Publications by authors named "Jaehyun Kim"

88 Publications

Chemically Tunable Organic Dielectric Layer on an Oxide TFT: Poly(-xylylene) Derivatives.

ACS Appl Mater Interfaces 2021 Sep 2;13(36):43123-43133. Epub 2021 Sep 2.

Department of Chemical Engineering and Applied Chemistry, College of Engineering, Chungnam National University, 34134 Daejeon, Republic of Korea.

Inorganic materials such as SiO and SiN are commonly used as dielectric layers in thin-film transistors (TFTs), but recent advancements in TFT devices, such as inclusion in flexible electronics, require the development of novel types of dielectric layers. In this study, CVD-deposited poly(-xylylene) (PPx)-based polymers were evaluated as alternative dielectric layers. CVD-deposited PPx can produce thin, conformal, and pinhole-free polymer layers on various surfaces, including oxides and metals, without interfacial defects. Three types of commercial polymers were successfully deposited on various substrates and exhibited stable dielectric properties under frequency and voltage sweeps. Additionally, TFTs with PPx as a dielectric material and an oxide semiconductor exhibited excellent device performance; a mobility as high as 22.72 cm/(V s), which is the highest value among organic gate dielectric TFTs, to the best of our knowledge. Because of the low-temperature deposition process and its unprecedented mechanical flexibility, TFTs with CVD-deposited PPx were successfully fabricated on a flexible plastic substrate, exhibiting excellent durability over 10000 bending cycles. Finally, a custom-synthesized functionalized PPx was introduced into top-gated TFTs, demonstrating the possibility for expanding this concept to a wide range of chemistries with tunable gate dielectric layers.
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http://dx.doi.org/10.1021/acsami.1c13865DOI Listing
September 2021

Preoperative radiographic parameters in the case of using a narrow-version femoral implant in total knee arthroplasty.

Arch Orthop Trauma Surg 2021 Aug 17. Epub 2021 Aug 17.

Department of Orthopedic Surgery, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, 29, Saemunan-ro, Jongno-gu, Seoul, 03181, Republic of Korea.

Background: Recently, total knee arthroplasty (TKA) designs that allow the use of narrow-version femoral implants have been introduced to avoid femoral overhang. The purpose of this study was to investigate the frequency of the use of narrow-version femoral implants and identify the difference in radiographic parameters between using a narrow-version femoral implant and a standard-version femoral implant in TKA.

Methods: A retrospective study was conducted on 504 primary TKAs using a TKA system (Anthem or Persona) that allowed narrow-version femoral implants. Anteroposterior (AP) dimension, mediolateral (ML) dimension, and modified aspect percentage ratio (ML/AP dimension) of the distal femur in preoperative radiographs were compared between a standard-version group (n = 275) and a narrow-version group (n = 229). A cut-off value of a modified aspect percentage ratio indicating the need for a narrow-version femoral implant was determined using the receiver operating characteristic (ROC) curve.

Results: Mean ML dimension was 80.9 ± 6.1 mm in the standard-version group and 77.3 ± 4.4 mm in the narrow-version group (p < 0.001). Mean modified aspect percentage ratio was 138.8 ± 8.1% in the standard-version group and 131.7 ± 6.3% in the narrow-version group (p < 0.001). The optimum cut-off point of the modified aspect percentage ratio for narrow-version femoral implants was 135.4% (sensitivity: 72.0%; specificity: 66.7%) for Anthem and 133.3% (sensitivity: 75.9%, specificity: 76.4%) for Persona.

Conclusion: In the narrow-version femoral implant group, the ML dimension and the mean modified aspect percentage ratio were smaller than in the standard-version femoral implant group. A smaller modified aspect percentage ratio of the distal femur in preoperative radiographs could predict the need for narrow-version femoral implants in TKA. It was suggested that the cut-off point could be suggested as 135.4% for Anthem TKA design and 133.3% for Persona TKA design. These radiographic parameters are cost-effective and easily applicable for planning a TKA.A smaller modified aspect percentage ratio of the distal femur in preoperative radiographs could predict the need for narrow-version femoral implants in TKA. The cut-off point was 135.4% for Anthem TKA design and 133.3% for Persona TKA design.
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http://dx.doi.org/10.1007/s00402-021-04111-8DOI Listing
August 2021

The effects of a corticotomy on space closure by molar protraction using TSADs in patients with missing mandibular first molars.

Orthod Craniofac Res 2021 Jul 20. Epub 2021 Jul 20.

Department of Orthodontics, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

Introduction: The purpose of this study was to evaluate the effects of a triangular-shaped corticotomy on the protraction of second and third molars in patients with missing mandibular first molars.

Subjects And Methods: The corticotomy and non-corticotomy groups consisted of sixteen first molars in fifteen patients (28.6 ± 9.4 years) and nineteen first molars in fifteen patients (26.6 ± 8.4 years), respectively. A triangular-shaped corticotomy was performed between the second premolar and molar. Temporary skeletal anchorage devices (TSADs) were placed between the first and second premolars in both groups. Mandibular dentition variables were measured on the pre and post-treatment panoramic radiographs and lateral cephalograms. Analysis of covariance was performed.

Results: The corticotomy group exhibited 2.8 mm more inter-radicular correction between the second molar to second premolar roots (P < .001) and 1.6 mm more inter-radicular distance correction between the third molar to second premolar roots compared to the non-corticotomy group (P < .01). The corticotomy group required 5.5 months less treatment time for space closure (P < .05), but the total treatment time was the same for both groups.

Conclusions: The inter-radicular distance between the mandibular second premolar and molar and treatment times for space closure was significantly reduced in the corticotomy group.
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http://dx.doi.org/10.1111/ocr.12519DOI Listing
July 2021

Conformally Gated Surface Conducting Behaviors of Single-Walled Carbon Nanotube Thin-Film-Transistors.

