James Dalton

James Dalton

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James Dalton

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Artificial Intelligence: A Novel Approach for Drug Discovery.

Trends Pharmacol Sci 2019 Aug 3;40(8):550-551. Epub 2019 Jul 3.

Laboratory of Molecular Neuropharmacology and Bioinformatics, Unitat de Bioestadística and Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, 08193, Bellaterra, Spain; Unitat de Neurociència Traslacional, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí (I3PT), Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2019.06.005DOI Listing
August 2019

Pediatric Supratentorial Ependymoma: Surgical, Clinical, and Molecular Analysis.

Neurosurgery 2019 Jul;85(1):41-49

Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee.

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http://dx.doi.org/10.1093/neuros/nyy239DOI Listing
July 2019

Health-Care Administrator Perspectives on Prevention Guidelines and Healthy Lifestyle Counseling in a Primary Care Setting in New York State.

Health Serv Res Manag Epidemiol 2019 Jan-Dec;6:2333392819862122. Epub 2019 Jul 23.

Department of Public Health and Clinical Medicine, Epidemiology and Global Health Unit, Faculty of Medicine, Umeå University, Umeå, Sweden.

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http://dx.doi.org/10.1177/2333392819862122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657119PMC
July 2019

Revealing the Mechanism of Agonist-Mediated Cannabinoid Receptor 1 (CB1) Activation and Phospholipid-Mediated Allosteric Modulation.

J Med Chem 2019 Jun 29;62(11):5638-5654. Epub 2019 May 29.

Instituto de Salud Carlos III , Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM , 08193 Bellaterra , Spain.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00612DOI Listing
June 2019

Distinct Dopamine D₂ Receptor Antagonists Differentially Impact D₂ Receptor Oligomerization.

Int J Mol Sci 2019 Apr 4;20(7). Epub 2019 Apr 4.

Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.

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https://www.mdpi.com/1422-0067/20/7/1686
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http://dx.doi.org/10.3390/ijms20071686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480712PMC
April 2019

Gr1 Cells Dominate the Early Phagocyte Response to Mycobacterial Lung Infection in Mice.

Front Microbiol 2019 8;10:402. Epub 2019 Mar 8.

Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.3389/fmicb.2019.00402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418015PMC
March 2019

Structure and evolution of double minutes in diagnosis and relapse brain tumors.

Acta Neuropathol 2019 Jan 28;137(1):123-137. Epub 2018 Sep 28.

Department of Computational Biology, St. Jude Children's Research Hospital, MS1135, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s00401-018-1912-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338707PMC
January 2019

Lifestyle counseling in primary care in the United States and Sweden: a comparison of patients' expectations and experiences.

Glob Health Action 2018 ;11(1):1438238

a Department of Public Health and Clinical Medicine, Epidemiology and Global Health , Umeå University , Umeå , Sweden.

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http://dx.doi.org/10.1080/16549716.2018.1438238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844052PMC
October 2018

Synthesis toward Bivalent Ligands for the Dopamine D and Metabotropic Glutamate 5 Receptors.

J Med Chem 2018 09 18;61(18):8212-8225. Epub 2018 Sep 18.

Laboratory for Medicinal Chemistry (FFW) , Ghent University , Ottergemsesteenweg 460 , B-9000 Ghent , Belgium.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00671DOI Listing
September 2018

A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-κB.

Cell Rep 2018 06;23(13):3787-3797

Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA; Seattle Tumor Translational Research (STTR), Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA; Alvord Brain Tumor Center, University of Washington, Seattle, WA 98109, USA; Department of Neurosurgery, University of Washington, Seattle, WA 98109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411037PMC
June 2018

Development of selective androgen receptor modulators (SARMs).

Mol Cell Endocrinol 2018 04 15;465:134-142. Epub 2017 Jun 15.

College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2017.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896569PMC
April 2018

Structural insights into positive and negative allosteric regulation of a G protein-coupled receptor through protein-lipid interactions.

Sci Rep 2018 03 13;8(1):4456. Epub 2018 Mar 13.

Laboratory of Molecular Neuropharmacology and Bioinformatics, Institut de Neurociències and Unitat de Bioestadística, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.

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http://dx.doi.org/10.1038/s41598-018-22735-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849739PMC
March 2018

A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance.

Cancer Res 2018 01 27;78(1):265-277. Epub 2017 Nov 27.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0577DOI Listing
January 2018

A Novel Restraint Device for Injection of Larvae that Minimizes the Risk of Accidental Operator Needle Stick Injury.

