James Boyer

James Boyer

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Bile acid metabolism and T cell responses in cholangiopathy: Not one-way traffic.

J Hepatol 2019 Oct 22;71(4):657-659. Epub 2019 Aug 22.

Yale Liver Center, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.jhep.2019.07.012DOI Listing
October 2019

Bile-Derived Organoids From Patients With Primary Sclerosing Cholangitis Recapitulate Their Inflammatory Immune Profile.

Hepatology 2019 Sep 13;70(3):871-882. Epub 2019 Mar 13.

Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1002/hep.30470DOI Listing
September 2019

Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies.

Methods Mol Biol 2019 ;1981:363-372

Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1007/978-1-4939-9420-5_24DOI Listing
August 2019

Tensile force exerted by suture during renorrhaphy using current techniques.

J Robot Surg 2019 Jul 12. Epub 2019 Jul 12.

Advanced Urology Associates, 1541 Riverboat Center Drive, Joliet, IL, 60431, USA.

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http://dx.doi.org/10.1007/s11701-019-00999-yDOI Listing
July 2019

Harold J. Fallon, M.D. (1931-2018).

Authors:
James L Boyer

Hepatology 2019 May 27;69(5):2308-2309. Epub 2019 Mar 27.

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http://dx.doi.org/10.1002/hep.30585DOI Listing
May 2019

Bile Infarcts: New Insights Into the Pathogenesis of Obstructive Cholestasis.

Hepatology 2019 Feb 16;69(2):473-475. Epub 2019 Jan 16.

The Liver Center, Yale University School of Medicine, New Haven, Connecticut.

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http://doi.wiley.com/10.1002/hep.30291
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http://dx.doi.org/10.1002/hep.30291DOI Listing
February 2019

Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases.

Hepatology 2019 Jan 6;69(1):394-419. Epub 2018 Nov 6.

University of Texas Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1002/hep.30145DOI Listing
January 2019

Histologic features of autoimmune hepatitis: a critical appraisal.

Hum Pathol 2018 12 21;82:51-60. Epub 2018 Jul 21.

Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520-8023, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183028
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http://dx.doi.org/10.1016/j.humpath.2018.07.014DOI Listing
December 2018

Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis.

Gastroenterology 2018 11 29;155(5):1578-1592.e16. Epub 2018 Jul 29.

Cholestatic Liver Diseases Center and Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183481
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http://dx.doi.org/10.1053/j.gastro.2018.07.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221191PMC
November 2018

Cenicriviroc, a cytokine receptor antagonist, potentiates all-trans retinoic acid in reducing liver injury in cholestatic rodents.

Liver Int 2018 06 13;38(6):1128-1138. Epub 2018 Feb 13.

Liver Center, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1111/liv.13698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032984PMC
June 2018

Primary Sclerosing Cholangitis Is Not Rare Among Blacks in a Multicenter North American Consortium.

Clin Gastroenterol Hepatol 2018 04 2;16(4):591-593. Epub 2017 Nov 2.

Division of Gastroenterology and Hepatology, University of California-Davis School of Medicine, Sacramento, California.

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http://dx.doi.org/10.1016/j.cgh.2017.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860952PMC
April 2018

OSTα-OSTβ Guards the Ileal Enterocyte From the Accumulation of Toxic Levels of Bile Acids.

Authors:
James L Boyer

Cell Mol Gastroenterol Hepatol 2018 10;5(4):649-650. Epub 2018 Feb 10.

Liver Center, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1016/j.jcmgh.2018.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924743PMC
February 2018

Maintaining a Vibrant and Productive Laboratory as a Senior Investigator.

Authors:
James L Boyer

Cell Mol Gastroenterol Hepatol 2017 Sep 7;4(2):299-300. Epub 2017 Jun 7.

Ensign Professor of Medicine, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1016/j.jcmgh.2017.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560913PMC
September 2017

Mechanisms of bile acid mediated inflammation in the liver.

