Publications by authors named "Jalal Hassan"

14 Publications

  • Page 1 of 1

Degradation of phosalone by silver ion catalytic hydrolysis.

Toxicol Mech Methods 2021 Mar 20;31(3):182-187. Epub 2020 Dec 20.

College of Public Health, University of South Florida, Tampa, FL, USA.

Pesticides application is expanding globally as the worldwide population increases demanding a secure and safe food supply. Organophosphorus (OP) pesticides, as a group, are widely used because they are rapidly degraded in the environment and because they have excellent efficacy and an acceptable price point. However, the chemical fate of organophosphorus pesticides is influenced by several factors, including their chemistry in aquatic environments. Among many degradation choices, hydrolysis by metal ions appears to be a good approach. Dissolved metal ions have been shown to promote the hydrolysis of organophosphorus pesticides. Using silver ion, we showed the effectiveness under and conditions for this metal ion to decontaminate water polluted by the organophosphorus phosalone. Phosalone was completely degraded in the presence of silver ions in a mole ratio of 7:1 in 20 min. Rainbow trout were divided into experimental groups to investigate the most effective ratio of silver/phosalone for pesticide degradation. Silver ion (2%) at a concentration of 0.75 and 0.1 mL removed phosalone (2%) at concentrations of 0.4 and 0.5 mL. All the rainbow trout survived in these two groups. This experiment suggested that silver ions can be beneficial at ratios in the range of 1:4 to 1:6 by hydrolyzing phosalone by attacking the electron-deficient phosphorus atom in the pesticide.
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http://dx.doi.org/10.1080/15376516.2020.1861672DOI Listing
March 2021

Doxorubicin-induced senescence through NF-κB affected by the age of mouse mesenchymal stem cells.

J Cell Physiol 2020 03 13;235(3):2336-2349. Epub 2019 Sep 13.

Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

The senescence is proposed as a defense mechanism against many anticancer drugs. This complication is marked by differences in cell appearance and inner structures underlying the impairment in function. In this experiment, doxorubicin-induced senescence was assessed in mesenchymal stem cells (MSCs) isolated from the bone marrow of different-aged Balb/c mice (1, 8, and 16 months old). In addition, doxorubicin kinetics in culture medium were investigated to compare the drug absorption rate by different-aged MSCs. Several methods were exerted including Sandwich ELISA for NF-κB activation, propidium iodide staining for cell cycle analysis, Flow-fluorescent in-situ hybridization (Flow-FISH) assay for telomere length measurement, and specific staining for evaluation of β-galactosidase. Determination of doxorubicin in a medium was performed by high-performance liquid chromatography technique. Following doxorubicin exposure, cells underwent substantial telomere shortening, cell cycle arresting in G2 phase, and increased β-galactosidase activity. Interestingly, the enhanced level of NF-κB was observed in all age groups. The highest and lowest sensitivity to telomere shortening attributed to 1- and 8-month-old MSCs, respectively. In consistent with Flow-FISH results, the β-galactosidase activity was higher in young-aged MSCs after treatment. Statistical analysis indicated a correlation between the reduction of telomere length and cessation in G2 phase. Regarding the obtained kinetics equations, the rate of doxorubicin absorption by all aged MSCs followed the same trend. In conclusion, the changing of some elements involved in doxorubicin-induced senescence can be affected by the age of the cells significantly in young MSCs than two other age groups. Hereupon, these changing patterns can open new insights to develop anticancer therapeutic strategies.
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http://dx.doi.org/10.1002/jcp.29140DOI Listing
March 2020

Evaluation of the acute and sub-acute toxicity of the black caraway seed essential oil in Wistar rats.

Toxicol Rep 2019 24;6:869-874. Epub 2019 Aug 24.

Division of Pharmacology, Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

The aim of the present study was to evaluate the acute toxicity as lethal dose 50% (LD) and sub-acute toxicity of the black caraway Bioss) seed essential oil in male Wistar rats. The compounds of were identified by GC/MS and amount of each compound was evaluated. 21 different compounds were determined in the essential oil and the main components were: carvone, p-cymene, gamma-terpinene, p-cymene-8-ol, limonene, isoterpinolene, and 2-beta pinene. For acute toxicity evaluation, the animals were randomly divided into nine group (n = 6) and received 500, 1000, 1500, 2000, 2500, 3000, 3500 and 4000 mg/kg seed essential oil, respectively and the LD value for black caraway seed essential oil was obtained above 4000 mg/kg body weight. According to data, treatment with the black caraway seed essential oil sub-acute toxicity study attenuated histopathological changes in lung, liver, kidney, testes and spleen tissues and the results of this study show that the black caraway essential oil can not affect the immune and blood system, important enzymes and vital organs of the body..
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http://dx.doi.org/10.1016/j.toxrep.2019.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719284PMC
August 2019

In vivo toxicological evaluation of graphene oxide nanoplatelets for clinical application.