Front Cell Infect Microbiol 2017 28;7:99. Epub 2017 Mar 28.

Bioluminescent Superbugs Lab, University of AucklandAuckland, New Zealand; Department of Molecular Medicine and Pathology, University of AucklandAuckland, New Zealand; Maurice Wilkins Centre for Molecular BiodiscoveryAuckland, New Zealand.

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http://dx.doi.org/10.3389/fcimb.2017.00099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368263PMC
December 2017

Do surgical helmet systems affect intraoperative wound contamination? A randomised controlled trial.

Arch Orthop Trauma Surg 2017 Nov 16;137(11):1565-1569. Epub 2017 Sep 16.

Department of Orthopaedic Surgery, North Shore Hospital, University of Auckland, 124 Shakespeare Road, Takapuna Private Bag 93-503, Auckland, 0740, New Zealand.

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http://dx.doi.org/10.1007/s00402-017-2795-7DOI Listing
November 2017

The long and winding road for selective androgen receptor modulators.

Authors:
James T Dalton

Br J Clin Pharmacol 2017 10 17;83(10):2131-2133. Epub 2017 Jul 17.

University of Michigan College of Pharmacy, Ann Arbor, MI, USA.

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http://doi.wiley.com/10.1111/bcp.13345
Publisher Site
http://dx.doi.org/10.1111/bcp.13345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595949PMC
October 2017

Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas.

J Clin Oncol 2017 Sep 20;35(25):2934-2941. Epub 2017 Jul 20.

Alvaro Lassaletta, Michal Zapotocky, Matthew Mistry, Vijay Ramaswamy, Marion Honnorat, Rahul Krishnatry, Ana Guerreiro Stucklin, Nataliya Zhukova, Anthony Arnoldo, Scott Ryall, Catriona Ling, Tara McKeown, Jim Loukides, James T. Rutka, Peter Dirks, Michael D. Taylor, Shiyi Chen, Ute Bartels, Annie Huang, Eric Bouffet, Cynthia Hawkins, and Uri Tabori, The Hospital for Sick Children, Toronto; Adam Fleming, McMaster Children's Hospital, McMaster University, Hamilton; Shayna Zelcer, Children's Hospital of Western Ontario, London, Ontario; David Eisenstat and Bev Wilson, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta; Anne Sophie Carret, Hospital Sainte Justine; Nada Jabado, McGill University, Montreal; Valerie Larouche, Centre Hospitalier Universitaire de Québec, Québec City, Quebec, Canada; Ofelia Cruz and Carmen de Torres, Hospital Sant Joan de Déu, Barcelona, Spain; Cheng-Ying Ho, University of Maryland School of Medicine, Baltimore, MD; Roger J. Packer, Children's National Health System, Washington, DC; Ruth Tatevossian, Ibrahim Qaddoumi, Julie H. Harreld, James D. Dalton, and David W. Ellison, St Jude Children's Research Hospital, Memphis, TN; Jean Mulcahy-Levy and Nicholas Foreman, Children's Hospital Colorado, Aurora, CO; Matthias A. Karajannis, Shiyang Wang, and Matija Snuderl, New York University Langone Medical Center, New York, NY; Amulya Nageswara Rao and Caterina Giannini, The Mayo Clinic, Rochester, MN; Mark Kieran and Keith L. Ligon, Dana-Farber Cancer Institute, Boston Children's Hospital, Boston, MA; Maria Luisa Garre, Paolo Nozza, Samantha Mascelli, and Alessandro Raso, Istituto Giannina Gaslini, Genoa, Italy; Sabine Mueller and Theodore Nicolaides, University of California, San Francisco, San Francisco, CA; Karen Silva and Romain Perbet, Hospices Civils de Lyon; Alexandre Vasiljevic, Cécile Faure Conter, and Didier Frappaz, Institute of Pediatric Hematology and Oncology, Lyon, France; Sarah Leary and Courtney Crane, Seattle Children's Hospital, Seattle, WA; Aden Chan and Ho-Keung Ng, The Chinese University of Hong Kong, Hong Kong; Zhi-Feng Shi and Ying Mao, Huashan Hospital, Fudan University, Shanghai, People's Republic of China; Elizabeth Finch, University of North Carolina, School of Medicine, Chapel Hill, NC; Peter Hauser, Semmelweis University, Budapest, Hungary; and David Sumerauer and Lenka Krskova, University Hospital Motol, Charles University, 2nd Medical School, Prague, Czech Republic.

