James Connor

James Connor

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James Connor

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Oroxylum indicum (L.) extract protects human neuroblastoma SH‑SY5Y cells against β‑amyloid‑induced cell injury.

Mol Med Rep 2019 Aug 21;20(2):1933-1942. Epub 2019 Jun 21.

George M. Leader Laboratory, Department of Neurosurgery, Pennsylvania State University, Hershey Medical Center, Hershey, PA 17033, USA.

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http://dx.doi.org/10.3892/mmr.2019.10411DOI Listing
August 2019

Transferrin and H-ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype.

J Neurochem 2019 Jul 24. Epub 2019 Jul 24.

Department of Neurosurgery, Penn State College of Medicine, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1111/jnc.14834DOI Listing
July 2019

Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology.

Trends Neurosci 2019 Jun 29;42(6):384-401. Epub 2019 Apr 29.

Department of Radiology, C.J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.tins.2019.03.009DOI Listing
June 2019

Iron uptake at the blood-brain barrier is influenced by sex and genotype.

Adv Pharmacol 2019 22;84:123-145. Epub 2019 Mar 22.

Department of Neurosurgery, Penn State College of Medicine, Hershey, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.apha.2019.02.005DOI Listing
March 2019

Semaphorin4A causes loss of mature oligodendrocytes and demyelination in vivo.

J Neuroinflammation 2019 Feb 8;16(1):28. Epub 2019 Feb 8.

Department of Neurosurgery, Penn State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.

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http://dx.doi.org/10.1186/s12974-019-1420-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368782PMC
February 2019

Pharmaceutical iron formulations do not cross a model of the human blood-brain barrier.

PLoS One 2018 11;13(6):e0198775. Epub 2018 Jun 11.

Department of Neurosurgery, Penn State Hershey Medical Center, Hershey, PA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198775PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995392PMC
January 2019

Exosomes and their implications in central nervous system tumor biology.

Prog Neurobiol 2019 01 9;172:71-83. Epub 2018 Jul 9.

Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pneurobio.2018.06.006DOI Listing
January 2019

Emerging and Dynamic Biomedical Uses of Ferritin.

Pharmaceuticals (Basel) 2018 Nov 13;11(4). Epub 2018 Nov 13.

Department of Neurosurgery, Penn State College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.3390/ph11040124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316788PMC
November 2018

Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes.

Mov Disord 2018 09 14;33(9):1432-1439. Epub 2018 May 14.

Departments of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.

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http://doi.wiley.com/10.1002/mds.27381
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http://dx.doi.org/10.1002/mds.27381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185787PMC
September 2018

Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients.

Mov Disord 2018 09 14;33(9):1423-1431. Epub 2018 May 14.

Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.

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http://dx.doi.org/10.1002/mds.27318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185755PMC
September 2018

Semaphorin4A and H-ferritin utilize Tim-1 on human oligodendrocytes: A novel neuro-immune axis.

Glia 2018 07 19;66(7):1317-1330. Epub 2018 Feb 19.

Department of Neurosurgery, Penn State University College of Medicine, Hershey, Pennsylvania.

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http://dx.doi.org/10.1002/glia.23313DOI Listing
July 2018

Endothelial cells are critical regulators of iron transport in a model of the human blood-brain barrier.

J Cereb Blood Flow Metab 2018 06 18:271678X18783372. Epub 2018 Jun 18.

1 Department of Neurosurgery, Penn State College of Medicine, Hershey, PA, USA.

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http://dx.doi.org/10.1177/0271678X18783372DOI Listing
June 2018

CSF ferritin predicts CSF Aβ decline in biomarker-determined Alzheimer's disease.

Authors:
James R Connor

J Neurol Neurosurg Psychiatry 2018 05 8;89(5):445. Epub 2017 Dec 8.

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http://dx.doi.org/10.1136/jnnp-2017-317050DOI Listing
May 2018

HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity.

