Publications by authors named "James A Decaprio"

95Publications

The Merkel Cell Polyomavirus T Antigens Function as Tumor Promoters in Murine Skin.

Cancers (Basel) 2021 Jan 9;13(2). Epub 2021 Jan 9.

McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.

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January 2021

Predictors of immunotherapy benefit in Merkel cell carcinoma.

Oncotarget 2020 Nov 24;11(47):4401-4410. Epub 2020 Nov 24.

GJS Associated with Laboratory of Cellular Oncology, CCR/NCI, Bethesda, MD, USA.

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November 2020

Pervasive generation of non-canonical subgenomic RNAs by SARS-CoV-2.

Genome Med 2020 12 1;12(1):108. Epub 2020 Dec 1.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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December 2020

Molecular Pathogenesis of Merkel Cell Carcinoma.

Authors:
James A DeCaprio

Annu Rev Pathol 2020 Nov 23. Epub 2020 Nov 23.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA; email:

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November 2020

Association between treatment center experience and survival after diagnosis of stage I to III Merkel cell carcinoma treated with surgery with or without postoperative radiation therapy.

J Am Acad Dermatol 2020 Nov 7. Epub 2020 Nov 7.

Department of Radiation Oncology, Brigham & Women's Hospital/Dana-Farber Cancer Institute, Boston, Massachusetts; Merkel Cell Carcinoma Center of Excellence, Brigham & Women's Hospital/Dana-Farber Cancer Institute, Boston, Massachusetts. Electronic address:

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November 2020

ViroPanel: Hybrid Capture and Massively Parallel Sequencing for Simultaneous Detection and Profiling of Oncogenic Virus Infection and Tumor Genome.

J Mol Diagn 2020 04 15;22(4):476-487. Epub 2020 Feb 15.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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April 2020

RB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activation.

Nucleic Acids Res 2019 12;47(21):11197-11208

Program in Virology, Division of Medical Sciences, Graduate School of Arts and Sciences, Harvard University, Boston, MA 02115, USA.

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December 2019

Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB.

Oncogene 2019 06 4;38(25):4962-4976. Epub 2019 Mar 4.

Program in Virology, Division of Medical Sciences, Graduate School of Arts and Sciences, Harvard University, Boston, MA, 02115, USA.

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June 2019

DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.

Cell Cycle 2019 03 17;18(5):531-551. Epub 2019 Feb 17.

a Division of Hematology, Oncology, and Palliative Care, Department of Internal Medicine , Virginia Commonwealth University , Richmond , VA , USA.

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March 2019

Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response.

Proc Natl Acad Sci U S A 2019 01 31;116(3):1027-1032. Epub 2018 Dec 31.

Program in Virology, Graduate School of Arts and Sciences, Harvard University, Cambridge, MA 02138;

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January 2019

Merkel Cell Carcinoma in the HIV-1/AIDS Patient.

Cancer Treat Res 2019;177:211-229

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.

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June 2019

Contribution of DNA Replication to the FAM111A-Mediated Simian Virus 40 Host Range Phenotype.

J Virol 2019 01 10;93(1). Epub 2018 Dec 10.

Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA

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January 2019

The biology and treatment of Merkel cell carcinoma: current understanding and research priorities.

Nat Rev Clin Oncol 2018 12;15(12):763-776

Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and National Cancer Institute (NCI), NIH, Bethesda, MD, USA.

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December 2018

Merkel cell carcinoma.

Nat Rev Dis Primers 2017 Oct 26;3:17077. Epub 2017 Oct 26.

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington, USA.

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October 2017

Merkel cell polyomavirus and Merkel cell carcinoma.

Authors:
James A DeCaprio

Philos Trans R Soc Lond B Biol Sci 2017 Oct;372(1732)

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA

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October 2017

Transcriptional landscape of the human cell cycle.

Proc Natl Acad Sci U S A 2017 03 13;114(13):3473-3478. Epub 2017 Mar 13.

Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada;

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March 2017

Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation.

PLoS Pathog 2016 Nov 23;12(11):e1006020. Epub 2016 Nov 23.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.

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November 2016

Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo.

PLoS Genet 2016 Nov 9;12(11):e1006429. Epub 2016 Nov 9.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.

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November 2016

Merkel Cell Carcinoma: A Population Analysis on Survival.

J Natl Compr Canc Netw 2016 10;14(10):1247-1257

From Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School; Department of Radiation Oncology, and Department of Medical Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute; and Merkel Cell Carcinoma Clinic, Department of Dermatology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts.