Mol Aspects Med 2017 08 1;56:45-53. Epub 2017 Jul 1.

The Liver Center, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00982997173003
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http://dx.doi.org/10.1016/j.mam.2017.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662014PMC
August 2017

A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization.

PLoS One 2016 28;11(6):e0158269. Epub 2016 Jun 28.

Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158269PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924846PMC
July 2017

Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury.

Inflamm Cell Signal 2017 19;4(2). Epub 2017 Jun 19.

Department of Internal Medicine and Liver Center, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553904PMC
June 2017

The Role of Inflammation in the Mechanisms of Bile Acid-Induced Liver Damage.

Dig Dis 2017 1;35(3):232-234. Epub 2017 Mar 1.

Liver Center, Yale University, School of Medicine, New Haven, Conn., USA.

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http://dx.doi.org/10.1159/000450916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051694PMC
May 2017

Na-taurocholate cotransporting polypeptide (NTCP/SLC10A1) ortholog in the marine skate is not a physiological bile salt transporter.

Am J Physiol Regul Integr Comp Physiol 2017 04 11;312(4):R477-R484. Epub 2017 Jan 11.

Department of Internal Medicine and Liver Center, Yale University School of Medicine, New Haven, Connecticut; and

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http://www.physiology.org/doi/10.1152/ajpregu.00302.2016
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http://dx.doi.org/10.1152/ajpregu.00302.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407083PMC
April 2017

Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.

JCI Insight 2017 03 9;2(5):e90780. Epub 2017 Mar 9.

Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1172/jci.insight.90780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333973PMC
March 2017

Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study.

J Clin Gastroenterol 2017 Feb;51(2):e11-e16

*Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine †Research Pharmacy, Yale-New Haven Hospital §Yale University School of Public Health, New Haven, CT ‡Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN ∥Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center ¶Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH #College of Health Solutions, Arizona State University, Tempe, AZ.

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http://dx.doi.org/10.1097/MCG.0000000000000591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218875PMC
February 2017

CFTR-associated ligand is a negative regulator of Mrp2 expression.

Am J Physiol Cell Physiol 2017 Jan 9;312(1):C40-C46. Epub 2016 Nov 9.

The Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut

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http://dx.doi.org/10.1152/ajpcell.00100.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283898PMC
January 2017

A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients.

Dig Dis Sci 2016 12 1;61(12):3506-3512. Epub 2016 Oct 1.

Section of Digestive Diseases, Yale University School of Medicine, 333 Cedar St, 1080 LMP, New Haven, CT, 06510, USA.

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http://dx.doi.org/10.1007/s10620-016-4322-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106299PMC
December 2016

Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis.

Hepatology 2016 12 28;64(6):2151-2164. Epub 2016 Oct 28.

Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1002/hep.28826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115990PMC
December 2016

Treatment of chronic cholestasis: What we know and what we will know?

Authors:
James L Boyer

Clin Liver Dis (Hoboken) 2016 Dec 30;8(6):140-144. Epub 2016 Dec 30.

Department of Internal Medicine Yale University School of Medicine New Haven CT.

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http://dx.doi.org/10.1002/cld.591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490239PMC
December 2016

APC controls asymmetric Wnt/β-catenin signaling and cardiomyocyte proliferation gradient in the heart.

J Mol Cell Cardiol 2015 Dec 19;89(Pt B):287-96. Epub 2015 Oct 19.

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Room 293, Dwan Variety Club Cardiovascular Research Center, 425 E River Pkwy, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801005PMC
December 2015

Fibrates and cholestasis.

Hepatology 2015 Aug 23;62(2):635-43. Epub 2015 Mar 23.

Department of Internal Medicine, Liver Center, Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1002/hep.27744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515188PMC
August 2015

The origins of hepatobiliary and gastrointestinal physiology.

Authors:
James L Boyer

Hepatology 2015 May 18;61(5):1452-4. Epub 2015 Mar 18.

