Publications by authors named "James A Bonner"

100Publications

Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapies.

Genes Dis 2019 Sep 3;6(3):232-246. Epub 2019 Jul 3.

Department of Radiation Oncology, The University of Alabama at Birmingham School of Medicine, Birmingham, AL, 35233, USA.

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September 2019

Metabolic checkpoints in neurodegenerative T helper 17 (T17) and neuroregenerative regulatory T (T) cells as new therapeutic targets for multiple sclerosis.

Neural Regen Res 2020 Feb;15(2):267-269

Department of Radiation Oncology; O'Neal Comprehensive Cancer Center; Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL, USA; Program in Immunology, The University of Alabama at Birmingham, Birmingham, AL, USA.

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February 2020

Differential escape mechanisms in cetuximab-resistant head and neck cancer cells.

Biochem Biophys Res Commun 2019 09 13;517(1):36-42. Epub 2019 Jul 13.

Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, 35249, USA. Electronic address:

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September 2019

Qualitative Assessment of Academic Radiation Oncology Department Chairs' Insights on Diversity, Equity, and Inclusion: Progress, Challenges, and Future Aspirations.

Int J Radiat Oncol Biol Phys 2018 05 9;101(1):30-45. Epub 2018 Jan 9.

Center for Bioethics and Social Science in Medicine, University of Michigan, Ann Arbor, Michigan; Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan. Electronic address:

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May 2018

Combining Survival and Toxicity Effect Sizes from Clinical Trials: NCCTG 89-20-52 (Alliance).

Int J Stat Med Res 2018 16;7(4):137-146. Epub 2018 Nov 16.

Division of Biomedical Statistics and Bioinformatics, Mayo Clinic, Rochester, MN 55905, USA.

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November 2018

A Multi-institutional Comparison of SBRT and IMRT for Definitive Reirradiation of Recurrent or Second Primary Head and Neck Cancer.

Int J Radiat Oncol Biol Phys 2018 03 24;100(3):595-605. Epub 2017 Apr 24.

Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; Division of Head and Neck Surgery, Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania. Electronic address:

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March 2018

Emotional Intelligence and Burnout in Academic Radiation Oncology Chairs.

J Healthc Manag 2017 Sep/Oct;62(5):302-313

Emma B. Holliday, MD, assistant professor, Division of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston; James A. Bonner, MD, chair, Department of Radiation Oncology, University of Alabama, Birmingham; Silvia C. Formenti, MD, chair, Department of Radiation Oncology, Weill Cornell Medical College, New York, New York; Stephen M. Hahn, MD, chair, Division of Radiation Oncology, University of Texas MD Anderson Cancer Center; Shalom Kalnicki, MD, chair, Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York; Fei-Fei Liu, MD, chair, Radiation Medicine Program, University Health Network, Princess Margaret Cancer Centre, University of Toronto, Ontario, Canada; Benjamin Movsas, MD, chair, Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan; Clifton D. Fuller, MD, PhD, associate professor, Division of Radiation Oncology, University of Texas MD Anderson Cancer Center; and Charles R. Thomas, Jr., MD, chair, Department of Radiation Medicine, Knight Cancer Institute, Oregon Health & Science University, Portland.

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July 2018

Development and Validation of Nomograms Predictive of Overall and Progression-Free Survival in Patients With Oropharyngeal Cancer.

J Clin Oncol 2017 Dec 4;35(36):4057-4065. Epub 2017 Aug 4.

Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-Tân and Louise Lambert, Centre Hospitalier de l'Université de Montréal, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Québec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M. Trotti III, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL; William L. Barrett, University of Cincinnati Cancer Institute, Cincinnati, OH; Wade L. Thorstad, Washington University, St Louis, MO; Christopher U. Jones, Sutter General Hospital, Sacramento; Sue S. Yom, University of California San Francisco, San Francisco; Shyam S.D. Rao, University of California Davis, Davis; Quynh-Thu Le, Stanford University, Stanford, CA; Stuart J. Wong, Medical College of Wisconsin, Milwaukee, WI; James A. Bonner, University of Alabama at Birmingham Medical Center, Birmingham, AL; David Raben, University of Colorado, Aurora, CO; and Mahesh R. Kudrimoti, University of Kentucky, Lexington, KY.

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December 2017

Cetuximab and Radiotherapy in Laryngeal Preservanion-Reply.

