015.139501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004357PMC
May 2016

Chimeric Filoviruses for Identification and Characterization of Monoclonal Antibodies.

J Virol 2016 Apr 28;90(8):3890-3901. Epub 2016 Mar 28.

Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA

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http://dx.doi.org/10.1128/JVI.00101-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810552PMC
April 2016

Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization.

Proc Natl Acad Sci U S A 2016 Apr 4;113(16):4446-51. Epub 2016 Apr 4.

Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN 37232; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232;

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http://dx.doi.org/10.1073/pnas.1518405113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843476PMC
April 2016

Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations.

Mol Immunol 2016 Feb 31;70:94-103. Epub 2015 Dec 31.

Department of Pathology, Microbiology and Immunology Vanderbilt University Medical Center, Nashville, TN 37232, United States; The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, United States. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2015.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762738PMC
February 2016

Immunogenicity and efficacy of alphavirus-derived replicon vaccines for respiratory syncytial virus and human metapneumovirus in nonhuman primates.

Vaccine 2016 Feb 7;34(7):950-6. Epub 2016 Jan 7.

The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; The Department of Vanderbilt University Medical Center, Nashville, TN 37232, USA; The Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.12.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731299PMC
February 2016

Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies.

MBio 2016 Feb 23;7(1):e02154-15. Epub 2016 Feb 23.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA

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http://dx.doi.org/10.1128/mBio.02154-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791852PMC
February 2016

Dengue Virus prM-Specific Human Monoclonal Antibodies with Virus Replication-Enhancing Properties Recognize a Single Immunodominant Antigenic Site.

J Virol 2016 01 28;90(2):780-9. Epub 2015 Oct 28.

Department of Pediatrics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA

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http://jvi.asm.org/content/early/2015/10/22/JVI.01805-15.ful
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http://dx.doi.org/10.1128/JVI.01805-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702676PMC
January 2016

Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection.

Cell 2016 Jan 21;164(3):392-405. Epub 2016 Jan 21.

Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733404PMC
January 2016

Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress.

Cell 2015 Nov 6;163(5):1095-1107. Epub 2015 Nov 6.

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.10.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659373PMC
November 2015

DENGUE VIRUS. Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.

Science 2015 Jul;349(6243):88-91

Program in Emerging Infectious Diseases, Duke-National University of Singapore Graduate Medical School, Singapore. Centre for BioImaging Sciences, National University of Singapore, Singapore.

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http://dx.doi.org/10.1126/science.aaa8651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672004PMC
July 2015

Design of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences.

PLoS Comput Biol 2015 Jul 6;11(7):e1004300. Epub 2015 Jul 6.

Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1004300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493036PMC
July 2015

Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus.

Cell Host Microbe 2015 Jul;18(1):86-95

Department of Pediatrics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501771PMC
July 2015

Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites.

Proc Natl Acad Sci U S A 2015 Jul 13;112(30):9346-51. Epub 2015 Jul 13.

Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232; Department of Pharmacology and Center for Structural Biology, Vanderbilt University School of Medicine, Nashville, TN 37232

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http://dx.doi.org/10.1073/pnas.1502762112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522792PMC
July 2015