Publications by authors named "James A Johnston"

64Publications

Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma.

Eur Respir J 2016 09 23;48(3):715-25. Epub 2016 Jun 23.

Centre for Infection and Immunity, Health Sciences Building, Queens University Belfast, Belfast, UK

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http://dx.doi.org/10.1183/13993003.00400-2015DOI Listing
September 2016

A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17.

Biochem J 2014 Jan;457(2):289-300

*School of Pharmacy, Queen's University Belfast, McClay Research Building, 97 Lisburn Road, Belfast BT9 7BL, U.K.

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http://dx.doi.org/10.1042/BJ20131213DOI Listing
January 2014

Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization.

Int J Cancer 2013 Nov 29;133(9):2102-12. Epub 2013 May 29.

School of Pharmacy, Queen's University Belfast, Lisburn Road, Belfast, BT9 7BL, United Kingdom.

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http://dx.doi.org/10.1002/ijc.28238DOI Listing
November 2013

Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes.

FEBS Lett 2013 May 12;587(10):1571-8. Epub 2013 Apr 12.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.febslet.2013.03.041DOI Listing
May 2013

Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.

J Immunol 2013 Apr 1;190(7):3235-45. Epub 2013 Mar 1.

Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast BT9 7AE, Northern Ireland, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1201396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607399PMC
April 2013

Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization.

Immunity 2013 Jan 21;38(1):66-78. Epub 2012 Nov 21.

Centre for Infection and Immunity, School of Medicine Dentistry and Biomedical Sciences, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S10747613120047
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http://dx.doi.org/10.1016/j.immuni.2012.09.013DOI Listing
January 2013

Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.

J Immunol 2012 Sep 25;189(5):2079-83. Epub 2012 Jul 25.

Centre for Infection and Immunity, Queen's University Belfast, Belfast BT9 7AE, Northern Ireland.

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http://dx.doi.org/10.4049/jimmunol.1200131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424384PMC
September 2012

Regulation of cellular responses by deubiquitinating enzymes: an update.

Front Biosci (Landmark Ed) 2012 Jan 1;17:1184-200. Epub 2012 Jan 1.

School of Pharmacy, Faculty of Medicine, Health and Life Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, Northern Ireland BT9 7BL.

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http://dx.doi.org/10.2741/3980DOI Listing
January 2012

Ubiquitination: Added complexity in Ras and Rho family GTPase function.

Small GTPases 2011 Jul 1;2(4):192-201. Epub 2011 Jul 1.

Centre for Infection and Immunity; School of Medicine, Dentistry and Biomedical Sciences; Queen's University; Belfast, UK.

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http://dx.doi.org/10.4161/sgtp.2.4.16707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225908PMC
July 2011

Regulation of CD4+ T-cell polarization by suppressor of cytokine signalling proteins.

Immunology 2012 Feb;135(2):101-11

The Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, University Road, Belfast, Northern Ireland.

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http://doi.wiley.com/10.1111/j.1365-2567.2011.03520.x
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http://dx.doi.org/10.1111/j.1365-2567.2011.03520.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277712PMC
February 2012

Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas.

Biochimie 2012 Feb 31;94(2):487-93. Epub 2011 Aug 31.

Fusion Antibodies Ltd., Springbank Industrial Estate, Pembroke Loop Road, Belfast BT17 0QL, UK.

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http://dx.doi.org/10.1016/j.biochi.2011.08.017DOI Listing
February 2012

Stable expression and purification of a functional processed Fab' fragment from a single nascent polypeptide in CHO cells expressing the mCAT-1 retroviral receptor.

J Immunol Methods 2011 Sep 19;372(1-2):30-41. Epub 2011 Jul 19.

Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Science, Queen's University of Belfast, 97 Lisburn Rd, Belfast BT9 7BL, Northern Ireland, United Kingdom.

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http://dx.doi.org/10.1016/j.jim.2011.06.029DOI Listing
September 2011

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.

Nat Commun 2011 Mar 29;2:259. Epub 2011 Mar 29.

Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast BT9 7BL, Northern Ireland.

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http://dx.doi.org/10.1038/ncomms1243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072070PMC
March 2011

Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11.

FEBS Lett 2010 Nov 8;584(21):4469-74. Epub 2010 Oct 8.

Centre for Infection & Immunity, School of Medicine, Dentistry & Biomedical Science, Queen's University of Belfast, United Kingdom.