Int J Nanomedicine 2018 22;13:4757-4769. Epub 2018 Aug 22.

NanoRegMed ltd, Nanotechnology and Regenerative Medicine Commercialization Centre, The London Bioscience Innovation Centre, London, UK.

Background: Graphene is considered as a wonder material; it is the strongest material on the planet, super-elastic, and conductive. Its application in biomedicine is huge, with a multibillion-dollar industry, and will revolutionize the diagnostic and treatment of diseases. However, its safety and potential toxicity is the main challenge.

Methods: This study assessed the potential toxicity of graphene oxide nanoplatelets (GONs) in an in vivo animal model using systemic, hematological, biochemical, and histopathological examinations. Normal saline (control group) or GONs (3-6 layers, lateral dimension=5-10 μm, and thickness=0.8-2 nm) at dose rate of 50, 150, or 500 mg/kg were intraperitoneally injected into adult male Wistar rats (n=5) every 48 hours during 1 week to receive each animal a total of four doses. The animals were allowed 2 weeks to recover after the last dosing. Then, animals were killed and the blood was collected for hematological and biochemical analysis. The organs including the liver, kidney, spleen, lung, intestine, brain, and heart were harvested for histopathological evaluations.

Results: The results showed GONs prevented body weight gain in animals after 21 days, treated at 500 mg/kg, but not in the animals treated at 150 or 50 mg/kg GONs. The biochemical analysis showed a significant increase in total bilirubin, with a significant decrease in triglycerides and high-density lipoprotein in animals treated at 500 mg/kg. Nonetheless, other hematological and biochemical parameters remained statistically insignificant in all GONs treated animals. The most common histopathological findings in the visceral organs were granulomatous reaction with giant cell formation and accumulation of GONs in capsular regions. Also, small foci of neuronal degeneration and necrosis were the most outstanding findings in the brain, including the cerebellum.

Conclusion: In conclusion, this study shows that GONs without functionalization are toxic. The future study is a comparison of the functionalized with non-functionalized GONs.
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http://dx.doi.org/10.2147/IJN.S168731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110298PMC
October 2018

A nanocomposite prepared from a zinc-based metal-organic framework and polyethersulfone as a novel coating for the headspace solid-phase microextraction of organophosphorous pesticides.

Mikrochim Acta 2017 12 18;185(1):62. Epub 2017 Dec 18.

Toxicology and Poisoning Research Center, Department of Toxicology, Faculty of Veterinary Medicine, University of Tehran, P.O. Box 14155-6453, Tehran, Iran.

The authors describe a zinc-based metal-organic framework/polyethersulfone nanocomposite (TMU-4/PES) coating deposited on a stainless steel wire via a single-phase inversion method. The nanocomposite represents a novel fiber coating for headspace solid-phase microextraction of organophosphorous pesticides (OPPs) from environmental water and soil samples. The synergistic effects of the high surface area and unique porous structure of TMU-4 as well as the rich π electron stacking and mechanical attributes of the PES polymer result in a high affinity of the composite for OPPs. Following thermal desorption, the OPPS were quantified by gas chromatography with a nitrogen-phosphorus detector. The preparation of the coating is simple, and the coated fiber is highly stable and reusable in that it can be used in about 100 consecutive extractions/desorption cycles. A central composite design was used for assessing the effect of the experimental parameters on the extraction process. Under optimized conditions, the limits of detection are in the 5-8 ng mL range for the OPPs diazinon, fenitrothion, malathion and chlorpyrifos. The average repeatability and fiber-to-fiber reproducibility are 6.5% and 8.7%, respectively. The method was applied to the trace determination of OPPs in (spiked) water and soil samples where it gave good recovery (88-108%) and satisfactory reproducibility (5.9-10.1%). Graphical abstract A zinc-based metal-organic framework/polyethersulfone nanocomposite coating was prepared on a stainless steel wire via phase inversion. It was used as a novel fiber coating for headspace solid phase microextraction of organophosphorous pesticides from water and soil samples.
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http://dx.doi.org/10.1007/s00604-017-2607-3DOI Listing
December 2017

Polychlorinated biphenyls hot and cold seasons distribution in sea water, sediment, and fish samples in the Khour-e-Mousa (Mah-Shahr), Iran.

