Publications by authors named "James C Mulloy"

78Publications

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.

Cancer Cell 2020 Jul 11;38(1):79-96.e11. Epub 2020 Jun 11.

Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; City of Hope Comprehensive Cancer Center and Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA 91010, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2020.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363590PMC
July 2020

Rapid desensitization of humanized mice with anti-human FcεRIα monoclonal antibodies.

J Allergy Clin Immunol 2020 Mar 11;145(3):907-921.e3. Epub 2019 Dec 11.

Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.12.003DOI Listing
March 2020

Improved chemotherapy modeling with RAG-based immune deficient mice.

PLoS One 2019 20;14(11):e0225532. Epub 2019 Nov 20.

Division of Experimental Hematology and Cancer Biology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225532PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867639PMC
March 2020

Alternative translation initiation generates the N-terminal truncated form of RUNX1 that retains hematopoietic activity.

Exp Hematol 2019 04 26;72:27-35. Epub 2019 Jan 26.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2019.01.008DOI Listing
April 2019

Improved multilineage human hematopoietic reconstitution and function in NSGS mice.

PLoS One 2018 12;13(12):e0209034. Epub 2018 Dec 12.

Division of Experimental Hematology and Cancer Biology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209034PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291127PMC
May 2019

Comparative utility of NRG and NRGS mice for the study of normal hematopoiesis, leukemogenesis, and therapeutic response.

Exp Hematol 2018 11 17;67:18-31. Epub 2018 Aug 17.

Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA; James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA; Department of Medicine, University of Louisville, Louisville, KY, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200600PMC
November 2018

Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells.

Methods Mol Biol 2018 ;1821:257-266

Cancer & Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-8612-5_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457108PMC
March 2019

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/mA/MYC/CEBPA Signaling.

Cell 2018 01 14;172(1-2):90-105.e23. Epub 2017 Dec 14.

Department of Cancer Biology, University of Cincinnati, Cincinnati, OH 45219, USA; Gehr Family Center for Leukemia Research, City of Hope, 1500 E. Duarte Rd., Duarte, CA 91010, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2017.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766423PMC
January 2018

A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program.

Blood 2017 09 14;130(10):1213-1222. Epub 2017 Jul 14.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2016-11-750976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606002PMC
September 2017

The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitment.

Blood 2017 08 21;130(7):903-907. Epub 2017 Jun 21.

Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2017-04-777185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561902PMC
August 2017

RUNX1-ETO Leukemia.

Adv Exp Med Biol 2017 ;962:151-173

Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-981-10-3233-2_11DOI Listing
September 2017

Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.

Autophagy 2017 May 15;13(5):955-966. Epub 2017 Feb 15.

a Division of Experimental Hematology and Cancer Biology , Cincinnati Children's Research Foundation , Cincinnati , OH , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15548627.2017.1287652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446057PMC
May 2017

MISTRG extends PDX modeling to favorable AMLs.

Blood 2016 10;128(17):2111-2112

CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2016-09-738757DOI Listing
October 2016

Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation.

Oncotarget 2016 Aug;7(35):55939-55950

Cancer and Blood Disease Institute, Cincinnati Children's Hospital Research Center, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.11093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302887PMC
August 2016

Supraphysiologic levels of the AML1-ETO isoform AE9a are essential for transformation.

Proc Natl Acad Sci U S A 2016 08 25;113(32):9075-80. Epub 2016 Jul 25.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1524225113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987773PMC
August 2016

The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation.

EMBO Rep 2016 06 26;17(6):887-900. Epub 2016 Apr 26.

Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, AL, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embr.201541970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278610PMC
June 2016

A ROS-Activatable Agent Elicits Homologous Recombination DNA Repair and Synergizes with Pathway Compounds.

Chembiochem 2015 Nov 2;16(17):2513-21. Epub 2015 Nov 2.

Department of Chemistry, University of Cincinnati, 404 Crosley Tower, Cincinnati, OH, 45221-0172, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201500304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758217PMC
November 2015

Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells.

Stem Cells 2015 Dec 5;33(12):3635-42. Epub 2015 Oct 5.

Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/stem.2208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713243PMC
December 2015

MAPK8-mediated stabilization of SP1 is essential for RUNX1-RUNX1T1 - driven leukaemia.

Br J Haematol 2016 Mar 8;172(5):807-10. Epub 2015 Jun 8.

Molecular Cytogenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.13536DOI Listing
March 2016

Xenograft models for normal and malignant stem cells.

Blood 2015 Apr 11;125(17):2630-40. Epub 2015 Mar 11.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2014-11-570218DOI Listing
April 2015

Design of a hydrogen peroxide-activatable agent that specifically targets cancer cells.

