Publications by authors named "Jae Min Chung"

44 Publications

Penile circumference and stretched penile length in prepubertal children: A retrospective, single-center pilot study.

Investig Clin Urol 2021 May;62(3):324-330

Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.

Purpose: To determine references for penile circumference according to age in prepubertal children and whether this measurement can be used as a basic penile parameter along with stretched penile length in prepubertal children.

Materials And Methods: A total of 750 children (mean age, 4.2±3.4 years) aged under 14 years without penile problems were enrolled in this study. Children with penile or testicular abnormalities were excluded. All data were gathered at the outpatient clinic by a single pediatric urologist from July 2017 to April 2020. Penile parameters (baseline and stretched penile length, penile circumference) and testicular volumes were measured by using an elastic ruler and a Prader orchidometer, respectively.

Results: Mean baseline and stretched penile lengths were 3.0±1.0 cm and 4.2±1.0 cm, respectively. The mean penile circumference was 4.2±0.9 cm. The stretched penile length was similar to penile circumference (p=0.425). This similarity was found for each age group except for the 0-1-year-old and 3-4-year-old age groups (p=0.001 and p=0.034, respectively). As children grow into adolescence, stretched penile length increases significantly compared to penile circumference.

Conclusions: Penile circumference increased with age like stretched penile length and testicular volume in prepubertal children. Stretched penile length and penile circumference were found to be similar. This study can be used as a basic reference for penile circumference values in prepubertal children.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4111/icu.20200495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100007PMC
May 2021

Concealed index for concealed penis in prepubertal children.

Investig Clin Urol 2021 Mar;62(2):217-223

Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.

Purpose: The concealed penis (CP) is a congenital or acquired genital anomaly that requires surgical correction. To construct an objective CP severity index, we compared the penile parameters of a CP with a normal penis (NP) and postoperative outcomes of CP patients.

Materials And Methods: In this retrospective study, 391 boys under 14 years who visited our hospital between September 2017 and February 2020 were included. Among these boys, 105 patients had a CP and 286 boys had a NP without CP. The stretched penile length (SPL), penile circumference (PC), and penile length above baseline skin level (BPL) were measured using a ruler (cm), and the testicular volume was measured using an orchidometer (mL). We defined the concealed index according to SPL (CIs) as BPL/SPL and the concealed index according to circumference (CIc) as BPL/PC. A repair of the CP was performed in the CP patients. All parameters were measured before surgery and after three months.

Results: The CP had significantly shorter SPL and BPL, and smaller CIs, and CIc than the NP. The cutoff values for the CIs and CIc were 0.68 and 0.58, respectively (sensitivity 86.7% and 86.7%; specificity 65.0% and 88.5%, respectively). After repair of the CP, all penile parameters were significantly improved.

Conclusions: The CIs and CIc are useful and objective parameters for checking the severity of CP, and evaluating the postoperative outcome of CP repair. We newly introduced cutoff values for the CIs (0.68) and CIc (0.58) for diagnosing and evaluating CP repair.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4111/icu.20200401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940854PMC
March 2021

Pediatric laparoscopic pyeloplasty of pelvic ectopic kidney with UPJO - A case report.

Urol Case Rep 2021 Jan 23;34:101507. Epub 2020 Nov 23.

Department of Urology, Pusan National University Yangsan Hospital, Yangsan, South Korea.

Prevalence of pelvic ectopic kidney with obstruction is not common. Associated anomalies may produce technical difficulties and surgical challenges in treatment. Diagnostic tools such as USG KUB, renal scintigraphic studies (DMSA, DTPA), MRI, and preoperative RGP are very informative examinations to properly decide the timing of the operation and method of it. The patient was under close surveillance from the detection of antenatal hydronephrosis until the development of UPJ obstruction. Herein, we report the case of a patient with this anomaly who successfully underwent laparoscopic reconstruction.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eucr.2020.101507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701345PMC
January 2021

Risk factors for fistula recurrence after urethrocutaneous fistulectomy in children with hypospadias.

Turk J Urol 2020 Nov 30. Epub 2020 Nov 30.

Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.

