Publications by authors named "James Brierley"

100Publications

Stereotactic body radiation therapy for hepatocellular carcinoma with Macrovascular invasion.

Radiother Oncol 2020 Dec 5;156:120-126. Epub 2020 Dec 5.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada. Electronic address:

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December 2020

Current and future cancer staging after neoadjuvant treatment for solid tumors.

CA Cancer J Clin 2020 Nov 6. Epub 2020 Nov 6.

American Joint Committee on Cancer, American College of Surgeons, Chicago, Illinois.

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November 2020

Long term outcomes of stereotactic body radiation therapy for hepatocellular carcinoma without macrovascular invasion.

Eur J Cancer 2020 07 24;134:41-51. Epub 2020 May 24.

Department of Radiation Oncology, University of Toronto, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Electronic address:

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July 2020

Long-term outcomes following salvage surgery for locally recurrent rectal cancer: A 15-year follow-up study.

Eur J Surg Oncol 2020 06 10;46(6):1131-1137. Epub 2020 Mar 10.

Department of Surgical Oncology, Princess Margaret Cancer Centre and Mount Sinai Hospital, Toronto, Canada; Division of General Surgery, Department of Surgery, University of Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada. Electronic address:

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June 2020

Global Consultation on Cancer Staging: promoting consistent understanding and use.

Nat Rev Clin Oncol 2019 12 6;16(12):763-771. Epub 2019 Aug 6.

Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.

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December 2019

Essential TNM: a registry tool to reduce gaps in cancer staging information.

Lancet Oncol 2019 02;20(2):e103-e111

Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada; Union for International Cancer Control, Geneva, Switzerland.

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February 2019

Cancer in Canada: Stage at diagnosis.

Health Rep 2018 12;29(12):21-25

Health Statistics Division, Statistics Canada, Ottawa, Ontario.

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December 2018

Global trends in colorectal cancer mortality: projections to the year 2035.

Int J Cancer 2019 06 8;144(12):2992-3000. Epub 2019 Jan 8.

Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France.

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June 2019

Patient and Physician Preferences for Nonoperative Management for Low Rectal Cancer: Is It a Reasonable Treatment Option?

Dis Colon Rectum 2018 11;61(11):1281-1289

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

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November 2018

Symptom burden in adults with thyroid cancer.

Psychooncology 2018 10 31;27(10):2517-2519. Epub 2018 Aug 31.

Department of Supportive Care, Princess Margaret Cancer Centre and University of Toronto, Toronto, Ontario, Canada.

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October 2018

Baseline Albumin-Bilirubin (ALBI) Score in Western Patients With Hepatocellular Carcinoma Treated With Stereotactic Body Radiation Therapy (SBRT).

Int J Radiat Oncol Biol Phys 2018 07 12;101(4):900-909. Epub 2018 Apr 12.

Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Electronic address:

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July 2018

Evaluation of Bony Anatomy Versus Endobiliary Stents as Surrogates for Volumetric Image Guidance in Pancreatic Cancer.

J Med Imaging Radiat Sci 2017 Dec 31;48(4):352-359. Epub 2017 May 31.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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December 2017

Differentiated and anaplastic thyroid carcinoma: Major changes in the American Joint Committee on Cancer eighth edition cancer staging manual.

CA Cancer J Clin 2018 01 1;68(1):55-63. Epub 2017 Nov 1.

Endochrinologist, Endocrinology Service, Memorial Sloan Kettering Cancer Center, New York, NY.

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January 2018

Long-Term Outcomes of Phase 1 and 2 Studies of SBRT for Hepatic Colorectal Metastases.

Int J Radiat Oncol Biol Phys 2017 10 13;99(2):388-395. Epub 2017 Apr 13.

Radiation Medicine Program, Princess Margaret Cancer Centre, and Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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October 2017

An Exploratory Study of Fatigue and Physical Activity in Canadian Thyroid Cancer Patients.

Thyroid 2017 09 14;27(9):1156-1163. Epub 2017 Aug 14.

1 Division of Endocrinology, Department of Medicine, University of Toronto , Toronto, Canada .

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September 2017

The TNM classification of malignant tumours-towards common understanding and reasonable expectations.

Lancet Oncol 2017 07;18(7):849-851

Princess Margaret Cancer Centre, Department of Radiation Oncology, University of Toronto, Toronto, ON, M5G 2M9, Canada. Electronic address:

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July 2017

Dosimetric analysis of liver toxicity after liver metastasis stereotactic body radiation therapy.

Pract Radiat Oncol 2017 Sep - Oct;7(5):e331-e337. Epub 2017 Mar 9.