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October 2016

APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry.

Cell Rep 2016 09;16(12):3359-3372

Lineberger Comprehensive Cancer Center and Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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September 2016

Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks.

Nucleic Acids Res 2016 Jul 8;44(13):6070-86. Epub 2016 Jun 8.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

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July 2016

Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.

Mol Cell 2016 06 26;62(6):929-942. Epub 2016 May 26.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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June 2016

Does Arabidopsis thaliana DREAM of cell cycle control?

EMBO J 2015 Aug 18;34(15):1987-9. Epub 2015 Jun 18.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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August 2015

Tumorigenic activity of merkel cell polyomavirus T antigens expressed in the stratified epithelium of mice.

Cancer Res 2015 Mar 16;75(6):1068-79. Epub 2015 Jan 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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March 2015

Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors.

J Virol 2015 Jan 15;89(1):857-62. Epub 2014 Oct 15.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Program in Virology, Harvard University Graduate School of Arts and Sciences, Division of Medical Sciences, Boston, Massachusetts, USA Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA

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January 2015

SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter.

Virology 2014 Nov 16;468-470:311-321. Epub 2014 Sep 16.

Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, United States. Electronic address:

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November 2014

PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length.

Mol Cell 2014 Jun 22;54(6):932-45. Epub 2014 May 22.

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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June 2014

The DREAM complex in antitumor activity of imatinib mesylate in gastrointestinal stromal tumors.

Curr Opin Oncol 2014 Jul;26(4):415-21

aDepartment of Medical Oncology, Dana-Farber Cancer Institute bDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts cCancer Therapeutics Program, University of Pittsburgh Cancer Institute, Hillman Cancer Center dDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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July 2014

Loss of the mammalian DREAM complex deregulates chondrocyte proliferation.

Mol Cell Biol 2014 Jun 7;34(12):2221-34. Epub 2014 Apr 7.

London Regional Cancer Program, Western University, London, Ontario, Canada Children's Health Research Institute, Western University, London, Ontario, Canada Department of Biochemistry, Western University, London, Ontario, Canada Department of Oncology, Western University, London, Ontario, Canada

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June 2014

Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA.

Proc Natl Acad Sci U S A 2013 Nov 6;110(47):E4492-501. Epub 2013 Nov 6.

Departments of Microbiology and Immunobiology, and Medicine and Program in Virology, Harvard Medical School, Boston, MA 02115.

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November 2013

The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor.

Mol Biol Cell 2013 Nov 4;24(21):3350-7. Epub 2013 Sep 4.

Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, Barcelona 08003, Spain Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.

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November 2013

The DREAM complex: master coordinator of cell cycle-dependent gene expression.

Nat Rev Cancer 2013 08 11;13(8):585-95. Epub 2013 Jul 11.

Institute for Stem Cell Biology and Regenerative Medicine, National Centre for Biological Sciences (TIFR), Bellary Road, Bangalore 560065, India.

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August 2013

Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities.

J Virol 2013 Jun 20;87(11):6118-26. Epub 2013 Mar 20.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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June 2013

A cornucopia of human polyomaviruses.

Nat Rev Microbiol 2013 Apr 11;11(4):264-76. Epub 2013 Mar 11.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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April 2013

The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression.

Genes Dev 2012 Mar;26(5):474-89

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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March 2012

The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes.

Nucleic Acids Res 2012 Feb 7;40(4):1561-78. Epub 2011 Nov 7.

Molecular Oncology, Medical School, University of Leipzig, Semmelweisstrasse 14, 04103 Leipzig, Germany.

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February 2012

A kinase shRNA screen links LATS2 and the pRB tumor suppressor.

Genes Dev 2011 Apr;25(8):814-30

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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April 2011

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

Genes Dev 2011 Apr;25(8):801-13

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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April 2011

Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens.

Semin Cancer Biol 2009 Aug 31;19(4):218-28. Epub 2009 Mar 31.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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August 2009

How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40.

Authors:
James A DeCaprio

Virology 2009 Feb 17;384(2):274-84. Epub 2009 Jan 17.

Department of Medical Oncology, Dana-Farber Cancer Institute, USA.

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February 2009

Does a new polyomavirus contribute to Merkel cell carcinoma?

Genome Biol 2008 17;9(6):228. Epub 2008 Jun 17.

Department of Medicine, University of Washington, Seattle, WA 98109, USA.

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August 2008

AMP-activated protein kinase is essential for survival in chronic hypoxia.

