James Adjaye

James Adjaye

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James Adjaye

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Characterization of burn wound healing gel prepared from human amniotic membrane and Aloe vera extract.

BMC Complement Altern Med 2019 Jun 3;19(1):115. Epub 2019 Jun 3.

Institute of Tissue Banking and Biomaterial Research, Atomic Energy Research Establishment, Dhaka, 1349, Bangladesh.

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http://dx.doi.org/10.1186/s12906-019-2525-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547555PMC
June 2019

Human mid-trimester amniotic fluid (stem) cells lack expression of the pluripotency marker OCT4A.

Sci Rep 2019 May 31;9(1):8126. Epub 2019 May 31.

University College London, Institute for Women's Health, Maternal and Fetal Medicine Department, London, UK.

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http://dx.doi.org/10.1038/s41598-019-44572-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544653PMC
May 2019

Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells.

Stem Cells Int 2019 2;2019:3298432. Epub 2019 May 2.

Institute for Stem Cell Research and Regenerative Medicine, University Hospital Duesseldorf, 40225 Duesseldorf, Germany.

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http://dx.doi.org/10.1155/2019/3298432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525793PMC
May 2019

Author Correction: ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors.

Nat Cell Biol 2019 04;21(4):531-532

Cancer Biology and Genetics Program, Center for Cell Engineering, Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute for Cancer Research, and Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York, 10065, USA.

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http://www.nature.com/articles/s41556-018-0269-y
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http://dx.doi.org/10.1038/s41556-018-0269-yDOI Listing
April 2019

The quest for pluripotency: a comparative analysis across mammalian species.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

S Sudheer, Department of Genomic Science, Central University of Kerala, Periye , India.

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http://dx.doi.org/10.1530/REP-18-0083DOI Listing
April 2019

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature.

Stem Cell Res Ther 2019 Mar 18;10(1):100. Epub 2019 Mar 18.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.

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https://stemcellres.biomedcentral.com/articles/10.1186/s1328
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http://dx.doi.org/10.1186/s13287-019-1209-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423778PMC
March 2019

Imidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs.

iScience 2019 Feb 11;12:168-181. Epub 2019 Jan 11.

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, ImNeuenheimer Feld 364, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354736PMC
February 2019

Cell fate decisions of human iPSC-derived bipotential hepatoblasts depend on cell density.

PLoS One 2018 10;13(7):e0200416. Epub 2018 Jul 10.

Institute for Stem Cell Research and Regenerative Medicine, Medical faculty, Heinrich-Heine University, Düsseldorf, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200416PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039024PMC
January 2019

Fibroblast-derived integration-free iPSC line ISRM-NBS1 from an 18-year-old Nijmegen Breakage Syndrome patient carrying the homozygous NBN c.657_661del5 mutation.

Stem Cell Res 2019 01 27;34:101372. Epub 2018 Dec 27.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.101372DOI Listing
January 2019

Molecular Phenotyping of Telomerized Human Bone Marrow Skeletal Stem Cells Reveals a Genetic Program of Enhanced Proliferation and Maintenance of Differentiation Responses.

JBMR Plus 2018 Sep 24;2(5):257-267. Epub 2018 May 24.

Systems Biology Initiative School of Biotechnology and Biomolecular Sciences University of New South Wales Sydney Australia.

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http://doi.wiley.com/10.1002/jbm4.10050
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http://dx.doi.org/10.1002/jbm4.10050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139702PMC
September 2018

Establishment and characterization of an iPSC line from a 35 years old high grade patient with nonalcoholic fatty liver disease (30-40% steatosis) with homozygous wildtype PNPLA3 genotype.

Stem Cell Res 2018 08 25;31:113-116. Epub 2018 Jul 25.

Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.07.015DOI Listing
August 2018

Establishment and characterization of an iPSC line from a 58 years old high grade patient with nonalcoholic fatty liver disease (70% steatosis) with homozygous wildtype PNPLA3 genotype.