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http://doi.wiley.com/10.1016/j.febslet.2010.10.007
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http://dx.doi.org/10.1016/j.febslet.2010.10.007DOI Listing
November 2010

Vasodilator-stimulated phosphoprotein regulates inside-out signaling of beta2 integrins in neutrophils.

J Immunol 2010 Jun 10;184(12):6575-84. Epub 2010 May 10.

Centre for Infection and Immunity, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0903910
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http://dx.doi.org/10.4049/jimmunol.0903910DOI Listing
June 2010

The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.

BMC Genomics 2010 Apr 19;11:250. Epub 2010 Apr 19.

Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Faculty of Medicine, Health and Life Sciences, Queen's University, Belfast, Northern Ireland.

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http://dx.doi.org/10.1186/1471-2164-11-250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874809PMC
April 2010

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.

Cancer Res 2010 Apr 13;70(8):3329-39. Epub 2010 Apr 13.

Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical, Queen's University Belfast, Belfast, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4152DOI Listing
April 2010

The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.

J Biol Chem 2010 Apr 10;285(16):12028-36. Epub 2010 Feb 10.

Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast BT9 7BL, Northern Ireland.

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http://dx.doi.org/10.1074/jbc.M109.081448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852940PMC
April 2010

Expression and purification of diagnostically sensitive mycobacterial (Mycobacterium bovis) antigens and profiling of their humoral immune response in a rabbit model.

Res Vet Sci 2010 Aug 22;89(1):41-7. Epub 2010 Jan 22.

Fusion Antibodies Ltd., Springbank Ind. Est. Belfast, Belfast BT17 0QL, Northern Ireland, United Kingdom.

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http://dx.doi.org/10.1016/j.rvsc.2009.12.015DOI Listing
August 2010

Antibody-mediated inhibition of cathepsin S blocks colorectal tumor invasion and angiogenesis.

Clin Cancer Res 2009 Oct 29;15(19):6042-51. Epub 2009 Sep 29.

School of Pharmacy, Queen's University Belfast, Belfast, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1262DOI Listing
October 2009

SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases.

Haematologica 2009 Apr 19;94(4):576-80. Epub 2009 Feb 19.

Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, QUB, 2 floor, Whitla Medical Building, 97 Lisburn Rd, Belfast BT97BL, Northern Ireland.

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http://dx.doi.org/10.3324/haematol.2008.002352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663621PMC
April 2009

USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.

J Biol Chem 2009 Apr 2;284(14):9587-95. Epub 2009 Feb 2.

Division of Infection and Immunity, Centre for Cancer Research and Cell Biology, School of Biomedical Sciences, Queen's University Belfast, University Road, Belfast BT7 1NN, Northern Ireland.

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http://dx.doi.org/10.1074/jbc.M807216200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666611PMC
April 2009

A Novel High-Throughput Technique for Identifying Monoclonal Antibodies Capable of Death Receptor Induced Apoptosis.

J Cell Death 2009 2;2:45-51. Epub 2009 Dec 2.

Fusion Antibodies Ltd., Springbank Ind. Est. Belfast, Northern Ireland BT17 0QL.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474333PMC
http://dx.doi.org/10.4137/jcd.s3660DOI Listing
June 2015

CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression.

J Leukoc Biol 2009 Feb 29;85(2):289-97. Epub 2008 Oct 29.

Infection and Immunity, Cancer Research and Cell Biology, School of Biomedical Science, Queen's University of Belfast, Belfast, Northern Ireland.

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http://dx.doi.org/10.1189/jlb.0708394DOI Listing
February 2009

The suppressors of cytokine signalling E3 ligases behave as tumour suppressors.

Biochem Soc Trans 2008 Jun;36(Pt 3):464-8

Infection and Immunity Group, Centre for Cancer Research and Cell Biology, School of Biomedical Sciences, Faculty of Medicine, Health and Life Sciences, Queen's University, Whitla Medical Building, Belfast BT9 7BL, N. Ireland, UK.

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http://dx.doi.org/10.1042/BST0360464DOI Listing
June 2008

Substitution of pseudokinase domain residue Val-617 by large non-polar amino acids causes activation of JAK2.

J Biol Chem 2008 May 6;283(19):12941-8. Epub 2008 Mar 6.

Ludwig Institute for Cancer Research, B-1200 Brussels, Belgium.

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http://dx.doi.org/10.1074/jbc.M709302200DOI Listing
May 2008

The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3.

Blood 2007 Jun 22;109(11):4924-9. Epub 2007 Feb 22.