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http://dx.doi.org/10.1200/JCO.2016.71.8726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791837PMC
September 2017

Analysis of positive and negative allosteric modulation in metabotropic glutamate receptors 4 and 5 with a dual ligand.

Sci Rep 2017 07 10;7(1):4944. Epub 2017 Jul 10.

Laboratory of Molecular Neuropharmacology and Bioinformatics, Institut de Neurociències and Unitat de Bioestadística, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.

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http://dx.doi.org/10.1038/s41598-017-05095-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504000PMC
July 2017

Angiotensin II type 1/adenosine A receptor oligomers: a novel target for tardive dyskinesia.

Sci Rep 2017 05 12;7(1):1857. Epub 2017 May 12.

Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL-Universitat de Barcelona, L'Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.1038/s41598-017-02037-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431979PMC
May 2017

Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu negative allosteric modulation.

Eur J Med Chem 2017 Feb 12;127:567-576. Epub 2017 Jan 12.

MCS, Laboratory of Medicinal Chemistry & Synthesis, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.01.013DOI Listing
February 2017

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective.

Curr Neuropharmacol 2016 ;14(5):441-54

Laboratory of Molecular Neuropharmacology and Bioinformatics, Institut de Neurociències and Unitat de Bioestadística, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983757PMC
January 2017

Androgen Receptor: A Complex Therapeutic Target for Breast Cancer.

Cancers (Basel) 2016 Dec 2;8(12). Epub 2016 Dec 2.

College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.

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http://www.mdpi.com/2072-6694/8/12/108
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http://dx.doi.org/10.3390/cancers8120108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187506PMC
December 2016

The tuberculocidal activity of polyaniline and functionalised polyanilines.

PeerJ 2016 20;4:e2795. Epub 2016 Dec 20.

Department of Molecular Medicine and Pathology, University of Auckland , Auckland , New Zealand.

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http://dx.doi.org/10.7717/peerj.2795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178338PMC
December 2016

SAR and identification of 2-(quinolin-4-yloxy)acetamides as cytochrome inhibitors.

Medchemcomm 2016 Nov 22;7(11):2122-2127. Epub 2016 Aug 22.

School of Chemical Sciences , University of Auckland , Private Bag 92019 , Auckland 1142 , New Zealand . Email: ; ; Tel: +64 9 3737599.

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http://dx.doi.org/10.1039/c6md00236fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292992PMC
November 2016

Effect of common and experimental anti-tuberculosis treatments on growing as biofilms.

PeerJ 2016 22;4:e2717. Epub 2016 Nov 22.

Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand; Bioluminescent Superbugs Lab, University of Auckland, Auckland, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.

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http://dx.doi.org/10.7717/peerj.2717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126618PMC
November 2016

Pharmacokinetic drug interactions of the selective androgen receptor modulator GTx-024(Enobosarm) with itraconazole, rifampin, probenecid, celecoxib and rosuvastatin.

Invest New Drugs 2016 08 22;34(4):458-67. Epub 2016 Apr 22.

Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church St, Ann Arbor, MI, 48109-1065, USA.

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http://dx.doi.org/10.1007/s10637-016-0353-8DOI Listing
August 2016

Comparison of high-dose intermittent and low-dose continuous oral artemisinin in dogs with naturally occurring tumors.

J Am Anim Hosp Assoc 2014 Nov-Dec;50(6):390-5. Epub 2014 Sep 23.

Departments of Veterinary Clinical Sciences and Veterinary Biosciences (K.H., C.C., C.L., W.K.) and Division of Pharmaceutics, College of Pharmacy (M.P., J.D.), The Ohio State University, Columbus, OH.

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http://dx.doi.org/10.5326/JAAHA-MS-6145DOI Listing
July 2016

The in vitro and in vivo effects of constitutive light expression on a bioluminescent strain of the mouse enteropathogen Citrobacter rodentium.

PeerJ 2016 22;4:e2130. Epub 2016 Jun 22.

Bioluminescent Superbugs Lab, University of Auckland, Auckland, New Zealand; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, New Zealand.

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http://dx.doi.org/10.7717/peerj.2130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924136PMC
July 2016

GNAO1 encephalopathy: further delineation of a severe neurodevelopmental syndrome affecting females.

Orphanet J Rare Dis 2016 Apr 12;11:38. Epub 2016 Apr 12.

Grup de Recerca en Neurologia Pediàtrica, Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain.

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http://dx.doi.org/10.1186/s13023-016-0416-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830060PMC
April 2016

Volatile Organic Compounds Off-gassing from Firefighters' Personal Protective Equipment Ensembles after Use.