Chemosphere 2013 Mar 27;90(9):2477-82. Epub 2012 Dec 27.

Department of Toxicology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

The concentrations of polychlorinated biphenyls (PCBs) were assessed at four sites in Khour-e-Mousa (Mah-Shahr), Iran. Sea water, sediment and fish (cynoglossus bilineatus) samples were taken at each site and were analysed for PCB levels. To investigate the possible source of PCBs found in fish samples, sediments and waters were collected from four sites (D1, D2, D3, and D4) and studied. The relationship between PCB concentrations in sediment, water and fish is discussed. The results indicate that PCBs are detected in all fish samples and its concentration range from 3.2 to 102.7 μg kg(-1) dry weight and 5.4-149.7 μg kg(-1) dry weight in cold and warm seasons, respectively. The D2 and D4 sites were found to have the highest and lowest levels of PCB concentrations, respectively. Total congener PCB (CB, 28, 52, 44, 101, 149, 118, 153, 138, and 180) concentrations at the sediment samples for D1, D2, D3, and D4 sites ranged from 1.6 to 30.9 μg kg(-1) dry weight and 2.3-47.1 μg kg(-1) dry weight in cold and warm seasons, respectively. The total PCB concentrations for D2 site were found to be significantly higher than other three sites. Total water congener PCB (CB, 28, 52, 44, 101, 149, 118, 153, 138, and 180) concentrations ranged from 0.01 to 0.25 μg L(-1) and 0.02-0.39 μg L(-1) in cold and warm seasons, respectively.
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http://dx.doi.org/10.1016/j.chemosphere.2012.11.006DOI Listing
March 2013

Extraction of ultra traces of polychlorinated biphenyls in aqueous samples using suspended liquid-phase microextraction and gas chromatography-electron capture detection.

Environ Monit Assess 2013 May 16;185(5):3637-44. Epub 2012 Aug 16.

Department of Toxicology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

This study reports the feasibility of applying directly suspended liquid-phase microextraction (DSLPME)-gas chromatography detection for the pre-concentration and determination of low levels of eight polychlorinated biphenyls (PCBs) in aqueous samples. The technique requires minimal sample preparation, analysis time and solvent consumption and represents significant advantages over conventional analytical methods. The experimental parameters such as salt content, sample temperature, stirring rate, extraction time, micro-drop volume and breakthrough volume were investigated and found to have significant influences on DSLPME. Under the optimal experimental conditions, the enrichment factor ranged from 578 to 729, and the recovery was above 93 %. Calibration curves possessed good linearity (R(2) > 0.99) over a wide concentration range of 0.1-10.0 μg L(-1) with limits of detection ranging from 0.01 to 0.07 μg L(-1). The relative standard deviations for 1.0 μg L(-1) of PCBs in water by using internal standard were in the range 2-14 % (n = 3). The proposed simple, accurate and sensitive analytical method was applied successfully to the determination of trace amounts of PCBs in water samples.
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http://dx.doi.org/10.1007/s10661-012-2815-6DOI Listing
May 2013

³¹P-NMR evaluation of organophosphorus pesticides degradation through metal ion promoted hydrolysis.

Environ Monit Assess 2012 Dec 21;184(12):7383-93. Epub 2012 Jan 21.

Department of Chemistry, Tarbiat Modares University, Tehran, Iran.

The degradation of some organophosphorus pesticides (OPPs) in the presence of metal ions was studied by (31)P-NMR spectroscopy. Both (31)P-NMR and gas chromatography/mass spectroscopy results were used in order to determine the nature of metabolites formed after degradation. The degraded organophosphorus pesticide were investigated for chlorpyrifos and phoxim in the presence of several metal ions including Hg(2+), Cu(2+), Cd(2+), Ni(2+), Pb(2+), and Ag(+). (31)P-NMR results indicated Ag(+) and Hg(2+) ion promoted degradation of OPPs and other metal ions formed complex with OPPs and cannot degrade OPPs. We found that the degradation of chlorpyrifos and phoxim with Ag(+) or Hg(2+) led to the formation of O,O-diethyl-O-methyl phosphorothionate, (C(2)H(5)O)(2)(CH(3)O)PS, at metal ion/pesticide mole ratios ≤1.0 and completely decomposed at a higher mole ratio of 10. Finally, the method was successfully applied to the degradation study of a number of technical and formulated pesticides in the presence of Ag(+) ion at a metal ion/pesticide mole ratio of 10.
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http://dx.doi.org/10.1007/s10661-011-2507-7DOI Listing
December 2012

Determination of aflatoxin B1 in cereals by homogeneous liquid-liquid extraction coupled to high performance liquid chromatography-fluorescence detection.