Objective: This study aimed to investigate the risk factors of fistula recurrence after primary urethrocutaneous fistulectomy in children with hypospadias.

Material And Methods: The study included 63 children who underwent fistulectomy for urethrocutaneous fistula (UCFs) that occurred after urethroplasty for hypospadias, between February 2009 and December 2018. The patients were divided into 2 groups: successful group 1 and failed group 2. For data analysis, we included the demographics of the patients, the details of the previous urethroplasty (the type of hypospadias and the location of the meatus after complete chordectomy), the presence of meatal stenosis or urethral stricture after urethroplasty, and the size of the UCFs. The Student t-test and the chi-square test were performed to analyze the data using the Statistical Package for Social Sciences software.

Results: The overall success rate of primary urethrocutaneous fistulectomy was 81.0% (51/63 children). The most common location of a secondary fistula was the penoscrotal area 5 (41.6%). There were no statistically significant differences in age (p=0.501), weight (p=0.063), body mass index (p=0.924), history of low birth weight (p=0.454), and history of prematurity (p=0.381). The type of hypospadias (p=0.007) and urethral defect length (p=0.021) were identified as independent risk factors for failed urethrocutaneous fistulectomy. There were no statistically significant differences in meatal stenosis (p=0.431), postoperative stricture (p=0.587), fistula location (p=0.173), multiplicity (p=0.588), and fistula size (p=0.530).

Conclusion: The type of hypospadias and the length of the urethral defect are the significant risk factors for secondary fistula recurrence after primary urethrocutaneous fistulectomy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5152/tud.2020.20323DOI Listing
November 2020

Wilms Tumor with dilated hypertensive cardiomyopathy, acute myocarditis, pulmonary edema, and heart failure.

Urol Case Rep 2020 Nov 25;33:101391. Epub 2020 Aug 25.

Department of Urology, Pusan National University School of Medicine, Yangsan, South Korea.

An 11-month-old boy with unilateral Wilms tumor had an unusual presentation, with dilated hypertensive cardiomyopathy, acute myocarditis, pulmonary edema, and congestive heart failure secondary to the Wilms tumor and requiring intensive care. After surgery, all of the findings were normalized. According to the literature review there were reported previously in only seven cases with dilated cardiomyopathy. Wilms tumor should be included in the differential diagnosis of any child with dilated cardiomyopathy and an abdominal mass, regardless of the presence of hypertension, especially less than one year old. Also, vasoactive mediators including renin should be evaluated in the case of hypertension.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eucr.2020.101391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574032PMC
November 2020

Evaluation of Functional Bladder Capacity in Children with Nocturnal Enuresis According to Type and Treatment Outcome.

Res Rep Urol 2020 15;12:383-389. Epub 2020 Sep 15.

Department of Urology, Pusan National University School of Medicine, Yangsan, Korea.

Purpose: This study aimed to identify whether functional bladder capacity (FBC) differs among subgroups of nocturnal enuresis (NE) patients and can be used to predict treatment response.

Methods: A total of 69 children with NE were included in this study between July 2017 and February 2019 according to medical chart review, retrospectively. All patients completed a questionnaire about voiding symptoms and 48-hour frequency/volume (48-h F/V) charts. FBC was obtained from the 48-h F/V charts and uroflowmetry (UFM) with post-void residual volume (PVR). All patients were primarily treated with standard urotherapy and pharmacological therapy. The response rate was analyzed at 3 months after treatment.

Results: The mean age of the 69 patients (42 male, 27 female) was 83.3 ± 22.4 months (range, 5-13 years) at the first visit. The percentages of children with monosymptomatic NE (MNE) and non-monosymptomatic NE (NMNE) on the questionnaire were 40.6% (28/69) and 59.4% (41/69), respectively. FBC of all patients was lower than the normal range of expected bladder capacity, and there were no significant differences between measurement methods, NE types (MNE vs NMNE), or response rates (p > 0.05).

Conclusion: Children with NE had diminished FBC in both 48-h F/V charts and UFM with PVR. We found no difference in FBC by NE type or treatment outcome. Therefore, FBC cannot be used to distinguish between NE types or predict treatment responses.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2147/RRU.S267417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501990PMC
September 2020

Analysis of the clinical and aesthetic results of facial dimple creation surgery.