J Neurochem 2018 05 1;145(4):299-311. Epub 2018 Apr 1.

Department of Neurosurgery, M.S. Hershey Penn State University College of Medicine, M.S. Hershey Medical Center, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1111/jnc.14299DOI Listing
May 2018

Involvement of the central somatosensory system in restless legs syndrome: A neuroimaging study.

Neurology 2018 05 25;90(21):e1834-e1841. Epub 2018 Apr 25.

From the Department of Radiology (B.-Y.L.), University of Minnesota, Minneapolis; Biomedical Engineering (J.K.), Duke University, Durham, NC; Departments of Neurosurgery (J.R.C.), Neurology (G.D.P.), and Radiology, Neurosurgery, and Bioengineering (Q.X.Y.), Pennsylvania State Hershey Medical Center; and Department of Radiological Science (Y.R.), Gachon University, South Korea.

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http://dx.doi.org/10.1212/WNL.0000000000005562DOI Listing
May 2018

Dietary lipophilic iron accelerates regional brain iron-load in C57BL6 mice.

Brain Struct Funct 2018 Apr 22;223(3):1519-1536. Epub 2017 Nov 22.

Department of Neurosurgery, The Pennsylvania State University - College of Medicine, Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, 17033, USA.

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http://dx.doi.org/10.1007/s00429-017-1565-1DOI Listing
April 2018

A role for sex and a common HFE gene variant in brain iron uptake.

J Cereb Blood Flow Metab 2018 03 28;38(3):540-548. Epub 2017 Mar 28.

1 Department of Neurosurgery, Penn State Hershey Medical Center, Hershey, PA, USA.

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http://dx.doi.org/10.1177/0271678X17701949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851144PMC
March 2018

Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice.

Metallomics 2018 03 9;10(3):426-443. Epub 2018 Feb 9.

Department of Neurosurgery, The Pennsylvania State University - College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA and Department of Radiology (Center for NMR Research), The Pennsylvania State University - College of Medicine, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1039/c8mt00004bDOI Listing
March 2018

The role of HFE genotype in macrophage phenotype.

J Neuroinflammation 2018 Feb 1;15(1):30. Epub 2018 Feb 1.

Department of Neurosurgery, The Pennsylvania State University College of Medicine, M.S. Hershey Medical Center, Hershey, PA, 17033, USA.

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http://dx.doi.org/10.1186/s12974-018-1057-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796391PMC
February 2018

A Possible Role for Platelet-Activating Factor Receptor in Amyotrophic Lateral Sclerosis Treatment.

Front Neurol 2018 6;9:39. Epub 2018 Feb 6.

Department of Biochemistry, Penn State College of Medicine, Institute for Personalized Medicine, Hershey, PA, United States.

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http://dx.doi.org/10.3389/fneur.2018.00039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810282PMC
February 2018

Reduced Cerebral White Matter Integrity Assessed by DTI in Cognitively Normal H63D-HFE Polymorphism Carriers.

J Neuroimaging 2018 01 3;28(1):126-133. Epub 2017 Aug 3.

Department of Neurosurgery, The Pennsylvania State University - College of Medicine, Milton S. Hershey Medical Center, Hershey, PA.

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http://dx.doi.org/10.1111/jon.12461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760459PMC
January 2018

Regulatory mechanisms for iron transport across the blood-brain barrier.

Biochem Biophys Res Commun 2017 12 17;494(1-2):70-75. Epub 2017 Oct 17.

Department of Neurosurgery, Penn State Hershey Medical Center, Hershey, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.10.083DOI Listing
December 2017

Analysis of single nucleotide variants of HFE gene and association to survival in The Cancer Genome Atlas GBM data.

PLoS One 2017 30;12(3):e0174778. Epub 2017 Mar 30.

Department of Neurosurgery, The Pennsylvania State University College of Medicine, Penn State Hershey Medical Center, Hershey, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174778PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373638PMC
August 2017

HFE genotype affects exosome phenotype in cancer.