Ensign Professor of Medicine, Yale University School of Medicine, New Haven, CT 06519.

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http://dx.doi.org/10.1002/hep.27737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447183PMC
May 2015

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats.

Science 2015 Mar 26;347(6227):1253-6. Epub 2015 Feb 26.

Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1126/science.aaa0672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495920PMC
March 2015

The hepatobiliary paracellular pathway: a paradigm revisited.

Authors:
James L Boyer

Gastroenterology 2014 Nov 26;147(5):965-8. Epub 2014 Sep 26.

Department of Medicine and Liver Center, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.09.018DOI Listing
November 2014

Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations.

Mol Aspects Med 2014 Jun 15;37:3-14. Epub 2013 May 15.

Yale University School of Medicine, Department of Internal Medicine, New Haven, CT 06520, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2013.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784619PMC
June 2014

Reversible posterior leukoencephalopathy syndrome during regorafenib treatment: a case report and literature review of reversible posterior leukoencephalopathy syndrome associated with multikinase inhibitors.

Clin Colorectal Cancer 2014 Jun 27;13(2):127-30. Epub 2013 Dec 27.

Division of Hematology/Oncology, Department of Medicine and the UVA Cancer Center, University of Virginia Health System, Charlottesville, VA.

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http://dx.doi.org/10.1016/j.clcc.2013.12.003DOI Listing
June 2014

Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice.

Am J Physiol Gastrointest Liver Physiol 2014 Apr 30;306(8):G670-6. Epub 2014 Jan 30.

Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1152/ajpgi.00334.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989703PMC
April 2014

All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice.

J Pharmacol Exp Ther 2014 Apr 3;349(1):94-8. Epub 2014 Feb 3.

Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut.

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http://jpet.aspetjournals.org/content/349/1/94.full.pdf
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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.113.20935
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http://dx.doi.org/10.1124/jpet.113.209353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965885PMC
April 2014

Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice.

J Hepatol 2014 Jan 23;60(1):160-6. Epub 2013 Aug 23.

Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2013.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054607PMC
January 2014

Bile formation and secretion.

Authors:
James L Boyer

Compr Physiol 2013 Jul;3(3):1035-78

Department of Medicine and Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1002/cphy.c120027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091928PMC
July 2013

Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion.

Hepatology 2013 Jun;57(6):2418-26

Department of Internal Medicine and Liver Center, Yale University School of Medicine, New Haven, CT; Mount Desert Island Biological Laboratory, Salisbury Cove, ME, USA.

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http://dx.doi.org/10.1002/hep.26161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604052PMC
June 2013

Nodular regenerative hyperplasia in common variable immunodeficiency.

J Clin Immunol 2013 May 19;33(4):748-58. Epub 2013 Feb 19.

Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s10875-013-9873-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731765PMC
May 2013

Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2).

J Lipid Res 2012 Aug 5;53(8):1535-42. Epub 2012 Jun 5.

Department of Internal Medicine and Liver Center, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1194/jlr.M025726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540847PMC
August 2012

A C-terminal tyrosine-based motif in the bile salt export pump directs clathrin-dependent endocytosis.

Hepatology 2012 Jun 25;55(6):1901-11. Epub 2012 Apr 25.

Liver Center, Yale University School of Medicine, New Haven, CT06520-8019, USA.

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http://dx.doi.org/10.1002/hep.25523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319652PMC
June 2012

A cholecystohepatic shunt pathway: does the gallbladder protect the liver?

Gastroenterology 2012 Jun 26;142(7):1416-9. Epub 2012 Apr 26.

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http://dx.doi.org/10.1053/j.gastro.2012.04.036DOI Listing
June 2012

Ostα depletion protects liver from oral bile acid load.

Am J Physiol Gastrointest Liver Physiol 2011 Sep 30;301(3):G574-9. Epub 2011 Jun 30.

