Publications by authors named "James C Sacchettini"

188Publications

Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis.

Authors:
Jared S Mackenzie Dirk A Lamprecht Rukaya Asmal John H Adamson Khushboo Borah Dany J V Beste Bei Shi Lee Kevin Pethe Simon Rousseau Inna Krieger James C Sacchettini Joel N Glasgow Adrie J C Steyn

Nat Commun 2020 11 30;11(1):6092. Epub 2020 Nov 30.

Africa Health Research Institute, Durban, 4001, South Africa.

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November 2020

A low-cost, novel endoscopic repeated-access port for small animal research.

Authors:
Shannon N Ingram Andrew B Robbins Stacy J Gillenwater Vince Gresham James C Sacchettini Michael R Moreno

MethodsX 2020 29;7:101049. Epub 2020 Aug 29.

Department of Biomedical Engineering, at Texas A&M University, United States.

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August 2020

Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases.

Authors:
Landys Lopez Quezada Robert Smith Tania J Lupoli Zainab Edoo Xiaojun Li Ben Gold Julia Roberts Yan Ling Sae Woong Park Quyen Nguyen Frank J Schoenen Kelin Li Jean-Emmanuel Hugonnet Michel Arthur James C Sacchettini Carl Nathan Jeffrey Aubé

Front Microbiol 2020 23;11:1248. Epub 2020 Jun 23.

Chemical Methodologies & Library Development Center, The University of Kansas, Lawrence, KS, United States.

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June 2020

The Structural Basis of T4 Phage Lysis Control: DNA as the Signal for Lysis Inhibition.

Authors:
Inna V Krieger Vladimir Kuznetsov Jeng-Yih Chang Junjie Zhang Samir H Moussa Ryland F Young James C Sacchettini

J Mol Biol 2020 07 17;432(16):4623-4636. Epub 2020 Jun 17.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA. Electronic address:

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July 2020

Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice.

Authors:
Liam M Guthrie Shivatheja Soma Sai Yuan Andres Silva Mohammad Zulkifli Thomas C Snavely Hannah Faith Greene Elyssa Nunez Brogan Lynch Courtney De Ville Vinit Shanbhag Franklin R Lopez Arjun Acharya Michael J Petris Byung-Eun Kim Vishal M Gohil James C Sacchettini

Science 2020 05;368(6491):620-625

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.

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May 2020

Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis.

Authors:
Robert S Jansen Lungelo Mandyoli Ryan Hughes Shoko Wakabayashi Jessica T Pinkham Bruna Selbach Kristine M Guinn Eric J Rubin James C Sacchettini Kyu Y Rhee

Nat Commun 2020 04 23;11(1):1960. Epub 2020 Apr 23.

Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, NY, 10065, USA.

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April 2020

Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): a structure-activity relationship study of KES4 assisted by in silico structure-based drug screening.

Authors:
Junichi Taira Tomohiro Umei Keitaro Inoue Mitsuru Kitamura Francois Berenger James C Sacchettini Hiroshi Sakamoto Shunsuke Aoki

J Antibiot (Tokyo) 2020 06 9;73(6):372-381. Epub 2020 Mar 9.

Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka, 820-8502, Japan.

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June 2020

The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD.

Authors:
Qingan Sun Xiaojun Li Lisa M Perez Wanliang Shi Ying Zhang James C Sacchettini

Nat Commun 2020 01 17;11(1):339. Epub 2020 Jan 17.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.

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January 2020

Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor.

Authors:
Su Tang Nathan D Hicks Yu-Shan Cheng Andres Silva Sarah M Fortune James C Sacchettini

Nucleic Acids Res 2019 10;47(18):9934-9949

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77840, USA.

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October 2019

Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness.

Authors:
Marte S Dragset Thomas R Ioerger Yanjia J Zhang Mali Mærk Zekarias Ginbot James C Sacchettini Trude H Flo Eric J Rubin Magnus Steigedal

Sci Rep 2019 08 6;9(1):11394. Epub 2019 Aug 6.

NTNU Norwegian University of Science and Technology, Centre of Molecular Inflammation Research and Department of Clinical and Molecular Medicine, Trondheim, 7491, Norway.

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August 2019

Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.