JAMA Otolaryngol Head Neck Surg 2017 05;143(5):526

Department of Radiation Oncology, Hazelrig-Salter Radiation Oncology Center, University of Alabama at Birmingham, Birmingham.

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May 2017

Association of Human Papillomavirus and p16 Status With Outcomes in the IMCL-9815 Phase III Registration Trial for Patients With Locoregionally Advanced Oropharyngeal Squamous Cell Carcinoma of the Head and Neck Treated With Radiotherapy With or Without Cetuximab.

J Clin Oncol 2016 Apr 28;34(12):1300-8. Epub 2015 Dec 28.

David I. Rosenthal, Diana Bell, and Kian K. Ang, The University of Texas MD Anderson Cancer Center, Houston, TX; Paul M. Harari, University of Wisconsin, Madison, WI; Jordi Giralt, Hospital Vall d'Hebron, Barcelona, Spain; David Raben, University of Colorado School of Medicine, Aurora, CO; Joyce Liu, Merck Serono, Beijing, People's Republic of China; Jeltje Schulten, Merck KGaA, Darmstadt, Germany; and James A. Bonner, University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL.

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April 2016

Enhancement of Cetuximab-Induced Radiosensitization by JAK-1 Inhibition.

BMC Cancer 2015 Oct 12;15:673. Epub 2015 Oct 12.

The University of Alabama at Birmingham, Department of Radiation Oncology, Hazelrig-Salter Radiation Oncology Center, Suite 2262, 1700 6th Avenue South, Birmingham, AL, 35249, UK.

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October 2015

Pazopanib combined with radiation: in vivo model of interaction.

Cancer Biother Radiopharm 2014 Aug 19;29(6):247-50. Epub 2014 Jun 19.

1 Department of Radiation Oncology, University of Alabama at Birmingham , Birmingham, Alabama.

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August 2014

Burnout in United States academic chairs of radiation oncology programs.

Int J Radiat Oncol Biol Phys 2014 Feb 1;88(2):363-8. Epub 2013 Nov 1.

Department of Radiation Oncology, Northwestern University, Chicago, Ilinois.

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February 2014

Patterns of prophylactic gastrostomy tube placement in head and neck cancer patients: a consideration of the significance of social support and practice variation.

Laryngoscope 2013 Aug 7;123(8):1918-25. Epub 2013 Feb 7.

Department of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham, Birmingham, Alabama, USA.

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August 2013

Prognostic significance of thyroid or cricoid cartilage invasion in laryngeal or hypopharyngeal cancer treated with organ preserving strategies.

Radiat Oncol 2012 Dec 21;7:219. Epub 2012 Dec 21.

Department of Radiation Oncology, University of Alabama at Birmingham, Hazelrig-Salter Radiation Oncology Center, 1700 6th Avenue South, Birmingham, AL 35249-6832, USA.

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December 2012

HER2 overexpression renders human breast cancers sensitive to PARP inhibition independently of any defect in homologous recombination DNA repair.

Cancer Res 2012 Sep;72(18):4796-806

Department of Radiation Oncology, Comprehensive Cancer Center, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.

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September 2012

Kinomic profiling approach identifies Trk as a novel radiation modulator.

Radiother Oncol 2012 Jun 5;103(3):380-7. Epub 2012 May 5.

Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, AL 35249-6832, USA.

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June 2012

Locoregional failure and the risk of distant metastasis after modern radiotherapy for head and neck cancer.

Head Neck 2013 Mar 9;35(3):381-7. Epub 2012 Mar 9.

Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.

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March 2013

Emerging roles of glycogen synthase kinase 3 in the treatment of brain tumors.

Front Mol Neurosci 2011 25;4:47. Epub 2011 Nov 25.

Department of Radiation Oncology, Comprehensive Cancer Center, University of Alabama-Birmingham School of Medicine Birmingham, AL, USA.

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October 2012

Small-cell lung cancer: prognostic factors and changing treatment over 15 years.

Clin Lung Cancer 2012 Mar 14;13(2):115-22. Epub 2011 Oct 14.

University of Colorado School of Medicine, Department of Radiation Oncology, 1665 Aurora Court, Suite 1032, MS F706, Aurora, CO 80045-0510, USA.

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March 2012

Impact of average weekly dose of radiation during radiotherapy alone or chemoradiotherapy in head and neck cancer.

