James Brugarolas

James Brugarolas

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James Brugarolas

Publications by authors named "James Brugarolas"

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DEFOR: depth- and frequency-based somatic copy number alteration detector.

Bioinformatics 2019 Oct;35(19):3824-3825

Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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https://academic.oup.com/bioinformatics/advance-article/doi/
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http://dx.doi.org/10.1093/bioinformatics/btz170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761943PMC
October 2019

Inflammatory Reaction Secondary to Immune Checkpoint Inhibitor Therapy Mimicking a Post-Operative Brain Abscess.

World Neurosurg 2019 Sep 14;129:354-358. Epub 2019 Jun 14.

Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2019.06.024DOI Listing
September 2019

SCINA: A Semi-Supervised Subtyping Algorithm of Single Cells and Bulk Samples.

Genes (Basel) 2019 07 12;10(7). Epub 2019 Jul 12.

Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.3390/genes10070531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678337PMC
July 2019

Current Challenges in Diagnosis and Assessment of the Response of Locally Advanced and Metastatic Renal Cell Carcinoma.

Radiographics 2019 Jul-Aug;39(4):998-1016. Epub 2019 Jun 14.

From the Department of Radiology (A.D.d.L., A.P., D.N.C., I.P.), Advanced Imaging Research Center (D.N.C., I.P.), Department of Pathology (P.K.), Department of Urology (P.K.), Kidney Cancer Program-Simmons Comprehensive Cancer Center (P.K., H.H., J.B., I.P.), and Department of Internal Medicine (H.H., J.B.), UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390.

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http://dx.doi.org/10.1148/rg.2019180178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677287PMC
June 2019

Improved Survival Outcomes for Kidney Cancer Patients With Brain Metastases.

Clin Genitourin Cancer 2019 04 5;17(2):e263-e272. Epub 2018 Dec 5.

Kidney Cancer Program, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX; Division of Hematology and Oncology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534272PMC
April 2019

Stereotactic Radiosurgery for Multiple Brain Metastases From Renal-Cell Carcinoma.

Clin Genitourin Cancer 2019 04 22;17(2):e273-e280. Epub 2018 Nov 22.

Kidney Cancer Program, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX; Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1016/j.clgc.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563340PMC
April 2019

Renal Cell Carcinoma Pseudoprogression with Clinical Deterioration: To Hospice and Back.

Clin Genitourin Cancer 2018 12 20;16(6):485-488. Epub 2018 Jul 20.

Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2018.07.015DOI Listing
December 2018

Whole-body MRI for metastatic cancer detection using T -weighted imaging with fat and fluid suppression.

Magn Reson Med 2018 10 14;80(4):1402-1415. Epub 2018 Feb 14.

Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1002/mrm.27117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092263PMC
October 2018

Reliable gene mutation prediction in clear cell renal cell carcinoma through multi-classifier multi-objective radiogenomics model.

Phys Med Biol 2018 10 24;63(21):215008. Epub 2018 Oct 24.

School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, People's Repubic of China.

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http://iopscience.iop.org/article/10.1088/1361-6560/aae5cd
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http://dx.doi.org/10.1088/1361-6560/aae5cdDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240911PMC
October 2018

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization.

EMBO J 2018 06 15;37(11). Epub 2018 May 15.

Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli (Naples), Italy

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http://dx.doi.org/10.15252/embj.201798804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983138PMC
June 2018

What is the role of nephrectomy following complete response to checkpoint inhibitors?

Urol Case Rep 2018 May 14;18:60-63. Epub 2018 Mar 14.

University of Texas Southwestern Medical Center, Department of Urology, Dallas, TX, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22144420183001
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http://dx.doi.org/10.1016/j.eucr.2018.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958820PMC
May 2018

Personalized Management of Advanced Kidney Cancer.

Am Soc Clin Oncol Educ Book 2018 May;38:330-341

From the Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada; Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX; Karmanos Cancer Institute, Wayne State University, Detroit, MI.

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http://dx.doi.org/10.1200/EDBK_201215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865066PMC
May 2018

Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma.

J Clin Oncol 2018 03 19;36(9):867-874. Epub 2017 Dec 19.

Kevin D. Courtney and James Brugarolas, University of Texas Southwestern Medical Center; Naseem J. Zojwalla, Ann M. Lowe, Keshi Wang, Eli M. Wallace, and John A. Josey, Peloton Therapeutics, Dallas, TX; Jeffrey R. Infante, TN Oncology and Sarah Cannon Research Institute, Nashville, TN; Elaine T. Lam, University of Colorado Cancer Center, Aurora, CO; Robert A. Figlin, Cedars-Sinai Medical Center, Los Angeles, CA; Brian I. Rini, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH; Toni K. Choueiri, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2017.74.2627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946714PMC
March 2018

Development of a Patient-specific Tumor Mold Using Magnetic Resonance Imaging and 3-Dimensional Printing Technology for Targeted Tissue Procurement and Radiomics Analysis of Renal Masses.