Infection and Immunity Group, Centre for Cancer Research and Cell Biology, Queen's University, 97 Lisburn Road, Belfast, Northern Ireland, UK.

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http://dx.doi.org/10.1182/blood-2006-08-039735DOI Listing
June 2007

Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase.

J Virol 2007 Apr 24;81(7):3428-36. Epub 2007 Jan 24.

Molecular Immunity, Infection and Immunity Group, Centre for Cancer Research and Cell Biology, Queens University Belfast, Whitla Medical Building, 97 Lisburn Rd., Belfast BT9 7BL, Northern Ireland.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.02303-06
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http://dx.doi.org/10.1128/JVI.02303-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866062PMC
April 2007

SOCS3 targets Siglec 7 for proteasomal degradation and blocks Siglec 7-mediated responses.

J Biol Chem 2007 Feb 30;282(6):3418-22. Epub 2006 Nov 30.

Division of Infection and Immunity, Centre for Cancer Research and Cell Biology, Queens University, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom.

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http://dx.doi.org/10.1074/jbc.C600216200DOI Listing
February 2007

CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover.

Blood 2007 Feb 28;109(3):1061-8. Epub 2006 Sep 28.

Infection and Immunity, centre for Cancer Research and Biology, Queens University, Belfast, UK.

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http://dx.doi.org/10.1182/blood-2006-05-023556DOI Listing
February 2007

SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation.

Mol Cell Biol 2005 Oct;25(20):9115-26

Infection and Immunity Group, Centre for Cancer Research and Cell Biology, Queens University, Belfast, UK.

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http://dx.doi.org/10.1128/MCB.25.20.9115-9126.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1265772PMC
October 2005

Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases.

J Biol Chem 2005 Sep 6;280(36):31478-88. Epub 2005 Jul 6.

Institut für Biochemie, Rheinisch-Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, D-52074 Aachen, Germany.

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http://dx.doi.org/10.1074/jbc.M506008200DOI Listing
September 2005

The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.

Genomics 2005 Apr;85(4):524-9

Department of Microbiology and Immunology, Queen's University, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland.

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http://dx.doi.org/10.1016/j.ygeno.2004.11.013DOI Listing
April 2005

SOCS: role in inflammation, allergy and homeostasis.

Trends Immunol 2004 Aug;25(8):434-40

Department of Microbiology and Immunology, Queen's University-Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK.

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http://dx.doi.org/10.1016/j.it.2004.05.012DOI Listing
August 2004

DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.

J Biol Chem 2004 Apr 29;279(14):13993-4000. Epub 2003 Dec 29.

Department of Microbiology and Immunology, Queen's University, Belfast, Northern Ireland.

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http://dx.doi.org/10.1074/jbc.M311291200DOI Listing
April 2004

Are SOCS suppressors, regulators, and degraders?

Authors:
James A Johnston

J Leukoc Biol 2004 May 23;75(5):743-8. Epub 2003 Dec 23.

Department of Microbiology and Immunology, Queen's University, Belfast, Northern Ireland.

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http://dx.doi.org/10.1189/jlb.1003507DOI Listing
May 2004

New interleukins: are there any more?

Curr Opin Infect Dis 2003 Jun;16(3):211-7

Department of Microbiology and Immunology, School of Medicine, The Queen's University of Belfast, Belfast, Northern Ireland, UK.

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http://dx.doi.org/10.1097/00001432-200306000-00005DOI Listing
June 2003

Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation.

J Biol Chem 2003 Aug 3;278(34):31972-9. Epub 2003 Jun 3.

Department of Immunology, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland.

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http://dx.doi.org/10.1074/jbc.M303170200DOI Listing
August 2003

Matching SOCS with function.

Nat Immunol 2003 Jun;4(6):507-9

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http://dx.doi.org/10.1038/ni0603-507DOI Listing
June 2003

Deacetylase activity is required for recruitment of the basal transcription machinery and transactivation by STAT5.

Mol Cell Biol 2003 Jun;23(12):4162-73

Department of Discovery Research, DNAX Research Inc, Palo Alto, California 94304, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC156147PMC
http://dx.doi.org/10.1128/mcb.23.12.4162-4173.2003DOI Listing
June 2003

Cytokine signalling and disease.

Expert Opin Ther Targets 2001 Dec;5(6):641-653

DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304, USA.

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http://dx.doi.org/10.1517/14728222.5.6.641DOI Listing
December 2001