Arch Plast Surg 2020 Sep 15;47(5):467-472. Epub 2020 Sep 15.

Department of Plastic and Reconstructive Surgery, Daegu Catholic University School of Medicine, Daegu, Korea.

Background: Dimples on the cheeks can make the smile look more cheerful and attractive. Therefore, some people who do not have dimples may choose to undergo dimple creation surgery. Although dimple surgery is quite common, those desiring this procedure often lack information about it. Therefore, we conducted the present study to share our surgical tips and clinical experiences regarding safe dimple creation surgery.

Methods: This study included 2,048 patients who underwent dimple creation surgery at our plastic surgery clinic between April 2010 and June 2014. These patients were selected from those who displayed no scarring from injury or tumor removal in the central face during the presurgical evaluation. Medical records were used to identify the age and sex of each patient, the location of dimple creation, any postoperative complications, reoperation, and the reason for reoperation.

Results: Of the 2,048 patients, 159 (7.7%) underwent reoperation. The reason for reoperation was undercorrection in 78 cases (49.0%), disappearance of the dimple in 62 cases (38.9%), and overcorrection in nine cases (5.6%). Five patients (3.1%) had their stitches removed to eliminate the created dimple because they changed their minds, and five patients (3.1%) had their stitches removed because of infection. No patients reported complications after reoperation, and no other complications, such as hyperpigmentation or foreign body reaction, were observed.

Conclusions: Safe surgery with minimal complications and satisfying cosmetic results can be achieved via accurate knowledge of the relevant anatomy and its relationship with dimples, as well as appropriate surgical methodology.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5999/aps.2020.00661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520249PMC
September 2020

Microbiology of smegma: Prospective comparative control study.

Investig Clin Urol 2019 03 25;60(2):127-132. Epub 2019 Feb 25.

Department of Urology, Pusan National University School of Medicine, Yangsan, Korea.

Purpose: The aim of the study was to investigate the common bacteria found in the smegma in the subpreputial space of asymptomatic boys prospectively, and to determine the difference of those bacteria according to the presence of smegma.

Materials And Methods: In our institution, 40 boys who performed penoplasty were recruited into the study. Swab was done using aseptic techniques on smegma and glans in the operation room. According to the presence of smegma in the subpreputial space, we classified glans as a group S (with smegma, n=20) and group C (without smegma, n=20). The swabs were immediately sent to microbiology laboratory for microscopy, culture, and sensitivity tests.

Results: The mean age was 30.4±26.4 months. Thirty-one bacteria were isolated from smegma, comprising 15 gram-positive species (48.4%) and 16 gram-negative species (51.6%). The most commonly isolated gram-negative bacterium was (25.8%), while the commonly isolated gram-positive bacteria were (19.4%) and (12.9%). Most of the bacterial isolates were multi-drug-resistant (61.3%). In group S, 12 boys had 22 bacterial isolates in the glans. The commonly isolated bacteria were (27.3%), (22.7%) and (18.2%). In group C, 13 boys had 21 bacterial isolates in the glans. The most commonly isolated bacterium was (28.6%).

Conclusions: Smegma in the subpreputial space of children was colonized by many kinds of uropathogen.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4111/icu.2019.60.2.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397923PMC
March 2019

Complete chloroplast genome of Ulleung Island endemic, (Onagraceae), in Korea.

Mitochondrial DNA B Resour 2018 Jun 27;3(2):703-704. Epub 2018 Jun 27.

Department of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea.

The first complete chloroplast genome sequences of Korean endemic in Ulleung Island, , were reported in this study. The plastome was 160,912 bp long, with the large single copy (LSC) region of 88,915 bp, the small single copy (SSC) region of 17,327 bp, and two inverted repeat (IR) regions of 27,335 bp. The plastome contained 131 genes, including 84 protein-coding, eight ribosomal RNA, and 37 transfer RNA genes. The overall GC content was 36.5%. Phylogenetic analysis of nine representative plastomes within the family Onagraceae suggests strongly that is sister to the clade containing species of in tribe Onagreae.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/23802359.2018.1481796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7800878PMC
June 2018

Can recording only the day-time voided volumes predict bladder capacity?

