Jakob Skou Pedersen

Jakob Skou Pedersen

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Jakob Skou Pedersen

Jakob Skou Pedersen

Publications by authors named "Jakob Skou Pedersen"

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33Publications

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Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer.

Authors:
Myrthe Jager Francis Blokzijl Ewart Kuijk Johanna Bertl Maria Vougioukalaki Roel Janssen Nicolle Besselink Sander Boymans Joep de Ligt Jakob Skou Pedersen Jan Hoeijmakers Joris Pothof Ruben van Boxtel Edwin Cuppen

Genome Res 2019 07 20;29(7):1067-1077. Epub 2019 Jun 20.

Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands.

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http://dx.doi.org/10.1101/gr.246223.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633256PMC
July 2019

ncdDetect2: improved models of the site-specific mutation rate in cancer and driver detection with robust significance evaluation.

Authors:
Malene Juul Tobias Madsen Qianyun Guo Johanna Bertl Asger Hobolth Manolis Kellis Jakob Skou Pedersen

Bioinformatics 2019 01;35(2):189-199

Department of Molecular Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus N, Denmark.

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http://dx.doi.org/10.1093/bioinformatics/bty511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330011PMC
January 2019

Regmex: a statistical tool for exploring motifs in ranked sequence lists from genomics experiments.

Authors:
Morten Muhlig Nielsen Paula Tataru Tobias Madsen Asger Hobolth Jakob Skou Pedersen

Algorithms Mol Biol 2018 8;13:17. Epub 2018 Dec 8.

1Department of Molecular Medicine (MOMA), Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1186/s13015-018-0135-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286601PMC
December 2018

APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells.

Authors:
Kristian Mark Jacobsen Nikolaj Lilholm Villadsen Thomas Tørring Camilla Bak Nielsen Trine Salomón Morten Muhlig Nielsen Michail Tsakos Christian Sibbersen Carsten Scavenius Rikke Nielsen Erik Ilsø Christensen Paula Fernandez Guerra Peter Bross Jakob Skou Pedersen Jan Johannes Enghild Mogens Johannsen Jørgen Frøkiær Jens Overgaard Michael R Horsman Morten Busk Thomas B Poulsen

Cell Chem Biol 2018 11 16;25(11):1337-1349.e12. Epub 2018 Aug 16.

Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.07.010DOI Listing
November 2018

DNA hypermethylation and differential gene expression associated with Klinefelter syndrome.

Authors:
Anne Skakkebæk Morten Muhlig Nielsen Christian Trolle Søren Vang Henrik Hornshøj Jakob Hedegaard Mikkel Wallentin Anders Bojesen Jens Michael Hertz Jens Fedder John Rosendahl Østergaard Jakob Skou Pedersen Claus Højbjerg Gravholt

Sci Rep 2018 09 13;8(1):13740. Epub 2018 Sep 13.

Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, 8000, Aarhus, Denmark.

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http://www.nature.com/articles/s41598-018-31780-0
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http://dx.doi.org/10.1038/s41598-018-31780-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137224PMC
September 2018

A site specific model and analysis of the neutral somatic mutation rate in whole-genome cancer data.

Authors:
Johanna Bertl Qianyun Guo Malene Juul Søren Besenbacher Morten Muhlig Nielsen Henrik Hornshøj Jakob Skou Pedersen Asger Hobolth

BMC Bioinformatics 2018 04 19;19(1):147. Epub 2018 Apr 19.

Department of Molecular Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N, DK-8200, Denmark.

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http://dx.doi.org/10.1186/s12859-018-2141-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909259PMC
April 2018

Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival.

Authors:
Henrik Hornshøj Morten Muhlig Nielsen Nicholas A Sinnott-Armstrong Michał P Świtnicki Malene Juul Tobias Madsen Richard Sallari Manolis Kellis Torben Ørntoft Asger Hobolth Jakob Skou Pedersen

NPJ Genom Med 2018 11;3. Epub 2018 Jan 11.

1Department of Molecular Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus, Denmark.