Materials (Basel) 2021 Jun 17;14(12). Epub 2021 Jun 17.

Department of Electrical and Electronics Engineering, Chung-Ang University, Seoul 06974, Korea.

Semiconducting single-walled carbon nanotubes (s-SWCNTs) have gathered significant interest in various emerging electronics due to their outstanding electrical and mechanical properties. Although large-area and low-cost fabrication of s-SWCNT field effect transistors (FETs) can be easily achieved via solution processing, the electrical performance of the solution-based s-SWCNT FETs is often limited by the charge transport in the s-SWCNT networks and interface between the s-SWCNT and the dielectrics depending on both s-SWCNT solution synthesis and device architecture. Here, we investigate the surface and interfacial electro-chemical behaviors of s-SWCNTs. In addition, we propose a cost-effective and straightforward process capable of minimizing polymers bound to s-SWCNT surfaces acting as an interfering element for the charge carrier transport via a heat-assisted purification (HAP). With the HAP treated s-SWCNTs, we introduced conformal dielectric configuration for s-SWCNT FETs, which are explored by a carefully designed wide array of electrical and chemical characterizations with finite-element analysis (FEA) computer simulation. For more favorable gate-field-induced surface and interfacial behaviors of s-SWCNT, we implemented conformally gated highly capacitive s-SWCNT FETs with ion-gel dielectrics, demonstrating field-effect mobility of ~8.19 cm/V⋅s and on/off current ratio of ~10 along with negligible hysteresis.
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http://dx.doi.org/10.3390/ma14123361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234559PMC
June 2021

Transparent Omni-Directional Stretchable Circuit Lines Made by a Junction-Free Grid of Expandable Au Lines.

Adv Mater 2021 Aug 21;33(31):e2100299. Epub 2021 Jun 21.

Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam, Pohang, 37673, Republic of Korea.

Although various stretchable optoelectronic devices have been reported, omni-directionally stretchable transparent circuit lines have been a great challenge. Cracks are engineered and fabricated to be highly conductive patterned metal circuit lines in which gold (Au) grids are embedded. Au is deposited selectively in the cracks to form a grid without any junction between the grid lines. Since each grid line is expandable under stretching, the circuit lines are stretchable in all the directions. This study shows that a thin coating of aluminum on the oxide surface enables precise control of the cracks (crack density, crack depth) in the oxide layer. High optical transparency and high stretchability can be achieved simultaneously by controlling the grid density in the circuit line. Light-emitting diodes are integrated directly on the circuit lines and stable operation is demonstrated under 100% stretching.
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http://dx.doi.org/10.1002/adma.202100299DOI Listing
August 2021

Anti-Melanogenic Properties of Velutin and Its Analogs.

Molecules 2021 May 19;26(10). Epub 2021 May 19.

Department of Bio-Health Technology, Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Korea.

Velutin, one of the flavones contained in natural plants, has various beneficial activities, such as skin whitening, as well as anti-inflammatory, anti-allergic, antioxidant, and antimicrobial activities. However, the relationship between the structure of velutin and its anti-melanogenesis activity is not yet investigated. In this study, we obtained 12 velutin derivatives substituted at C5, C7, C3', and C4' of the flavone backbone with hydrogen, hydroxyl, and methoxy functionalities by chemical synthesis, to perform SAR analysis of velutin structural analogues. The SAR study revealed that the substitution of functional groups at C5, C7, C3', and C4' of the flavone backbone affects biological activities related to melanin synthesis. The coexistence of hydroxyl and methoxy at the C5 and C7 position is essential for inhibiting tyrosinase activity. However, 1,2-diol compounds substituted at C3' and C4' of flavone backbone induce apoptosis of melanoma cells. Further, substitution at C3' and C4' with methoxy or hydrogen is essential for inhibiting melanogenesis. Thus, this study would be helpful for the development of natural-derived functional materials to regulate melanin synthesis.
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http://dx.doi.org/10.3390/molecules26103033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160911PMC
May 2021

A neuro-symbolic method for understanding free-text medical evidence.

J Am Med Inform Assoc 2021 07;28(8):1703-1711

Department of Biomedical Informatics, Columbia University, New York, USA.

Objective: We introduce Medical evidence Dependency (MD)-informed attention, a novel neuro-symbolic model for understanding free-text clinical trial publications with generalizability and interpretability.

Materials And Methods: We trained one head in the multi-head self-attention model to attend to the Medical evidence Ddependency (MD) and to pass linguistic and domain knowledge on to later layers (MD informed). This MD-informed attention model was integrated into BioBERT and tested on 2 public machine reading comprehension benchmarks for clinical trial publications: Evidence Inference 2.0 and PubMedQA. We also curated a small set of recently published articles reporting randomized controlled trials on COVID-19 (coronavirus disease 2019) following the Evidence Inference 2.0 guidelines to evaluate the model's robustness to unseen data.

Results: The integration of MD-informed attention head improves BioBERT substantially in both benchmark tasks-as large as an increase of +30% in the F1 score-and achieves the new state-of-the-art performance on the Evidence Inference 2.0. It achieves 84% and 82% in overall accuracy and F1 score, respectively, on the unseen COVID-19 data.

Conclusions: MD-informed attention empowers neural reading comprehension models with interpretability and generalizability via reusable domain knowledge. Its compositionality can benefit any transformer-based architecture for machine reading comprehension of free-text medical evidence.
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http://dx.doi.org/10.1093/jamia/ocab077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135980PMC
July 2021

Comparison and Contrast of Bone and Dentin in Genetic Disorder, Morphology and Regeneration: A Review.

J Bone Metab 2021 Feb 28;28(1):1-10. Epub 2021 Feb 28.

Laboratory for the Study of Regenerative Dental Medicine, Department of Oral Histology-Developmental Biology & Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.