Investig Clin Urol 2018 05 19;59(3):194-199. Epub 2018 Mar 19.

Department of Urology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.

Purpose: This study aimed to demonstrate a method to easily assess bladder capacity using knowledge of day-time voided volumes, which can be obtained even from patients with nocturnal enuresis where the first morning void cannot accurately predict the bladder capacity due to bladder emptying overnight.

Materials And Methods: We evaluated 177 healthy children from 7 Korean medical centres entered the study between January 2008 and January 2009. Voided volumes measured for more than 48 hours were recorded in the frequency volume chart (FVC).

Results: Most voided volumes during day-time were showed between 30% and 80% of the maximal voided volume (MVV). The maximal voided volume during day-time (MVVDT) was significantly less than the MVV (179.5±71.1 mL vs. 227.0±79.2 mL, p<0.001). The correlation coefficients with the MVV were 0.801 for the estimated MVV using the MVVDT (MVVDT×1.25), which suggested a fairly strong relationship between the MVVDT×1.25 and the MVV.

Conclusions: The MVV derived from the FVC excluding the FMV was less than if the FMV had been included. When an accurate first morning voided volume cannot be obtained, as in patients with nocturnal enuresis, calculating MVVDT×1.25 allows estimation of the bladder capacity in place of the MVV.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4111/icu.2018.59.3.194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934282PMC
May 2018

Current Issues in Adolescent Varicocele: Pediatric Urological Perspectives.

World J Mens Health 2018 May 22;36(2):123-131. Epub 2018 Mar 22.

Department of Urology, Pusan National University School of Medicine, Yangsan, Korea.

While varicocele is the most common cause of surgically correctable infertility in adult males, with repair resulting in improved semen parameters in 60% to 80% of men and a higher likelihood of conception in up to 60% of men, the rationale for varicocele repair in the pediatric population is less clear. Additionally, prepubertal varicoceles are much less common and their management is controversial. Adolescents with a varicocele are often in the midst of a progressive disease process. Despite the high prevalence of varicocele and its association with progressive disease processes, the indications for adolescent varicocele repair and the effects thereof on paternity have been persistently challenging to study. This review will briefly present some of the current issues regarding adolescent varicocele from a pediatric urological point of view, including the evaluation of adolescent varicocele, the optimal surgical indications, the optimal choice of surgical intervention to be performed, and outcomes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5534/wjmh.170053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924953PMC
May 2018

The safety of a mixture of bupivacaine and lidocaine in children after urologic inguinal and scrotal surgery.

Investig Clin Urol 2018 03 1;59(2):141-147. Epub 2018 Feb 1.

Department of Urology, Pusan National University School of Medicine, Yangsan, Korea.

Purpose: Local anesthetic agents such as bupivacaine and lidocaine are commonly used after surgery for pain control. The aim of this prospective study was to evaluate the safety of a mixture of bupivacaine and lidocaine in children who underwent urologic inguinal and scrotal surgery.

Materials And Methods: Fifty-five patients who underwent pediatric urologic outpatient surgeries, were prospectively enrolled in this study. The patients were divided into three groups according to age (group I: under 2 years, group II: between 3-4 years, and group III: 5 years and above). Patients were further sub-divided into unilateral and bilateral groups. All patients were injected with a mixture of 0.5% bupivacaine and 2% lidocaine (2:1 volume ratio) at the surgical site, just before the surgery ended. Hemodynamic and electrocardiographic parameters were measured before local anesthesia, 30 minutes after administration of local anesthesia, and 60 minutes after administration.

Results: The patients' mean age was 40.5±39.9 months. All patients had normal hemodynamic and electrocardiographic parameters before local anesthesia, after 30 minutes, and after 60 minutes. Also, results of all intervals were within normal values, when analyzed by age and laterality. No mixture related adverse events (nausea, vomiting, pruritus, sedation, respiratory depression) or those related to electrocardiographic parameters (arrhythmias and asystole) were reported in any patients.

