Jake Baum

Jake Baum

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Jake Baum

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Structure-Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes.

J Med Chem 2020 Mar 20;63(5):2240-2262. Epub 2019 Sep 20.

Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, United Kingdom.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00898DOI Listing
March 2020

A biosynthetic platform for antimalarial drug discovery.

Antimicrob Agents Chemother 2020 Mar 9. Epub 2020 Mar 9.

Department of Life Sciences, Imperial College London, UK

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http://dx.doi.org/10.1128/AAC.02129-19DOI Listing
March 2020

Quantitative and rapid Plasmodium falciparum malaria diagnosis and artemisinin-resistance detection using a CMOS Lab-on-Chip platform.

Biosens Bioelectron 2019 Dec 7;145:111678. Epub 2019 Sep 7.

Centre for Bio-Inspired Technology, Department of Electrical and Electronic Engineering, Imperial College London, UK.

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http://dx.doi.org/10.1016/j.bios.2019.111678DOI Listing
December 2019

Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion.

EMBO Rep 2019 12 4;20(12):e48896. Epub 2019 Oct 4.

Wellcome Centre For Integrative Parasitology, Institute of Infection, Immunity & Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.15252/embr.201948896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893294PMC
December 2019

The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection.

Malar J 2019 Nov 29;18(1):381. Epub 2019 Nov 29.

Department of Life Sciences, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1186/s12936-019-3016-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884832PMC
November 2019

The antimalarial screening landscape-looking beyond the asexual blood stage.

Curr Opin Chem Biol 2019 06 12;50:1-9. Epub 2019 Mar 12.

Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cbpa.2019.01.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591700PMC
June 2019

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 04 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
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http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019

Allele-Specific Isothermal Amplification Method Using Unmodified Self-Stabilizing Competitive Primers.

Anal Chem 2018 10 2;90(20):11972-11980. Epub 2018 Oct 2.

Centre for Bio-Inspired Technology, Department of Electrical and Electronic Engineering , Imperial College London , London , SW7 2AZ , United Kingdom.

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http://dx.doi.org/10.1021/acs.analchem.8b02416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195307PMC
October 2018

Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum.

ACS Infect Dis 2018 04 5;4(4):523-530. Epub 2018 Feb 5.

Unité Biologie des Interactions Hôte-Parasite, Département de Parasites et Insectes Vecteurs , Institut Pasteur , 25-28 Rue du Dr Roux , Paris 75015 , France.

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http://dx.doi.org/10.1021/acsinfecdis.7b00228DOI Listing
April 2018

Reconstitution of the core of the malaria parasite glideosome with recombinant class XIV myosin A and actin.

J Biol Chem 2017 11 4;292(47):19290-19303. Epub 2017 Oct 4.

From the Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405 and

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http://dx.doi.org/10.1074/jbc.M117.813972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702669PMC
November 2017

Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage development.

BMC Biol 2017 08 15;15(1):70. Epub 2017 Aug 15.

Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity & Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow, G12 8TA, UK.

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http://dx.doi.org/10.1186/s12915-017-0406-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557482PMC
August 2017

Malaria Parasite Invasion: Achieving Superb Resolution.

Cell Host Microbe 2017 Mar;21(3):294-296

Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.chom.2017.02.006DOI Listing
March 2017

Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion.

J Med Chem 2016 12 2;59(24):10994-11005. Epub 2016 Dec 2.

Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01109DOI Listing
December 2016

Reassessing the mechanics of parasite motility and host-cell invasion.

J Cell Biol 2016 08;214(5):507-15

Department of Life Sciences, Imperial College London, London SW7 2AZ, England, UK

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http://dx.doi.org/10.1083/jcb.201605100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004448PMC
August 2016

The Actin Filament-Binding Protein Coronin Regulates Motility in Plasmodium Sporozoites.

PLoS Pathog 2016 07 13;12(7):e1005710. Epub 2016 Jul 13.

Integrative Parasitology, Center for Infectious Diseases, University of Heidelberg Medical School, Heidelberg, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1005710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943629PMC
July 2016

The mechanics of malaria parasite invasion of the human erythrocyte - towards a reassessment of the host cell contribution.

Cell Microbiol 2016 Mar 11;18(3):319-29. Epub 2016 Jan 11.

Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1111/cmi.12557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819681PMC
March 2016

Plasmodium actin is incompletely folded by heterologous protein-folding machinery and likely requires the native Plasmodium chaperonin complex to enter a mature functional state.

FASEB J 2016 Jan 6;30(1):405-16. Epub 2015 Oct 6.

*Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia; Department of Life Sciences and Department of Chemistry, Imperial College London, South Kensington, London, United Kingdom

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http://dx.doi.org/10.1096/fj.15-276618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423778PMC
January 2016

Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasion.

J Cell Sci 2016 Jan 24;129(1):228-42. Epub 2015 Nov 24.

Department of Life Sciences, Imperial College, London SW7 2AZ, UK

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http://dx.doi.org/10.1242/jcs.177741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732298PMC
January 2016

Motorizing pathogens.

Semin Cell Dev Biol 2015 Oct 30;46:78-81. Epub 2015 Sep 30.

Integrative Parasitology, Center for Infectious Diseases, University of Heidelberg Medical School, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2015.09.019DOI Listing
October 2015

Disassembly activity of actin-depolymerizing factor (ADF) is associated with distinct cellular processes in apicomplexan parasites.

Mol Biol Cell 2015 Sep 8;26(17):3001-12. Epub 2015 Jul 8.

Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia Department of Life Sciences, Imperial College, London SW7 2AZ, United Kingdom

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http://dx.doi.org/10.1091/mbc.E14-10-1427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551315PMC
September 2015

Membrane-wrapping contributions to malaria parasite invasion of the human erythrocyte.

Biophys J 2014 Jul;107(1):43-54

Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Jülich, Jülich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184798PMC
July 2014

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.

Elife 2014 Jun 9;3. Epub 2014 Jun 9.

Structural Studies, Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.

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http://dx.doi.org/10.7554/eLife.03080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086275PMC
June 2014

Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion.

Cell Microbiol 2013 Sep 22;15(9):1457-72. Epub 2013 Mar 22.

Advanced Microscopy Facility and Center of Excellence for Coherent X-ray Science, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Vic., 3010, Australia.

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http://dx.doi.org/10.1111/cmi.12132DOI Listing
September 2013

PfSec13 is an unusual chromatin-associated nucleoporin of Plasmodium falciparum that is essential for parasite proliferation in human erythrocytes.

J Cell Sci 2013 Jul 17;126(Pt 14):3055-69. Epub 2013 May 17.

Department of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada, The Kuvin Center for the Study of Infectious and Tropical Diseases, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

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http://dx.doi.org/10.1242/jcs.122119DOI Listing
July 2013

Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles.

Cell 2013 May 15;153(5):1120-33. Epub 2013 May 15.

Division of Infection and Immunity, the Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1016/j.cell.2013.04.029DOI Listing
May 2013

Static and dynamic imaging of erythrocyte invasion and early intra-erythrocytic development in Plasmodium falciparum.

Methods Mol Biol 2013 ;923:269-80

Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-62703-026-7_18DOI Listing
January 2013

Mammalian and malaria parasite cyclase-associated proteins catalyze nucleotide exchange on G-actin through a conserved mechanism.

J Biol Chem 2013 Jan 26;288(2):984-94. Epub 2012 Nov 26.

Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland.

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http://dx.doi.org/10.1074/jbc.M112.435719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543048PMC
January 2013

Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast.

Malar J 2013 Jan 19;12:25. Epub 2013 Jan 19.

Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, Im Neuenheimer Feld 324, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1186/1475-2875-12-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662607PMC
January 2013

Malaria parasite signal peptide peptidase is an ER-resident protease required for growth but not for invasion.

Traffic 2012 Nov 23;13(11):1457-65. Epub 2012 Aug 23.

Infection and Immunity, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1111/j.1600-0854.2012.01402.xDOI Listing
November 2012

The cellular and molecular basis for malaria parasite invasion of the human red blood cell.

J Cell Biol 2012 Sep;198(6):961-71

The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Victoria, 3052, Australia.

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http://dx.doi.org/10.1083/jcb.201206112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444787PMC
September 2012

A GFP-actin reporter line to explore microfilament dynamics across the malaria parasite lifecycle.

Mol Biochem Parasitol 2012 Mar-Apr;182(1-2):93-6. Epub 2011 Nov 25.

Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1016/j.molbiopara.2011.11.008DOI Listing
May 2012

Malaria parasite colonisation of the mosquito midgut--placing the Plasmodium ookinete centre stage.