J Occup Environ Hyg 2015 ;12(6):404-14

a Division of Surveillance, Hazard Evaluations, and Field Studies , National Institute for Occupational Safety and Health , Cincinnati , Ohio.

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http://dx.doi.org/10.1080/15459624.2015.1025135DOI Listing
March 2016

Biologically Active Acetylenic Amino Alcohol and N-Hydroxylated 1,2,3,4-Tetrahydro-β-carboline Constituents of the New Zealand Ascidian Pseudodistoma opacum.

J Nat Prod 2016 Mar 15;79(3):607-10. Epub 2015 Dec 15.

Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 CNRS, Muséum National d'Histoire Naturelle , 57 Rue Cuvier (C.P. 54), 75005 Paris, France.

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http://dx.doi.org/10.1021/acs.jnatprod.5b00770DOI Listing
March 2016

Helix 3 acts as a conformational hinge in Class A GPCR activation: An analysis of interhelical interaction energies in crystal structures.

J Struct Biol 2015 Dec 29;192(3):545-553. Epub 2015 Oct 29.

Laboratory of Molecular Neuropharmacology and Bioinformatics, Institut de Neurociències and Unitat de Bioestadística, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jsb.2015.10.019DOI Listing
December 2015

Regional Intraosseous Administration of Prophylactic Antibiotics is More Effective Than Systemic Administration in a Mouse Model of TKA.

Clin Orthop Relat Res 2015 Nov 30;473(11):3573-84. Epub 2015 Jul 30.

Bioluminescent Superbugs Laboratory, Faculty of Medical & Health Sciences, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1007/s11999-015-4464-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586203PMC
November 2015

Selective Protonation of Acidic Residues Triggers Opsin Activation.

J Phys Chem B 2015 Jul 17;119(30):9510-9. Epub 2015 Jul 17.

Laboratory of Molecular Neuropharmacology and Bioinformatics, Institut de Neurociències and Unitat de Bioestadística, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.

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http://dx.doi.org/10.1021/acs.jpcb.5b01908DOI Listing
July 2015

CONSERTING: integrating copy-number analysis with structural-variation detection.

Nat Methods 2015 Jun 4;12(6):527-30. Epub 2015 May 4.

1] Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. [2] Pediatric Cancer Genome Project, St. Jude Children's Research Hospital and Washington University School of Medicine, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nmeth.3394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591043PMC
June 2015

Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes.

Cancer Cell 2015 May;27(5):712-27

Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA; Department of Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458854PMC
May 2015

Quantifying conformational changes in GPCRs: glimpse of a common functional mechanism.

BMC Bioinformatics 2015 Apr 23;16:124. Epub 2015 Apr 23.

Laboratory of Molecular Neuropharmacology and Bioinformatics, Institut de Neurociències and Unitat de Bioestadística, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12859-015-0567-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422131PMC
April 2015

Crashes involving young drivers.

BMJ 2015 Feb 11;350:h659. Epub 2015 Feb 11.

Association of British Insurers, London, UK.

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http://dx.doi.org/10.1136/bmj.h659DOI Listing
February 2015

Selective androgen receptor modulators as improved androgen therapy for advanced breast cancer.

Steroids 2014 Nov 16;90:94-100. Epub 2014 Jun 16.

GTx, Inc., Memphis, TN 38103, United States. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2014.06.010DOI Listing
November 2014

An allosteric modulator to control endogenous G protein-coupled receptors with light.

Nat Chem Biol 2014 Oct 31;10(10):813-5. Epub 2014 Aug 31.

1] Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain. [2] Network Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Zaragoza, Spain. [3] Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. [4].

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http://dx.doi.org/10.1038/nchembio.1612DOI Listing
October 2014

Design, synthesis, and biological evaluation of stable colchicine binding site tubulin inhibitors as potential anticancer agents.

J Med Chem 2014 Sep 26;57(17):7355-66. Epub 2014 Aug 26.

Department of Pharmaceutical Sciences, University of Tennessee , Health Science Center, Memphis, Tennessee 38163, United States.

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http://dx.doi.org/10.1021/jm500764vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161160PMC
September 2014

Systemic exposure to PAHs and benzene in firefighters suppressing controlled structure fires.

Ann Occup Hyg 2014 Aug 6;58(7):830-45. Epub 2014 Jun 6.

6.Research and Development Section, Training Division, Chicago Fire Department, 558 West DeKoven Street, Chicago, IL 60607, USA.