Head Neck 2011 Nov 9;33(11):1551-6. Epub 2010 Dec 9.

Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

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November 2011

Cetuximab augments cytotoxicity with poly (adp-ribose) polymerase inhibition in head and neck cancer.

PLoS One 2011 30;6(8):e24148. Epub 2011 Aug 30.

Department of Radiation Oncology, Comprehensive Cancer Center, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States of America.

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December 2011

Dosimetric impact of target definitions on normal structures in head and neck cancer.

Head Neck Oncol 2011 Aug 11;3:34. Epub 2011 Aug 11.

Department of Radiation Oncology, The University of Alabama at Birmingham, 1700 Sixth Avenue South, Birmingham, AL 35249, USA. .

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August 2011

Treatment of small cell lung cancer with TRA-8 in combination with cisplatin and radiation.

Radiother Oncol 2011 Oct 30;101(1):183-9. Epub 2011 Jun 30.

Department of Radiation Oncology, The University of Alabama, Birmingham, AL 35249, USA.

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October 2011

The poly(ADP-Ribose) polymerase inhibitor ABT-888 reduces radiation-induced nuclear EGFR and augments head and neck tumor response to radiotherapy.

Radiother Oncol 2011 Jun 28;99(3):331-8. Epub 2011 Jun 28.

Department of Radiation Oncology, University of Alabama at Birmingham School of Medicine, USA.

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June 2011

Inhibition of STAT-3 results in greater cetuximab sensitivity in head and neck squamous cell carcinoma.

Radiother Oncol 2011 Jun 23;99(3):339-43. Epub 2011 Jun 23.

Department of Radiation Oncology, The University of Alabama at Birmingham, USA.

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June 2011

Gastrostomy tube placement and use in patients with head and neck cancer.

Head Neck 2012 Mar 20;34(3):422-8. Epub 2011 May 20.

Department of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham, Birmingham, Alabama, USA.

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March 2012

Examination of laryngoesophageal dysfunction-free survival as an endpoint in nonsurgical treatment of squamous cell carcinomas of the larynx and hypopharynx.

Cancer 2011 Oct 22;117(19):4447-51. Epub 2011 Mar 22.

Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, Mississippi, USA.

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October 2011

Diagnosis-to-treatment interval and control of locoregionally advanced head and neck cancer.

Arch Otolaryngol Head Neck Surg 2011 Mar;137(3):282-5

Department of Radiation Oncology, University of Mississippi Medical Center, 350 Woodrow Wilson Dr, Ste 1600, Jackson, MS 39213, USA.

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March 2011

RapidArc radiation therapy: first year experience at the University of Alabama at Birmingham.

Int J Radiat Oncol Biol Phys 2010 Jul 6;77(3):932-41. Epub 2010 Mar 6.

Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

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July 2010

Synthesis and preliminary biological evaluation of high-drug-load paclitaxel-antibody conjugates for tumor-targeted chemotherapy.

J Med Chem 2010 Jan;53(2):586-94

Department of Radiation Oncology, School of Medicine, University of Alabama at Birmingham,Birmingham, Alabama 35294, USA.

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January 2010

Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinoma.

Radiother Oncol 2009 Sep 16;92(3):339-44. Epub 2009 Jul 16.

Department of Radiation Oncology, The University of Alabama at Birmingham, AL 35233, USA.

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September 2009

Comparison of methods to reduce dose to swallowing-related structures in head and neck cancer.

Int J Radiat Oncol Biol Phys 2010 Jun 4;77(2):462-7. Epub 2009 Jul 4.

Department of Radiation Oncology, University of Alabama at Birmingham, USA.

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June 2010

Dosimetric factors associated with long-term dysphagia after definitive radiotherapy for squamous cell carcinoma of the head and neck.

Int J Radiat Oncol Biol Phys 2010 Feb 19;76(2):403-9. Epub 2009 May 19.

Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL 35249, USA.

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February 2010

Margin on gross tumor volume and risk of local recurrence in head-and-neck cancer.

Int J Radiat Oncol Biol Phys 2010 Jan;76(1):164-8

Department of Radiation Oncology, University of Alabama-Birmingham, Birmingham, AL 35249, USA.

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January 2010

Stage-specific survival differences associated with postoperative radiotherapy for gastrointestinal cancers.

J Gastrointest Cancer 2008 18;39(1-4):86-99. Epub 2009 Mar 18.