Biochim Biophys Acta Gen Subj 2017 Aug 17;1861(8):1921-1928. Epub 2017 May 17.

Department of Neurosurgery, Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2017.05.014DOI Listing
August 2017

Interleukin-13 conjugated quantum dots for identification of glioma initiating cells and their extracellular vesicles.

Acta Biomater 2017 08 3;58:205-213. Epub 2017 Jun 3.

Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, United States.

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http://dx.doi.org/10.1016/j.actbio.2017.06.002DOI Listing
August 2017

Association of Iron Deficiency Anemia With Hearing Loss in US Adults.

JAMA Otolaryngol Head Neck Surg 2017 04;143(4):350-354

Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey.

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http://dx.doi.org/10.1001/jamaoto.2016.3631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787694PMC
April 2017

Iron and restless legs syndrome: treatment, genetics and pathophysiology.

Sleep Med 2017 03 10;31:61-70. Epub 2016 Nov 10.

The Johns Hopkins University, Dep of neuroloy, Baltimore, MD USA.

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http://dx.doi.org/10.1016/j.sleep.2016.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334282PMC
March 2017

Reduced white matter MRI transverse relaxation rate in cognitively normal H63D-HFE human carriers and H67D-HFE mice.

Brain Imaging Behav 2016 12;10(4):1231-1242

Department of Neurosurgery, The Pennsylvania State University - College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, USA.

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http://dx.doi.org/10.1007/s11682-015-9494-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903093PMC
December 2016

Statins accelerate disease progression and shorten survival in SOD1(G93A) mice.

Muscle Nerve 2016 08 19;54(2):284-91. Epub 2016 May 19.

Department of Neurosurgery, Penn State College of Medicine, Mailcode H110, 500 University Drive, Hershey, Pennsylvania, 17033, USA.

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http://dx.doi.org/10.1002/mus.25048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848093PMC
August 2016

Iron uptake and transport across physiological barriers.

Biometals 2016 08 25;29(4):573-91. Epub 2016 Jul 25.

Department of Neurosurgery, The Pennsylvania State University College of Medicine, Hershey, PA, USA.

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http://dx.doi.org/10.1007/s10534-016-9952-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972853PMC
August 2016

The Deterioration Seen in Myelin Related Morphophysiology in Vanadium Exposed Rats is Partially Protected by Concurrent Iron Deficiency.

Niger J Physiol Sci 2016 Aug 30;31(1):11-22. Epub 2016 Aug 30.

1Department of Veterinary Anatomy, University of Ibadan and Department of Veterinary Anatomy, University of Abuja.

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August 2016

MRI contrast agent for targeting glioma: interleukin-13 labeled liposome encapsulating gadolinium-DTPA.

Neuro Oncol 2016 05 31;18(5):691-9. Epub 2015 Oct 31.

Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania (X.L., A.B.M., K.A.D., E.R., B.S.-W., J.M.S., J.R.C., Q.X.Y.); Department of Radiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania (X.L., P.A.M., Q.X.Y.); Department of Microbiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania (S.H.).

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http://dx.doi.org/10.1093/neuonc/nov263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827043PMC
May 2016

Increased R2* in the Caudate Nucleus of Asymptomatic Welders.

Toxicol Sci 2016 Apr 14;150(2):369-77. Epub 2016 Jan 14.

*Department of Neurology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina; Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; Department of Radiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; and Department of Kinesiology, Pennsylvania State University, University Park, Pennsylvania

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http://dx.doi.org/10.1093/toxsci/kfw003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857156PMC
April 2016

Quantitative susceptibility mapping of the midbrain in Parkinson's disease.

Mov Disord 2016 Mar 12;31(3):317-24. Epub 2015 Sep 12.

Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.

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http://dx.doi.org/10.1002/mds.26417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315570PMC
March 2016

Semaphorin4A Is Cytotoxic to Oligodendrocytes and Is Elevated in Microglia and Multiple Sclerosis.