Authors:
Allison F Carey Jeremy M Rock Inna V Krieger Michael R Chase Marta Fernandez-Suarez Sebastien Gagneux James C Sacchettini Thomas R Ioerger Sarah M Fortune

PLoS Pathog 2019 Jun 4;15(6):e1007846. Epub 2019 Jun 4.

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June 2019

A DNA-Binding Protein Tunes Septum Placement during Sporulation.

Authors:
Emily E Brown Allyssa K Miller Inna V Krieger Ryan M Otto James C Sacchettini Jennifer K Herman

J Bacteriol 2019 08 24;201(16). Epub 2019 Jul 24.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA

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August 2019

Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.

Authors:
Roberto A Crespo Qun Dang Nian E Zhou Liam M Guthrie Thomas C Snavely Wen Dong Kimberly A Loesch Takao Suzuki Lanying You Wei Wang Theresa O'Malley Tanya Parish David B Olsen James C Sacchettini

J Med Chem 2019 05 19;62(9):4483-4499. Epub 2019 Apr 19.

Department of Biochemistry and Biophysics , Texas A&M University , College Station , Texas 77843 , United States.

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May 2019

Minocycline and Silver Dual-Loaded Polyphosphoester-Based Nanoparticles for Treatment of Resistant Pseudomonas aeruginosa.

Authors:
Qingquan Chen Kush N Shah Fuwu Zhang Adam J Salazar Parth N Shah Richen Li James C Sacchettini Karen L Wooley Carolyn L Cannon

Mol Pharm 2019 04 12;16(4):1606-1619. Epub 2019 Mar 12.

Department of Microbial Pathogenesis and Immunology , Texas A&M Health Science Center , College Station , Texas 77843 , United States.

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April 2019

R pyocin tail fiber structure reveals a receptor-binding domain with a lectin fold.

Authors:
Adam J Salazar Mukul Sherekar Jennifer Tsai James C Sacchettini

PLoS One 2019 5;14(2):e0211432. Epub 2019 Feb 5.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, United States of America.

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November 2019

SatS is a chaperone for the SecA2 protein export pathway.

Authors:
Brittany K Miller Ryan Hughes Lauren S Ligon Nathan W Rigel Seidu Malik Brandon R Anjuwon-Foster James C Sacchettini Miriam Braunstein

Elife 2019 01 3;8. Epub 2019 Jan 3.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, North Carolina, United States.

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January 2019

Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research.

Authors:
Shelby Daniel-Wayman Getahun Abate Daniel L Barber Luiz E Bermudez Rhea N Coler Michael H Cynamon Charles L Daley Rebecca M Davidson Thomas Dick R Andres Floto Emily Henkle Steven M Holland Mary Jackson Richard E Lee Eric L Nuermberger Kenneth N Olivier Diane J Ordway D Rebecca Prevots James C Sacchettini Max Salfinger Christopher M Sassetti Christine F Sizemore Kevin L Winthrop Adrian M Zelazny

Am J Respir Crit Care Med 2019 04;199(8):947-951

28 Microbiology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland.

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April 2019

A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis.

Authors:
Emily S C Rittershaus Seung-Hun Baek Inna V Krieger Samantha J Nelson Yu-Shan Cheng Subhalaxmi Nambi Richard E Baker John D Leszyk Scott A Shaffer James C Sacchettini Christopher M Sassetti

Cell Chem Biol 2018 12 11;25(12):1495-1505.e3. Epub 2018 Oct 11.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 368 Plantation St. AS8-2051, Worcester, MA 01650, USA. Electronic address:

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December 2018

Anion-π Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids.

Authors:
Jill F Ellenbarger Inna V Krieger Hsiao-Ling Huang Silvia Gómez-Coca Thomas R Ioerger James C Sacchettini Steven E Wheeler Kim R Dunbar

J Chem Inf Model 2018 10 12;58(10):2085-2091. Epub 2018 Sep 12.

Department of Chemistry , Texas A&M University , P.O. Box 30012, College Station , Texas 77842 , United States.

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October 2018

Structure-guided design of a potent peptide inhibitor targeting the interaction between CRK and ABL kinase.

Authors:
Qingliang Shen Veer S Bhatt Inna Krieger James C Sacchettini Jae-Hyun Cho

Medchemcomm 2018 Mar 1;9(3):519-524. Epub 2018 Feb 1.

Department of Biochemistry and Biophysics , Texas A&M University , College Station , Texas , USA . Email:

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March 2018