The bone and dentin have distinct healing processes. The healing process of bones is regenerative, as newly formed tissues are morphologically and functionally similar to the original bone structures. In contrast, the healing process of dentin is reparative due to its failure to replicate some of its key morphological features. In this review, we compare and contrast the healing processes of bone and dentin. We describe how distinct morphological and physiological structures of the 2 tissues translate into different signaling molecules, growth factors, and matrix protein secretion.
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http://dx.doi.org/10.11005/jbm.2021.28.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973397PMC
February 2021

A Study of Leisure Walking Intensity Levels on Mental Health and Health Perception of Older Adults.

Gerontol Geriatr Med 2021 Jan-Dec;7:2333721421999316. Epub 2021 Feb 27.

Department of Recreation, Therapeutic Recreation, and Tourism, State University of New York, College, Brockport, USA.

Research suggests that different levels of intensity of leisure walking can affect the mental health of older adults. Unfortunately, insufficient evidence exists as to the recommended intensity levels of leisure walking for their health benefits. The purpose of this study was to investigate how leisure walking intensity levels are associated with the mental health and health perceptions of older adults. Using a purposive sampling method, the data of 4,737 adults over the age of 65 were drawn from the 2017 California Health and Interview Survey. The results of analysis of these data showed that older adults who engaged in moderate and vigorous leisure walking reported higher health perceptions than those involved in light leisure walking. In addition, older adults who participated in moderate leisure walking reported higher mental health than those who engaged in light leisure walking. This study suggests that moderate and/or vigorous leisure walking can increase the mental health and health perceptions of older adults.
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http://dx.doi.org/10.1177/2333721421999316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923965PMC
February 2021

Factors associated with the maxillary third molar position after total arch distalization using a modified C-palatal plate in adolescents.

Orthod Craniofac Res 2021 Mar 2;24 Suppl 1:31-38. Epub 2021 Mar 2.

Department of Orthodontics, Seoul St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.

Introduction: The purpose of this study was to evaluate the long-term position of erupted third molars after maxillary total arch distalization using modified C-palatal plates (MCPPs) in adolescents and to identify factors associated with these positions.

Setting And Sample Population: Sixty-two third molars (male: 20, female: 42) in Class II patients treated with MCPPs and thirty-nine teeth for the Control group (male: 22, female: 17).

Materials And Methods: Samples were analyzed using panoramic radiographs taken initially (T0), after treatment (T1) and after >3 years retention (T2). Third molars were classified as downward (Group A, N = 31; males: 12, females: 19) and upward (Group B, N = 31; males: 8, females: 23) based on their vertical position after treatment. Analysis of variance and multiple logistic regression analysis were performed.

Results: The vertical position of the third molars of Group A, Group B, and the Control showed a 2.2, 3.5 and 2.7 mm downward movement at T2. However, there was no difference in the amount of third molar eruption among the groups. Regarding factors affecting the vertical distance of the third molar, Age, C8-OP, ∠8-OP and D7-T at the initial affected vertical position of the third molars after molar distalization (P < .05).

Conclusions: Group A and B showed no difference in the third molar eruption during retention after total arch distalization. This study suggests that it might be unnecessary to extract the developing third molar before molar distalization in Class II adolescents.
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http://dx.doi.org/10.1111/ocr.12468DOI Listing
March 2021

Recent advances in tumor microenvironment-targeted nanomedicine delivery approaches to overcome limitations of immune checkpoint blockade-based immunotherapy.

J Control Release 2021 04 8;332:109-126. Epub 2021 Feb 8.

Department of Bioengineering, Institute for Bioengineering and Biopharmaceutical Research Hanyang University, 04763 Seoul, South Korea; BK 21 FOUR Education and Research Group for Biopharmaceutical Inovation Leader, Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea. Electronic address:

Cancer immunotherapy has revolutionized the standard of care for solid tumors in multiple disease sites. In light of this, immune checkpoint blockade, directly interfering with various immunosuppressive mechanisms in tumor sites, has been actively studied. Inhibitors of cytotoxic T-lymphocyte-associated protein 4 (CTLA 4) and programmed cell death 1 receptor (PD-1) / programmed cell death receptor ligand 1 (PD-L1) could successfully increase survival rate in patients with advanced cancers including melanoma and non-small cell lung cancer, leading to increased survival and different patterns of response including durable response and pseudo-progression. Despite continued development of the immune checkpoint blockades, however, fairly low overall response rate (ORR) levels have been reported for patients with various types of cancer. Fewer than 13% of patients with cancer were reported to respond to immune checkpoint blockades and some patients were diagnosed with severe immune-related adverse events (irAEs). The tumor microenvironment, controlled via various components and mediators, is regarded as the primary cause responsible for failure of immune checkpoint blockades in clinical investigations. In fact, there has been a clinical report that epidermal growth factor receptor (EGFR) inhibition in tumor microenvironment enhanced ORR of PD-1 inhibitors for 29.7% in EGFR-mutated non-small-cell lung carcinoma (NSCLC) patients. Therefore, to enhance the effectiveness and reduce adverse effects of immune checkpoint blockades, the majority of studies have focused on targeting and suppressing the immunosuppressive characteristics of the tumor microenvironment. Herein, we review the components and mediators of tumor microenvironment responsible for failure of immune checkpoint blockades and introduce the recent approaches of tumor microenvironment component-targeted nanomedicine delivery capable of enhancing the efficacy of immune checkpoint blockades. Understanding the active targeting candidates of tumor microenvironment components and the associated treatment strategies could offer insights into the development of combination therapeutics boosting immune checkpoint blockades for clinical applications.
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http://dx.doi.org/10.1016/j.jconrel.2021.02.002DOI Listing
April 2021

Atypical Antipsychotics Augmentation in Patients with Depressive Disorder and Risk of Subsequent Dementia: A Nationwide Population-Based Cohort Study.

