Publications by authors named "James C Sacchettini"

188Publications

A low-cost, novel endoscopic repeated-access port for small animal research.

MethodsX 2020 29;7:101049. Epub 2020 Aug 29.

Department of Biomedical Engineering, at Texas A&M University, United States.

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August 2020

The Structural Basis of T4 Phage Lysis Control: DNA as the Signal for Lysis Inhibition.

J Mol Biol 2020 07 17;432(16):4623-4636. Epub 2020 Jun 17.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA. Electronic address:

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July 2020

Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis.

Nat Commun 2020 04 23;11(1):1960. Epub 2020 Apr 23.

Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, NY, 10065, USA.

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April 2020

Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): a structure-activity relationship study of KES4 assisted by in silico structure-based drug screening.

J Antibiot (Tokyo) 2020 06 9;73(6):372-381. Epub 2020 Mar 9.

Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka, 820-8502, Japan.

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June 2020

The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD.

Nat Commun 2020 01 17;11(1):339. Epub 2020 Jan 17.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.

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January 2020

Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor.

Nucleic Acids Res 2019 10;47(18):9934-9949

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77840, USA.

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October 2019

Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness.

Sci Rep 2019 08 6;9(1):11394. Epub 2019 Aug 6.

NTNU Norwegian University of Science and Technology, Centre of Molecular Inflammation Research and Department of Clinical and Molecular Medicine, Trondheim, 7491, Norway.

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August 2019

A DNA-Binding Protein Tunes Septum Placement during Sporulation.

J Bacteriol 2019 08 24;201(16). Epub 2019 Jul 24.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA

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August 2019

Minocycline and Silver Dual-Loaded Polyphosphoester-Based Nanoparticles for Treatment of Resistant Pseudomonas aeruginosa.

Mol Pharm 2019 04 12;16(4):1606-1619. Epub 2019 Mar 12.

Department of Microbial Pathogenesis and Immunology , Texas A&M Health Science Center , College Station , Texas 77843 , United States.

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April 2019

R pyocin tail fiber structure reveals a receptor-binding domain with a lectin fold.

PLoS One 2019 5;14(2):e0211432. Epub 2019 Feb 5.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, United States of America.

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November 2019

SatS is a chaperone for the SecA2 protein export pathway.

Elife 2019 01 3;8. Epub 2019 Jan 3.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, North Carolina, United States.

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January 2019

A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis.

Cell Chem Biol 2018 12 11;25(12):1495-1505.e3. Epub 2018 Oct 11.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 368 Plantation St. AS8-2051, Worcester, MA 01650, USA. Electronic address:

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December 2018

Anion-π Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids.

J Chem Inf Model 2018 10 12;58(10):2085-2091. Epub 2018 Sep 12.

Department of Chemistry , Texas A&M University , P.O. Box 30012, College Station , Texas 77842 , United States.

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October 2018

Structure-guided design of a potent peptide inhibitor targeting the interaction between CRK and ABL kinase.

Medchemcomm 2018 Mar 1;9(3):519-524. Epub 2018 Feb 1.

Department of Biochemistry and Biophysics , Texas A&M University , College Station , Texas , USA . Email:

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March 2018