Urology 2018 Feb 19;112:209-214. Epub 2017 Oct 19.

Department of Radiology, UT Southwestern Medical Center, Dallas, TX; Department of Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX; Department of Urology, UT Southwestern Medical Center, Dallas, TX. Electronic address:

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http://dx.doi.org/10.1016/j.urology.2017.08.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885749PMC
February 2018

Multicenter Validation of Enhancer of Zeste Homolog 2 Expression as an Independent Prognostic Marker in Localized Clear Cell Renal Cell Carcinoma.

J Clin Oncol 2017 Nov 4;35(32):3706-3713. Epub 2017 Oct 4.

Thai Huu Ho, Mayo Clinic, Phoenix, AZ; Jeanette E. Eckel-Passow, John C. Cheville, and R. Houston Thompson, Mayo Clinic, Rochester, MN; Payal Kapur, Alana Christie, Vandana Panwar, and James Brugarolas, University of Texas Southwestern Medical Center; Payal Kapur, Farrah Homayoun, and James Brugarolas, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX; and Richard W. Joseph, Daniel J. Serie, and Alexander S. Parker, Mayo Clinic, Jacksonville, FL.

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http://dx.doi.org/10.1200/JCO.2017.73.3238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678341PMC
November 2017

Renal Cell Carcinoma With Pulmonary Metastasis and Metachronous Non-Small Cell Lung Cancer.

Clin Genitourin Cancer 2017 08 6;15(4):e675-e680. Epub 2017 Feb 6.

Division of Hematology-Oncology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX; Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2017.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537023PMC
August 2017

Modeling Renal Cell Carcinoma in Mice: and Inactivation Drive Tumor Grade.

Cancer Discov 2017 08 4;7(8):900-917. Epub 2017 May 4.

Department of Internal Medicine, Hematology-Oncology Division, The University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540776PMC
August 2017

Correction for Wolff et al., "Cell-Type-Dependent Regulation of mTORC1 by REDD1 and the Tumor Suppressors TSC1/TSC2 and LKB1 in Response to Hypoxia".

Mol Cell Biol 2017 07 15;37(13). Epub 2017 Jun 15.

Department of Internal Medicine, Hematology-Oncology Division, University of Texas Southwestern Medical Center, Dallas, Texas 75390.

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http://mcb.asm.org/lookup/doi/10.1128/MCB.00224-17
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http://dx.doi.org/10.1128/MCB.00224-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472833PMC
July 2017

Safety and Efficacy of Stereotactic Ablative Radiation Therapy for Renal Cell Carcinoma Extracranial Metastases.

Int J Radiat Oncol Biol Phys 2017 05;98(1):91-100

Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2017.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555369PMC
May 2017

Multistep regulation of TFEB by MTORC1.

Autophagy 2017 Mar 5;13(3):464-472. Epub 2017 Jan 5.

a Kidney Cancer Program, Simmons Comprehensive Cancer Center , University of Texas Southwestern Medical Center , Dallas , TX , USA.

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http://dx.doi.org/10.1080/15548627.2016.1271514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361595PMC
March 2017

Intratumor Heterogeneity of Perfusion and Diffusion in Clear-Cell Renal Cell Carcinoma: Correlation With Tumor Cellularity.

Clin Genitourin Cancer 2016 12 22;14(6):e585-e594. Epub 2016 Apr 22.

Department of Radiology, UT Southwestern Medical Center, Dallas, TX; Kidney Cancer Program, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX; Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075271PMC
http://dx.doi.org/10.1016/j.clgc.2016.04.007DOI Listing
December 2016

Fibroblast Growth Factor Receptor-Dependent and -Independent Paracrine Signaling by Sunitinib-Resistant Renal Cell Carcinoma.

Mol Cell Biol 2016 07 15;36(13):1836-55. Epub 2016 Jun 15.

Kidney Cancer Program, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA Department of Internal Medicine, Oncology Division, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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http://dx.doi.org/10.1128/MCB.00189-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911743PMC
July 2016

Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity.

Cell Rep 2016 07 23;16(2):508-519. Epub 2016 Jun 23.

AIRC Division of Metabolic Mechanisms of Disease, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951107PMC
July 2016

Predictive Biomarkers for Molecularly Targeted Therapies in Renal Cell Carcinoma.

Authors:
James Brugarolas

J Natl Compr Canc Netw 2016 07;14(7):925-7

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http://dx.doi.org/10.6004/jnccn.2016.0095DOI Listing
July 2016

Identification of CREB3L1 as a Biomarker Predicting Doxorubicin Treatment Outcome.

