Jake Shortt

Jake Shortt

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Jake Shortt

Jake Shortt

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Dose-adjusted EPOCH-R therapy in MYC-rearranged diffuse large B-cell lymphoma: not yet the standard of care.

Lancet Haematol 2019 Mar;6(3):e119

The Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(19)30013-4DOI Listing
March 2019

A Comprehensive Protocol Resource for Performing Pooled shRNA and CRISPR Screens.

Methods Mol Biol 2018 ;1725:201-227

Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-4939-7568-6_17DOI Listing
January 2019

Chronic myeloid leukaemia and tyrosine kinase inhibitor therapy: assessment and management of cardiovascular risk factors.

Intern Med J 2018 02;48 Suppl 2:5-13

Department of Cardiology, Mater Hospital and University of Queensland, Brisbane, Queensland, Australia.

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http://doi.wiley.com/10.1111/imj.13716
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http://dx.doi.org/10.1111/imj.13716DOI Listing
February 2018

A chemical probe toolbox for dissecting the cancer epigenome.

Nat Rev Cancer 2017 02;17(3):160-183

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nrc.2016.148DOI Listing
February 2017

Development of single and mixed isoform selectivity PI3Kδ inhibitors by targeting Asn836 of PI3Kδ.

Bioorg Med Chem Lett 2016 10 11;26(19):4790-4794. Epub 2016 Aug 11.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1016/j.bmcl.2016.08.028DOI Listing
October 2016

BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members.

Mol Cancer Ther 2016 09 12;15(9):2030-41. Epub 2016 Jul 12.

Gene Regulation Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0924DOI Listing
September 2016

Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model.

Int J Cancer 2016 Jul 10;139(1):194-204. Epub 2016 Mar 10.

Peter MacCallum Cancer Centre, Translational Research Laboratory, East Melbourne, VIC, Australia.

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http://dx.doi.org/10.1002/ijc.30056DOI Listing
July 2016

The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia.

Cancer Res 2016 Mar 1;76(5):1158-69. Epub 2015 Dec 1.

Gene Regulation Laboratory, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, Australia. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1070DOI Listing
March 2016

Infusional dose-adjusted epoch plus bortezomib for the treatment of plasmablastic lymphoma.

Ann Hematol 2016 Mar 23;95(4):667-8. Epub 2016 Jan 23.

Monash Haematology, Monash Medical Centre, Level 4, 246 Clayton Road, Clayton, VIC, Australia, 3168.

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http://dx.doi.org/10.1007/s00277-016-2601-6DOI Listing
March 2016

Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts.

Ann Surg Oncol 2016 Jan 18;23(1):305-11. Epub 2015 Feb 18.

Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1245/s10434-015-4425-3DOI Listing
January 2016

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma.

Cancer Discov 2016 Jan 21;6(1):59-70. Epub 2015 Oct 21.

Division of Research, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia. Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0673DOI Listing
January 2016

Manipulation of B-cell responses with histone deacetylase inhibitors.

Nat Commun 2015 Apr 27;6:6838. Epub 2015 Apr 27.

1] Cancer Therapeutics Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia [2] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1038/ncomms7838DOI Listing
April 2015

Inter-laboratory discordance of beta-2 microglobulin results: impact on the validity of the international staging system for multiple myeloma.

Br J Haematol 2014 Sep 30;166(6):951-3. Epub 2014 Apr 30.

Monash Haematology, Monash Medical Centre, Clayton, Vic., Australia.

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http://dx.doi.org/10.1111/bjh.12922DOI Listing
September 2014

N-Acetylcysteine for thrombotic thrombocytopenic purpura: is a von Willebrand factor-inhibitory dose feasible in vivo?

Transfusion 2014 Sep;54(9):2362-3

Monash Haematology, Monash University, Clayton, Victoria, Australia; Southern Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1111/trf.12787DOI Listing
September 2014

Combination anti-CD137 and anti-CD40 antibody therapy in murine myc-driven hematological cancers.

Leuk Res 2014 Aug 2;38(8):948-54. Epub 2014 Jun 2.

Division of Cancer Research, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville 3010, Australia; Department of Immunology, Monash University, Prahran 3181, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2014.05.010DOI Listing
August 2014

Rational combination therapies targeting survival signaling in aggressive B-cell leukemia/lymphoma.

Curr Opin Hematol 2014 Jul;21(4):297-308

aCancer Therapeutics Program, Gene Regulation Laboratory, The Peter MacCallum Cancer Centre, Melbourne bMonash Haematology, Monash Medical Centre cSouthern Clinical School, Monash University, Faculty of Medicine, Dentistry and Health Sciences, Clayton dSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.