Biochem Biophys Res Commun 2008 May 24;370(2):230-4. Epub 2008 Mar 24.

Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Mayer Building 440, 44 Binney Street, Boston, MA 02115, USA.

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May 2008

Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice.

Mol Cell Biol 2008 Jan 12;28(2):743-51. Epub 2007 Nov 12.

Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115, USA.

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January 2008

The tumor suppressor PP2A Abeta regulates the RalA GTPase.

Cell 2007 Jun;129(5):969-82

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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June 2007

Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.

Mol Cell 2007 May;26(4):539-51

Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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May 2007

Inhibition of Simian virus 40 large T antigen helicase activity by fluoroquinolones.

Antivir Ther 2007 ;12(1):1-6

Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan.

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June 2007

PARC and CUL7 form atypical cullin RING ligase complexes.

Cancer Res 2007 Mar;67(5):2006-14

Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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March 2007

Is there a role for SV40 in human cancer?

J Clin Oncol 2006 Sep;24(26):4356-65

Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.

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September 2006

A novel p53-binding domain in CUL7.

Biochem Biophys Res Commun 2006 Sep 13;348(1):132-8. Epub 2006 Jul 13.

Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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September 2006

Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53.

J Virol 2006 May;80(9):4292-303

Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Mayer Building 457, 44 Binney Street, Boston, Massachusetts 02115, USA.

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May 2006

The carboxyl-terminal domain of large T antigen rescues SV40 host range activity in trans independent of acetylation.

Virology 2006 May 28;349(1):212-21. Epub 2006 Feb 28.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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May 2006

Simian virus 40 large T antigen's association with the CUL7 SCF complex contributes to cellular transformation.

J Virol 2005 Sep;79(18):11685-92

Dana-Farber Cancer Institute, Department of Medical Oncology and Harvard Medical School, Mayer Building 457, 44 Binney Street, Boston, MA 02115, USA.

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September 2005

Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development.

Mol Cell Biol 2005 Jul;25(13):5579-89

Dana-Farber Cancer Institute, Department of Medical Oncology and Harvard Medical School, Mayer Building 457, 44 Binney Street, Boston, Massachusetts 02115, USA.

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July 2005

Glycogen synthase kinase 3 phosphorylates RBL2/p130 during quiescence.

Mol Cell Biol 2004 Oct;24(20):8970-80

Dana-Farber Cancer Institute, Mayer 457, 44 Binney St., Boston, MA 02115, USA.

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October 2004

p53 targets simian virus 40 large T antigen for acetylation by CBP.

J Virol 2004 Aug;78(15):8245-53

Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.

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August 2004

Activation of a DNA damage checkpoint response in a TAF1-defective cell line.

Mol Cell Biol 2004 Jun;24(12):5332-9

Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.

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June 2004

14-3-3 family members act coordinately to regulate mitotic progression.

Cell Cycle 2004 May 15;3(5):672-7. Epub 2004 May 15.

Department of Adult Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA. sdalal@

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May 2004

Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation.

J Virol 2004 Mar;78(6):2749-57

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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March 2004

Molecular cloning and characterization of the von Hippel-Lindau-like protein.

Mol Cancer Res 2004 Jan;2(1):43-52

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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January 2004

SV40 large T antigen promotes dephosphorylation of p130.

J Biol Chem 2003 Nov 10;278(47):46482-7. Epub 2003 Sep 10.

Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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November 2003

Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis.

Proc Natl Acad Sci U S A 2003 Aug 6;100(17):9855-60. Epub 2003 Aug 6.

Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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August 2003

Telomerase maintains telomere structure in normal human cells.

Cell 2003 Jul;114(2):241-53

Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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July 2003

Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen.

Nature 2003 May;423(6939):512-8

Department of Biochemistry and Molecular Genetics, University of Colorado Health Science Center, School of Medicine, Denver, Colorado 80262, USA.

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May 2003

Processing, localization, and requirement of human separase for normal anaphase progression.

Proc Natl Acad Sci U S A 2003 Apr 2;100(8):4574-9. Epub 2003 Apr 2.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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April 2003

Western blot screening for monoclonal antibodies against human separase.

J Immunol Methods 2003 Mar;274(1-2):105-13

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Mayer 457, 44 Binney Street, Boston, MA 02115, USA.

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March 2003

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport.

J Cell Biol 2002 Mar 25;156(5):817-28. Epub 2002 Feb 25.

Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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March 2002

Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism.

Mol Cell Biol 2002 Jan;22(2):453-68

Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA.

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January 2002