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http://dx.doi.org/10.1093/annhyg/meu036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124999PMC
August 2014

Computational analysis of negative and positive allosteric modulator binding and function in metabotropic glutamate receptor 5 (in)activation.

J Chem Inf Model 2014 May 13;54(5):1476-87. Epub 2014 May 13.

Laboratory of Molecular Neuropharmacology and Bioinformatics, Institut de Neurociències and Unitat de Bioestadística, Universitat Autònoma de Barcelona , 08193 Bellaterra, Barcelona, Spain.

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http://dx.doi.org/10.1021/ci500127cDOI Listing
May 2014

TMPRSS2:ERG gene fusion predicts subsequent detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia.

J Clin Oncol 2014 Jan 2;32(3):206-11. Epub 2013 Dec 2.

Kyung Park, Christopher E. Barbieri, and Mark A. Rubin, Weill Medical College of Cornell University, New York, NY; James T. Dalton, Ramesh Narayanan, Michael L. Hancock, and Mitchell S. Steiner, GTx, Memphis, TN; and David G. Bostwick, Bostwick Laboratories, Glen Allen, VA.

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http://ascopubs.org/doi/10.1200/JCO.2013.49.8386
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http://dx.doi.org/10.1200/JCO.2013.49.8386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887478PMC
January 2014

Green paper on safety of young drivers has stalled.

BMJ 2014 Jan 28;348:g476. Epub 2014 Jan 28.

Public Health Wales, Cardiff CF11 9LJ , UK.

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http://dx.doi.org/10.1136/bmj.g476DOI Listing
January 2014

Estrogen regulates histone deacetylases to prevent cardiac hypertrophy.

Mol Biol Cell 2013 Dec 23;24(24):3805-18. Epub 2013 Oct 23.

Division of Endocrinology, Department of Medicine, University of California, Irvine, Irvine, CA 92717 Department of Veterans Affairs Medical Center, Long Beach, CA 90822 GTx, Inc., Memphis, TN 38163 Division of Cardiology, Department of Medicine, University of Colorado, Aurora, CO 80045.

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http://dx.doi.org/10.1091/mbc.E13-08-0444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861078PMC
December 2013

Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer.

Curr Opin Support Palliat Care 2013 Dec;7(4):345-51

All authors work for GTx, Inc., Memphis, Tennessee, USA.

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http://dx.doi.org/10.1097/SPC.0000000000000015DOI Listing
December 2013

ERβ selective agonist inhibits angiotensin-induced cardiovascular pathology in female mice.

Endocrinology 2013 Nov 22;154(11):4352-64. Epub 2013 Aug 22.

MD, Medical Service (111-I), Long Beach Veterans Affairs Medical Center, 5901 East Seventh Street, Long Beach, California 90822.

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http://dx.doi.org/10.1210/en.2013-1358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398592PMC
November 2013

Steroidogenic enzyme AKR1C3 is a novel androgen receptor-selective coactivator that promotes prostate cancer growth.

Clin Cancer Res 2013 Oct 30;19(20):5613-25. Epub 2013 Aug 30.

Authors' Affiliations: Preclinical Research and Development, GTx Inc.; and Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1151DOI Listing
October 2013

Comparison on intracochlear disturbances between drilling a manual and robotic cochleostomy.

Proc Inst Mech Eng H 2013 Sep 26;227(9):1002-8. Epub 2013 Jun 26.

Brunel Institute for Bioengineering, Brunel University, Uxbridge, UK.

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http://dx.doi.org/10.1177/0954411913488507DOI Listing
September 2013

An analysis of PLAG1 and HMGA2 rearrangements in salivary duct carcinoma and examination of the role of precursor lesions.

Histopathology 2013 Aug 6;63(2):250-62. Epub 2013 Jun 6.

Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1111/his.12152DOI Listing
August 2013

Discovery of 4-Aryl-2-benzoyl-imidazoles as tubulin polymerization inhibitor with potent antiproliferative properties.

J Med Chem 2013 Apr 9;56(8):3318-29. Epub 2013 Apr 9.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1021/jm4001117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668676PMC
April 2013

Robustness analysis of a smart surgical drill for cochleostomy.

Int J Med Robot 2013 Mar 19;9(1):119-26. Epub 2012 Oct 19.

Brunel Institute for Bioengineering, Brunel University, Uxbridge, UK.

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http://dx.doi.org/10.1002/rcs.1462DOI Listing
March 2013

Role of nuclear receptors in lipid dysfunction and obesity-related diseases.