Radiation Medicine Program, Princess Margaret Cancer Centre, Department of Radiation Oncology, University of Toronto, Toronto, Canada. Electronic address:

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May 2018

Predictors of Liver Toxicity Following Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma.

Int J Radiat Oncol Biol Phys 2017 04 1;97(5):939-946. Epub 2017 Feb 1.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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April 2017

Effect of Intensity Modulated Radiation Therapy With Concurrent Chemotherapy on Survival for Patients With Cervical Esophageal Carcinoma.

Int J Radiat Oncol Biol Phys 2017 05 9;98(1):186-195. Epub 2017 Jan 9.

Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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May 2017

Phase I trial of radiation therapy and sorafenib in unresectable liver metastases.

Radiother Oncol 2017 05 13;123(2):234-239. Epub 2017 Feb 13.

Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Canada. Electronic address:

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May 2017

The principles of cancer staging.

Ecancermedicalscience 2016 24;10:ed61. Epub 2016 Nov 24.

Department of Radiation Oncology, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

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November 2016

Investigation of volumetric apparent diffusion coefficient histogram analysis for assessing complete response and clinical outcomes following pre-operative chemoradiation treatment for rectal carcinoma.

Abdom Radiol (NY) 2017 05;42(5):1310-1318

Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital and Women's College Hospital, University of Toronto, 610 University Ave, 3-957, Toronto, ON, M5G 2M9, Canada.

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May 2017

Staging, Tumor Profile, and Prognostic Groups in Lung Cancer or the New Tower of Babel.

J Thorac Oncol 2016 08;11(8):1201-1203

Academic Department of Thoracic Surgery, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College, London, United Kingdom.

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August 2016

Concerns of low-risk thyroid cancer survivors.

Acta Oncol 2016 Sep - Oct;55(9-10):1252-1253. Epub 2016 May 13.

e Department of Otolaryngology-Head and Neck Surgery , University Health Network and University of Toronto , Toronto , Ontario , Canada.

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May 2016

Changes in Liver Volume Observed Following Sorafenib and Liver Radiation Therapy.

Int J Radiat Oncol Biol Phys 2016 Mar 17;94(4):729-37. Epub 2015 Dec 17.

Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada. Electronic address:

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March 2016

Phase 1 Trial of Sorafenib and Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma.

Int J Radiat Oncol Biol Phys 2016 Mar 17;94(3):580-7. Epub 2015 Dec 17.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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March 2016

Unmet Information Needs of Low-Risk Thyroid Cancer Survivors.

Thyroid 2016 Mar 15;26(3):474-5. Epub 2016 Jan 15.

4 Department of Otolaryngology-Head and Neck Surgery, University Health Network and University of Toronto , Toronto, Canada .

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March 2016

Thyroid cancer survivors' perceptions of survivorship care follow-up options: a cross-sectional, mixed-methods survey.

Support Care Cancer 2016 May 3;24(5):2007-2015. Epub 2015 Nov 3.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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May 2016

Accumulated Delivered Dose Response of Stereotactic Body Radiation Therapy for Liver Metastases.

Int J Radiat Oncol Biol Phys 2015 Nov 26;93(3):639-48. Epub 2015 Jul 26.

Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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November 2015

Prospective Longitudinal Assessment of Quality of Life for Liver Cancer Patients Treated With Stereotactic Body Radiation Therapy.

Int J Radiat Oncol Biol Phys 2015 Sep;93(1):16-25

Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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September 2015

Principles of Cancer Staging for Clinical Obstetrics and Gynecology.

Best Pract Res Clin Obstet Gynaecol 2015 Aug 11;29(6):767-75. Epub 2015 Jun 11.

Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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August 2015

Effect of Multidisciplinary Cancer Conference on Treatment Plan for Patients With Primary Rectal Cancer.

Dis Colon Rectum 2015 Jul;58(7):653-8

1 Department of Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada 2 Zane Cohen Centre for Digestive Diseases, Toronto, Ontario, Canada 3 Joint Department of Medical Imaging, Mount Sinai Hospital, University Health Network, Women's College, Toronto, Ontario, Canada 4 Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada 5 Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada 6 Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada 7 Institute of the Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

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July 2015

Long-Term Outcomes Following Therapy in Differentiated Thyroid Carcinoma: NTCTCS Registry Analysis 1987-2012.

J Clin Endocrinol Metab 2015 Sep 14;100(9):3270-9. Epub 2015 Jul 14.