J Sep Sci 2011 Jun 13;34(11):1333-7. Epub 2011 Apr 13.

International Goods Inspection Company, Tehran, Iran.

A simple and rapid method based on homogeneous liquid-liquid extraction coupled to HPLC with fluorescence detection was developed for the determination of aflatoxin B1 (AFB1) in the rice and grain samples after post-column derivatization. The proposed method eliminated the use of immunoaffinity columns for clean-up in the determination of AFB1. The parameters affecting recovery and preconcentration such as type and volume of organic solvent, volume ratio of water/methanol, concentration of phase separator reagent and extraction time were optimized. Under the optimized conditions, the calibration graph was linear in the concentration range of 0.01-1.0 ng/g with the detection limit of 0.003 ng/g. This method was successfully applied for the analysis of AFB1 in different cereal samples.
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http://dx.doi.org/10.1002/jssc.201000882DOI Listing
June 2011

Rapid and simple low density miniaturized homogeneous liquid-liquid extraction and gas chromatography/mass spectrometric determination of pesticide residues in sediment.

J Hazard Mater 2010 Dec 13;184(1-3):869-871. Epub 2010 Aug 13.

Department of Environmental, Iranian Mineral Processing Research Center, Ministry of Industry and Mineral, Karaj, Iran.

A simple, rapid and environmentally friendly analytical methodology is developed for extraction of pesticides (diazinon, chlorpyrifos and trifluralin) from sediment samples based on a technique called low density miniaturized homogenous liquid-liquid extraction (LDMHLLE) prior gas chromatography mass spectrometry determination. The method based on homogeneous liquid-liquid extraction with methanol containing n-hexane as a solvent of lower density than water (n-hexane). After addition of water, n-hexane solvent immediately forms a distinct water immiscible phase at the top of the vial, which can be easily separated and injected to the GC/MS instrument for quantification. Acquisition was performed in the selected ion monitoring mode. The limits of detection were estimated for the individual pesticides as 3S(b) (three times of the standard deviation of baseline) of the measured chromatogram for pesticides. The proposed method is very fast, simple, and sensitive without any need for stirring and centrifugation and applied to real sediment samples, successfully.
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http://dx.doi.org/10.1016/j.jhazmat.2010.08.008DOI Listing
December 2010

A novel miniaturized homogenous liquid-liquid solvent extraction-high performance liquid chromatographic-fluorescence method for determination of ultra traces of polycyclic aromatic hydrocarbons in sediment samples.

J Chromatogr A 2010 Jul 31;1217(30):4877-82. Epub 2010 May 31.

Department of Chemistry, Faculty of Sciences, Razi University, Kermanshah, Iran.

A novel technique called miniaturized homogeneous liquid-liquid extraction (MHLLE) followed by high performance liquid chromatographic-fluorescence detection (HPLC-FL) was developed for the extraction and determination of some polycyclic aromatic hydrocarbons (PAHs) as model for analytical problem in sediment samples. The method is based on the rapid extraction of PAHs from a methanolic sample solution into 0.5 mL n-hexane, as a solvent of lower density than water. After addition of water, the extracting solvent immediately forms a distinct water-immiscible phase at the top of the vial, which can be easily separated, evaporated and re-dissolved in 25 microL of methanol and injected to the HPLC instrument. The parameters affecting the extraction process such as type and volume of organic extraction solvent, extraction time, and salt addition were investigated and the partition coefficient between methanol/water-n-hexane phases was evaluated and used to predict the extraction efficiency. Under optimal conditions, the limits of detection were estimated for the individual PAHs as 3Sb (three times of the standard deviation of baseline) of the measured chromatogram, are in the range of 0.003-0.04 ng g(-1) for sediment samples. The relative recoveries of PAHs at spiking levels of 1.0 ng g(-1) for sediment samples were in the range of 81-92%. The method was also applied to a corresponding standard references materials (IAEA-408) successfully. The proposed method is very fast, simple, and sensitive without any need for stirring and centrifugation.
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http://dx.doi.org/10.1016/j.chroma.2010.05.038DOI Listing
July 2010

Simultaneous trace multielement determination by ICP-OES after solid phase extraction with modified octadecyl silica gel.

J Hazard Mater 2009 Oct 5;170(1):151-5. Epub 2009 May 5.

Iranian Mineral Processing Research Center, Ministry of Industry and Mineral, Karaj, Iran.

