Jamal Khalife

Jamal Khalife

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Jamal Khalife

Jamal Khalife

Publications by authors named "Jamal Khalife"

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Essential role of GEXP15, a specific Protein Phosphatase type 1 partner, in Plasmodium berghei in asexual erythrocytic proliferation and transmission.

PLoS Pathog 2019 Jul 26;15(7):e1007973. Epub 2019 Jul 26.

Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR8204 - CIIL - Center for Infection and Immunity of Lille, Lille, France.

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http://dx.doi.org/10.1371/journal.ppat.1007973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685639PMC
July 2019

The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum.

Parasitol Res 2019 Jun 18;118(6):1993-1998. Epub 2019 Apr 18.

LOEWE Centre for Translational Biodiversity Genomics (LOEWE-TBG), Senckenberganlage 25, 60325, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s00436-019-06305-xDOI Listing
June 2019

Plasmodium pseudo-Tyrosine Kinase-like binds PP1 and SERA5 and is exported to host erythrocytes.

Sci Rep 2019 May 31;9(1):8120. Epub 2019 May 31.

Center for Infection and Immunity of Lille, Inserm U1019-CNRS UMR 8204, Université de Lille, Institut Pasteur de Lille, 1 Rue du Professeur Calmette, F-59000, Lille, France.

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http://dx.doi.org/10.1038/s41598-019-44542-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544628PMC
May 2019

Identification of novel quinazoline derivatives as potent antiplasmodial agents.

Eur J Med Chem 2019 Jan 17;161:277-291. Epub 2018 Oct 17.

CIIL U1019-CNRS UMR 8204, Université de Lille, Institut Pasteur de Lille, 1 rue du Professeur Calmette, 59019, Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.10.041DOI Listing
January 2019

Characterization of a Protein Phosphatase Type-1 and a Kinase Anchoring Protein in .

Front Microbiol 2018 31;9:2617. Epub 2018 Oct 31.

INSERM U1019-CNRS UMR 8204, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Université de Lille, Lille, France.

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02617
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http://dx.doi.org/10.3389/fmicb.2018.02617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220109PMC
October 2018

Peptides derived from leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro.

Drug Des Devel Ther 2018 9;12:85-88. Epub 2018 Jan 9.

Center for Infection and Immunity of Lille, U1019 - UMR 8204, Institut Pasteur de Lille, Université de Lille, Lille Cedex.

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https://www.dovepress.com/peptides-derived-from-plasmodium-f
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http://dx.doi.org/10.2147/DDDT.S153095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765974PMC
September 2018

Antiplasmodial Activity Is an Ancient and Conserved Feature of Tick Defensins.

Front Microbiol 2016 24;7:1682. Epub 2016 Oct 24.

Institute of Parasitology, Biology Centre of the Czech Academy of Sciences (ACVR)České Budějovice, Czech Republic; Department of Virology, Veterinary Research InstituteBrno, Czech Republic.

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http://dx.doi.org/10.3389/fmicb.2016.01682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075766PMC
October 2016

Identification of Plasmodium falciparum Translation Initiation eIF2β Subunit: Direct Interaction with Protein Phosphatase Type 1.

Front Microbiol 2016 26;7:777. Epub 2016 May 26.

Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - Centre d'Infection et d'Immunité de Lille, Université de Lille Lille, France.

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http://dx.doi.org/10.3389/fmicb.2016.00777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881399PMC
June 2016

Relationship Between Pneumocystis carinii Burden and the Degree of Host Immunosuppression in an Airborne Transmission Experimental Model.

J Eukaryot Microbiol 2016 05 24;63(3):309-17. Epub 2015 Nov 24.

Biology and Diversity of Emerging Eukaryotic Pathogens (BDPEE), Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Center for Infection and Immunity of Lille, F-59000, Lille, France.

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http://dx.doi.org/10.1111/jeu.12280DOI Listing
May 2016

Phosphatases are emerging as novel druggable targets in Plasmodium.