Yale Liver Center, Yale University School of Medicine, New Haven, CT 06520-8019, USA.

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http://ajpgi.physiology.org/content/ajpgi/early/2011/06/24/a
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http://ajpgi.physiology.org/cgi/doi/10.1152/ajpgi.00141.2011
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http://dx.doi.org/10.1152/ajpgi.00141.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174539PMC
September 2011

Drug-induced cholestasis.

Hepatology 2011 Apr;53(4):1377-87

Division of Gastroenterology, Centennial Hills Hospital Medical Center, Las Vegas, NV, USA.

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http://dx.doi.org/10.1002/hep.24229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089004PMC
April 2011

Small-duct sclerosing cholangitis associated with Schistosoma mansoni.

Hepatology 2011 Feb 29;53(2):712-3. Epub 2010 Sep 29.

Liver Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8019, USA.

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http://dx.doi.org/10.1002/hep.23958DOI Listing
February 2011

Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis in mice.

Toxicol Appl Pharmacol 2011 Feb 4;251(1):59-69. Epub 2010 Dec 4.

Centre for Liver Research, School of Digestive & Liver Diseases, Institute of Post Graduate Medical Education & Research, Kolkata, India.

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http://dx.doi.org/10.1016/j.taap.2010.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745774PMC
February 2011

Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells.

Hepatology 2011 Feb 10;53(2):548-57. Epub 2010 Dec 10.

Yale Liver Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1002/hep.24047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069505PMC
February 2011

Psychological stress is associated with relapse in type 1 autoimmune hepatitis.

Liver Int 2010 Nov 16;30(10):1439-47. Epub 2010 Sep 16.

Liver Center, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1111/j.1478-3231.2010.02333.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735904PMC
November 2010

Role of breast cancer resistance protein in the adaptive response to cholestasis.

Drug Metab Dispos 2010 Oct 2;38(10):1673-8. Epub 2010 Jul 2.

Department of Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8019, USA.

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http://dx.doi.org/10.1124/dmd.110.034512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957168PMC
October 2010

Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.

J Lipid Res 2010 Aug 25;51(8):2265-74. Epub 2010 Mar 25.

Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M005546
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http://dx.doi.org/10.1194/jlr.M005546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903807PMC
August 2010

Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.

Am J Physiol Gastrointest Liver Physiol 2010 Jul 15;299(1):G126-35. Epub 2010 Apr 15.

Department of Medicine and Liver Center, Yale University School of Medicine, New Haven, CT 06520-8019, USA.

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http://ajpgi.physiology.org/content/ajpgi/299/1/G126.full.pd
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http://ajpgi.physiology.org/cgi/doi/10.1152/ajpgi.00522.2010
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http://dx.doi.org/10.1152/ajpgi.00522.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904108PMC
July 2010

NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function.

J Biol Chem 2010 Jun 19;285(25):19299-307. Epub 2010 Apr 19.

Liver Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1074/jbc.M109.096081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885208PMC
June 2010

Cholestasis: genetic and acquired.

Authors:
James L Boyer

Semin Liver Dis 2010 May 26;30(2):113-5. Epub 2010 Apr 26.

Liver Center, Yale University School of Medicine, New Haven, Connecticut 06510-8019, USA.

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http://dx.doi.org/10.1055/s-0030-1253220DOI Listing
May 2010

The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease.

Semin Liver Dis 2010 May 26;30(2):125-33. Epub 2010 Apr 26.

Liver Center, Yale University School of Medicine, New Haven, Connecticut 06510-8019, USA.

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http://dx.doi.org/10.1055/s-0030-1253222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008346PMC
May 2010

Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis.

Semin Liver Dis 2010 May 26;30(2):178-85. Epub 2010 Apr 26.

Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven Connecticut 06520-8019, USA.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0030-1253226
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http://dx.doi.org/10.1055/s-0030-1253226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713633PMC
May 2010

Arsenic (+ 3 oxidation state) methyltransferase and the methylation of arsenicals in the invertebrate chordate Ciona intestinalis.

