Publications by authors named "Jaeki Min"

49Publications

Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay.

Bioconjug Chem 2020 Oct 18. Epub 2020 Oct 18.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 1000, Memphis, Tennessee 38105, United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.0c00507DOI Listing
October 2020

Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation.

J Med Chem 2019 09 13;62(18):8429-8442. Epub 2019 Sep 13.

Department of Pharmaceutical Sciences , University of Kentucky , Lexington , Kentucky 40508 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228038PMC
September 2019

Mechanistic Insight on the Mode of Action of Colletoic Acid.

J Med Chem 2019 08 24;62(15):6925-6940. Epub 2019 Jul 24.

Department of Medicine , The University of Tennessee Health Science Center , Memphis , Tennessee 38163 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00187DOI Listing
August 2019

Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

J Med Chem 2018 04 26;61(7):2680-2693. Epub 2018 Mar 26.

Department of Chemical Biology and Theraputics , St. Jude Children's Research Hospital , Memphis , Tennessee 38105 United States.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898815PMC
April 2018

Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening.

PLoS Negl Trop Dis 2017 12 29;11(12):e0006157. Epub 2017 Dec 29.

Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0006157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764437PMC
December 2017

Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway.

ACS Chem Biol 2017 09 29;12(9):2436-2447. Epub 2017 Aug 29.

Departments of Hematology, ‡Chemical Biology and Therapeutics, §Tumor Cell Biology, and ∥Computational Biology, St. Jude Children's Research Hospital , Memphis, Tennessee, United States.

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http://dx.doi.org/10.1021/acschembio.7b00527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676454PMC
September 2017

Performance of a docking/molecular dynamics protocol for virtual screening of nutlin-class inhibitors of Mdmx.

J Mol Graph Model 2017 06 24;74:54-60. Epub 2017 Feb 24.

Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2017.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508530PMC
June 2017

Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic β-hairpins.

Org Biomol Chem 2016 Nov;14(44):10386-10393

Department of Chemistry and Molecular Biology, University of Gothenburg, SE-41296 Gothenburg, Sweden. and Swedish NMR Centre, Medicinaregatan 5, SE-41390 Gothenburg, Sweden.

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http://dx.doi.org/10.1039/c6ob01510gDOI Listing
November 2016

Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides.

J Med Chem 2016 09 25;59(17):7950-62. Epub 2016 Aug 25.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital , 262 Danny Thomas Place, Memphis, Tennessee 38105 United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573263PMC
September 2016

Monitoring Ligand-Induced Protein Ordering in Drug Discovery.

J Mol Biol 2016 Mar 23;428(6):1290-1303. Epub 2016 Jan 23.

Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826315PMC
March 2016

Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents.

J Med Chem 2016 Jan 12;59(2):559-77. Epub 2016 Jan 12.

Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke University School of Medicine , 422 Seeley Mudd Building, Durham, North Carolina 27710, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01092DOI Listing
January 2016

Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen.

Antimicrob Agents Chemother 2015 Mar 15;59(3):1389-97. Epub 2014 Dec 15.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA Department of Biology, Loyola University Chicago, Chicago, Illinois, USA

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http://dx.doi.org/10.1128/AAC.01930-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325765PMC
March 2015

Comparison of the enzymatic and functional properties of three cytosolic carboxypeptidase family members.

J Biol Chem 2015 Jan 21;290(2):1222-32. Epub 2014 Nov 21.

From the Departments of Developmental Neurobiology and

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http://dx.doi.org/10.1074/jbc.M114.604850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294487PMC
January 2015

Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978.

Am J Trop Med Hyg 2014 Jun 31;90(6):1156-8. Epub 2014 Mar 31.

College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland

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http://www.ajtmh.org/content/90/6/1156.full.pdf
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http://www.ajtmh.org/cgi/doi/10.4269/ajtmh.14-0029
Publisher Site
http://dx.doi.org/10.4269/ajtmh.14-0029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047746PMC
June 2014

Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites.

Antimicrob Agents Chemother 2014 23;58(3):1516-22. Epub 2013 Dec 23.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/AAC.02148-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957893PMC
October 2014

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.