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https://insights.ovid.com/crossref?an=00062752-201407000-000
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http://dx.doi.org/10.1097/MOH.0000000000000045DOI Listing
July 2014

The drug vehicle and solvent N-methylpyrrolidone is an immunomodulator and antimyeloma compound.

Cell Rep 2014 May 9;7(4):1009-19. Epub 2014 May 9.

Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3002, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.04.008DOI Listing
May 2014

From anecdote to targeted therapy: the curious case of thalidomide in multiple myeloma.

Cancer Cell 2014 Jan;25(1):9-11

Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia.

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http://dx.doi.org/10.1016/j.ccr.2013.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984916PMC
January 2014

An intact immune system is required for the anticancer activities of histone deacetylase inhibitors.

Cancer Res 2013 Dec 24;73(24):7265-76. Epub 2013 Oct 24.

Authors' Affiliations: Cancer Therapeutics Program, and Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria; The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba; Queensland Institute of Medical Research; and School of Medicine, University of Queensland, Herston, Queensland, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0890DOI Listing
December 2013

AKT signalling is required for ribosomal RNA synthesis and progression of Eμ-Myc B-cell lymphoma in vivo.

FEBS J 2013 Nov 13;280(21):5307-16. Epub 2013 Feb 13.

Division of Research, Peter MacCallum Cancer Centre, East Melbourne, Vic., Australia.

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http://dx.doi.org/10.1111/febs.12135DOI Listing
November 2013

FISH detection of PML-RARA fusion in ins(15;17) acute promyelocytic leukaemia depends on probe size.

Biomed Res Int 2013 28;2013:164501. Epub 2013 Mar 28.

Victorian Cancer Cytogenetics Service, St Vincent's Hospital Melbourne, Fitzroy, VIC 3065, Australia.

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http://dx.doi.org/10.1155/2013/164501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625549PMC
September 2013

Oncogenes in cell survival and cell death.

Cold Spring Harb Perspect Biol 2012 Dec 1;4(12). Epub 2012 Dec 1.

Cancer Therapeutics Program, Gene Regulation Laboratory, Peter MacCallum Cancer Centre, East Melbourne 3002, Victoria, Australia.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a009829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504432PMC
December 2012

Serum protein electrophoresis: a precautionary tale.

Pathology 2012 Jun;44(4):371-373

Department of Clinical Haematology, Southern Health, Clayton, Australia.

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http://dx.doi.org/10.1097/PAT.0b013e328353be32DOI Listing
June 2012

Failure of eculizumab to correct paroxysmal cold hemoglobinuria.

Ann Hematol 2011 Aug 26;90(8):989-90. Epub 2010 Nov 26.

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http://dx.doi.org/10.1007/s00277-010-1123-xDOI Listing
August 2011

Acute splenic sequestration complicating sickle cell disease.

Eur J Haematol 2008 Jul 10;81(1):81. Epub 2008 Mar 10.

Haematology Unit, Alfred Pathology Service, The Alfred Hospital, Melbourne, Australia.

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http://dx.doi.org/10.1111/j.1600-0609.2008.01070.xDOI Listing
July 2008

Oxidative haemolysis due to 'poppers'.

Br J Haematol 2008 Jul 8;142(3):328. Epub 2008 May 8.

Haematology Unit, Alfred Pathology Service, The Alfred Hospital, Melbourne, Vic., Australia.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07150.xDOI Listing
July 2008

Blood transfusion requirements for patients undergoing chemotherapy for acute myeloid leukemia how much is enough?

Haematologica 2007 Jul;92(7):996-7

Clinical Haematology/Bone Marrow Transplant Unit, Alfred Pathology Service, The Alfred Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.3324/haematol.11019DOI Listing
July 2007

AIDS-related plasmablastic lymphoma of the oral cavity associated with an IGH/MYC translocation--treatment with autologous stem-cell transplantation in a patient with severe haemophilia-A.

Haematologica 2007 Jan;92(1):e11-2

Clinical Haematology/Bone Marrow Transplant Department, The Alfred, Commercial Road, Prahran, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.3324/haematol.10933DOI Listing
January 2007

Carotid artery haemorrhage: an uncommon complication of constipation in a patient with severe haemophilia A.

Eur J Haematol 2006 Dec 19;77(6):544. Epub 2006 Sep 19.

Ronald Sawers Haemophilia Centre, Alfred Hospital, Melbourne, Vic., Australia.

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http://dx.doi.org/10.1111/j.1600-0609.2006.00761.xDOI Listing
December 2006