James D Clark

James D Clark

UNVERIFIED PROFILE

Are you James D Clark?   Register this Author

Register author
James D Clark

James D Clark

Publications by authors named "James D Clark"

Are you James D Clark?   Register this Author

33Publications

952Reads

6Profile Views

Network pharmacology of JAK inhibitors.

Proc Natl Acad Sci U S A 2016 08 11;113(35):9852-7. Epub 2016 Aug 11.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1610253113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024632PMC
August 2016

Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases.

J Med Chem 2014 Jun 23;57(12):5023-38. Epub 2014 Jan 23.

Pfizer Immunosciences , 200 CambridgePark, Cambridge, Massachusetts 02140, United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/jm401490p
Publisher Site
http://dx.doi.org/10.1021/jm401490pDOI Listing
June 2014

Effect of perzinfotel and a proprietary phospholipase A(2) inhibitor on kinetic gait and subjective lameness scores in dogs with sodium urate-induced synovitis.

Am J Vet Res 2011 Jun;72(6):757-63

Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2460/ajvr.72.6.757DOI Listing
June 2011

A human CXCL13-induced actin polymerization assay measured by fluorescence plate reader.

Assay Drug Dev Technol 2010 Feb;8(1):73-84

Pfizer Inflammation and Immunology, Cambridge, Massachusetts 02140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/adt.2008.0187DOI Listing
February 2010

Benzhydrylquinazolinediones: novel cytosolic phospholipase A2alpha inhibitors with improved physicochemical properties.

Bioorg Med Chem 2009 Jul 18;17(13):4383-405. Epub 2009 May 18.

Chemical and Screening Sciences, Wyeth Research, MA 02140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2009.05.027DOI Listing
July 2009

Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors.

J Med Chem 2009 Feb;52(4):1156-71

Department of Chemical and Screening Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm8009876DOI Listing
February 2009

Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors.

Anal Biochem 2008 Dec 30;383(2):217-25. Epub 2008 Aug 30.

Department of Inflammation, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S000326970800579
Publisher Site
http://dx.doi.org/10.1016/j.ab.2008.08.025DOI Listing
December 2008

Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.

J Med Chem 2007 Mar 17;50(6):1380-400. Epub 2007 Feb 17.

Department of Chemical and Screening Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm061131zDOI Listing
March 2007

1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2alpha inhibitors.

Bioorg Med Chem Lett 2006 Jun 20;16(11):2978-81. Epub 2006 Mar 20.

Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2006.02.067DOI Listing
June 2006

Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization.

J Med Chem 2006 Jan;49(1):135-58

Department of Chemical and Screening Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm0507882DOI Listing
January 2006

A fluorescence-based assay for fatty acid amide hydrolase compatible with high-throughput screening.

Anal Biochem 2005 Aug;343(1):143-51

Inflammation Department, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2005.04.032DOI Listing
August 2005

Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics.

Bioorg Med Chem Lett 2003 Dec;13(24):4501-4

Departments of Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2003.08.070DOI Listing
December 2003

Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis.

J Exp Med 2003 May 12;197(10):1297-302. Epub 2003 May 12.

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20030016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193788PMC
May 2003