ASN Neuro 2015 May-Jun;7(3). Epub 2015 May 29.

Department of Neurosurgery, Penn State University College of Medicine, Hershey, PA, USA

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http://dx.doi.org/10.1177/1759091415587502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449839PMC
February 2016

Characterization of a novel anti-cancer compound for astrocytomas.

PLoS One 2014 25;9(9):e108166. Epub 2014 Sep 25.

Department of Neurosurgery, Pennsylvania State University College of Medicine, Penn State M.S. Hershey Medical Center, Hershey, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108166PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177861PMC
December 2015

Cytoprotective effects of ferritin on doxorubicin-induced breast cancer cell death.

Oncol Rep 2015 Nov 8;34(5):2790-6. Epub 2015 Sep 8.

Department of Neurosurgery, The Pennsylvania State University Hershey Medical Center, Hershey, PA 17033, USA.

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http://dx.doi.org/10.3892/or.2015.4250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583531PMC
November 2015

The HFE genotype and a formulated diet controlling for iron status attenuate experimental cerebral malaria in mice.

Int J Parasitol 2015 Oct 19;45(12):797-808. Epub 2015 Aug 19.

Dept of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpara.2015.07.003DOI Listing
October 2015

The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin.

Neurobiol Dis 2015 Sep 22;81:49-65. Epub 2015 Aug 22.

Department of Neurosurgery, The Pennsylvania State University, College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, USA; Department of Radiology, The Center for NMR Research, The Pennsylvania State University, College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672943PMC
September 2015

From adaption to death: endoplasmic reticulum stress as a novel target of selective neurodegeneration?

Neural Regen Res 2015 Sep;10(9):1397-8

Department of Neurosurgery, Pennsylvania State University, M.S. Hershey Medical Center, 500 University Drive, Hershey, PA, USA.

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http://dx.doi.org/10.4103/1673-5374.165227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625498PMC
September 2015

Cortical iron regulation and inflammatory response in Alzheimer's disease and APPSWE/PS1ΔE9 mice: a histological perspective.

Front Neurosci 2015 23;9:255. Epub 2015 Jul 23.

Department of Neurosurgery, Milton S. Hershey Medical Center, The Pennsylvania State University - College of Medicine Hershey, PA, USA ; Department of Radiology (The Center for NMR Research), Milton S. Hershey Medical Center, The Pennsylvania State University - College of Medicine Hershey, PA, USA.

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http://dx.doi.org/10.3389/fnins.2015.00255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511841PMC
August 2015

Adaptive endoplasmic reticulum stress alters cellular responses to the extracellular milieu.

J Neurosci Res 2015 May 12;93(5):766-76. Epub 2015 Jan 12.

Department of Neurosurgery, Pennsylvania State University, M.S. Hershey Medical Center, Hershey, Pennsylvania.

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http://dx.doi.org/10.1002/jnr.23541DOI Listing
May 2015

Histological-MRI correlation in the primary motor cortex of patients with amyotrophic lateral sclerosis.

J Magn Reson Imaging 2015 Mar 26;41(3):665-75. Epub 2014 Feb 26.

Department of Neurosurgery, The Pennsylvania State University - College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA; Department of Radiology (Center for NMR Research), The Pennsylvania State University - College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1002/jmri.24582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145061PMC
March 2015

HFE polymorphisms affect survival of brain tumor patients.

J Neurooncol 2015 Mar 10;122(1):97-104. Epub 2014 Dec 10.

Department of Neurosurgery, H110, The Pennsylvania State University College of Medicine, Penn State Hershey Medical Center, Penn State Hershey Cancer Institute, 500 University Drive (H110), Hershey, PA, 17033-0850, USA,

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http://dx.doi.org/10.1007/s11060-014-1681-1DOI Listing
March 2015

Serum ferritin is elevated in amyotrophic lateral sclerosis patients.

