James B Brewer

James B Brewer

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James B Brewer

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High-Throughput Mass Spectrometry Assay for Quantifying β-Amyloid 40 and 42 in Cerebrospinal Fluid.

Clin Chem 2019 Dec 18;65(12):1572-1580. Epub 2019 Oct 18.

Quest Diagnostics Nichols Institute, San Juan Capistrano, CA;

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http://dx.doi.org/10.1373/clinchem.2018.300947DOI Listing
December 2019

Associations Between Microstructure, Amyloid, and Cognition in Amnestic Mild Cognitive Impairment and Dementia.

J Alzheimers Dis 2019 Nov 23. Epub 2019 Nov 23.

Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.3233/JAD-190871DOI Listing
November 2019

Tau and atrophy: domain-specific relationships with cognition.

Alzheimers Res Ther 2019 Jul 27;11(1):65. Epub 2019 Jul 27.

Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1186/s13195-019-0518-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661099PMC
July 2019

Trajectories of cognitive decline differ in hippocampal sclerosis and Alzheimer's disease.

Neurobiol Aging 2019 03 22;75:169-177. Epub 2018 Nov 22.

Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492933PMC
March 2019

Microstructural brain changes track cognitive decline in mild cognitive impairment.

Neuroimage Clin 2018 26;20:883-891. Epub 2018 Sep 26.

Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA; Department of Radiology, University of California, San Diego, La Jolla, CA, USA; Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2018.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171091PMC
January 2019

Combined Biomarker Prognosis of Mild Cognitive Impairment: An 11-Year Follow-Up Study in the Alzheimer's Disease Neuroimaging Initiative.

J Alzheimers Dis 2019 ;68(4):1549-1559

Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.3233/JAD-181243DOI Listing
January 2019

A phase 3 trial of IV immunoglobulin for Alzheimer disease.

Neurology 2017 May 5;88(18):1768-1775. Epub 2017 Apr 5.

From Weill Cornell Medicine (N.R.R., P.S.), New York, NY; University of California (R.G.T., R.A.R., J.B.B.), San Diego; University of Southern California (M.S.R., R.R., P.S.A.), Los Angeles; Yale University (C.H.v.D.), New Haven, CT; Mayo Clinic (C.R.J., D.S.K.), Rochester, MN; Mount Sinai School of Medicine (M.S.), New York, NY; and Baxalta (D.M.G., S.F.), Bannockburn, IL.

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http://dx.doi.org/10.1212/WNL.0000000000003904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409846PMC
May 2017

I know I've seen you before: Distinguishing recent-single-exposure-based familiarity from pre-existing familiarity.

Brain Res 2017 03 7;1658:11-24. Epub 2017 Jan 7.

Department of Psychology, The Hebrew University in Jerusalem, Mount Scopus, Jerusalem 91905, Israel; Department of Cognitive Sciences, The Hebrew University in Jerusalem, Mount Scopus, Jerusalem 91905, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2017.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867277PMC
March 2017

Dose-Dependent Cortical Thinning After Partial Brain Irradiation in High-Grade Glioma.

Int J Radiat Oncol Biol Phys 2016 Feb 21;94(2):297-304. Epub 2015 Oct 21.

Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2015.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747044PMC
February 2016

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease.

Neurology 2015 Oct 11;85(16):1383-91. Epub 2015 Sep 11.

From the Department of Neurology (R.S.T., B.A.R.), Georgetown University, Washington, DC; the Department of Neurosciences (R.G.T., J.B.B., R.A.R., R.R., P.S.A.), University of California, San Diego, La Jolla; the Department of Internal Medicine (S.C.), Wake Forest University, Winston-Salem, NC; the Departments of Psychiatry, Neurology, and Neurobiology (C.H.v.D.), Yale University, New Haven, CT; and the Clinical Biotechnology Research Institute (J.M.), Roper St. Francis Healthcare, Charleston, SC.

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http://www.neurology.org/content/early/2015/09/11/WNL.000000
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http://www.neurology.org/content/early/2015/09/11/WNL.000000
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000203
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http://dx.doi.org/10.1212/WNL.0000000000002035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626244PMC
October 2015

The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome.

Front Behav Neurosci 2015 14;9:239. Epub 2015 Sep 14.

Alzheimer's Disease Cooperative Study, Department of Neurosciences, UC San Diego School of Medicine, University of California, San Diego La Jolla, CA, USA.

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http://dx.doi.org/10.3389/fnbeh.2015.00239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568340PMC
October 2015

Prospective longitudinal MRI study of brain volumes and diffusion changes during the first year after moderate to severe traumatic brain injury.