J Alzheimers Dis 2021 ;80(1):197-207

Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: While atypical antipsychotic medications are widely used for treating depressive disorders, their long-term effects on the risk of subsequent dementia have not been studied adequately.

Objective: To investigate whether the risk of dementia differs according to the use of atypical antipsychotic drugs, and compare the effects of antipsychotic agents on dementia risk in individuals with late-life depressive disorders.

Methods: A nationwide population-based retrospective cohort study was conducted using data from the National Health Insurance Service-Senior Cohort of South Korea. Atypical antipsychotic dosages were standardized using a defined daily dose, and the cumulative dosage was calculated. Participants were observed from January 2008 to December 2015. Cox proportional hazard regression analysis was used to estimate the hazard ratios.

Results: The cohort included 43,788 elderly adults with depressive disorders: 9,901 participants (22.6%) were diagnosed with dementia. Findings showed that atypical antipsychotics were prescribed to 1,967 participants (4.5%). Compared with non-users, users of atypical antipsychotics experienced a significantly higher risk for dementia with an adjusted hazard ratio (aHR) of 1.541 (95% confidence interval [CI], 1.415-1.678). A cumulative dose-response relationship was observed (test for trend, p < 0.0001). Among atypical antipsychotics, risperidone displayed the highest risk for dementia (aHR 1.767, [95% CI, 1.555-2.009]).

Conclusion: In this study of elderly individuals with depressive disorders, atypical antipsychotic use was associated with a significantly higher risk of subsequent dementia. Healthcare professionals should be aware of this potential long-term risk. A limitation that should be mentioned is that we could not exclude patients with bipolar depression.
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http://dx.doi.org/10.3233/JAD-200994DOI Listing
September 2021

Arachis hypogaea resveratrol synthase 3 alters the expression pattern of UDP-glycosyltransferase genes in developing rice seeds.

PLoS One 2021 14;16(1):e0245446. Epub 2021 Jan 14.

Department of Plant Science, Research Institute for Agriculture and Life Sciences, and Plant Genomics and Breeding Institute, Seoul National University, Seoul, Republic of Korea.

The resveratrol-producing rice (Oryza sativa L.) inbred lines, Iksan 515 (I.515) and Iksan 526 (I.526), developed by the expression of the groundnut (Arachis hypogaea) resveratrol synthase 3 (AhRS3) gene in the japonica rice cultivar Dongjin, accumulated both resveratrol and its glucoside, piceid, in seeds. Here, we investigated the effect of the AhRS3 transgene on the expression of endogenous piceid biosynthesis genes (UGTs) in the developing seeds of the resveratrol-producing rice inbred lines. Ultra-performance liquid chromatography (UPLC) analysis revealed that I.526 accumulates significantly higher resveratrol and piceid in seeds than those in I.515 seeds and, in I.526 seeds, the biosynthesis of resveratrol and piceid reached peak levels at 41 days after heading (DAH) and 20 DAH, respectively. Furthermore, RNA-seq analysis showed that the expression patterns of UGT genes differed significantly between the 20 DAH seeds of I.526 and those of Dongjin. Quantitative real-time PCR (RT-qPCR) analyses confirmed the data from RNA-seq analysis in seeds of Dongjin, I.515 and I.526, respectively, at 9 DAH, and in seeds of Dongjin and I.526, respectively, at 20 DAH. A total of 245 UGTs, classified into 31 UGT families, showed differential expression between Dongjin and I.526 seeds at 20 DAH. Of these, 43 UGTs showed more than 2-fold higher expression in I.526 seeds than in Dongjin seeds. In addition, the expression of resveratrol biosynthesis genes (PAL, C4H and 4CL) was also differentially expressed between Dongjin and I.526 developing seeds. Collectively, these data suggest that AhRS3 altered the expression pattern of UGT genes, and PAL, C4H and 4CL in developing rice seeds.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245446PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808588PMC
September 2021

Design and Fabrication of a High-Speed Atomic Force Microscope Scan-Head.

Sensors (Basel) 2021 Jan 7;21(2). Epub 2021 Jan 7.

Department of Mechanical Engineering, Kyungpook National University, Daegu 41566, Korea.

A high-speed atomic force microscope (HS-AFM) requires a specialized set of hardware and software and therefore improving video-rate HS-AFMs for general applications is an ongoing process. To improve the imaging rate of an AFM, all components have to be carefully redesigned since the slowest component determines the overall bandwidth of the instrument. In this work, we present a design of a compact HS-AFM scan-head featuring minimal loading on the Z-scanner. Using a custom-programmed controller and a high-speed lateral scanner, we demonstrate its working by obtaining topographic images of Blu-ray disk data tracks in contact- and tapping-modes. Images acquired using a contact-mode cantilever with a natural frequency of 60 kHz in constant deflection mode show good tracking of topography at 400 Hz. In constant height mode, tracking of topography is demonstrated at rates up to 1.9 kHz for the scan size of 1μm×1μm with 100×100 pixels.
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http://dx.doi.org/10.3390/s21020362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825750PMC
January 2021

The patterns of deleterious mutations during the domestication of soybean.

Nat Commun 2021 01 4;12(1):97. Epub 2021 Jan 4.

Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungbuk, 28116, Korea.

Globally, soybean is a major protein and oil crop. Enhancing our understanding of the soybean domestication and improvement process helps boost genomics-assisted breeding efforts. Here we present a genome-wide variation map of 10.6 million single-nucleotide polymorphisms and 1.4 million indels for 781 soybean individuals which includes 418 domesticated (Glycine max), 345 wild (Glycine soja), and 18 natural hybrid (G. max/G. soja) accessions. We describe the enhanced detection of 183 domestication-selective sweeps and the patterns of putative deleterious mutations during domestication and improvement. This predominantly selfing species shows 7.1% reduction of overall deleterious mutations in domesticated soybean relative to wild soybean and a further 1.4% reduction from landrace to improved accessions. The detected domestication-selective sweeps also show reduced levels of deleterious alleles. Importantly, genotype imputation with this resource increases the mapping resolution of genome-wide association studies for seed protein and oil traits in a soybean diversity panel.
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http://dx.doi.org/10.1038/s41467-020-20337-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782591PMC
January 2021

Enhanced Electro-Optical Performance of Inorganic Perovskite/a-InGaZnO Phototransistors Enabled by Sn-Pb Binary Incorporation with a Selective Photonic Deactivation.