Amyotroph Lateral Scler Frontotemporal Degener 2015 Mar 18;16(1-2):102-7. Epub 2014 Dec 18.

Department of Neurosurgery, Penn State College of Medicine , Hershey, Pennsylvania , USA.

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http://dx.doi.org/10.3109/21678421.2014.984723DOI Listing
March 2015

The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's disease.

NMR Biomed 2015 Mar 22;28(3):297-305. Epub 2014 Dec 22.

Department of Neurosurgery, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, USA; Department of Radiology (Center for NMR Research), Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, USA.

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http://dx.doi.org/10.1002/nbm.3247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526111PMC
March 2015

C282Y-HFE gene variant affects cholesterol metabolism in human neuroblastoma cells.

PLoS One 2014 12;9(2):e88724. Epub 2014 Feb 12.

Department of Neurosurgery, The Pennsylvania State University College of Medicine, Penn State Hershey Cancer Institute, Penn State M.S. Hershey Medical Center, Hershey, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088724PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922969PMC
January 2015

A novel model for brain iron uptake: introducing the concept of regulation.

J Cereb Blood Flow Metab 2015 Jan 15;35(1):48-57. Epub 2014 Oct 15.

1] Department of Neural and Behavioral Sciences, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA [2] Department of Neurosurgery, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1038/jcbfm.2014.168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294394PMC
January 2015

H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis.

Biochim Biophys Acta 2014 Dec 5;1842(12 Pt A):2413-26. Epub 2014 Oct 5.

Department of Neurosurgery, The Pennsylvania State University, M. S. Hershey Medical Center, Hershey, PA 17033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.09.016DOI Listing
December 2014

Evidence for the Influence of the Iron Regulatory MHC Class I Molecule HFE on Tumor Progression in Experimental Models and Clinical Populations.

Transl Oncogenomics 2014 4;6:1-12. Epub 2014 Dec 4.

Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA, USA.

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http://dx.doi.org/10.4137/TOG.S19064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259395PMC
December 2014

Altered brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease).

Sleep Med 2014 Nov 16;15(11):1288-301. Epub 2014 Jun 16.

Department of Neurology, The Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.sleep.2014.05.009DOI Listing
November 2014

HFE gene variants, iron, and lipids: a novel connection in Alzheimer's disease.

Front Pharmacol 2014 8;5:165. Epub 2014 Jul 8.

Departments of Neurosurgery, Neural and Behavioral Sciences and Pediatrics, Center for Aging and Neurodegenerative Diseases, Penn State Hershey Medical Center Hershey, PA, USA.

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http://dx.doi.org/10.3389/fphar.2014.00165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086322PMC
July 2014

H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.

Neurobiol Aging 2014 Jun 25;35(6):1511.e1-12. Epub 2013 Dec 25.

Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.12.014DOI Listing
June 2014

Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research.

Muscle Nerve 2014 Jun 8;49(6):786-803. Epub 2014 Apr 8.

Department of Neurosurgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1002/mus.24198DOI Listing
June 2014

The NFκB inhibitor, SN50, induces differentiation of glioma stem cells and suppresses their oncogenic phenotype.

Cancer Biol Ther 2014 May 20;15(5):602-11. Epub 2014 Feb 20.

Department of Pharmacology; College of Pharmaceutical Sciences; Soochow University; Suzhou, PR China; Department of Pharmacology; The Penn State Hershey Cancer Institute; The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center; Hershey, PA USA.

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http://www.tandfonline.com/doi/abs/10.4161/cbt.28158
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http://dx.doi.org/10.4161/cbt.28158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026083PMC
May 2014

Mechanism of metabolic stroke and spontaneous cerebral hemorrhage in glutaric aciduria type I.

Acta Neuropathol Commun 2014 Jan 27;2:13. Epub 2014 Jan 27.