Department of Radiation Oncology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.

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September 2009

Adjuvant radiotherapy for pancreatic cancer is associated with a survival benefit primarily in stage IIB patients.

J Gastroenterol 2009 22;44(1):84-91. Epub 2009 Jan 22.

Department of Radiation Oncology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294-3300, USA.

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March 2009

Factors associated with long-term dysphagia after definitive radiotherapy for locally advanced head-and-neck cancer.

Int J Radiat Oncol Biol Phys 2009 Feb 16;73(2):410-5. Epub 2008 Jul 16.

Department of Radiation Oncology, University of Alabama-Birmingham, Birmingham, AL, USA.

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February 2009

More on severe cutaneous reaction with radiotherapy and cetuximab.

N Engl J Med 2007 Nov;357(18):1872-3; author reply 1873

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November 2007

Design and development of water-soluble curcumin conjugates as potential anticancer agents.

J Med Chem 2007 Nov 1;50(24):6284-8. Epub 2007 Nov 1.

Department of Radiation Oncology, University of Alabama at Birmingham, 1824 6th Avenue S., Birmingham, AL 35294-6832, USA.

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November 2007

Is cetuximab active in patients with cisplatin-refractory squamous cell carcinoma of the head and neck?

Nat Clin Pract Oncol 2007 Dec 2;4(12):690-1. Epub 2007 Oct 2.

Department of Radiation Oncology, University of Alabama, Birmingham, AL 35233, USA.

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December 2007

Biology of interactions: antiepidermal growth factor receptor agents.

J Clin Oncol 2007 Sep;25(26):4057-65

Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

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September 2007

Patterns of surgical care of lung cancer patients.

Ann Thorac Surg 2005 Dec;80(6):2051-6; discussion 2056

Department of Surgery, Wright State University School of Medicine, Dayton, Ohio, USA.

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December 2005

Limited-stage small-cell lung cancer (stages I-III): observations from the National Cancer Data Base.

Clin Lung Cancer 2005 May;6(6):355-60

Department of Radiation Oncology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045-0510, USA.

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May 2005

Site-specifically traced drug release and biodistribution of a paclitaxel-antibody conjugate toward improvement of the linker structure.

Bioconjug Chem 2004 Nov-Dec;15(6):1264-74

Department of Radiation Oncology and Medicine, Biostatistics and Bioinformatics Unit, and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

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April 2005

Quality of life in 650 lung cancer survivors 6 months to 4 years after diagnosis.

Mayo Clin Proc 2004 Aug;79(8):1024-30

Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA.

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August 2004

Anti-EGFR-mediated radiosensitization as a result of augmented EGFR expression.

Int J Radiat Oncol Biol Phys 2004 ;59(2 Suppl):2-10

Department of Radiation Oncology, The University of Alabama School of Medicine, Birmingham, 35294-3300, USA.

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June 2004

Radiosensitization by antisense anti-MDM2 mixed-backbone oligonucleotide in in vitro and in vivo human cancer models.

Clin Cancer Res 2004 Feb;10(4):1263-73

Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0019, USA.

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February 2004

Validation of target volume and position in respiratory gated CT planning and treatment.

Med Phys 2003 Dec;30(12):3196-205

Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.

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December 2003

The possible use of uniform PORT doses is important in the SEER analysis, but undetected selection bias remains an issue.

Authors:
James A Bonner

Clin Lung Cancer 2002 Jul;4(1):45-6

Department of Radiation Oncology, University of Alabama at Birmingham, USA.

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July 2002

Differential responses by pancreatic carcinoma cell lines to prolonged exposure to Erbitux (IMC-C225) anti-EGFR antibody.

J Surg Res 2003 May;111(2):274-83

Division of General Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294-0016, USA.

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May 2003

Intraoperative radiotherapy for head and neck and skull base cancer.

Head Neck 2003 Mar;25(3):217-25; discussion 225-6

Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota 55905, USA.

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March 2003

Treatment of pancreatic cancer xenografts with Erbitux (IMC-C225) anti-EGFR antibody, gemcitabine, and radiation.

Int J Radiat Oncol Biol Phys 2002 Nov;54(4):1180-93

Department of Radiation Oncology, University of Alabama at Birmingham, Wallace Tumor Institute, Room 674, 1824 6th Avenue South, Birmingham, AL 35294, USA.

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November 2002