ACS Appl Mater Interfaces 2020 Dec 17;12(52):58038-58048. Epub 2020 Dec 17.

Department of Electrical and Electronics Engineering, Chung-Ang University, Seoul 06974, Republic of Korea.

Optoelectronic applications using perovskites have emerged as one of the most promising platforms such as phototransistors, photovoltaics, and photodetectors. However, high-performance and reliable perovskite photonic devices are often hindered by the limited spectral ranges of the perovskite system along with the lack of appropriate processing technologies for the implementation of reliable device architectures. Here, we explore a hybrid phototransistor with a heterojunction of a Sn-Pb binary mixed halide perovskite (CsSnPbIBr) light absorber and an amorphous-In-Ga-Zn-O (a-IGZO) charge carrying layer. By incorporating Sn-Pb binary components with an all-inorganic base, broadening of light-absorbing spectral ranges with enhanced stability has been achieved, indicating inevitable highly increased conductivity, which triggers a high off-current of the devices. Accordingly, the selectively ultraviolet (UV)-irradiated electrical deactivation (SUED) process is carried out to suppress the high off-current with a reliable device structure. Particularly, it is noted that the selective UV irradiation can facilitate oxidation and distortion of the chemical structure in specific perovskite regions, providing enhanced gate bias modulation of the phototransistor with an increased on/off-current ratio from ∼10 to ∼10. Finally, the SUED-processed phototransistor exhibits an improvement in the photosensitivity by more than 3 orders of magnitude up to 8.0 × 10 and detects in the spectral range from visible to near-infrared (NIR) light (∼860 nm) with good on/off switching behaviors.
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http://dx.doi.org/10.1021/acsami.0c17862DOI Listing
December 2020

Characterization of Caffeoylquinic Acids from and Their Melanogenesis Inhibitory Activity.

ACS Omega 2020 Dec 20;5(48):30946-30955. Epub 2020 Nov 20.

Department of Bio-Health Technology, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.

Hyperpigmentation resulting from the overactivation of tyrosinase leads to darker spots or patches on the human skin. Although these phenomena are harmless, there is still great demand for melanogenesis inhibitors to prevent hyperpigmentation by inhibiting the tyrosinase, a rate-limiting enzyme in melanogenesis. Although has been used in folk remedies as a diuretic and hemostatic agent, its effect on melanogenesis has not yet been reported. In this study, we prepared an extract and its solvent fractions and evaluated their biological activity against free radical and melanin synthesis. The extract of inhibited mushroom tyrosinase activity more efficiently than, and with similar antioxidant activity to, arbutin . Comparative evaluation of the anti-melanogenesis and anti-tyrosinase activity of solvent fractions demonstrated that, by inhibiting tyrosinase activity, the butanol fraction has the highest potential for the inhibition of melanogenesis in melanoma cells. We found by structural analysis using high-performance liquid chromatography (HPLC) and NMR spectroscopy that the major compounds in butanol fraction were three caffeoylquinic acid derivatives. The three derivatives had similar radical scavenging and anti-tyrosinase activities , while only 5-caffeoylquinic acid had an inhibitory effect on α-MSH-induced melanogenesis. The inhibitory effect of 5-caffeoylquinic acid was verified by the determination of the melanin content and tyrosinase activity in melanoma after treating the cells with a commercial compound. Further, we revealed that 5-caffeoylquinic acid inhibited melanogenesis by chelating a copper cation from a copper-tyrosinase complex. Thus, 5-caffeoylquinic acid or butanol fraction isolated from might be useful in cosmetics as a skin-whitening agent.
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http://dx.doi.org/10.1021/acsomega.0c03752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726789PMC
December 2020

Investigating relationships among coping, personal growth, and life satisfaction among individuals with physical disabilities.

Health Promot Perspect 2020 7;10(4):401-408. Epub 2020 Nov 7.

Department of Recreation, Therapeutic Recreation, and Tourism, State University of New York, College at Brockport, NY, USA.

It is well-documented that active coping strategies can lead to better positive adjustment and psycho-social outcomes among individuals with disabilities and illnesses. However, little information exists related to exploring how coping is related to health benefits such as personal growth and life satisfaction in an international context. Thus, this study examined how the use of coping strategies is associated with personal growth and life satisfaction among individuals with physical disabilities in non-Western settings. In this cross-sectional study, we employed a nonprobability methodology, purposivesampling, to recruit 351 participants who adults over the age of 18 living with a physicaldisability and currently enrolled in the Korean Disability Association. A hierarchical linearregression analysis was conducted to determine which types of coping strategies predictedpersonal growth and life satisfaction, while controlling for the effects of the demographicvariables (i.e., gender and age). With regard to personal growth, problem-solving coping strategy (β = 0.663, P < 0.001,95% CI [0.51, 0.70]) was the strongest predictor, followed by avoidance coping strategy(β = -0.263, P < 0.001, 95% CI [-0.37, -0.20]). As for life satisfaction, problem-solving copingstrategy (β = 0.268, P < 0.001, 95% CI [0.18, 0.70]) was the strongest predictor, followed bysocial support seeking coping strategy (β = 0.264, P < 0.001, 95% CI [-0.19, 0.10]). Our study suggests that problem-focused and social support coping strategies playimportant roles in improving the personal growth and life satisfaction among Korean individualswith physical disabilities. This study provides implications for health professionals seeking waysto facilitate the personal growth and enhance the life satisfaction of individuals with physicaldisabilities.
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http://dx.doi.org/10.34172/hpp.2020.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723005PMC
November 2020

Relationship of perceived environmental characteristics to self-efficacy and leisure time physical activity among Asian immigrants in the U.S.