Stem Cell Res 2018 08 27;31:131-134. Epub 2018 Jul 27.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.07.011DOI Listing
August 2018

Lymphoblast-derived integration-free iPSC line AD-TREM2-3 from a 74 year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant.

Stem Cell Res 2018 07 1;30:141-144. Epub 2018 Jun 1.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.05.018DOI Listing
July 2018

Lymphoblast-derived integration-free iPSC line AD-TREM2-1 from a 67year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant.

Stem Cell Res 2018 05 20;29:60-63. Epub 2018 Mar 20.

Institute for Stem Cell Research and Regenerative Medicine (ISRM), Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.03.011DOI Listing
May 2018

Modeling Late-Onset Sporadic Alzheimer's Disease through BMI1 Deficiency.

Cell Rep 2018 05;23(9):2653-2666

Stem Cell and Developmental Biology Laboratory, Hôpital Maisonneuve-Rosemont, 5415 Boul. l'Assomption, Montreal, QC H1T 2M4, Canada; Department of Neurosciences, University of Montreal, Montreal, QC Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.097DOI Listing
May 2018

The presence of human mesenchymal stem cells of renal origin in amniotic fluid increases with gestational time.

Stem Cell Res Ther 2018 04 25;9(1):113. Epub 2018 Apr 25.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225, Düsseldorf, Germany.

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http://dx.doi.org/10.1186/s13287-018-0864-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918774PMC
April 2018

Human pluripotent stem cell derived HLC transcriptome data enables molecular dissection of hepatogenesis.

Sci Data 2018 03 13;5:180035. Epub 2018 Mar 13.

Medical Faculty, Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1038/sdata.2018.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848791PMC
March 2018

Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis.

Glia 2018 01 22;66(1):145-160. Epub 2017 Sep 22.

Department of Neurology, Neuroregeneration, Medical Faculty, Heinrich-Heine-University, Düsseldorf, D-40225, Germany.

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http://dx.doi.org/10.1002/glia.23233DOI Listing
January 2018

Lymphoblast-derived integration-free ISRM-CON9 iPS cell line from a 75year old female.

Stem Cell Res 2018 01 13;26:76-79. Epub 2017 Dec 13.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18735061173026
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http://dx.doi.org/10.1016/j.scr.2017.12.007DOI Listing
January 2018

Derivation and characterization of integration-free iPSC line ISRM-UM51 derived from SIX2-positive renal cells isolated from urine of an African male expressing the CYP2D6 *4/*17 variant which confers intermediate drug metabolizing activity.

Stem Cell Res 2017 12 7;25:18-21. Epub 2017 Oct 7.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2017.10.004DOI Listing
December 2017

Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro.

Stem Cell Res 2017 12 26;25:72-82. Epub 2017 Oct 26.

IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany; Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2017.10.013DOI Listing
December 2017

Isolation and Molecular Characterization of Amniotic Fluid-Derived Mesenchymal Stem Cells Obtained from Caesarean Sections.

Stem Cells Int 2017 31;2017:5932706. Epub 2017 Oct 31.

Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1155/2017/5932706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684599PMC
October 2017

ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors.

Nat Cell Biol 2017 Sep 28;19(9):1037-1048. Epub 2017 Aug 28.

Cancer Biology and Genetics Program, Center for Cell Engineering, Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute for Cancer Research, and Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncb3598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843481PMC
September 2017

New insights into human primordial germ cells and early embryonic development from single-cell analysis.

FEBS Lett 2017 08 2;591(15):2226-2240. Epub 2017 Jul 2.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.

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http://dx.doi.org/10.1002/1873-3468.12716DOI Listing
August 2017

Nijmegen Breakage Syndrome fibroblasts and iPSCs: cellular models for uncovering disease-associated signaling pathways and establishing a screening platform for anti-oxidants.

Sci Rep 2017 08 8;7(1):7516. Epub 2017 Aug 8.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.