Conclusions: A mixture of bupivacaine and lidocaine can be safely used in children undergoing urologic inguinal and scrotal surgery. An appropriate dose has no clinically significant hemodynamic or cardiac changes and adverse effects.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4111/icu.2018.59.2.141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840119PMC
March 2018

Comparison of penile length at 6-24 months between children with unilateral cryptorchidism and a healthy normal cohort.

Investig Clin Urol 2018 01 15;59(1):55-60. Epub 2017 Dec 15.

Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.

Purpose: Urologic diseases affected by testosterone can be associated with smaller penis size compared to the normal population. We sought to compare penile length in children with unilateral cryptorchidism and normative data from a cohort of healthy Korean boys.

Materials And Methods: This study was performed in 259 Korean boys (212, normal cohort; 47, cryptorchidism) aged 6-24 months, each of whom had been brought to an outpatient clinic at one of five tertiary hospitals (Gyeongsangnam-do Province) between April 2014 and June 2015. Penile length was measured via stretched penile length (SPL) and testicular size was measured using orchidometry (mL).

Results: SPL in children with cryptorchidism was significantly shorter compared to a cohort of healthy Korean boys aged 6-24 months (3.7±0.5 cm and 4.3±0.8 cm, p<0.001), although there were no differences with regard to height, body weight and contralateral testicular size between the two groups. According to the stratified ages (6-12, 12-18, and 18-24 months), SPL in children with cryptorchidism was persistently shorter at their ages than those without.

Conclusions: It might be that the penile length aged 6-24 months of children with unilateral cryptorchidism is shorter than that of a cohort of healthy Korean boys.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4111/icu.2018.59.1.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754584PMC
January 2018

Impact of repeated extracorporeal shock wave lithotripsy on prepubertal rat kidney.

Urolithiasis 2018 Nov 8;46(6):549-558. Epub 2017 Nov 8.

Department of Urology, Pusan National University School of Medicine, Yangsan, Korea.

This study aimed to investigate the effects of repeated extracorporeal shock wave lithotripsy (ESWL) on the kidneys of prepubertal and adult rats. Thirty rats were used: 15 were prepubertal (3 weeks of age) with an average body weight of 72.3 ± 3.3 g, and 15 were adults with of 265 ± 11.3 g. The prepubertal and adult rats were separately and randomly allocated to three groups, each consisting of five rats. Following anesthetization, the left kidney of each rat in each group received shock waves in one, two, or three sessions separated by 72 h. The rats in each group were killed 72 h after the last ESWL session, and both kidneys were harvested; the right kidney was used as the control. Renal injury was examined with histological analysis, immunohistochemistry, and Western blot to detecting the expression of heat-shock protein-70, tumor necrosis factor-alpha-α, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 as markers of renal damage. All of these markers were similarly increased with increased ESWL sessions in both age groups. Histological analysis revealed more serious fibrosis and inflammation in the ESWL-treated kidneys in both groups than in the controls, with the damage increasing with increasing numbers of sessions. ESWL on the kidney increased renal damage according to the number of sessions in both age groups of rats, and the effects of ESWL on renal injury were similar in the two groups. However, there were generally no significant differences in the effects of ESWL on molecular indicators of renal injury between prepubertal and adult rats.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00240-017-1011-0DOI Listing
November 2018

Efficacy and Tolerability of Solifenacin 5 mg Fixed Dose in Korean Children with Newly Diagnosed Idiopathic Overactive Bladder: a Multicenter Prospective Study.

J Korean Med Sci 2017 Feb;32(2):329-334

Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.