Health Promot Perspect 2020 7;10(4):366-372. Epub 2020 Nov 7.

Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA.

Given the high prevalence of physical inactivity among Asian immigrants and its potential negative effects on health, more attention should be paid to identifying factors that might affect their participation in leisure time physician activity (LTPA). This study examined how perceived environmental characteristics are related to self-efficacy and LTPA among Asian immigrants in the United States. This cross-sectional study collected data from an on-line survey administered through Qualtrics, a web-based survey software company. In the data analysis, 512 Asian immigrants were included. As independent variables, we assessed perceived environmental characteristics with regard to the perceived accessibility of LTPA-related sites and neighborhood quality. As mediating and outcome variables, we measured self-efficacy and LTPA, respectively. Using AMOS version 22, a path analysis was conducted to measure model fit. The perceived accessibility of the LTPA-related sites (b = 0.10, P = 0.04) and self-efficacy(b = 0.26, P = 0.001) were positively related to LTPA. Perceived neighborhood quality (b = 0.11,P = 0.012 was positively associated with self-efficacy, yet not directly associated with LTPA. Self-efficacy mediated the relationship between the perceived accessibility of LTPA-related sites and LTPA (estimate=0.036, 95% CI=0.015-0.067, P = 0.003). This study suggests that perceiving easy access to LTPA-related sites and living in quality neighborhoods can encourage people to participate in LTPA more often by increasing their self-efficacy toward LTPA. These findings highlight a need for public infrastructural investments to improve accessibility to LTPA-related resources and neighborhood quality, which can potentially increase self-efficacy and promote LTPA among Asian immigrants.
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http://dx.doi.org/10.34172/hpp.2020.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723007PMC
November 2020

A Retrospective Comparison of Single-Bundle Anterior Cruciate Ligament Reconstruction With Lateral Extra-Articular Tenodesis With Double-Bundle Anterior Cruciate Ligament Reconstruction.

Arthroscopy 2021 03 12;37(3):976-984. Epub 2020 Nov 12.

Department of Orthopedic Surgery, Dongguk University Ilsan Hospital, Gyeonggido, Republic of Korea.

Purpose: To compare postoperative objective knee stability and clinical outcomes between double-bundle (DB) anterior cruciate ligament reconstruction (ACLR) and single-bundle (SB) ACLR combined with lateral extra-articular tenodesis (LET).

Methods: ACL-injured patients with grade 3 pivot-shift who underwent either DB ACLR (DB ACLR group) or SB ACLR with LET (SB ACLR+LET group) were enrolled. All patients who met inclusion and exclusion criteria were retrospectively evaluated for knee laxity (the anterior translation and pivot-shift grade), clinical outcomes using the International Knee Documentation Committee (IKDC) examination form, Kellgren-Lawrence grade, graft maturation score on second-look arthroscopy, and revision rates at the last follow-up.

Results: From an initial cohort of 171 consecutive patients over a 3-year period, 95 (56%) met inclusion and exclusion criteria. The SB ACLR+LET group (n = 47) showed significantly better results in pivot-shift grade at the last follow-up as compared with the DB ACLR group (n = 48) (P = .021). In the SB ACLR+LET group, 93.6% (44/47) were grade 0, whereas 72.9% (35/48) in the DB ACLR group were grade 0. The SB ACLR+LET group (grade A: 42, grade B: 4 and grade C: 1) showed significantly superior results in IKDC objective grade compared with the DB ACLR group (grade A: 32; grade B: 8; and grade C: 8) (P = .017). However, no statistically significant difference could be shown in anterior translation, subjective functional IKDC score, or revision rate between the 2 groups. The mean follow-up duration was 49.7 ± 5.7 months.

Conclusions: SB ACLR + LET demonstrated fewer pivot-shifts (P = .021) and superior IKDC objective grades (P = .017) than a DB ACLR at a mean follow-up of almost 50 months.

Level Of Evidence: Level III, retrospective comparative study.
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http://dx.doi.org/10.1016/j.arthro.2020.11.011DOI Listing
March 2021

Selective Transfer of Light-Emitting Diodes onto a Flexible Substrate via Laser Lissajous Scanning.

ACS Omega 2020 Nov 22;5(43):27749-27755. Epub 2020 Oct 22.

University of Science and Technology (UST), 217 Gajeong-ro, Yoseong-gu, Daejeon 34113, South Korea.

As the light-emitting diode (LED) size gradually decreases, it is difficult to conventionally transfer an LED onto a donor substrate. In this paper, we propose a print transfer method that selectively transfers an LED onto a UV release tape, i.e., the donor substrate, via focused laser scanning with Lissajous patterns. We implemented an optical system based on focused laser scanning to perform selective transfer; this can adjust the scanning area immediately without changing the donor substrate size according to the LED size. Because the commercialized UV release tape is utilized as a donor substrate, the adhesion between the LED and donor substrate can be constantly maintained even after repeated experiments. In this study, several LEDs were transferred to a flexible printed circuit board-arranged in a circular and square shape to demonstrate a high degree of freedom of the system-and turned on.
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http://dx.doi.org/10.1021/acsomega.0c01425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643072PMC
November 2020

Leisure-time physical activity, coping and life satisfaction among Korean individuals with physical disabilities.

Health Promot Int 2021 Aug;36(3):774-783

Research Professor, Korea University Center for Curriculum and Institute of Studies, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, South Korea.