Neuroimage Clin 2014 28;5:128-40. Epub 2014 Mar 28.

Department of Medical Imaging, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway ; Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

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http://www.cortechslabs.com/wp-content/uploads/2015/07/Prosp
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http://linkinghub.elsevier.com/retrieve/pii/S221315821400042
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http://dx.doi.org/10.1016/j.nicl.2014.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110353PMC
February 2015

Mean signal and response time influences on multivoxel signals of contextual retrieval in the medial temporal lobe.

Brain Behav 2015 Feb 24;5(2):e00302. Epub 2014 Dec 24.

Department of Neurosciences, University of California, San Diego 9500 Gilman Dr., La Jolla, California, 92093-0949 ; Department of Radiology, University of California, San Diego 9500 Gilman Dr., La Jolla, California, 92093-0949.

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http://dx.doi.org/10.1002/brb3.302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312925PMC
February 2015

Elaboration versus suppression of cued memories: influence of memory recall instruction and success on parietal lobe, default network, and hippocampal activity.

PLoS One 2014 19;9(2):e89037. Epub 2014 Feb 19.

Department of Neurosciences, University of California San Diego, San Diego, California, United States of America ; Department of Radiology, University of California San Diego, San Diego, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089037PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929625PMC
January 2015

Neuropsychiatric symptoms and regional neocortical atrophy in mild cognitive impairment and Alzheimer's disease.

Am J Alzheimers Dis Other Demen 2014 Mar 27;29(2):159-65. Epub 2013 Oct 27.

1Department of Neurosciences, University of California, San Diego, CA, USA.

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http://dx.doi.org/10.1177/1533317513507373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351414PMC
March 2014

The role of clusterin in amyloid-β-associated neurodegeneration.

JAMA Neurol 2014 Feb;71(2):180-7

Department of Radiology, University of California, San Diego, La Jolla2Department of Psychiatry, University of California, San Diego, La Jolla.

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http://dx.doi.org/10.1001/jamaneurol.2013.4560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118752PMC
February 2014

Imbalance of incidental encoding across tasks: an explanation for non-memory-related hippocampal activations?

J Exp Psychol Gen 2013 Nov 17;142(4):1171-9. Epub 2013 Jun 17.

Department of Neurosciences.

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http://dx.doi.org/10.1037/a0033461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834009PMC
November 2013

Heart fatty acid binding protein and Aβ-associated Alzheimer's neurodegeneration.

Mol Neurodegener 2013 Oct 2;8:39. Epub 2013 Oct 2.

Department of Radiology, University of California, San Diego, 8950 Villa La Jolla Drive, Suite C101, La Jolla, CA 92037-0841, USA.

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http://dx.doi.org/10.1186/1750-1326-8-39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850652PMC
October 2013

Effortful retrieval reduces hippocampal activity and impairs incidental encoding.

Hippocampus 2013 May 2;23(5):367-79. Epub 2013 Feb 2.

Department of Neurosciences, University of California, San Diego, California, USA.

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http://dx.doi.org/10.1002/hipo.22096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049294PMC
May 2013

Retrieval search and strength evoke dissociable brain activity during episodic memory recall.

J Cogn Neurosci 2013 Feb 28;25(2):219-33. Epub 2012 Nov 28.

University of California, San Diego, CA, USA.

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http://dx.doi.org/10.1162/jocn_a_00335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091972PMC
February 2013

Erratum: search-related suppression of hippocampus and default network activity during associative memory retrieval.

Front Hum Neurosci 2013 24;7. Epub 2013 Jan 24.

Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.3389/fnhum.2013.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553375PMC
January 2013

Amyloid-β--associated clinical decline occurs only in the presence of elevated P-tau.

Arch Neurol 2012 Jun;69(6):709-13

Department of Radiology, University of California–San Diego, 8950 Villa La Jolla Dr, Ste C101, La Jolla, CA 92037-0841, USA.

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http://dx.doi.org/10.1001/archneurol.2011.3354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423526PMC
June 2012

Biomarkers for the clinical evaluation of the cognitively impaired elderly: amyloid is not enough.

Imaging Med 2012 Jun;4(3):343-357

Departments of Radiology & Neurosciences, University of California, 9500 Gilman Drive, MC 0949, La Jolla, San Diego, CA 92093-0949, USA.

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http://dx.doi.org/10.2217/iim.12.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573528PMC
June 2012

Interregional correlations in Parkinson disease and Parkinson-related dementia with resting functional MR imaging.

Radiology 2012 Apr 27;263(1):226-34. Epub 2012 Feb 27.