J Med Chem 2012 May 18;55(9):4205-19. Epub 2012 Apr 18.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/jm201642zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349818PMC
May 2012

Development of a high-affinity inhibitor of the prostaglandin transporter.

J Pharmacol Exp Ther 2011 Nov 17;339(2):633-41. Epub 2011 Aug 17.

Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Belfer 1008, Bronx, NY 10461, USA.

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.111.18
Publisher Site
http://dx.doi.org/10.1124/jpet.111.181354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199986PMC
November 2011

Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.

J Virol 2011 Jul 20;85(13):6381-9. Epub 2011 Apr 20.

McIntyre Medical Sciences Building, Rm. 810, 3655 Promenade Sir William Osler, McGill University, Montreal, Quebec, Canada H3G 1Y6.

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http://dx.doi.org/10.1128/JVI.00078-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126520PMC
July 2011

A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration.

J Neurosci 2010 Mar;30(13):4693-706

Departments of Pharmacology, Neurological Surgery, and Ophthalmology, and Miami Project to Cure Paralysis, Neuroscience Program, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.0302-10.2
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http://dx.doi.org/10.1523/JNEUROSCI.0302-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855497PMC
March 2010

Potent non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex.

J Med Chem 2008 Jul 5;51(13):3731-41. Epub 2008 Jun 5.

Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm701239a
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http://dx.doi.org/10.1021/jm701239aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587337PMC
July 2008

Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents.

Bioorg Med Chem Lett 2008 Feb 11;18(4):1308-11. Epub 2008 Jan 11.

Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA.

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http://ytchang.science.nus.edu.sg/pages/reprint/2008_triazin
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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0800045
Publisher Site
http://dx.doi.org/10.1016/j.bmcl.2008.01.031DOI Listing
February 2008

Discovery of cyclin-dependent kinase inhibitor, CR229, using structurebased drug screening.

J Microbiol Biotechnol 2007 Oct;17(10):1712-6

Department of Medical Genetics, College of Medicine, Hanyang University, Seoul, Korea.

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October 2007

Combinatorial dapoxyl dye library and its application to site selective probe for human serum albumin.

J Comb Chem 2007 Nov-Dec;9(6):1079-83. Epub 2007 Sep 29.

Department of Chemistry, New York University, New York, New York 10003, USA.

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http://dx.doi.org/10.1021/cc0700546DOI Listing
February 2008

Styryl-based compounds as potential in vivo imaging agents for beta-amyloid plaques.

Chembiochem 2007 Sep;8(14):1679-87

Department of Chemistry, New York University, School of Medicine, New York, NY 11219, USA.

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http://dx.doi.org/10.1002/cbic.200700154DOI Listing
September 2007

A high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide.

ACS Chem Biol 2006 Aug;1(7):461-9

Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.

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http://dx.doi.org/10.1021/cb600135wDOI Listing
August 2006

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.

Nat Chem Biol 2007 Jan 19;3(1):55-9. Epub 2006 Nov 19.

Department of Chemistry, New York University, New York, New York 10003, USA.

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http://dx.doi.org/10.1038/nchembio833DOI Listing
January 2007

Myoseverin is a potential angiogenesis inhibitor by inhibiting endothelial cell function and endothelial progenitor cell differentiation.

DNA Cell Biol 2006 Sep;25(9):514-22

Department of Biomedical Sciences, Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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http://dx.doi.org/10.1089/dna.2006.25.514DOI Listing
September 2006

Triazine-based tyrosinase inhibitors identified by chemical genetic screening.

Pigment Cell Res 2005 Dec;18(6):447-53

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1111/j.1600-0749.2005.00273.xDOI Listing
December 2005

Identification of 12Cysbeta on tubulin as the binding site of tubulyzine.

Bioorg Med Chem 2006 Feb 2;14(4):1169-75. Epub 2005 Nov 2.

National Institute of Diabetes, Digestive, Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.bmc.2005.09.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1408322PMC
February 2006

5-Demethoxyfumagillol, a potent angiogenesis inhibitor isolated from Aspergillus fumigatus.

Chem Pharm Bull (Tokyo) 2004 Apr;52(4):447-50

Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Korea.

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http://dx.doi.org/10.1248/cpb.52.447DOI Listing
April 2004