PLoS One 2015 25;10(6):e0129233. Epub 2015 Jun 25.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129233PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482141PMC
April 2016

Stereotactic radiation therapy of renal cancer inferior vena cava tumor thrombus.

Cancer Biol Ther 2015 ;16(5):657-61

a Department of Radiation Oncology; Harold C Simmons Cancer Center; University of Texas at Southwestern Medical Center ; Dallas , TX , USA.

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http://dx.doi.org/10.1080/15384047.2015.1026506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622024PMC
March 2016

Tumor Vascularity in Renal Masses: Correlation of Arterial Spin-Labeled and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Assessments.

Clin Genitourin Cancer 2016 Feb 29;14(1):e25-36. Epub 2015 Aug 29.

Department of Radiology, UT Southwestern Medical Center, Dallas, TX; Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2015.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698181PMC
February 2016

Clear Cell Renal Cell Carcinoma Subtypes Identified by BAP1 and PBRM1 Expression.

J Urol 2016 Jan 20;195(1):180-7. Epub 2015 Aug 20.

Division of Medical Oncology, Departments of Health Sciences Research and Medicine and Division of Cancer Biology, Mayo Clinic Florida, Jacksonville, Florida; Department of Pathology, Kidney Cancer Program, Simmons Comprehensive Cancer Center, Division of Hematology-Oncology, Department of Internal Medicine and Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Health Sciences Research, Mayo Clinic Rochester, Rochester, Minnesota; Division of Medical Oncology, Mayo Clinic Arizona, Phoenix, Arizona. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2015.07.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221690PMC
January 2016

Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin.

Cell Rep 2015 Oct 8;13(3):495-503. Epub 2015 Oct 8.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618234PMC
October 2015

Selective Efficacy of Temsirolimus on Bone Metastases in Chromophobe Renal Cell Carcinoma.

Clin Genitourin Cancer 2015 Aug 20;13(4):e321-e323. Epub 2014 Dec 20.

Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX; Internal Medicine, Medical Oncology Division/Developmental Biology, The University of Texas Southwestern Medical Center, Dallas, TX. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2014.12.007DOI Listing
August 2015

Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis.

Proc Natl Acad Sci U S A 2014 Nov 30;111(46):16538-43. Epub 2014 Oct 30.

Hematology-Oncology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; Departments of Developmental Biology, Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1414789111
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http://dx.doi.org/10.1073/pnas.1414789111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246264PMC
November 2014

Establishing a human renal cell carcinoma tumorgraft platform for preclinical drug testing.

Nat Protoc 2014 Aug 10;9(8):1848-59. Epub 2014 Jul 10.

1] Kidney Cancer Program, University of Texas (UT) Southwestern Medical Center, Dallas, Texas, USA. [2] Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA. [3] Department of Developmental Biology, UT Southwestern Medical Center, Dallas, Texas, USA. [4] Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1038/nprot.2014.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314943PMC
August 2014

REDD1/DDIT4-independent mTORC1 inhibition and apoptosis by glucocorticoids in thymocytes.

Mol Cancer Res 2014 Jun 10;12(6):867-77. Epub 2014 Mar 10.

Authors' Affiliations: Division of Hematology-Oncology, Department of Internal Medicine, Department of Developmental Biology, and the Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260655PMC
June 2014

Molecular genetics of clear-cell renal cell carcinoma.

Authors:
James Brugarolas

J Clin Oncol 2014 Jun 12;32(18):1968-76. Epub 2014 May 12.

From the Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1200/JCO.2012.45.2003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050206PMC
June 2014

BAP1 immunohistochemistry predicts outcomes in a multi-institutional cohort with clear cell renal cell carcinoma.

J Urol 2014 Mar 25;191(3):603-10. Epub 2013 Sep 25.

Department of Pathology (PK), University of Texas Southwestern Medical Center, Dallas, Texas; Department of Urology (PK, YL, VM), University of Texas Southwestern Medical Center, Dallas, Texas; Department of Internal Medicine (JB), University of Texas Southwestern Medical Center, Dallas, Texas; Department of Developmental Biology (JB), University of Texas Southwestern Medical Center, Dallas, Texas; Simmons Cancer Center (XJX, JB), University of Texas Southwestern Medical Center, Dallas, Texas; Department of Urology, Penn State Milton S. Hershey Medical Center (JDR), Hershey, Pennsylvania; Department of Pathology, University of Pittsburgh Medical Center (MTT), Pittsburgh, Pennsylvania; Department of Urology, University of Munich (PN, AB), Munich, Germany; Department of Urology, Paracelsus-Klinik Golzheim, Dusseldorf, Germany (PB); Department of Urology, Central Hospital of Bolzano (CS), Bolzano, Italy; Department of Urology, Medical University of Vienna, Vienna General Hospital (CS, SFS), Vienna, Austria; Department of Urology and Pathology, University of Rennes (KB, NR-L), Rennes, France.