Bioorg Med Chem 2014 Dec 30;22(24):6885-92. Epub 2014 Oct 30.

Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2014.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292800PMC
December 2014

OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues.

Blood 2014 Jun 28;123(24):e134-44. Epub 2014 Apr 28.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2014-02-556340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055932PMC
June 2014

A new inducible model for t(8;21) AML.

Authors:
James C Mulloy

EMBO Mol Med 2013 Dec 4;5(12):1795-7. Epub 2013 Nov 4.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/emmm.201303483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914533PMC
December 2013

NF-κB: a coordinator for epigenetic regulation by MLL.

Cancer Cell 2013 Oct;24(4):401-2

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2013.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147035PMC
October 2013

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells.

J Clin Invest 2013 Sep 27;123(9):3876-88. Epub 2013 Aug 27.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI68557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754260PMC
September 2013

The rate of spontaneous mutations in human myeloid cells.

Mutat Res 2013 Sep 6;749(1-2):49-57. Epub 2013 Jun 6.

Division of Hematology, Department of Veterans Affairs New York Harbor Healthcare System, United States; Division of Hematology, Department of Medicine, NYU School of Medicine and the NYU Langone Cancer Center, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mrfmmm.2013.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524336PMC
September 2013

Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia.

Bioorg Med Chem Lett 2013 May 26;23(10):2951-4. Epub 2013 Mar 26.

Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2013.03.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677216PMC
May 2013

AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model.

Blood 2013 Mar 24;121(12):e90-7. Epub 2013 Jan 24.

Division of Experimental Hematology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2012-10-464677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606073PMC
March 2013

Making healthy stem cells: the new role of TPO.

Cell Stem Cell 2013 Jan;12(1):8-9

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S19345909120071
Publisher Site
http://dx.doi.org/10.1016/j.stem.2012.12.008DOI Listing
January 2013

The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO.

Blood 2012 Jul 14;120(4):709-19. Epub 2012 Feb 14.

Divisions of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2012-01-403212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412344PMC
July 2012

Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects.

Int J Hematol 2011 Aug 3;94(2):126-133. Epub 2011 May 3.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12185-011-0858-zDOI Listing
August 2011

The thrombopoietin/MPL pathway in hematopoiesis and leukemogenesis.

J Cell Biochem 2011 Jun;112(6):1491-8

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.23089DOI Listing
June 2011

N-Ras(G12D) induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene.

Blood 2011 Feb 3;117(7):2237-40. Epub 2011 Jan 3.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-01-264119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062331PMC
February 2011

Peripheral T cell lymphoma: new model + new insight.

Authors:
James C Mulloy

J Exp Med 2010 May 3;207(5):911-3. Epub 2010 May 3.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20100608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867292PMC
May 2010

Rho GTPases in hematopoiesis and hemopathies.

Blood 2010 Feb 24;115(5):936-47. Epub 2009 Nov 24.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2009-09-198127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817638PMC
February 2010

Core binding factor at the crossroads: determining the fate of the HSC.

J Cell Physiol 2010 Jan;222(1):50-6

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.21950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812028PMC
January 2010

Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction.

Methods Mol Biol 2009 ;538:263-85

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-418-6_13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825883PMC
May 2009

Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling.

Cell Cycle 2008 Nov 8;7(21):3314-9. Epub 2008 Nov 8.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812025PMC
http://dx.doi.org/10.4161/cc.7.21.6951DOI Listing
November 2008

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

Cancer Cell 2008 Jun;13(6):483-95

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2008.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486365PMC
June 2008

p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death.

Blood 2008 Feb 1;111(4):2190-9. Epub 2007 Nov 1.

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH 45226, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2007-06-093682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234055PMC
February 2008

Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability.

Blood 2006 Sep 2;108(5):1690-7. Epub 2006 May 2.

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45226, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2005-12-012773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1586104PMC
September 2006

AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.

Proc Natl Acad Sci U S A 2005 Mar 24;102(11):4016-21. Epub 2005 Feb 24.

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0404701102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC554792PMC
March 2005

Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.

Blood 2003 Dec 28;102(13):4369-76. Epub 2003 Aug 28.

Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Mail Location 7013, Cincinnati, OH 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2003-05-1762DOI Listing
December 2003

Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells.

Blood 2003 Mar 24;101(6):2206-14. Epub 2002 Oct 24.

Laboratory of Molecular Aspects of Hematopoiesis, Sloan-Kettering Institute, Division of Hematologic Oncology, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2002-05-1546DOI Listing
March 2003

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells.

Blood 2002 Jan;99(1):15-23

Laboratory of Molecular Hematopoiesis, Sloan-Kettering Institute, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.v99.1.15DOI Listing
January 2002