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0949, USA.

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http://pubs.rsna.org/doi/10.1148/radiol.12111280
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http://dx.doi.org/10.1148/radiol.12111280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309803PMC
April 2012

Stability of resting fMRI interregional correlations analyzed in subject-native space: a one-year longitudinal study in healthy adults and premanifest Huntington's disease.

Neuroimage 2012 Feb 10;59(3):2452-63. Epub 2011 Sep 10.

Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0949, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2011.08.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254727PMC
February 2012

Search-Related Suppression of Hippocampus and Default Network Activity during Associative Memory Retrieval.

Front Hum Neurosci 2011 30;5:112. Epub 2011 Oct 30.

Department of Neurosciences, University of California San Diego, CA, USA.

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http://dx.doi.org/10.3389/fnhum.2011.00112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202230PMC
November 2011

Amyloid-β associated volume loss occurs only in the presence of phospho-tau.

Ann Neurol 2011 Oct 14;70(4):657-61. Epub 2011 Oct 14.

Department of Radiology, University of California-San Diego, La Jolla 92037, CA.

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http://dx.doi.org/10.1002/ana.22509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368003PMC
October 2011

Default network correlations analyzed on native surfaces.

J Neurosci Methods 2011 Jun 14;198(2):301-11. Epub 2011 Apr 14.

Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0949, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2011.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111080PMC
June 2011

Early stages of figure-ground segregation during perception of the face-vase.

J Cogn Neurosci 2011 Apr 10;23(4):880-95. Epub 2010 Feb 10.

School of Medicine, Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive MC 0608, La Jolla, CA 92093-0608, USA.

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http://dx.doi.org/10.1162/jocn.2010.21438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071650PMC
April 2011

Parietal activity in episodic retrieval measured by fMRI and MEG.

Neuroimage 2011 Mar 4;55(2):788-93. Epub 2010 Dec 4.

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0949, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10538119100155
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http://dx.doi.org/10.1016/j.neuroimage.2010.11.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035726PMC
March 2011

Early parietal response in episodic retrieval revealed with MEG.

Hum Brain Mapp 2011 Feb;32(2):171-81

Department of Bioengineering, University of California, San Diego, California 92093-0949, USA.

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http://dx.doi.org/10.1002/hbm.21014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107600PMC
February 2011

Quantitative structural MRI for early detection of Alzheimer's disease.

Expert Rev Neurother 2010 Nov;10(11):1675-88

Department of Radiology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1586/ern.10.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182103PMC
November 2010

Functional brain imaging in the clinical assessment of consciousness.

PLoS Biol 2010 Nov 30;8(11):e1000548. Epub 2010 Nov 30.

Department of Neurosciences, University of California San Diego, San Diego, California, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1000548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994656PMC
November 2010

Brain atrophy in healthy aging is related to CSF levels of Aβ1-42.

Cereb Cortex 2010 Sep 4;20(9):2069-79. Epub 2010 Jan 4.

Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1093/cercor/bhp279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025722PMC
September 2010

Applications of neuroimaging to disease-modification trials in Alzheimer's disease.

Behav Neurol 2009 ;21(1):129-36

Department of Neurosciences, University of California, San Diego, USA.

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http://dx.doi.org/10.3233/BEN-2009-0241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444278PMC
December 2009

One-year brain atrophy evident in healthy aging.

J Neurosci 2009 Dec;29(48):15223-31

Center for the Study of Human Cognition, Department of Psychology, University of Oslo, 0317 Oslo, Norway.

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http://dx.doi.org/10.1523/JNEUROSCI.3252-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827793PMC
December 2009

Subregional neuroanatomical change as a biomarker for Alzheimer's disease.

Proc Natl Acad Sci U S A 2009 Dec;106(49):20954-9

Department of Neurosciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791580PMC
http://dx.doi.org/10.1073/pnas.0906053106DOI Listing
December 2009

High-throughput, fully automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairment.

Alzheimer Dis Assoc Disord 2009 Apr-Jun;23(2):139-45

Department of Radiology, University of California, San Diego, La Jolla, CA 92093-094, USA.

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http://dx.doi.org/10.1097/WAD.0b013e318192e745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688740PMC
July 2009

Imaging the medial temporal lobe: exploring new dimensions.

Trends Cogn Sci 2002 May;6(5):217-223

Dept of Neurology, Johns Hopkins Medical Institute, 600 North Wolfe Street, Pathology 509, 21287-7609, Baltimore, MD, USA

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http://dx.doi.org/10.1016/s1364-6613(02)01881-8DOI Listing
May 2002