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http://dx.doi.org/10.1038/s41598-017-07905-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548734PMC
August 2017

Generation and characterization of two iPSC lines from human epicardium-derived cells.

Stem Cell Res 2017 04 24;20:50-53. Epub 2017 Feb 24.

Department of Molecular Cardiology, Medical Faculty, Heinrich Heine University, 40225 Duesseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2017.02.007DOI Listing
April 2017

Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease.

World J Hepatol 2017 Mar;9(8):443-454

Wasco Wruck, James Adjaye, Medical Faculty, Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University, 40225 Düsseldorf, Germany.

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http://www.wjgnet.com/1948-5182/full/v9/i8/443.htm
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http://dx.doi.org/10.4254/wjh.v9.i8.443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355767PMC
March 2017

Concise Review: Current Status and Future Directions on Research Related to Nonalcoholic Fatty Liver Disease.

Stem Cells 2017 01 13;35(1):89-96. Epub 2016 Jul 13.

Medical Faculty, Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University, Düsseldorf, Germany.

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http://dx.doi.org/10.1002/stem.2454DOI Listing
January 2017

Characterization of dermal fibroblast-derived iPSCs from a patient with low grade steatosis.

Stem Cell Res 2016 11 20;17(3):547-549. Epub 2016 Oct 20.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2016.10.004DOI Listing
November 2016

Lymphoblast-derived integration-free iPS cell line from a female 67-year-old Alzheimer's disease patient with TREM2 (R47H) missense mutation.

Stem Cell Res 2016 11 20;17(3):553-555. Epub 2016 Oct 20.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2016.10.005DOI Listing
November 2016

Lymphoblast-derived integration-free iPSC lines from a female and male Alzheimer's disease patient expressing different copy numbers of a coding CNV in the Alzheimer risk gene CR1.

Stem Cell Res 2016 11 19;17(3):560-563. Epub 2016 Oct 19.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2016.10.003DOI Listing
November 2016

Characterization of dermal fibroblast-derived iPSCs from a patient with high grade steatosis.

Stem Cell Res 2016 11 19;17(3):568-571. Epub 2016 Oct 19.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2016.10.007DOI Listing
November 2016

Characterization of iPSCs derived from dermal fibroblasts from a healthy 19year old female.

Stem Cell Res 2016 11 19;17(3):597-599. Epub 2016 Oct 19.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2016.10.002DOI Listing
November 2016

3D culture of ovarian follicles: a system towards their engineering?

Int J Dev Biol 2015 ;59(4-6):211-6

Sezione di Anatomia, Istologia ed Embriologia, Dipartimento di Scienze Biomediche, Biotecnologiche e Traslazionali (S.Bi.Bi.T.), Università degli Studi di Parma, Italy.

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http://dx.doi.org/10.1387/ijdb.150172mzDOI Listing
August 2016

Chromosomal Instability and Molecular Defects in Induced Pluripotent Stem Cells from Nijmegen Breakage Syndrome Patients.

Cell Rep 2016 08 18;16(9):2499-511. Epub 2016 Aug 18.

Department of Genetics, Institute of Life Sciences, The Hebrew University, Givat-Ram, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.071DOI Listing
August 2016

Combined sequencing of mRNA and DNA from human embryonic stem cells.

Genom Data 2016 Jun 26;8:131-3. Epub 2016 Apr 26.

Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University, Moorenstr. 5, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1016/j.gdata.2016.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880790PMC
June 2016

Lymphoblast-derived integration-free iPS cell line from a 69-year-old male.

Stem Cell Res 2016 Jan 1;16(1):29-31. Epub 2015 Dec 1.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S18735061150016
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http://dx.doi.org/10.1016/j.scr.2015.11.016DOI Listing
January 2016

Episomal-based generation of an iPS cell line from human fetal foreskin fibroblasts.

Stem Cell Res 2016 Jan 17;16(1):67-9. Epub 2015 Dec 17.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany; Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.