Department of Endocrine Neoplasia and Hormonal Disorders (A.A.C., D.R.L., S.I.S.), The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Thyroid Unit (D.S.R.), Massachusetts General Hospital, Boston, Massachusetts 02114; Division of Endocrinology (J.J.), Department of Medicine, Georgetown University Medical Center, Washington, DC 20057; Division of Endocrinology and Metabolism (D.S.C., P.W.L., M.X.), The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; Department of Radiation Oncology (J.D.B.), Princess Margaret Hospital, Toronto, ON M5G 2M9, Canada; Department of Internal Medicine (K.B.A.), Veterans Affairs Medical Center and University of Kentucky, Lexington, Kentucky 40502; Division of Endocrinology and Metabolism (H.G.F.), Sinai Hospital, Baltimore, Maryland 21215; Division of Endocrinology, Metabolism, and Diabetes (B.R.H.), University of Colorado School of Medicine, Aurora, Colorado 80045; Genzyme (J.M.), a Sanofi Company, Cambridge, Massachusetts 02142; Diabetes, Endocrinology, Obesity Branch (M.C.S.), National Institutes of Health, Bethesda, Maryland 20892; Departments of Head and Neck Surgery (D.L.S.) and Nuclear Medicine (H.R.M.), University of Cincinnati Medical Center, Cincinnati, Ohio 45219.

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September 2015

Exploring the relationship between patients' information preference style and knowledge acquisition process in a computerized patient decision aid randomized controlled trial.

BMC Med Inform Decis Mak 2015 Jun 19;15:48. Epub 2015 Jun 19.

Department of Otolaryngology Head and Neck Surgery, Wharton Head and Neck Centre, University Health Network, 3-952, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

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June 2015

Metastatic thyroid carcinoma to the gastric body.

J Clin Endocrinol Metab 2014 Nov 30;99(11):3958-9. Epub 2014 Oct 30.

Departments of Medicine (K.G.H., M.K., S.E.) and Pathology (S.H.-B., E.S., S.L.A., O.M.), Division of Thoracic Surgery (A.P.), and Departments of Otolaryngology (D.B.) and Radiation Oncology (J.B.), University Health Network, University of Toronto, Toronto, ON M5G 2C4, Canada.

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November 2014

Indications for the use of external beam radiation in thyroid cancer.

Curr Opin Oncol 2014 Jan;26(1):45-50

aDepartment of Radiation Oncology, University of Toronto bDepartment of Radiation Oncology, Princess Margaret Cancer Centre, Toronto.

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January 2014

A randomized controlled trial of lorazepam to reduce liver motion in patients receiving upper abdominal radiation therapy.

Int J Radiat Oncol Biol Phys 2013 Dec 9;87(5):881-7. Epub 2013 Oct 9.

Princess Margaret Cancer Centre, University Health Network, Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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December 2013

Phase II trial of palliative radiotherapy for hepatocellular carcinoma and liver metastases.

J Clin Oncol 2013 Nov 23;31(31):3980-6. Epub 2013 Sep 23.

Hany Soliman, Odette Sunnybrook Cancer Centre, University of Toronto; Jolie Ringash, Haiyan Jiang, John Kim, Robert Dinniwell, Anthony Brade, Rebecca Wong, James Brierley, Bernard Cummings, Camilla Zimmermann, and Laura A. Dawson, Princess Margaret Cancer Centre, University of Toronto; and Jolie Ringash and Kawalpreet Singh, University of Toronto, Toronto, Ontario, Canada.

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November 2013

The value of collecting population-based cancer stage data to support decision-making at organizational, regional and population levels.

Healthc Q 2013 ;16(3):27-33

James. D. Brierley, MBBS, FRCPC, is a staff radiation oncologist in the Department of Radiation Oncology, University of Toronto, in Toronto, Ontario; a member of the Radiation Medicine Program at Princess Margaret Hospital; stage lead for Cancer Care Ontario (CCO); and surveillance lead for the Canadian Partnership Against Cancer (CPAC). Dr. Brierley can be contacted at 416-946-2124 or by email at

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June 2014

Closing the quality loop: facilitating improvement in oncology practice through timely access to clinical performance indicators.

J Oncol Pract 2013 Sep 2;9(5):e255-61. Epub 2013 Jul 2.

Cancer Care Ontario; University Health Network; Mount Sinai Hosptial; University of Toronto, Toronto; Trillium Health Partners, Mississauga; Grand River Hospital, Kitchener; and McMaster University, Hamilton, Ontario, Canada.

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September 2013

Progress in bioleaching: part B: applications of microbial processes by the minerals industries.

Appl Microbiol Biotechnol 2013 Sep 23;97(17):7543-52. Epub 2013 Jul 23.