Future Microbiol 2016 05 9;11:603-6. Epub 2016 May 9.

UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.

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http://dx.doi.org/10.2217/fmb-2016-0029DOI Listing
May 2016

Analysis of the interactome of the Ser/Thr Protein Phosphatase type 1 in Plasmodium falciparum.

BMC Genomics 2016 Mar 17;17:246. Epub 2016 Mar 17.

Center for Infection and Immunity of Lille, Inserm U1019-CNRS UMR 8204, University of Lille Nord de France, Institut Pasteur de Lille, 1 Rue du Professeur Calmette, Lille, France.

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http://dx.doi.org/10.1186/s12864-016-2571-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794898PMC
March 2016

Genome wide in silico analysis of Plasmodium falciparum phosphatome.

BMC Genomics 2014 Nov 25;15:1024. Epub 2014 Nov 25.

Structural and Computational Biology group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India.

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http://dx.doi.org/10.1186/1471-2164-15-1024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256932PMC
November 2014

Identification of a Plasmodium falciparum inhibitor-2 motif involved in the binding and regulation activity of protein phosphatase type 1.

FEBS J 2014 Oct 8;281(19):4519-34. Epub 2014 Sep 8.

Center for Infection and Immunity of Lille, Inserm U1019-CNRS UMR 8204, Université Lille Nord de France, Institut Pasteur de Lille, France.

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http://doi.wiley.com/10.1111/febs.12960
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http://dx.doi.org/10.1111/febs.12960DOI Listing
October 2014

PhosphoTyrosyl phosphatase activator of Plasmodium falciparum: identification of its residues involved in binding to and activation of PP2A.

Int J Mol Sci 2014 Feb 11;15(2):2431-53. Epub 2014 Feb 11.

Center for Infection and Immunity of Lille, Inserm U1019-CNRS UMR 8204, University of Lille Nord de France, Institut Pasteur de Lille, 1 Rue du Professeur Calmette, Lille 59019, Cedex, France.

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http://dx.doi.org/10.3390/ijms15022431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958860PMC
February 2014

The ferroquine antimalarial conundrum: redox activation and reinvasion inhibition.

Angew Chem Int Ed Engl 2013 Jul 13;52(30):7690-3. Epub 2013 Jun 13.

Université Lille1, Unité de Catalyse et Chimie du Solide-UMR CNRS 8181, B.P. 90108, 59652 Villeneuve d'Ascq Cedex, France.

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http://dx.doi.org/10.1002/anie.201303690DOI Listing
July 2013

Plasmodium falciparum encodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti-plasmodial therapy.

BMC Biol 2013 Jul 9;11:80. Epub 2013 Jul 9.

Center for Infection and Immunity of Lille, Inserm U1019-CNRS UMR 8204, University of Lille Nord de France, Institut Pasteur de Lille, 1 Rue du Professeur Calmette, 59019 Lille, Cedex, France.

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http://dx.doi.org/10.1186/1741-7007-11-80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735429PMC
July 2013

Inhibition of protein-protein interactions in Plasmodium falciparum: future drug targets.

Curr Pharm Des 2012 ;18(24):3522-30

CIIL, Inserm U 1019, CNRS UMR 8204, Universite Lille Nord de France, Institut Pasteur de Lille, 1 rue du Professeur Calmette, 59019 Lille, France.

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November 2012

Opening up the advantages of the ruthenocenic bioprobes of ferroquine: distribution and localization in Plasmodium falciparum-infected erythrocytes.

Metallomics 2012 Aug 15;4(8):780-3. Epub 2012 Jun 15.

Université Lille1, Unité de Glycobiologie Structurale et Fonctionnelle, CNRS UMR 8576, IFR 147, 59650 Villeneuve d'Ascq Cédex, France.

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http://dx.doi.org/10.1039/c2mt20063eDOI Listing
August 2012

Deciphering the Resistance-Counteracting Functions of Ferroquine in Plasmodium falciparum-Infected Erythrocytes.