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http://dx.doi.org/10.1038/s41525-017-0040-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765157PMC
January 2018

Optimized targeted sequencing of cell-free plasma DNA from bladder cancer patients.

Authors:
Emil Christensen Iver Nordentoft Søren Vang Karin Birkenkamp-Demtröder Jørgen Bjerggaard Jensen Mads Agerbæk Jakob Skou Pedersen Lars Dyrskjøt

Sci Rep 2018 01 30;8(1):1917. Epub 2018 Jan 30.

Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1038/s41598-018-20282-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789978PMC
January 2018

Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer.

Authors:
Trine Line Hauge Okholm Morten Muhlig Nielsen Mark P Hamilton Lise-Lotte Christensen Søren Vang Jakob Hedegaard Thomas Birkballe Hansen Jørgen Kjems Lars Dyrskjøt Jakob Skou Pedersen

NPJ Genom Med 2017 28;2:36. Epub 2017 Nov 28.

Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, 8200 Denmark.

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http://www.nature.com/articles/s41525-017-0038-z
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http://dx.doi.org/10.1038/s41525-017-0038-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705701PMC
November 2017

Significance evaluation in factor graphs.

Authors:
Tobias Madsen Asger Hobolth Jens Ledet Jensen Jakob Skou Pedersen

BMC Bioinformatics 2017 Mar 31;18(1):199. Epub 2017 Mar 31.

Department of Molecular Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus, Denmark.

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http://dx.doi.org/10.1186/s12859-017-1614-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374669PMC
March 2017

Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate.

Authors:
Malene Juul Johanna Bertl Qianyun Guo Morten Muhlig Nielsen Michał Świtnicki Henrik Hornshøj Tobias Madsen Asger Hobolth Jakob Skou Pedersen

Elife 2017 03 31;6. Epub 2017 Mar 31.

Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.7554/eLife.21778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440169PMC
March 2017

epiG: statistical inference and profiling of DNA methylation from whole-genome bisulfite sequencing data.

Authors:
Martin Vincent Kamilla Mundbjerg Jakob Skou Pedersen Gangning Liang Peter A Jones Torben Falck Ørntoft Karina Dalsgaard Sørensen Carsten Wiuf

Genome Biol 2017 02 21;18(1):38. Epub 2017 Feb 21.

Department of Mathematical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.

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http://dx.doi.org/10.1186/s13059-017-1168-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320668PMC
February 2017

Fast, Accurate and Automatic Ancient Nucleosome and Methylation Maps with epiPALEOMIX.

Authors:
Kristian Hanghøj Andaine Seguin-Orlando Mikkel Schubert Tobias Madsen Jakob Skou Pedersen Eske Willerslev Ludovic Orlando

Mol Biol Evol 2016 12 13;33(12):3284-3298. Epub 2016 Sep 13.

Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark

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http://dx.doi.org/10.1093/molbev/msw184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100044PMC
December 2016

SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization.

Authors:
Nkerorema Djodji Damas Michela Marcatti Christophe Côme Lise Lotte Christensen Morten Muhlig Nielsen Roland Baumgartner Helene Maria Gylling Giulia Maglieri Carsten Friis Rundsten Stefan E Seemann Nicolas Rapin Simon Thézenas Søren Vang Torben Ørntoft Claus Lindbjerg Andersen Jakob Skou Pedersen Anders H Lund

Nat Commun 2016 12 22;7:13875. Epub 2016 Dec 22.

Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaloes Vej 5 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1038/ncomms13875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192221PMC
December 2016

Paired Exome Analysis Reveals Clonal Evolution and Potential Therapeutic Targets in Urothelial Carcinoma.

Authors:
Philippe Lamy Iver Nordentoft Karin Birkenkamp-Demtröder Mathilde Borg Houlberg Thomsen Palle Villesen Søren Vang Jakob Hedegaard Michael Borre Jørgen Bjerggaard Jensen Søren Høyer Jakob Skou Pedersen Torben F Ørntoft Lars Dyrskjøt

Cancer Res 2016 10 3;76(19):5894-5906. Epub 2016 Aug 3.

Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0436DOI Listing
October 2016

ProbFold: a probabilistic method for integration of probing data in RNA secondary structure prediction.

Authors:
Sudhakar Sahoo Michał P Świtnicki Jakob Skou Pedersen

Bioinformatics 2016 09 21;32(17):2626-35. Epub 2016 Apr 21.

Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus N 8200, Denmark Bioinformatics Research Centre, Aarhus University, Aarhus C DK-8000, Denmark.

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http://dx.doi.org/10.1093/bioinformatics/btw175DOI Listing
September 2016

Widespread DNA hypomethylation and differential gene expression in Turner syndrome.

Authors:
Christian Trolle Morten Muhlig Nielsen Anne Skakkebæk Philippe Lamy Søren Vang Jakob Hedegaard Iver Nordentoft Torben Falck Ørntoft Jakob Skou Pedersen Claus Højbjerg Gravholt

Sci Rep 2016 Sep 30;6:34220. Epub 2016 Sep 30.

Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043230PMC
http://dx.doi.org/10.1038/srep34220DOI Listing
September 2016

miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells.

Authors:
Mads Heilskov Rasmussen Iben Lyskjær Rosa Rakownikow Jersie-Christensen Line Schmidt Tarpgaard Bjarke Primdal-Bengtson Morten Muhlig Nielsen Jakob Skou Pedersen Tine Plato Hansen Flemming Hansen Jesper Velgaard Olsen Per Pfeiffer Torben Falck Ørntoft Claus Lindbjerg Andersen

Nat Commun 2016 08 16;7:12436. Epub 2016 Aug 16.

Department of Molecular Medicine, Department of Clinical Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus, Denmark.

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http://dx.doi.org/10.1038/ncomms12436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990699PMC
August 2016

Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma.

Authors:
Jakob Hedegaard Philippe Lamy Iver Nordentoft Ferran Algaba Søren Høyer Benedicte Parm Ulhøi Søren Vang Thomas Reinert Gregers G Hermann Karin Mogensen Mathilde Borg Houlberg Thomsen Morten Muhlig Nielsen Mirari Marquez Ulrika Segersten Mattias Aine Mattias Höglund Karin Birkenkamp-Demtröder Niels Fristrup Michael Borre Arndt Hartmann Robert Stöhr Sven Wach Bastian Keck Anna Katharina Seitz Roman Nawroth Tobias Maurer Cane Tulic Tatjana Simic Kerstin Junker Marcus Horstmann Niels Harving Astrid Christine Petersen M Luz Calle Ewout W Steyerberg Willemien Beukers Kim E M van Kessel Jørgen Bjerggaard Jensen Jakob Skou Pedersen Per-Uno Malmström Núria Malats Francisco X Real Ellen C Zwarthoff Torben Falck Ørntoft Lars Dyrskjøt

Cancer Cell 2016 07 16;30(1):27-42. Epub 2016 Jun 16.

Department of Molecular Medicine, Aarhus University Hospital, Aarhus 8200, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.05.004DOI Listing
July 2016

Next-generation sequencing of RNA and DNA isolated from paired fresh-frozen and formalin-fixed paraffin-embedded samples of human cancer and normal tissue.

Authors:
Jakob Hedegaard Kasper Thorsen Mette Katrine Lund Anne-Mette K Hein Stephen Jacques Hamilton-Dutoit Søren Vang Iver Nordentoft Karin Birkenkamp-Demtröder Mogens Kruhøffer Henrik Hager Bjarne Knudsen Claus Lindbjerg Andersen Karina Dalsgaard Sørensen Jakob Skou Pedersen Torben Falck Ørntoft Lars Dyrskjøt

PLoS One 2014 30;9(5):e98187. Epub 2014 May 30.

Department of Molecular Medicine (MOMA), Molecular Diagnostic Laboratory, Aarhus University Hospital, Skejby, Aarhus, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098187PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039489PMC
January 2015

SNPest: a probabilistic graphical model for estimating genotypes.