Int J Parasitol 2012 May 3;42(6):519-27. Epub 2012 Mar 3.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S00207519120004
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http://dx.doi.org/10.1016/j.ijpara.2012.02.004DOI Listing
May 2012

Holding back the microfilament--structural insights into actin and the actin-monomer-binding proteins of apicomplexan parasites.

IUBMB Life 2012 May 27;64(5):370-7. Epub 2012 Mar 27.

Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1002/iub.1014DOI Listing
May 2012

Cytoskeletal and membrane remodelling during malaria parasite invasion of the human erythrocyte.

Br J Haematol 2011 Sep 1;154(6):680-9. Epub 2011 Jul 1.

Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical ResearchDepartment of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08766.xDOI Listing
September 2011

Biochemistry. Revealing a parasite's invasive trick.

Science 2011 Jul;333(6041):410-1

Division of Infection and Immunity, Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3052, Australia.

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http://dx.doi.org/10.1126/science.1209875DOI Listing
July 2011

Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites.

Nucleic Acids Res 2009 Jun 20;37(11):3788-98. Epub 2009 Apr 20.

The Walter & Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1093/nar/gkp239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699523PMC
June 2009

Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparum.

Infect Immun 2009 Apr 9;77(4):1689-99. Epub 2009 Feb 9.

The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia.

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http://dx.doi.org/10.1128/IAI.01331-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663147PMC
April 2009

Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum.

Int J Parasitol 2009 Feb 25;39(3):371-80. Epub 2008 Oct 25.

Division of Infection and Immunity, The Walter & Eliza Hall Institute of Medical Research, Vic., Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S002075190800388
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http://dx.doi.org/10.1016/j.ijpara.2008.10.006DOI Listing
February 2009

Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma.

Trends Parasitol 2008 Dec 1;24(12):557-63. Epub 2008 Oct 1.

Division of Infection and Immunity, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1016/j.pt.2008.08.006DOI Listing
December 2008

A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion.

Cell Host Microbe 2008 Mar;3(3):188-98

Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1016/j.chom.2008.02.006DOI Listing
March 2008

Regulation of apicomplexan actin-based motility.

Nat Rev Microbiol 2006 Aug;4(8):621-8

Division of Infection and Immunity, The Walter & Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1038/nrmicro1465DOI Listing
August 2006

A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites.

J Biol Chem 2006 Feb 1;281(8):5197-208. Epub 2005 Dec 1.

Division of Infection and Immunity, The Walter & Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

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http://www.jbc.org/content/281/8/5197.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M509807200
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http://dx.doi.org/10.1074/jbc.M509807200DOI Listing
February 2006

Invasion by P. falciparum merozoites suggests a hierarchy of molecular interactions.

PLoS Pathog 2005 Dec 16;1(4):e37. Epub 2005 Dec 16.

Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.plos.org/10.1371/journal.ppat.0010037
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http://dx.doi.org/10.1371/journal.ppat.0010037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315277PMC
December 2005

Signal-mediated export of proteins from the malaria parasite to the host erythrocyte.

J Cell Biol 2005 Nov;171(4):587-92

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia.

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http://dx.doi.org/10.1083/jcb.200508051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171567PMC
November 2005

Erythrocyte invasion phenotypes of Plasmodium falciparum in The Gambia.

Infect Immun 2003 Apr;71(4):1856-63

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152018PMC
http://dx.doi.org/10.1128/iai.71.4.1856-1863.2003DOI Listing
April 2003

Evidence for diversifying selection on erythrocyte-binding antigens of Plasmodium falciparum and P. vivax.

Genetics 2003 Apr;163(4):1327-36

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462517PMC
April 2003

In the blood--the remarkable ancestry of Plasmodium falciparum.

Trends Parasitol 2002 Aug;18(8):351-5

Dept of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London, UK WC1E 7HT.

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http://dx.doi.org/10.1016/s1471-4922(02)02316-4DOI Listing
August 2002

Natural selection on the erythrocyte surface.

Mol Biol Evol 2002 Mar;19(3):223-9

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine. Institute of Biological Anthropology, University of Oxford.

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http://academic.oup.com/mbe/article/19/3/223/980949
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http://dx.doi.org/10.1093/oxfordjournals.molbev.a004075DOI Listing
March 2002