ACS Med Chem Lett 2012 Jun 13;3(6):480-3. Epub 2012 Apr 13.

Université Lille 1 , UGSF, CNRS UMR 8576, IFR 147, 59650 Villeneuve d'Ascq Cédex, France.

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http://dx.doi.org/10.1021/ml300062qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025787PMC
June 2012

Plasmodium falciparum inhibitor-3 homolog increases protein phosphatase type 1 activity and is essential for parasitic survival.

J Biol Chem 2012 Jan 28;287(2):1306-21. Epub 2011 Nov 28.

Center for Infection and Immunity of Lille, Inserm U1019-CNRS UMR 8204, University of Lille Nord de France, Institut Pasteur de Lille, 1 Rue du Professeur Calmette, 59019 Lille Cedex, France.

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http://dx.doi.org/10.1074/jbc.M111.276865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256872PMC
January 2012

In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes.

Chem Commun (Camb) 2012 Jan 5;48(6):910-2. Epub 2011 Dec 5.

Université Lille Nord de France, Université Lille1, UCCS-UMR CNRS 8181, 59652 Villeneuve d'Ascq Cedex, France.

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http://xlink.rsc.org/?DOI=C1CC16211J
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http://dx.doi.org/10.1039/c1cc16211jDOI Listing
January 2012

Gene profiling analysis reveals the contribution of CD24 and P2Y6R to the susceptibility of young rats to Plasmodium berghei infection.

Cell Microbiol 2011 May 16;13(5):752-63. Epub 2011 Feb 16.

Center for Infection and Immunity of Lille, Institut Pasteur de Lille, INSERM U1019, CNRS UMR8204, University Lille Nord de France, IFR 142, 1 rue du Professeur A. Calmette, 59019 Lille, France.

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http://dx.doi.org/10.1111/j.1462-5822.2011.01574.xDOI Listing
May 2011

Plasmodium falciparum dynein light chain 1 interacts with actin/myosin during blood stage development.

J Biol Chem 2010 Jun 26;285(26):20180-91. Epub 2010 Apr 26.

Unité INSERM 547 and Center for Infection and Immunity of Lille INSERM U1019, CNRS UMR 8204, Université Lille Nord de France, Institut Pasteur de Lille, 1 rue du Prof. Calmette, 59019 Lille, France.

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http://dx.doi.org/10.1074/jbc.M110.102806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888431PMC
June 2010

Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach.

J Med Chem 2009 Dec;52(24):7954-7

Universite de Lille 1, CNRS UMR 8181, ENSCL,Villeneuve d'Ascq Cedex, France.

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http://dx.doi.org/10.1021/jm901357nDOI Listing
December 2009

Ferroquine, an ingenious antimalarial drug: thoughts on the mechanism of action.

Molecules 2008 Nov 20;13(11):2900-7. Epub 2008 Nov 20.

Université des Sciences et Technologies de Lille, Unité de Catalyse et Chimie du Solide, UMR CNRS 8181, Ecole Nationale Supérieure de Chimie de Lille, Bâtiment C7, Villeneuve d'Ascq Cedex, France.

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http://dx.doi.org/10.3390/molecules13112900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245066PMC
November 2008

Census, molecular characterization and developmental expression of Leucine-Rich-Repeat proteins in Plasmodium falciparum.

Mol Biochem Parasitol 2007 Oct 7;155(2):161-6. Epub 2007 Jul 7.

Inserm, U 547 Lille, France.

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http://dx.doi.org/10.1016/j.molbiopara.2007.07.001DOI Listing
October 2007

A Toxoplasma gondii leucine-rich repeat protein binds phosphatase type 1 protein and negatively regulates its activity.

Eukaryot Cell 2007 Sep 27;6(9):1606-17. Epub 2007 Jul 27.

Unité INSERM 547, Institut Pasteur de Lille, 1 rue du Prof. Calmette, 59019 Lille, France.