Authors:
Stinus Lindgreen Anders Krogh Jakob Skou Pedersen

BMC Res Notes 2014 Oct 7;7:698. Epub 2014 Oct 7.

Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, Ole Maaloes Vej, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1186/1756-0500-7-698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203901PMC
October 2014

A dual program for translation regulation in cellular proliferation and differentiation.

Authors:
Hila Gingold Disa Tehler Nanna R Christoffersen Morten M Nielsen Fazila Asmar Susanne M Kooistra Nicolaj S Christophersen Lise Lotte Christensen Michael Borre Karina D Sørensen Lars D Andersen Claus L Andersen Esther Hulleman Tom Wurdinger Elisabeth Ralfkiær Kristian Helin Kirsten Grønbæk Torben Ørntoft Sebastian M Waszak Orna Dahan Jakob Skou Pedersen Anders H Lund Yitzhak Pilpel

Cell 2014 Sep;158(6):1281-1292

Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.08.011DOI Listing
September 2014

Mutational context and diverse clonal development in early and late bladder cancer.

Authors:
Iver Nordentoft Philippe Lamy Karin Birkenkamp-Demtröder Karey Shumansky Søren Vang Henrik Hornshøj Malene Juul Palle Villesen Jakob Hedegaard Andrew Roth Kasper Thorsen Søren Høyer Michael Borre Thomas Reinert Niels Fristrup Lars Dyrskjøt Sohrab Shah Jakob Skou Pedersen Torben F Ørntoft

Cell Rep 2014 Jun 15;7(5):1649-1663. Epub 2014 May 15.

Department of Molecular Medicine, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200 Aarhus, Denmark. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(14)00340-4.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471400340
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http://dx.doi.org/10.1016/j.celrep.2014.04.038DOI Listing
June 2014

Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome.

Authors:
Jakob Skou Pedersen Eivind Valen Amhed M Vargas Velazquez Brian J Parker Morten Rasmussen Stinus Lindgreen Berit Lilje Desmond J Tobin Theresa K Kelly Søren Vang Robin Andersson Peter A Jones Cindi A Hoover Alexei Tikhonov Egor Prokhortchouk Edward M Rubin Albin Sandelin M Thomas P Gilbert Anders Krogh Eske Willerslev Ludovic Orlando

Genome Res 2014 Mar 3;24(3):454-66. Epub 2013 Dec 3.

Department of Molecular Medicine (MOMA), Aarhus University Hospital, Skejby, DK-8200 Aarhus N, Denmark;

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http://genome.cshlp.org/cgi/doi/10.1101/gr.163592.113
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http://dx.doi.org/10.1101/gr.163592.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941110PMC
March 2014

Identification of expressed and conserved human noncoding RNAs.

Authors:
Morten Muhlig Nielsen Disa Tehler Søren Vang Frantisek Sudzina Jakob Hedegaard Iver Nordentoft Torben Falck Orntoft Anders H Lund Jakob Skou Pedersen

RNA 2014 Feb 16;20(2):236-51. Epub 2013 Dec 16.

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http://dx.doi.org/10.1261/rna.038927.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895275PMC
February 2014

New families of human regulatory RNA structures identified by comparative analysis of vertebrate genomes.

Authors:
Brian J Parker Ida Moltke Adam Roth Stefan Washietl Jiayu Wen Manolis Kellis Ronald Breaker Jakob Skou Pedersen

Genome Res 2011 Nov 12;21(11):1929-43. Epub 2011 Oct 12.

The Bioinformatics Centre, Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1101/gr.112516.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205577PMC
November 2011

Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis.

Authors:
Kasper Thorsen Troels Schepeler Bodil Øster Mads H Rasmussen Søren Vang Kai Wang Kristian Q Hansen Philippe Lamy Jakob Skou Pedersen Asger Eller Francisco Mansilla Kirsti Laurila Carsten Wiuf Søren Laurberg Lars Dyrskjøt Torben F Ørntoft Claus L Andersen

BMC Genomics 2011 Oct 14;12:505. Epub 2011 Oct 14.