Toxicol Sci 2010 Jan 15;113(1):70-6. Epub 2009 Oct 15.

Pharmacokinetics Branch, Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.

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https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
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http://dx.doi.org/10.1093/toxsci/kfp250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902911PMC
January 2010

Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis.

Hepatology 2010 Jan;51(1):181-90

Yale Liver Center, Yale University School of Medicine, New Haven, CT 06520-8019, USA.

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http://dx.doi.org/10.1002/hep.23265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819820PMC
January 2010

Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression.

Hepatology 2009 Nov;50(5):1588-96

From the Department of Internal Medicine, Liver Center, Yale University, School of Medicine, New Haven, CT 06519-8019, USA.

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http://dx.doi.org/10.1002/hep.23151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013376PMC
November 2009

Bile canalicular secretion - tales from Vienna and Yale.

Authors:
James L Boyer

Wien Med Wochenschr 2008 ;158(19-20):534-8

Liver Center, Yale University School of Medicine, New Haven, CT 06520-8019, USA.

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http://dx.doi.org/10.1007/s10354-008-0591-2DOI Listing
June 2009

Hepatic uptake and biliary excretion of manganese in the little skate, Leucoraja erinacea.

Comp Biochem Physiol C Toxicol Pharmacol 2009 May 24;149(4):566-71. Epub 2008 Dec 24.

Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.cbpc.2008.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666776PMC
May 2009

ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained.

Gastroenterology 2009 Mar 1;136(3):1060-9. Epub 2008 Nov 1.

Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439851PMC
March 2009

It's all about bile.

Authors:
James L Boyer

Hepatology 2009 Mar;49(3):711-23

Department of Medicine, Liver Center, Yale University School of Medicine, New Haven, CT 06520-8019, USA.

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http://dx.doi.org/10.1002/hep.22719DOI Listing
March 2009

OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids.

Front Biosci (Landmark Ed) 2009 Jan 1;14:2829-44. Epub 2009 Jan 1.

Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA.

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http://dx.doi.org/10.2741/3416DOI Listing
January 2009

Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II.

Hepatology 2008 Nov;48(5):1558-69

Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://doi.wiley.com/10.1002/hep.22499
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http://dx.doi.org/10.1002/hep.22499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587109PMC
November 2008

N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta.

BMC Cell Biol 2008 Oct 10;9:57. Epub 2008 Oct 10.

Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1186/1471-2121-9-57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575201PMC
October 2008

Membrane trafficking of the human organic anion-transporting polypeptide C (hOATPC).

Pharm Res 2008 Feb 20;25(2):463-74. Epub 2007 Jul 20.

Department of Pediatrics, Mount Sinai School of Medicine, PO Box 1664, One Gustave L. Levy Place, New York, NY 10029-6574, USA.

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http://dx.doi.org/10.1007/s11095-007-9399-9DOI Listing
February 2008

Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases.

Am J Physiol Cell Physiol 2007 Nov 13;293(5):C1709-16. Epub 2007 Sep 13.

Liver Center and Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8019, USA.

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http://dx.doi.org/10.1152/ajpcell.00327.2007DOI Listing
November 2007

The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution.

Am J Physiol Regul Integr Comp Physiol 2007 Sep 13;293(3):R1400-9. Epub 2007 Jun 13.

Liver Center, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

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September 2007

Phloracetophenone-induced choleresis in rats is mediated through Mrp2.

Am J Physiol Gastrointest Liver Physiol 2007 Jul 15;293(1):G66-74. Epub 2007 Mar 15.

Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.

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July 2007

Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression.

Am J Physiol Gastrointest Liver Physiol 2007 May 1;292(5):G1221-7. Epub 2007 Feb 1.