Department of Neurology and Neurological Science, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1186/2051-5960-2-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940023PMC
January 2014

Introduction to cells comprising the nervous system.

Adv Neurobiol 2014;9:33-45

Department of Neurosurgery, Penn State Milton S. Hershey Medical Center, 500 University Drive, 850, Hershey, PA, 17033, USA.

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http://dx.doi.org/10.1007/978-1-4939-1154-7_2DOI Listing
January 2014

The significance of ferritin in cancer: anti-oxidation, inflammation and tumorigenesis.

Biochim Biophys Acta 2013 Dec 25;1836(2):245-54. Epub 2013 Jul 25.

Department of Neurosurgery, The Pennsylvania State University Hershey Medical Center, Hershey, PA, USA.

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http://dx.doi.org/10.1016/j.bbcan.2013.07.002DOI Listing
December 2013

Biomarker-based predictive models for prognosis in amyotrophic lateral sclerosis.

JAMA Neurol 2013 Dec;70(12):1505-11

George M. Leader Family Laboratory, Department of Neurosurgery, The Pennsylvania State University College of Medicine, Hershey.

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http://dx.doi.org/10.1001/jamaneurol.2013.4646DOI Listing
December 2013

H63D HFE polymorphisms are associated with increased disease duration and decreased muscle superoxide dismutase-1 expression in amyotrophic lateral sclerosis patients.

Muscle Nerve 2013 Aug 29;48(2):242-6. Epub 2013 Jun 29.

George M. Leader Family Laboratory, Department of Neurosurgery, The Pennsylvania State University College of Medicine, 500 University Drive-H110, Hershey, Pennsylvania 17033-0850, USA.

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http://dx.doi.org/10.1002/mus.23740DOI Listing
August 2013

Would they dope? Revisiting the Goldman dilemma.

Br J Sports Med 2013 Jul 23;47(11):697-700. Epub 2013 Jan 23.

School of Business, University of New South Wales, Canberra, Australian Capital Territory, Australia.

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http://www.oliverfinlay.com/assets/pdf/connor%20(2013)%20wou
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http://bjsm.bmj.com/cgi/doi/10.1136/bjsports-2012-091826
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http://dx.doi.org/10.1136/bjsports-2012-091826DOI Listing
July 2013

Application of fullerenes in nanomedicine: an update.

Nanomedicine (Lond) 2013 Jul;8(7):1191-208

Joint School of Nanoscience & Nanoengineering, 2907 East Lee Street, Greensboro, NC 27401, USA.

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http://dx.doi.org/10.2217/nnm.13.99DOI Listing
July 2013

A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice.

Biochim Biophys Acta 2013 Jun 18;1832(6):729-41. Epub 2013 Feb 18.

Department of Neurosurgery, The Pennsylvania State University, M. S. Hershey Medical Center, PA 17033, USA.

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http://dx.doi.org/10.1016/j.bbadis.2013.02.009DOI Listing
June 2013

Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/Willis-Ekbom disease.

Fluids Barriers CNS 2013 Jun 7;10(1):20. Epub 2013 Jun 7.

Department of Neurosurgery, Penn State University, Milton S, Hershey Medical Center, 500 University Drive, Hershey, Pennsylvania PA 17033, USA.

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http://dx.doi.org/10.1186/2045-8118-10-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680184PMC
June 2013

Quantitative proteomic analyses of cerebrospinal fluid using iTRAQ in a primate model of iron deficiency anemia.

Dev Neurosci 2012 26;34(4):354-65. Epub 2012 Sep 26.

Penn State University College of Medicine, Hershey, PA, USA.

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http://dx.doi.org/10.1159/000341919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373703PMC
April 2013

Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages.

Breast Cancer Res Treat 2013 Feb 11;137(3):733-44. Epub 2013 Jan 11.

Department of Neurosurgery, The Pennsylvania State University Hershey Medical Center, Hershey, PA, USA.