A few studies explored the relationships among leisure-time physical activity (LTPA), coping, and life satisfaction among individuals with physical disabilities. This study aims to investigate how LPTA contributes to coping and life satisfaction among Korean individuals with physical disabilities. Using a purposive sampling strategy, a total of 351 people with physical disabilities participated in this study. The results of this study find that participation in LTPA leads to the development of active coping strategies that contribute to increased life satisfaction. This study suggests that encouraging LTPA participation can be a critical task to healthcare providers working with individuals with physical disabilities.
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http://dx.doi.org/10.1093/heapro/daaa080DOI Listing
August 2021

sp. nov., a new interstitial copepod (Harpacticoida: Laophontidae) from Korea.

PeerJ 2020 22;8:e10007. Epub 2020 Sep 22.

Department of Life Science, Hanyang University, Seoul, South Korea.

We collected an undescribed laophontid copepod from a coarse sand habitat on the east coast of Korea and named it . We compared the detailed morphological characteristics of the new species with those of congeneric species. Among them, the new species shows a superficial resemblance to the Californian species Lang, 1965. However, the two species are easily distinguishable by the setation of the syncoxa on the maxilliped and the fourth swimming leg. The new species has the variable setation on the second to fourth swimming legs. The variations appear among individuals or between the left and right rami of a pair of legs in a single specimen. Although complex chaetotaxical polymorphism occur in this new species, we used myCOI and Cytb to confirm that the new species is not a species complex. Also, partial sequences of 18S and 28S ribosomal RNA genes were used to analyze the position of the new species within the family Laophontidae. The new speciesis the fourteenth species in the world and the second species in Korea.
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http://dx.doi.org/10.7717/peerj.10007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518157PMC
September 2020

The Association of Social Support and Leisure Time Physical Activity With Mental Health Among Individuals With Cancer.

Am J Health Promot 2021 03 30;35(3):362-368. Epub 2020 Sep 30.

Department of Health and Human Performance, 7174Texas State University, San Marcos, TX, USA.

Purpose: This study examined the relationship among social support, leisure time physical activity (LTPA), and mental health among people with cancer.

Design: Cross-sectional study.

Setting And Participants: Using the 2017 Health Information National Trends Survey, we extracted data of 504 respondents who had been diagnosed with any of the 22 types of cancer listed in the survey questionnaire.

Measures: As independent variables, we assessed 3 different types of support: emotional, informational, and tangible support. As mediating and outcome variables, we measured LTPA and mental health, respectively.

Analysis: Using AMOS version 22, a path analysis was conducted to measure model fit. A mediation test was then conducted using bootstrapping procedures.

Results: The hypothesized model provided an acceptable fit to the data. Specifically, emotional support ( = .15, p = .005), informational support ( = .13, p = .008), tangible support ( = .12, p = .010), and LTPA ( = .14, p = .001) were significantly associated with mental health. We revealed a significant mediating effect of LPTA on the relationship between emotional support and mental health (Estimate = .037, 95% CI = .001-.098, p < .05).

Conclusion: Social support and LTPA played a significant role in promoting mental health among people with cancer. In particular, the results confirmed that individuals with cancer who reported receiving emotional support tended to engage in LTPA and thus reported better mental health.
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http://dx.doi.org/10.1177/0890117120961321DOI Listing
March 2021

Lead-Free Dual-Phase Halide Perovskites for Preconditioned Conducting-Bridge Memory.

Small 2020 Oct 18;16(41):e2003225. Epub 2020 Sep 18.

Department of Materials Science and Engineering, Research Institute of Advanced Materials, Seoul National University, Seoul, 08826, Republic of Korea.

Organometallic and all-inorganic halide perovskites (HPs) have recently emerged as promising candidate materials for resistive switching (RS) nonvolatile memory due to their current-voltage hysteresis caused by fast ion migration. Lead-free and all-inorganic HPs have been researched for non-toxic and environmentally friendly RS memory devices. However, only HP-based devices with electrochemically active top electrode (TE) exhibit ultra-low operating voltages and high on/off ratio RS properties. The active TE easily reacts to halide ions in HP films, and the devices have a low device durability. Herein, RS memory devices based on an air-stable lead-free all-inorganic dual-phase HP (AgBi I -Cs Bi I ) are successfully fabricated with inert metal electrodes. The devices with Au TE show filamentary RS behavior by conducting-bridge involving Ag cations in HPs with ultra-low operating voltages (<0.15 V), high on/off ratio (>10 ), multilevel data storage, and long retention times (>5 × 10 s). The use of a closed-loop pulse switching method improves reversible RS properties up to 10 cycles with high on/off ratio above 10 . With an extremely small bending radius of 1 mm, the devices are operable with reasonable RS characteristics. This work provides a promising material strategy for lead-free all-inorganic HP-based nonvolatile memory devices for practical applications.
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http://dx.doi.org/10.1002/smll.202003225DOI Listing
October 2020

Universal inherent fluctuations in statistical counting of large particles in slurry used for semiconductor manufacturing.

Sci Rep 2020 Sep 7;10(1):14731. Epub 2020 Sep 7.

Samsung Electronics, Kiheung Campus, Yongin-si, Gyeonggi-do, 446-811, Korea.

In the chemical mechanical polishing process of semiconductor manufacturing, the concentration of 'large' particles ([Formula: see text]0.5 μm) in the slurry, which is considerably larger in size than the main abrasives ([Formula: see text] 0.1 μm), is a critical parameter that strongly influences manufacturing defects, yields, and reliabilities of large-scale-integrated circuits. Various instruments, so-called particle counters, based on light scattering, light extinction, and holography techniques have been developed to measure and monitor the large particle concentration in semiconductor fabs in real time. However, sizeable fluctuation in the measured particle concentration complicates the statistical process control in the fabs worldwide. Here, we show that an inherent fluctuation exists in the counting of large particles, which is universal, independent of instrument type, and quantitatively determined by the instrument's operation parameters. We analytically derive a statistical theory of the fluctuation based on Poisson statistics and validate the theory through experiments and Monte-Carlo simulation. Furthermore, we provide a strategy to enhance the measurement accuracy by statistically adjusting the instrumental parameters commonly involved in the particle counters. The present results and analyses could be useful for statistical process control in semiconductor fabs to prevent large particle-induced defects such as micro-scratches and pits on wafers.
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http://dx.doi.org/10.1038/s41598-020-71768-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477581PMC
September 2020

USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis.