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http://dx.doi.org/10.1016/j.scr.2015.12.009DOI Listing
January 2016

Lymphoblast-derived integration-free iPS cell line from a 65-year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant.

Stem Cell Res 2016 Jan 28;16(1):113-5. Epub 2015 Dec 28.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr, 5, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2015.12.017DOI Listing
January 2016

Episomal plasmid-based generation of induced pluripotent stem cells from fetal femur-derived human mesenchymal stromal cells.

Stem Cell Res 2016 Jan 28;16(1):128-32. Epub 2015 Dec 28.

Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany; Max Planck Institute for Molecular Genetics, Ihnestraße 63-73, 14195 Berlin, Germany.

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http://dx.doi.org/10.1016/j.scr.2015.12.013DOI Listing
January 2016

Molecular characterisation of stromal populations derived from human embryonic stem cells: Similarities to immortalised bone marrow derived stromal stem cells.

Bone Rep 2015 Dec 4;3:32-39. Epub 2015 Aug 4.

Molecular Endocrinology Laboratory, Odense University Hospital, University of Southern Denmark, Odense, Denmark; Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia; Danish Stem Cell Centre (DanStem), Institute of Cellular and Molecular Medicine, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.bonr.2015.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365211PMC
December 2015

CD34 defines an osteoprogenitor cell population in mouse bone marrow stromal cells.

Stem Cell Res 2015 Nov 21;15(3):449-458. Epub 2015 Sep 21.

Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital and University of Southern Denmark, Odense, Denmark; Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Saudi Arabia.

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http://dx.doi.org/10.1016/j.scr.2015.09.005DOI Listing
November 2015

Combined ultra-low input mRNA and whole-genome sequencing of human embryonic stem cells.

BMC Genomics 2015 Nov 12;16:925. Epub 2015 Nov 12.

Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 63-73, 14195, Berlin, Germany.

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http://dx.doi.org/10.1186/s12864-015-2025-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643517PMC
November 2015

Generation of an iPS cell line from bone marrow derived mesenchymal stromal cells from an elderly patient.

Stem Cell Res 2015 Nov 9;15(3):565-8. Epub 2015 Oct 9.

Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany; Max Planck Institut für Molekulare Genetik, Ihnestraße 63-73, 14195 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2015.10.003DOI Listing
November 2015

Generation of iPSC line epiHUVEC from human umbilical vein endothelial cells.

Stem Cell Res 2015 Nov 14;15(3):581-3. Epub 2015 Oct 14.

Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany; Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.

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http://dx.doi.org/10.1016/j.scr.2015.10.004DOI Listing
November 2015

Generation of iPSC lines from a Nijmegen Breakage Syndrome patient.

Stem Cell Res 2015 Nov 23;15(3):629-32. Epub 2015 Oct 23.

Max Planck Institute for Molecular Genetics, 14195, Berlin, Germany; Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2015.10.013DOI Listing
November 2015

Generation of iPSC lines from primary human chorionic villi cells.

Stem Cell Res 2015 Nov 23;15(3):697-9. Epub 2015 Oct 23.

Max Planck Institute for Molecular Genetics, 14195, Berlin, Germany; Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2015.10.011DOI Listing
November 2015

Generation of iPSC lines from primary human amniotic fluid cells.

Stem Cell Res 2015 Nov 11;15(3):712-4. Epub 2015 Nov 11.

Max Planck Institute for Molecular Genetics, 14195, Berlin, Germany; Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2015.11.003DOI Listing
November 2015

Age-Related Increase of EED Expression in Early Hematopoietic Progenitor Cells is Associated with Global Increase of the Histone Modification H3K27me3.

Stem Cells Dev 2015 Sep 23;24(17):2018-31. Epub 2015 Jun 23.

2 Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Düsseldorf , Medical Faculty, Düsseldorf, Germany .

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http://dx.doi.org/10.1089/scd.2014.0435DOI Listing
September 2015

Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4.