We investigated the efficacy and tolerability of solifenacin 5 mg fixed dose in children with newly diagnosed idiopathic overactive bladder (OAB). A total of 34 children (male/female patients = 16/18) aged under 13 years (mean age: 7.2 ± 2.3; range: 5-12) who were newly diagnosed with OAB from January 2012 to September 2014 were prospectively evaluated with open-label protocol. All patients were treated with solifenacin 5 mg fixed dose once daily for at least 4 weeks. The efficacy and tolerability of solifenacin were evaluated 4, 8, and 12 weeks after the initiation of treatment. The mean voiding frequency during daytime was decreased from 9.4 ± 3.0 to 6.5 ± 2.3 times after the 12-week treatment (P < 0.001). The mean total OAB symptom score (OABSS) decreased from 7.7 ± 4.2 to 3.1 ± 3.1 after the 12-week treatment (P < 0.001). The urgency and urgency urinary incontinence (UUI) domains significantly improved from the 12-week treatment, and complete resolution of urgency occurred in 38.9% of patients and the percentage of children with UUI among urgent patients decreased from 79.4% to 57.1%. According to 3-day voiding diaries, the average bladder capacity increased from 90.4 ± 44.4 to 156.2 ± 67.3 mL (P < 0.001). Drug-induced adverse effects (AEs) were reported in 7 patients (20.6%). Our results indicate that solifenacin 5 mg fixed dose is effective against OAB symptoms, and its tolerability is acceptable without significant AEs in children with OAB.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3346/jkms.2017.32.2.329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220001PMC
February 2017

The Change of Stretched Penile Length and Anthropometric Data in Korean Children Aged 0-14 Years: Comparative Study of Last 25 Years.

J Korean Med Sci 2016 Oct;31(10):1631-4

Department of Urology, Pusan National University Yangsan Hospital and Research Institute for Convergence of Biomedical Science and Technology, Yangsan, Korea.

There has been a great improvement in height and weight of Korean children owing to economic development over the last 25 years. This study aimed to evaluate the penile length of Korean children today and to compare it with a previous Korean study reported in 1987. The cross-sectional study was conducted with 909 Korean boys aged 0-14 years who had been brought to outpatient clinics of five tertiary hospitals (Busan, Ulsan, and Changwon) between September 2013 and May 2015. The stretched penile length (SPL) was measured and the testicular size was measured using orchidometry (mL). Student's t-test or Mann-Whitney U test was used to compare the result of our study and the study reported in 1987. SPL of Korean children gradually increased from 4.1 ± 0.8 cm at 0-1 year old to 9.6 ± 3.0 cm at 13-14 years old, the most rapidly during the age of 13. While body weight and testicular size significantly increased from 1987 in most of age groups, there were no significant changes in SPL although there was in some age groups. Height decreased in the infants < 1 year old and increased in the children > 6 years old. With the great economic development over the last quarter century in Korea, height, body weight, and testicular size of children significantly increased but there was no significant change in SPL except penile growth pattern.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3346/jkms.2016.31.10.1631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999407PMC
October 2016

Evaluation of the Efficacy of Solifenacin for Preventing Catheter-Related Bladder Discomfort After Transurethral Resection of Bladder Tumors in Patients With Non-Muscle Invasive Bladder Cancer: A Prospective, Randomized, Multicenter Study.

Clin Genitourin Cancer 2017 02 30;15(1):157-162. Epub 2016 May 30.

Center for Prostate Cancer, National Cancer Center, Goyang, Gyeonggi, Korea. Electronic address:

Background: Catheter-related bladder discomfort (CRBD) secondary to an indwelling urinary catheter is worse after transurethral resection of a bladder tumor (TUR-BT). We evaluated the incidence of CRBD and the efficacy of solifenacin for preventing CRBD after TUR-BT in patients with non-muscle invasive bladder cancer.

Patients And Methods: In the present prospective, randomized, multicenter trial, we enrolled 148 patients with non-muscle invasive bladder cancer who underwent elective TUR-BT under general anesthesia. The patients were randomized to group S (n = 72) or group C (n = 76). The primary outcome was evaluable for 134 patients, who were included in the final analysis. Group S received solifenacin (5 mg orally) on the day before, the day, and the day after TUR-BT. The control group (group C) received standard care. CRBD was assessed at 1 and 2 hours postoperatively. Pain was assessed for 3 days starting 6 hours after TUR-BT using the visual analog scale.

Results: The incidence rates of CRBD in groups C and S were 72.2% and 64.5% at 1 hour and 68.1% and 53.2% at 2 hours, respectively. The incidence rates and severity of CRBD at 1 and 2 hours were not different between the 2 groups (P > .05 for both). The visual analog scale scores and the postoperative consumption of analgesics were not different between the 2 groups (P > .05 for both). None of the patients who received solifenacin experienced an adverse event.