Liver Center, Yale Univ. School of Medicine, P.O. Box 208019, 333 Cedar St., 1080 LMP, New Haven, CT 06520-8019, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605854PMC
May 2007

New perspectives for the treatment of cholestasis: lessons from basic science applied clinically.

Authors:
James L Boyer

J Hepatol 2007 Mar 18;46(3):365-71. Epub 2006 Dec 18.

Liver Center, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208019, New Haven, CT 06520-8019, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847591PMC
March 2007

Differential effects of hydroxyacetophenone analogues on the transcytotic vesicular pathway in rat liver.

Eur J Pharmacol 2006 Oct 25;547(1-3):152-9. Epub 2006 Jul 25.

Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, Thailand.

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http://dx.doi.org/10.1016/j.ejphar.2006.07.018DOI Listing
October 2006

The comparative toxicogenomics database: a cross-species resource for building chemical-gene interaction networks.

Toxicol Sci 2006 Aug 4;92(2):587-95. Epub 2006 May 4.

Department of Bioinformatics, Mount Desert Island Biological Laboratory, Salisbury Cove, Maine 04672, USA.

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http://dx.doi.org/10.1093/toxsci/kfl008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1586111PMC
August 2006

Hepatic and extrahepatic synthesis and disposition of dinitrophenyl-S-glutathione in bile duct-ligated rats.

Drug Metab Dispos 2006 Aug 5;34(8):1301-9. Epub 2006 May 5.

Instituto de Fisiología Experimental, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 570 (S2002LRL)-Rosario, Argentina.

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http://dx.doi.org/10.1124/dmd.106.009415DOI Listing
August 2006

Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.

Am J Physiol Gastrointest Liver Physiol 2006 Jun 19;290(6):G1124-30. Epub 2006 Jan 19.

Liver Center, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1152/ajpgi.00539.2005DOI Listing
June 2006

Retention of structural and functional polarity in cultured skate hepatocytes undergoing in vitro morphogenesis.

Comp Biochem Physiol B Biochem Mol Biol 2006 Jun 6;144(2):167-79. Epub 2006 Mar 6.

Department of Environmental Medicine, Box EHSC, University of Rochester School of Medicine, Rochester, NY 14642, United States.

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http://dx.doi.org/10.1016/j.cbpb.2006.02.005DOI Listing
June 2006

FXR: a target for cholestatic syndromes?

Expert Opin Ther Targets 2006 Jun;10(3):409-21

Liver Center, Department of Medicine, Yale University School of Medicine, P.O. Box 208019, New Haven, CT 06520-8019, USA.

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http://dx.doi.org/10.1517/14728222.10.3.409 DOI Listing
June 2006

Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis.

Hepatology 2006 May;43(5):1013-21

Liver Center and Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1002/hep.21158DOI Listing
May 2006

OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia.

Hepatology 2005 Dec;42(6):1270-9

Department of Environmental Medicine, University of Rochester School of Medicine, NY 14642, USA.

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http://dx.doi.org/10.1002/hep.20961DOI Listing
December 2005

A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease.

Development 2005 Aug 6;132(15):3561-72. Epub 2005 Jul 6.

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge MA 02139, USA.

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http://dx.doi.org/10.1242/dev.01918DOI Listing
August 2005

Liver biopsy: evolving role in the new millennium.

J Clin Gastroenterol 2005 Aug;39(7):603-10

Department of Internal Medicine, Section of Digestive Diseases and Liver Center, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1097/01.mcg.0000170742.59134.60DOI Listing
August 2005

Nuclear receptor ligands: rational and effective therapy for chronic cholestatic liver disease?

Authors:
James L Boyer

Gastroenterology 2005 Aug;129(2):735-40

Liver Center, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, 06520, USA.

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August 2005

Cholestatic syndromes.

Curr Opin Gastroenterol 2002 May;18(3):314-29

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Karl-Franzens University, School of Medicine, Graz, Austria.

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May 2002