James Cantley

James Cantley

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James Cantley

James Cantley

Publications by authors named "James Cantley"

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Correction to: Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

BMC Biol 2019 04 9;17(1):32. Epub 2019 Apr 9.

Department of Physiology, Anatomy & Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1186/s12915-019-0650-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456947PMC
April 2019

Pancreatic PYY Is Critical in the Control of Insulin Secretion and Glucose Homeostasis in Female Mice.

Endocrinology 2015 Sep 30;156(9):3122-36. Epub 2015 Jun 30.

Neuroscience (Y.-C.S., K.Lo., K.Le., L.Z., J.La., H.H.) and Diabetes and Metabolism (M.B., J.C., J.Lu., D.R.L.) Divisions, Garvan Institute of Medical Research, St Vincent's Hospital, Darlinghurst NSW 2010, Sydney, Australia; Faculty of Medicine (Y.-C.S., K.Lo., J.C., D.R.L., H.H.), UNSW Australia, Sydney, NSW, 2052 Australia; and Department of Physiology, Anatomy and Genetics (J.C.), University of Oxford, Oxford, OX1 3QX United Kingdom.

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http://dx.doi.org/10.1210/en.2015-1168DOI Listing
September 2015

Circulating AFABP promotes insulin secretion.

Obesity (Silver Spring) 2015 Aug 6;23(8):1525. Epub 2015 Jul 6.

Department of Physiology, Anatomy and Genetics, University of Oxford, UK.

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http://dx.doi.org/10.1002/oby.21175DOI Listing
August 2015

Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity.

J Exp Med 2015 Jul 29;212(8):1239-54. Epub 2015 Jun 29.

Transplantation Immunology Group, Immunology Division, Cancer Bioinformatics, Cancer Division, B Cell Biology, Immunology Division, and Beta Cell Regeneration, Diabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia

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http://dx.doi.org/10.1084/jem.20150218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516791PMC
July 2015

Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

BMC Biol 2015 May 16;13:33. Epub 2015 May 16.

Department of Physiology, Anatomy & Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1186/s12915-015-0140-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435650PMC
May 2015

DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake.

Diabetologia 2014 Oct 9;57(10):2173-82. Epub 2014 Jul 9.

Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

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http://dx.doi.org/10.1007/s00125-014-3312-yDOI Listing
October 2014

The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis.

Authors:
James Cantley

Mamm Genome 2014 Oct 22;25(9-10):442-54. Epub 2014 Aug 22.

Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK,

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http://dx.doi.org/10.1007/s00335-014-9538-7DOI Listing
October 2014

Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity.

Mol Metab 2014 Jul 14;3(4):465-73. Epub 2014 Mar 14.

Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia ; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales 2010, Australia ; Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S22128778140005
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http://dx.doi.org/10.1016/j.molmet.2014.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060222PMC
July 2014

A preexistent hypoxic gene signature predicts impaired islet graft function and glucose homeostasis.

Cell Transplant 2013 31;22(11):2147-59. Epub 2012 Oct 31.

Diabetes and Obesity Research Program, Garvan Institute, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.3727/096368912X658728DOI Listing
May 2014

Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells.

Diabetologia 2014 Jan 23;57(1):129-39. Epub 2013 Oct 23.

Diabetes and Obesity Department, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia.

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http://dx.doi.org/10.1007/s00125-013-3083-xDOI Listing
January 2014

Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells.

J Biol Chem 2013 Sep 29;288(37):26569-82. Epub 2013 Jul 29.

From the Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria St., Darlinghurst, New South Wales 2010, Australia and.

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http://dx.doi.org/10.1074/jbc.M113.489310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772204PMC
September 2013

Sweet and sour β-cells: ROS and Hif1α induce Warburg-like lactate production during type 2 diabetes.

Diabetes 2013 Jun;62(6):1823-5

Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.2337/db13-0272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661644PMC
June 2013

Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice.

PLoS One 2012 30;7(7):e42115. Epub 2012 Jul 30.

Molecular Pharmacology for Diabetes, Health Innovations Research Institute and School of Health Sciences, RMIT University, Melbourne, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042115PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408432PMC
January 2013

Targeting triglyceride/fatty acid cycling in β-cells as a therapy for augmenting glucose-stimulated insulin secretion.

Islets 2010 Mar-Apr;2(2):127-9

Garvan Institute of Medical Research, Sydney, Australia.

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http://dx.doi.org/10.4161/isl.2.2.11240DOI Listing
March 2011

Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells.

Diabetes 2009 Aug 28;58(8):1826-34. Epub 2009 Apr 28.

Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.2337/db09-0132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712791PMC
August 2009

The diverse roles of protein kinase C in pancreatic beta-cell function.

Biochem Soc Trans 2008 Oct;36(Pt 5):916-9

Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia.

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http://biochemsoctrans.org/lookup/doi/10.1042/BST0360916
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http://dx.doi.org/10.1042/BST0360916DOI Listing
October 2008