Drug Metab Dispos 2013 Jan 4;41(1):1-11. Epub 2012 Oct 4.

Department of Molecular and Biomedical Pharmacology, MS305, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY40536, USA.

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http://dx.doi.org/10.1124/dmd.112.048694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533426PMC
January 2013

Activity of delafloxacin against methicillin-resistant Staphylococcus aureus: resistance selection and characterization.

J Antimicrob Chemother 2012 Dec 8;67(12):2814-20. Epub 2012 Aug 8.

Biology Department, Rib-X Pharmaceuticals, Inc, New Haven, CT 06511, USA.

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http://dx.doi.org/10.1093/jac/dks307DOI Listing
December 2012

Novel tubulin polymerization inhibitors overcome multidrug resistance and reduce melanoma lung metastasis.

Pharm Res 2012 Nov 13;29(11):3040-52. Epub 2012 Mar 13.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 847 Monroe Ave., Memphis, Tennessee 38163, USA.

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http://dx.doi.org/10.1007/s11095-012-0726-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659804PMC
November 2012

Orally bioavailable tubulin antagonists for paclitaxel-refractory cancer.

Pharm Res 2012 Nov 4;29(11):3053-63. Epub 2012 Jul 4.

Preclinical Research and Development, GTx Inc., Memphis, Tennessee 38163, USA.

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http://dx.doi.org/10.1007/s11095-012-0814-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646298PMC
November 2012

Discovery of novel 2-aryl-4-benzoyl-imidazole (ABI-III) analogues targeting tubulin polymerization as antiproliferative agents.

J Med Chem 2012 Aug 6;55(16):7285-9. Epub 2012 Aug 6.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.

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http://dx.doi.org/10.1021/jm300564bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426659PMC
August 2012

Pharmacokinetics, pharmacodynamics and metabolism of a novel anticancer agent for prostate cancer.

Int J Oncol 2012 Jul 20;41(1):337-44. Epub 2012 Apr 20.

Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.3892/ijo.2012.1442DOI Listing
July 2012

β-LGND2, an ERβ selective agonist, inhibits pathologic retinal neovascularization.

Invest Ophthalmol Vis Sci 2012 Jul 31;53(8):5066-75. Epub 2012 Jul 31.

Preclinical Research and Development, GTx Inc., 3 N. Dunlap Street. Memphis, TN 38163, USA.

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http://dx.doi.org/10.1167/iovs.12-9627DOI Listing
July 2012

New model of cystic fibrosis transmembrane conductance regulator proposes active channel-like conformation.

J Chem Inf Model 2012 Jul 12;52(7):1842-53. Epub 2012 Jul 12.

Computational Biochemistry and Biophysics Laboratory, Research Unit on Biomedical Informatics, IMIM Hospital del Mar and Universitat Pompeu Fabra, C/Doctor Aiguader, 88, 08003 Barcelona, Catalunya, Spain.

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http://dx.doi.org/10.1021/ci2005884DOI Listing
July 2012

Androgen receptor antagonists: a patent review (2008-2011).

Expert Opin Ther Pat 2012 May;22(5):541-65

Preclinical Research and Development, GTx, Inc., 3 North Dunlap Street, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1517/13543776.2012.682571DOI Listing
May 2012

Alanine aminotransferase regulation by androgens in non-hepatic tissues.

Pharm Res 2012 Apr 14;29(4):1046-56. Epub 2011 Dec 14.

Preclinical Research and Development, GTx, Inc., 3 North Dunlap Street, Memphis, Tennessee 38163, USA.

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http://dx.doi.org/10.1007/s11095-011-0649-5DOI Listing
April 2012

Preclinical characterization of a novel diphenyl benzamide selective ERα agonist for hormone therapy in prostate cancer.

Endocrinology 2012 Mar 31;153(3):1070-81. Epub 2012 Jan 31.

Preclinical Research and Development, GTx, Inc., 3 North Dunlap Street, Memphis, Tennessee 38163, USA.

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http://dx.doi.org/10.1210/en.2011-1608DOI Listing
March 2012

A subset of cutaneous and soft tissue mixed tumors are genetically linked to their salivary gland counterpart.

Genes Chromosomes Cancer 2012 Feb 28;51(2):140-8. Epub 2011 Oct 28.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1002/gcc.20938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233652PMC
February 2012

Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization.

Bioorg Med Chem 2011 Aug 1;19(16):4782-95. Epub 2011 Jul 1.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1016/j.bmc.2011.06.084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152597PMC
August 2011