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http://dx.doi.org/10.1128/EC.00260-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043371PMC
September 2007

Contribution of T cells and neutrophils in protection of young susceptible rats from fatal experimental malaria.

J Immunol 2007 Feb;178(3):1713-22

Institut National de la Santé et de la Recherche Médicale Unité 547, Institut Pasteur de Lille, Lille, France.

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http://dx.doi.org/10.4049/jimmunol.178.3.1713DOI Listing
February 2007

Prenatal stress has pro-inflammatory consequences on the immune system in adult rats.

Psychoneuroendocrinology 2007 Feb 19;32(2):114-24. Epub 2007 Jan 19.

Perinatal Stress Unit, University Lille 1, F-59655 Villeneuve d'Ascq, France.

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http://dx.doi.org/10.1016/j.psyneuen.2006.11.005DOI Listing
February 2007

Probing the role of the covalent linkage of ferrocene into a chloroquine template.

J Med Chem 2006 Jul;49(15):4707-14

Unité de Catalyse et Chimie du Solide - UMR CNRS 8181, ENSCL, Bâtiment C7, USTL, B.P. 90108, 59652, Villeneuve d' Ascq Cedex, France.

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http://dx.doi.org/10.1021/jm060259dDOI Listing
July 2006

Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities.

J Med Chem 2006 May;49(9):2845-9

Unité de Catalyse et Chimie du Solide - UMR CNRS 8181, ENSCL, Bâtiment C7, USTL, B.P. 90108, 59652 Villeneuve d' Ascq Cedex, France.

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http://dx.doi.org/10.1021/jm0601856DOI Listing
May 2006

Analysis of immune response patterns in naïve and Plasmodium berghei-infected young rats following a ferroquine treatment.

Int J Parasitol 2005 Dec 24;35(14):1601-10. Epub 2005 Aug 24.

Unité Inserm 547, IFR 17, Institut Pasteur de Lille, 1 rue du Prof. Calmette, 59019 Lille, France.

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http://dx.doi.org/10.1016/j.ijpara.2005.07.007DOI Listing
December 2005

Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts.

Am J Transplant 2005 Sep;5(9):2143-53

Institut National de la Santé et de la Recherche Médicale (INSERM), Unit 643 and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, France.

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http://dx.doi.org/10.1111/j.1600-6143.2005.01007.xDOI Listing
September 2005

Identification of a mitochondrial superoxide dismutase with an unusual targeting sequence in Plasmodium falciparum.

Mol Biochem Parasitol 2004 Sep;137(1):121-32

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, WTB/MSI Complex, DD15EH, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2004.05.005DOI Listing
September 2004

Immunobiological characterization of N -nitrosomethylurea-induced rat breast carcinomas: tumoral IL-10 expression as a possible immune escape mechanism.

Breast Cancer Res Treat 2004 Mar;84(2):107-16

Departamento de Bioquímica, Laboratorio de Oncologia Basica y Biologia Molecular, Facultad de Medicina, Montevideo, Uruguay.

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http://dx.doi.org/10.1023/B:BREA.0000018407.47909.78DOI Listing
March 2004

Age-related susceptibility and resistance to Plasmodium berghei in mice and rats.

Exp Parasitol 2003 May-Jun;104(1-2):81-5

Unité INSERM 547, IFR 17, Institut Pasteur de Lille, 1 rue du Prof. Calmette, Lille 59019, France.

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http://dx.doi.org/10.1016/s0014-4894(03)00134-6DOI Listing
October 2003

The age-related resistance of rats to Plasmodium berghei infection is associated with differential cellular and humoral immune responses.

Int J Parasitol 2003 Sep;33(10):1067-78

INSERM U547, IFR 17, Institut Pasteur de Lille, 1 rue du Pr. Calmette, 59019 Lille Cedex, France.

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http://dx.doi.org/10.1016/s0020-7519(03)00176-0DOI Listing
September 2003