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http://dx.doi.org/10.1007/s10549-012-2405-xDOI Listing
February 2013

Prioritising health in anti-doping: what Australians think.

J Sci Med Sport 2012 Sep 20;15(5):381-5. Epub 2012 May 20.

School of Business, University of New South Wales, Canberra, Australia.

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http://dx.doi.org/10.1016/j.jsams.2012.02.007DOI Listing
September 2012

Iron and ER stress in neurodegenerative disease.

Biometals 2012 Aug 12;25(4):837-45. Epub 2012 Apr 12.

Department of Neurosurgery, M.S. Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1007/s10534-012-9544-8DOI Listing
August 2012

Maturational and aging effects on human brain apparent transverse relaxation.

PLoS One 2012 21;7(2):e31907. Epub 2012 Feb 21.

Department of Radiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031907PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283700PMC
June 2012

Functional roles of transferrin in the brain.

Biochim Biophys Acta 2012 Mar 21;1820(3):393-402. Epub 2011 Nov 21.

Department of Neurosurgery, Penn State University, M.S. Hershey Medical Center, 500 University Dr., Hershey, PA 17033-0850, USA.

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http://dx.doi.org/10.1016/j.bbagen.2011.10.016DOI Listing
March 2012

Increased cellular iron levels affect matrix metalloproteinase expression and phagocytosis in activated microglia.

Neurosci Lett 2011 Aug 12;500(1):36-40. Epub 2011 Jun 12.

Department of Pre-clinic, Faculty of Medicine, Mahasarakham University, Nakhon Sawan Road, Mahasarakham 44000, Thailand.

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http://dx.doi.org/10.1016/j.neulet.2011.06.001DOI Listing
August 2011

Gender and iron genes may modify associations between brain iron and memory in healthy aging.

Neuropsychopharmacology 2011 Jun 9;36(7):1375-84. Epub 2011 Mar 9.

Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-6968, USA.

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http://dx.doi.org/10.1038/npp.2011.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096807PMC
June 2011

H-ferritin is the major source of iron for oligodendrocytes.

Glia 2011 Jun 28;59(6):927-35. Epub 2011 Mar 28.

Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1002/glia.21164DOI Listing
June 2011

Postmortem and imaging based analyses reveal CNS decreased myelination in restless legs syndrome.

Sleep Med 2011 Jun 12;12(6):614-9. Epub 2011 May 12.

Department of Neurosurgery, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA 17033-0850, USA.

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http://dx.doi.org/10.1016/j.sleep.2010.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110510PMC
June 2011

Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability.

J Biol Chem 2011 Apr 24;286(15):13161-70. Epub 2011 Feb 24.

Department of Neurosurgery, Pennsylvania State University, Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1074/jbc.M110.170944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075663PMC
April 2011

Profile of altered brain iron acquisition in restless legs syndrome.

Brain 2011 Apr 11;134(Pt 4):959-68. Epub 2011 Mar 11.

Department of Neurosurgery (H110), G.M. Leader Family Laboratory for Alzheimer's Disease Research, Penn State College of Medicine, 500 University Dr., Hershey, PA 17033, USA.

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http://dx.doi.org/10.1093/brain/awr012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069701PMC
April 2011

Detection of cancer cells in the cerebrospinal fluid: current methods and future directions.

Fluids Barriers CNS 2011 Mar 3;8(1):14. Epub 2011 Mar 3.

Department of Neurosurgery (H110), Penn State University M,S, Hershey Medical Center, 500 University Dr,, Hershey, PA, 17033-0850, USA.

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http://dx.doi.org/10.1186/2045-8118-8-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059292PMC
March 2011

Heavy chain ferritin siRNA delivered by cationic liposomes increases sensitivity of cancer cells to chemotherapeutic agents.

Cancer Res 2011 Mar 8;71(6):2240-9. Epub 2011 Mar 8.

Department of Neurosurgery, Penn State Cancer Institute, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1375DOI Listing
March 2011