J Med Chem 2015 Aug 23;58(15):5742-50. Epub 2015 Jul 23.

†Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00226DOI Listing
August 2015

miR-27 negatively regulates pluripotency-associated genes in human embryonal carcinoma cells.

PLoS One 2014 4;9(11):e111637. Epub 2014 Nov 4.

Institute for Stem Cell Research and Regenerative Medicine, Faculty of Medicine, Heinrich Heine University, Duesseldorf, Germany; Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111637PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219743PMC
June 2015

Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers.

J Med Chem 2015 Jun 7;58(12):4976-83. Epub 2015 May 7.

†Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00144DOI Listing
June 2015

Metabolic restructuring and cell fate conversion.

Cell Mol Life Sci 2015 May 14;72(9):1759-77. Epub 2015 Jan 14.

Max Delbrueck Center for Molecular Medicine (MDC), Robert-Roessle-Str. 10, 13125, Berlin, Germany,

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http://dx.doi.org/10.1007/s00018-015-1834-1DOI Listing
May 2015

A mitochondrial strategy for safeguarding the reprogrammed genome.

Cell Regen (Lond) 2014 29;3(1). Epub 2014 Mar 29.

Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Berlin, Germany ; Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University, Duesseldorf, Germany.

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http://dx.doi.org/10.1186/2045-9769-3-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230514PMC
November 2014

Mitochondrial function in pluripotent stem cells and cellular reprogramming.

Gerontology 2014 19;60(2):174-82. Epub 2013 Nov 19.

Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany.

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http://dx.doi.org/10.1159/000355050DOI Listing
October 2014

HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

Stem Cells 2014 Feb;32(2):364-76

Molecular Embryology and Ageing Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany; Department of Neuroproteomics, Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany.

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http://dx.doi.org/10.1002/stem.1552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730046PMC
February 2014

BMP10 as a potent inducer of trophoblast differentiation in human embryonic and induced pluripotent stem cells.

Biomaterials 2013 Dec 23;34(38):9789-802. Epub 2013 Sep 23.

Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 63-73, 14195 Berlin, Germany; Department of Biology, Chemistry and Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Thielallee 63, 14195 Berlin, Germany.

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http://dx.doi.org/10.1016/j.biomaterials.2013.08.084DOI Listing
December 2013

Qualitative modeling identifies IL-11 as a novel regulator in maintaining self-renewal in human pluripotent stem cells.

Front Physiol 2013 28;4:303. Epub 2013 Oct 28.

Quretec Ltd. Tartu, Estonia ; Faculty of Mathematics and Computer Science, Institute of Computer Science, University of Tartu Tartu, Estonia ; Faculty of Science and Technology, Institute of Molecular and Cellular Biology, University of Tartu Tartu, Estonia.

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http://dx.doi.org/10.3389/fphys.2013.00303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809568PMC
November 2013

Comparative molecular portraits of human unfertilized oocytes and primordial germ cells at 10 weeks of gestation.

Int J Dev Biol 2012 ;56(10-12):789-97

Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin, Germany.

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http://dx.doi.org/10.1387/ijdb.120230jaDOI Listing
August 2013

OCT4 and the acquisition of oocyte developmental competence during folliculogenesis.

Int J Dev Biol 2012 ;56(10-12):853-8

Dipartimento di Scienze Biomediche, Biotecnologiche e Traslazionali, Universitá degli Studi di Parma, Via Volturno 39, Parma, Italy.

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http://dx.doi.org/10.1387/ijdb.120174mzDOI Listing
August 2013

Mouse embryonic stem cells irradiated with γ-rays differentiate into cardiomyocytes but with altered contractile properties.

Mutat Res 2013 Aug 20;756(1-2):37-45. Epub 2013 Jun 20.

Laboratorio di Biologia dello Sviluppo, Dipartimento di Biologia e Biotecnologie 'Lazzaro Spallanzani', Università degli Studi di Pavia, Via Ferrata 9, 27100 Pavia, Italy.