Department of Molecular Medicine, Aarhus University Hospital, Skejby, 8200 Aarhus N, Denmark.

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http://dx.doi.org/10.1186/1471-2164-12-505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208247PMC
October 2011

Ancient human genome sequence of an extinct Palaeo-Eskimo.

Authors:
Morten Rasmussen Yingrui Li Stinus Lindgreen Jakob Skou Pedersen Anders Albrechtsen Ida Moltke Mait Metspalu Ene Metspalu Toomas Kivisild Ramneek Gupta Marcelo Bertalan Kasper Nielsen M Thomas P Gilbert Yong Wang Maanasa Raghavan Paula F Campos Hanne Munkholm Kamp Andrew S Wilson Andrew Gledhill Silvana Tridico Michael Bunce Eline D Lorenzen Jonas Binladen Xiaosen Guo Jing Zhao Xiuqing Zhang Hao Zhang Zhuo Li Minfeng Chen Ludovic Orlando Karsten Kristiansen Mads Bak Niels Tommerup Christian Bendixen Tracey L Pierre Bjarne Grønnow Morten Meldgaard Claus Andreasen Sardana A Fedorova Ludmila P Osipova Thomas F G Higham Christopher Bronk Ramsey Thomas V O Hansen Finn C Nielsen Michael H Crawford Søren Brunak Thomas Sicheritz-Pontén Richard Villems Rasmus Nielsen Anders Krogh Jun Wang Eske Willerslev

Nature 2010 Feb;463(7282):757-62

Centre for GeoGenetics, Natural History Museum of Denmark and Department of Biology, University of Copenhagen, Universitetsparken 15, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1038/nature08835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951495PMC
February 2010

Editing modifies the GABA(A) receptor subunit alpha3.

Authors:
Johan Ohlson Jakob Skou Pedersen David Haussler Marie Ohman

RNA 2007 May 16;13(5):698-703. Epub 2007 Mar 16.

Department of Molecular Biology and Functional Genomics, Stockholm University, SE-106 91 Stockholm, Sweden.

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http://www.rnajournal.org/cgi/doi/10.1261/rna.349107
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http://dx.doi.org/10.1261/rna.349107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852825PMC
May 2007

Identification and classification of conserved RNA secondary structures in the human genome.

Authors:
Jakob Skou Pedersen Gill Bejerano Adam Siepel Kate Rosenbloom Kerstin Lindblad-Toh Eric S Lander Jim Kent Webb Miller David Haussler

PLoS Comput Biol 2006 Apr 21;2(4):e33. Epub 2006 Apr 21.

Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California, USA.

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http://dx.doi.org/10.1371/journal.pcbi.0020033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440920PMC
April 2006

An evolutionary model for protein-coding regions with conserved RNA structure.

Authors:
Jakob Skou Pedersen Roald Forsberg Irmtraud Margret Meyer Jotun Hein

Mol Biol Evol 2004 Oct 30;21(10):1913-22. Epub 2004 Jun 30.

Bioinformatics Research Center, University of Aarhus, Aarhus, Denmark.

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http://dx.doi.org/10.1093/molbev/msh199DOI Listing
October 2004

A comparative method for finding and folding RNA secondary structures within protein-coding regions.

Authors:
Jakob Skou Pedersen Irmtraud Margret Meyer Roald Forsberg Peter Simmonds Jotun Hein

Nucleic Acids Res 2004 24;32(16):4925-36. Epub 2004 Sep 24.

Bioinformatics Research Center, Department of Ecology and Genetics, The Institute of Biological Sciences, University of Aarhus, Ny Munkegade, Building 550, 8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1093/nar/gkh839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC519121PMC
October 2004

Gene finding with a hidden Markov model of genome structure and evolution.

Authors:
Jakob Skou Pedersen Jotun Hein

Bioinformatics 2003 Jan;19(2):219-27

Bioinformatics Research Center, Department of Genetics and Ecology, The Institute of Biological Sciences, University of Aarhus, Building 550, Ny Munkegade, 8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1093/bioinformatics/19.2.219DOI Listing
January 2003