Mol Cell Biol 2020 10 13;40(21). Epub 2020 Oct 13.

Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

Precise regulation of RNA metabolism is crucial for dynamic gene expression and controlling cellular functions. In the nervous system, defects in RNA metabolism are implicated in the disturbance of brain homeostasis and development. Here, we report that deubiquitinating enzyme, ubiquitin specific peptidase 15 (USP15), deubiquitinates terminal uridylyl transferase 1 (TUT1) and changes global RNA metabolism. We found that the expression of USP15 redistributes TUT1 from the nucleolus to nucleoplasm, resulting in the stabilization of U6 snRNA. We also found that lack of the gene induces an impairment in motor ability with an unconventional cerebellar formation. Moreover, inhibition of the USP15-TUT1 cascade triggered mild and chronic endoplasmic reticulum (ER) stress. Therefore, our results suggest that USP15 is crucial for mRNA metabolism and maintains a healthy brain. These findings provide a possibility that disturbance of the USP15-TUT1 cascade induces chronic and mild ER stress, leading to an acceleration of the neurodegenerative phenotype.
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http://dx.doi.org/10.1128/MCB.00098-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556847PMC
October 2020

Placement Retargeting of Virtual Avatars to Dissimilar Indoor Environments.

IEEE Trans Vis Comput Graph 2020 Aug 21;PP. Epub 2020 Aug 21.

Rapidly developing technologies are realizing a 3D telepresence, in which geographically separated users can interact with each other through their virtual avatars. In this paper, we present novel methods to determine the avatar's position in an indoor space to preserve the semantics of the user's position in a dissimilar indoor space with different space configurations and furniture layouts. To this end, we first perform a user survey on the preferred avatar placements for various indoor configurations and user placements, and identify a set of related attributes, including interpersonal relation, visual attention, pose, and spatial characteristics, and quantify these attributes with a set of features. By using the obtained dataset and identified features, we train a neural network that predicts the similarity between two placements. Next, we develop avatar placement method that preserves the semantics of the placement of the remote user in a different space as much as possible. We show the effectiveness of our methods by implementing a prototype AR-based telepresence system and user evaluations.
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http://dx.doi.org/10.1109/TVCG.2020.3018458DOI Listing
August 2020

The contribution of physical and social activity participation to social support and happiness among people with physical disabilities.

Disabil Health J 2021 01 1;14(1):100974. Epub 2020 Aug 1.

Hospitality and Tourism Institute, Duy Tan University, 254 Nguyen Van Linh Street, Da Nang, Viet Nam. Electronic address:

Background: Prior studies have suggested that certain leisure activities provide health benefits to people with physical disabilities. Participation in social activities has been identified as a strong predictor of active coping strategies and social support from others. In addition, leisure-time physical activity (LTPA) has been found to be positively associated with health perceptions and quality of life.

Objectives: The purpose of this study was to investigate the relationships between social activity and LTPA to social support and life satisfaction among people with physical disabilities.

Methods: Data were collected from Korean Association of Persons with Physical Disabilities. A total of 351 surveys were used.

Results: Results indicated that social activity, emotional and informational support, and tangible and affectionate support were significantly associated with happiness. However, there were no direct effects of LTPA and positive social interaction support on happiness. The study results showed significant direct effects of LTPA on emotional and informational support and positive social interaction.

Conclusion: This study shows that it is important for people with physical disabilities not only to participate in LTPA, but also to be provided with opportunities for social activities. In particular, the importance of social activity to Korean people with physical disabilities as a means of receiving social support and increasing happiness was confirmed. The results suggest that practitioners need to create a variety of social activity opportunities, such as online social participation programs, community-based social programs, and social events for health.
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http://dx.doi.org/10.1016/j.dhjo.2020.100974DOI Listing
January 2021

Traumatic Subarachnoid Hemorrhage and Subdural Hematoma Due to Acute Rebleeding of a Pseudoaneurysm with Dural Arteriovenous Fistula Between Inferolateral Trunk of the Internal Carotid Artery and Middle Cerebral Vein.

World Neurosurg 2020 11 8;143:315-318. Epub 2020 Aug 8.

Department of Neurosurgery, Kangwon National University Hospital, Chuncheon-Si, Republic of Korea; Department of Neurosurgery, Kangwon National University College of Medicine, Chuncheon, Republic of Korea. Electronic address:

Background: According to previous reports, pseudoaneurysms that are concomitant with a dural arteriovenous fistula (dAVF) are associated with penetrating trauma, blunt trauma, and skull fractures. Moreover, dAVFs between the inferolateral trunk of the internal carotid artery and middle cerebral vein are a rare disease manifestation. Pseudoaneurysms concomitant with dural arteriovenous fistulas (dAVF) are rare and traumatic pseudoaneurysms with dAVF typically developed slowly with less rebleeding than isolated traumatic aneurysms.

Case Description: Here, we report an extremely rare case of a traumatic pseudoaneurysm with a dAVF between the inferolateral trunk and middle cerebral vein. The traumatic pseudoaneurysm presented with acute pseudoaneurysm formation and rebleeding within 1 day of the trauma and was managed with direct surgery.

Conclusions: The traumatic pseudoaneurysm was completely obliterated by surgical clipping, followed by decompressive craniectomy and postoperative coma therapy with propofol. Resulting from these surgical and postoperative treatments, 56 days after the operation the patient recovered fully and did not present any neurologic deficits.
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http://dx.doi.org/10.1016/j.wneu.2020.08.024DOI Listing
November 2020
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