Brierley Consultancy LLC, 2074 Terrace Drive, Highlands Ranch, CO 80126-2692, USA.

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September 2013

Esophageal cancer in Canada: trends according to morphology and anatomical location.

Can J Gastroenterol 2012 Oct;26(10):723-7

Centre for Chronic Disease Prevention and Control, Public Health Agency of Canada, Ottawa, Canada.

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October 2012

The role of external beam radiation and targeted therapy in thyroid cancer.

Semin Radiat Oncol 2012 Jul;22(3):254-62

Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital, Toronto, Ontario, Canada.

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July 2012

Comparability of stage data in cancer registries in six countries: lessons from the International Cancer Benchmarking Partnership.

Int J Cancer 2013 Feb 28;132(3):676-85. Epub 2012 Jun 28.

Cancer Research UK Cancer Survival Group, Department of Non-Communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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February 2013

Parathyroid cancer: outcome analysis of 16 patients treated at the Princess Margaret Hospital.

Head Neck 2013 Jan 31;35(1):35-9. Epub 2012 Jan 31.

Departments of Otolaryngology - Head and Neck Surgery/Surgical Oncology, Princess Margaret Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada.

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January 2013

Update on external beam radiation therapy in thyroid cancer.

Authors:
James D Brierley

J Clin Endocrinol Metab 2011 Aug;96(8):2289-95

Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada.

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August 2011

Do patients consider preoperative chemoradiation for primary rectal cancer worthwhile?

Cancer 2011 Jul 10;117(13):2853-62. Epub 2011 Jan 10.

Division of General Surgery, Toronto General Hospital and Toronto General Research Institute, Toronto, Ontario, Canada.

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July 2011

Differentiated thyroid cancer with extrathyroidal extension: prognosis and the role of external beam radiotherapy.

J Thyroid Res 2010 May 6;2010:183461. Epub 2010 May 6.

Department of Radiation Oncology, Tom Baker Cancer Centre, Calgary, AB, Canada T2N 4N2.

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May 2010

Decision aid on radioactive iodine treatment for early stage papillary thyroid cancer--a randomized controlled trial.

Trials 2010 Jul 26;11:81. Epub 2010 Jul 26.

Division of Endocrinology, Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, Canada.

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July 2010

Interfraction and respiratory organ motion during conformal radiotherapy in gastric cancer.

Int J Radiat Oncol Biol Phys 2010 May 6;77(1):53-9. Epub 2009 Aug 6.

Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada.

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May 2010

Phase I study of individualized stereotactic body radiotherapy of liver metastases.

J Clin Oncol 2009 Apr 2;27(10):1585-91. Epub 2009 Mar 2.

Radiation Medicine Program, Department of Biostatistics and Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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April 2009

Treatment of rectal cancer metastases to the thyroid gland: report of two cases.

Clin Colorectal Cancer 2008 Jul;7(4):280-2

Department of Medical Oncology and Hematology, University of Toronto, Princess Margaret Hospital, Ontario, Canada.

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July 2008

Adherence to surveillance guidelines after curative resection for stage II/III colorectal cancer.

Clin Colorectal Cancer 2008 May;7(3):191-6

Department of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, Ontario, Canada.

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May 2008

External beam radiation therapy for thyroid cancer.

Endocrinol Metab Clin North Am 2008 Jun;37(2):497-509, xi

Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital, Toronto, ON, Canada.

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June 2008

Neuroendocrine tumors of the gastrointestinal tract: a decade of experience at the Princess Margaret Hospital.

Am J Clin Oncol 2008 Feb;31(1):64-70

Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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February 2008

Effect of concurrent high-dose cisplatin chemotherapy and conformal radiotherapy on cervical esophageal cancer survival.

Int J Radiat Oncol Biol Phys 2008 Jul 31;71(3):735-40. Epub 2007 Dec 31.

Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada.

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July 2008

A systematic review of the gonadal effects of therapeutic radioactive iodine in male thyroid cancer survivors.

Clin Endocrinol (Oxf) 2008 Apr 31;68(4):610-7. Epub 2007 Oct 31.

Division of Endocrinology, Department of Medicine, University Health Network Toronto, Ontario, Canada.

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April 2008

Clinical management and outcome of papillary and follicular (differentiated) thyroid cancer presenting with distant metastasis at diagnosis.

Cancer 2007 Oct;110(7):1451-6

Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada.

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October 2007

An evidence-based review of poorly differentiated thyroid cancer.

World J Surg 2007 May;31(5):934-45

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA.

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May 2007