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http://dx.doi.org/10.1016/j.mrgentox.2013.06.007DOI Listing
August 2013

Current methods for inducing pluripotency in somatic cells.

Adv Mater 2013 May 26;25(20):2765-71. Epub 2013 Mar 26.

Ghent University, Laboratory of General Biochemistry and Physical Pharmacy, Ghent Research Group on Nanomedicines, Harelbekestraat 72, Ghent, Belgium.

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http://doi.wiley.com/10.1002/adma.201204874
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May 2013

Molecular signature of human amniotic fluid stem cells during fetal development.

Curr Stem Cell Res Ther 2013 Jan;8(1):73-81

Institute of Reproductive and Developmental Biology, Imperial College London, London, W12 0NN, United Kingdom.

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January 2013

FGF inhibition directs BMP4-mediated differentiation of human embryonic stem cells to syncytiotrophoblast.

Stem Cells Dev 2012 Nov 6;21(16):2987-3000. Epub 2012 Aug 6.

Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://dx.doi.org/10.1089/scd.2012.0099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475151PMC
November 2012

Human embryonic stem cells and embryonal carcinoma cells have overlapping and distinct metabolic signatures.

PLoS One 2012 29;7(6):e39896. Epub 2012 Jun 29.

Department of Vertebrate Genomics, Max-Planck-Institute for Molecular Genetics, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039896PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387229PMC
November 2012

Chromatin immunoprecipitation-based analysis of gene regulatory networks operative in human embryonic stem cells.

Methods Mol Biol 2012 ;873:269-80

Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://dx.doi.org/10.1007/978-1-61779-794-1_18DOI Listing
August 2012

Analysis of the methylome of human embryonic stem cells employing methylated DNA immunoprecipitation coupled to next-generation sequencing.

Methods Mol Biol 2012 ;873:281-95

Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://link.springer.com/10.1007/978-1-61779-794-1_19
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August 2012

Human induced pluripotent stem cells--from mechanisms to clinical applications.

J Mol Med (Berl) 2012 Jul 30;90(7):735-45. Epub 2012 May 30.

Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 63-73 14195, Berlin, Germany.

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http://dx.doi.org/10.1007/s00109-012-0913-0DOI Listing
July 2012

The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts.

Biomaterials 2012 Jun 28;33(16):4059-68. Epub 2012 Feb 28.

Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 63-73, 14195 Berlin, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01429612120020
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http://dx.doi.org/10.1016/j.biomaterials.2012.02.025DOI Listing
June 2012

Preparation of mouse embryonic fibroblast cells suitable for culturing human embryonic and induced pluripotent stem cells.

J Vis Exp 2012 Jun 21(64). Epub 2012 Jun 21.

Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics.

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http://dx.doi.org/10.3791/3854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471299PMC
June 2012

A strand-specific library preparation protocol for RNA sequencing.

Methods Enzymol 2011 ;500:79-98

Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Ihnestrasse 63-73, Berlin, Germany.

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http://dx.doi.org/10.1016/B978-0-12-385118-5.00005-0DOI Listing
January 2012

Quantitative real-time PCR-based analysis of gene expression.

Methods Enzymol 2011 ;500:99-109

Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics (Molecular Embryology and Aging group), Ihnestrasse 63-73, Berlin, Germany.

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http://dx.doi.org/10.1016/B978-0-12-385118-5.00006-2DOI Listing
January 2012

Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells.

Int J Dev Biol 2010 ;54(11-12):1729-41

Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://www.intjdevbiol.com/paper.php?doi=103198ap
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http://dx.doi.org/10.1387/ijdb.103198apDOI Listing
September 2011

Bioinformatics in aging research: a workshop report.

Rejuvenation Res 2010 Dec 4;13(6):763-7. Epub 2011 Jan 4.

Department of Medicine, Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University, Rostock, Germany.

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http://dx.doi.org/10.1089/rej.2010.1125DOI Listing
December 2010