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http://dx.doi.org/10.1016/j.juro.2013.09.041DOI Listing
March 2014

PBRM1 and BAP1 as novel targets for renal cell carcinoma.

Authors:
James Brugarolas

Cancer J 2013 Jul-Aug;19(4):324-32

Department of Internal Medicine, Oncology Division, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1097/PPO.0b013e3182a102d1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222578PMC
February 2014

Simultaneous isolation of high-quality DNA, RNA, miRNA and proteins from tissues for genomic applications.

Nat Protoc 2013 Nov 17;8(11):2240-55. Epub 2013 Oct 17.

1] Department of Internal Medicine, University of Texas (UT) Southwestern Medical Center, Dallas, Texas, USA. [2] Department of Developmental Biology, UT Southwestern Medical Center, Dallas, Texas, USA. [3] Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1038/nprot.2013.141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211643PMC
November 2013

Cooperation and antagonism among cancer genes: the renal cancer paradigm.

Cancer Res 2013 Jul 5;73(14):4173-9. Epub 2013 Jul 5.

Departments of Internal Medicine, Developmental Biology, and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051157PMC
July 2013

Prolonged survival of a patient with papillary renal cell carcinoma and brain metastases using pazopanib.

J Clin Oncol 2013 Mar 14;31(7):e114-7. Epub 2013 Jan 14.

University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9133, USA.

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http://dx.doi.org/10.1200/JCO.2012.46.0501DOI Listing
March 2013

Metabolism of kidney cancer: from the lab to clinical practice.

Eur Urol 2013 Feb 28;63(2):244-51. Epub 2012 Sep 28.

Department of Urology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1016/j.eururo.2012.09.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709870PMC
February 2013

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes.

Nat Immunol 2013 Jan 18;14(1):61-71. Epub 2012 Nov 18.

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1038/ni.2475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522772PMC
January 2013

Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2.

Cancer Cell 2011 Oct;20(4):418-20

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226726PMC
October 2011

Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma.

Mol Cancer Res 2011 Sep 28;9(9):1255-65. Epub 2011 Jul 28.

Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-11-0302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234675PMC
September 2011

mTORC1 activation in childhood ependymoma and response to sirolimus.

J Neurooncol 2011 Jul 13;103(3):797-801. Epub 2010 Nov 13.

Department of Pediatrics, University of Texas Southwestern Medical School at Dallas, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1007/s11060-010-0455-7DOI Listing
July 2011

Regulation of TFEB and V-ATPases by mTORC1.

EMBO J 2011 Jul 29;30(16):3242-58. Epub 2011 Jul 29.

Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2011.257
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http://dx.doi.org/10.1038/emboj.2011.257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160667PMC
July 2011

Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.

Mol Cell Biol 2011 May 7;31(9):1870-84. Epub 2011 Mar 7.

University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9133, USA.

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http://dx.doi.org/10.1128/MCB.01393-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133225PMC
May 2011

Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC.

Nat Rev Urol 2011 Mar 8;8(3):165-71. Epub 2011 Feb 8.

Department of Internal Medicine, Hematology-Oncology Division, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1038/nrurol.2010.234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055922PMC
March 2011

Structural analysis and functional implications of the negative mTORC1 regulator REDD1.

Biochemistry 2010 Mar;49(11):2491-501

Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1021/bi902135eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046781PMC
March 2010

Sirolimus and temsirolimus for epithelioid angiomyolipoma.

J Clin Oncol 2010 Feb 4;28(5):e65-8. Epub 2010 Jan 4.

Departments of Internal Medicine, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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February 2010

Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1.

Hum Mol Genet 2009 Nov 19;18(22):4428-41. Epub 2009 Aug 19.

Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9133, USA.

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http://dx.doi.org/10.1093/hmg/ddp398DOI Listing
November 2009

Sirolimus in metatastic renal cell carcinoma.

J Clin Oncol 2008 Jul;26(20):3457-60

Department of Internal Medicine (Oncology Division), Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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July 2008

Renal-cell carcinoma--molecular pathways and therapies.

Authors:
James Brugarolas

N Engl J Med 2007 Jan;356(2):185-7

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January 2007

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.

Genes Dev 2004 Dec 15;18(23):2893-904. Epub 2004 Nov 15.

Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC534650PMC
December 2004

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes.

Cancer Cell 2004 Jul;6(1):7-10

Dana-Farber Cancer Institute and Harvard Medical School, Howard Hughes Medical Institute, 44 Binney Street, Mayer 457, Boston, Massachusetts 02115, USA.

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July 2004

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.

Nat Med 2004 Jun 23;10(6):594-601. Epub 2004 May 23.

Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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June 2004

TSC2 regulates VEGF through mTOR-dependent and -independent pathways.

Cancer Cell 2003 Aug;4(2):147-58

Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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August 2003