Multielement simultaneous determination of 35 trace elements in environmental samples was carried out by inductively coupled plasma emission spectrometry (ICP-OES) after preconcentration with octadecyl silicagel, modified with aurin tricarboxylic acid (Aluminon). Optimal experimental conditions including pH of sample solution, sample volume, sample and eluent flow rate, type, concentration and volume of eluent and foreign ions effect were investigated and established. Trace element ions in aqueous solution were quantitatively adsorbed onto octadecyl silicagel modified with aurin tricarboxylic acid at pH 8.0 with a flow rate of 11.0 mL min(-1). The adsorbed element ions were eluted with 3-5 mL of 0.5 mol L(-1) HNO(3) at a flow rate of 10.0 mL min(-1) and analyzed by ICP-OES simultaneously. The proposed method has at least preconcentration factor of 100 in water samples, which results high sensitive detection of ultra-trace and trace analysis. The present methodology gave recoveries better than 70% and RSD less than 16%.
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http://dx.doi.org/10.1016/j.jhazmat.2009.04.119DOI Listing
October 2009

Trace analysis of chlorobenzenes in water samples using headspace solvent microextraction and gas chromatography/electron capture detection.

Talanta 2006 Jul 18;69(5):1088-94. Epub 2006 Jan 18.

Department of Chemistry, Tarbiat Modarres University, Tehran, Iran.

In the present work, a rapid method for the extraction and determination of chlorobenzenes (CBs) such as monochlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene, 1,2,3-trichlorobenzene and 1,2,4-trichlorobenzene in water samples using the headspace solvent microextraction (HSME) and gas chromatography/electron capture detector (ECD) has been described. A microdrop of the dodecane containing monobromobenzene (internal standard) was used as extracting solvent in this investigation. The analytes were extracted by suspending a 2.5 microl extraction drop directly from the tip of a microsyringe fixed above an extraction vial with a septum in a way that the needle passed through the septum and the needle tip appeared above the surface of the solution. After the extraction was finished, the drop was retracted back into the needle and injected directly into a GC column. Optimization of experimental conditions such as nature of the extracting solvent, microdrop and sample temperatures, stirring rate, microdrop and sample volumes, the ionic strength and extraction time were investigated. The optimized conditions were as follows: dodecane as the extracting solvent, the extraction temperature, 45 degrees C; the sodium chloride concentration, 2M; the extraction time, 5.0 min; the stirring rate, 500 rpm; the drop volume, 2.5 microl; the sample volume, 7 ml; the microsyringe needle temperature, 0.0 degrees C. The limit of detection (LOD) ranged from 0.1 microg/l (for 1,3-dichlorobenzene) to 3.0 microg/l (for 1,4-dichlorobenzene) and linear range of 0.5-3.0 microg/l for 1,2-dichlorobenzene, 1,3-dichlorobenzene and from 5.0 to 20.0 microg/l for monochlorobenzene and from 5.0 to 30 microg/l for 1,4-dichlorobenzene. The relative standard deviations (R.S.D.) for most of CBs at the 5 microg/l level were below 10%. The optimized procedure was successfully applied to the extraction and determination of CBs in different water samples.
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http://dx.doi.org/10.1016/j.talanta.2005.12.020DOI Listing
July 2006

Preconcentration of trace amounts of beryllium in water samples on octadecyl silica cartridges modified by quinalizarine and its determination with atomic absorption spectrometry.

Talanta 2002 Mar;56(3):375-81

Department of Chemistry, Tarbiat Modarres University, Tehran, Iran.

A simple method has been developed for rapid and selective extraction, preconcentration and determination of trace amounts of beryllium. The extraction is carried out by octadecyl silica cartridge, modified with quinalizarine as a chelating agent. The effect of different parameters, such as sample matrix, flowrates of sample solution and eluent, pH, type and least amount of eluent for elution of Be(+2) ions from cartridge, breakthrough volume and limit of detection, were evaluated. Also, the effects of various cationic and anionic interferences on percent recovery of Be(+2) were studied. Be(+2) was extracted from solution at pH 6-6.6 and was eluted from modified cartridge with 5 ml of 0.5 M HNO(3). Extraction efficiencies >99% were obtained by elution of the cartridges with minimal amount of eluent. A preconcentration factor of 200 and a detection limit of 200 ng per 1000 ml were obtained. The method was applied to the recovery and determination of Be(+2) in different water and alloy samples.
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http://dx.doi.org/10.1016/s0039-9140(01)00560-4DOI Listing
March 2002
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