Conclusion: Pretreatment with solifenacin (5 mg) failed to decrease the incidence and severity of CRBD after TUR-BT.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clgc.2016.05.006DOI Listing
February 2017

Secondary surgery for vesicoureteral reflux after failed endoscopic injection: Comparison to primary surgery.

Investig Clin Urol 2016 Jan 11;57(1):58-62. Epub 2016 Jan 11.

Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.

Purpose: As endoscopic treatment for vesicoureteral reflux (VUR) has increased, secondary ureteral reimplantation (UR) after failure of endoscopic treatment has increased. We studied the clinical feature and efficacy of secondary UR after failure of endoscopic treatment compared with primary UR.

Materials And Methods: Eighty-one children who had UR for VUR were enrolled. Charts were reviewed retrospectively for age, sex, grade of VUR before surgery, operative time, hospitalization period, postoperative complication, and success rate. Primary UR (group A, n=64) was compared with secondary UR after failed endoscopic treatment (group B, n=17). In group B, telephone survey for the satisfaction of endoscopic treatment and surgery was done.

Results: Mean age of each group was 49.6±37.1 and 56.6±22.5 months (p=0.236). There was no significant difference between each group in sex, mean operative time, postoperative transfusion, complication rate, and success rate. As telephone survey in group B, eleven responders preferred endoscopic treatment as primary treatment of VUR because it was a simple method and no hospitalization.

Conclusions: Secondary UR after failure of endoscopic treatment was similar to primary UR. Parents preferred endoscopic treatment as first line treatment for VUR in spite of the need for secondary UR after failure of endoscopic treatment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4111/icu.2016.57.1.58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778758PMC
January 2016

Individualized Treatment Guidelines for Postpubertal Cryptorchidism.

World J Mens Health 2015 Dec 23;33(3):161-6. Epub 2015 Dec 23.

Department of Urology, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.

Cryptorchidism is a well-known congenital anomaly in children. However, its diagnosis is often delayed for reasons including patient unawareness or denial of abnormal findings in the testis. Moreover, it has been difficult to establish an optimal treatment strategy for postpubertal cryptorchidism, given the small number of patients. Unlike cryptorchidism in children, postpubertal cryptorchidism is associated with an increased probability of neoplasms, which has led orchiectomy to be the recommended treatment. However, routine orchiectomy should be avoided in some cases due to quality-of-life issues and the potential risk of perioperative mortality. Based on a literature review, this study proposes individualized treatment guidelines for postpubertal cryptorchidism.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5534/wjmh.2015.33.3.161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709431PMC
December 2015

Postoperative ureteral obstruction after endoscopic treatment for vesicoureteral reflux.

Korean J Urol 2015 Jul 1;56(7):533-9. Epub 2015 Jul 1.

Department of Urology, Pusan National University School of Medicine, Yangsan, Korea. ; Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.

Purpose: We undertook this study to evaluate the incidence, risk factors, management, and outcome of postoperative ureteral obstruction after endoscopic treatment for vesicoureteral reflux (VUR).

Materials And Methods: Ninety patients undergoing endoscopic treatment for VUR were retrospectively reviewed and classified into two groups according to ureteral obstruction: the nonobstruction group (83 cases, 122 ureters; mean age, 7.0 ± 2.8 years) and the obstruction group (7 cases, 10 ureters; mean age, 6.2 ± 8.1 years). We analyzed the following factors: age, sex, injection material, laterality, voiding dysfunction, constipation, renal scarring, preoperative and postoperative ultrasound findings, endoscopic findings, injection number, and injection volume. Additionally, we reviewed the clinical manifestations, natural course, management, and outcome of ureteral obstruction after endoscopic treatment.

Results: The incidence of ureteral obstruction after endoscopic treatment was 7.6% (10/132 ureters). The type of bulking agent used and injection volume tended to be associated with ureteral obstruction. However, no significant risk factors for obstruction were identified between the two groups. Three patients showed no symptoms or signs after the onset of ureteral obstruction. Most of the patients with ureteral obstruction experienced spontaneous resolution within 1 month with conservative therapy. Two patients required temporary ureteral stents to release the ureteral obstruction.

Conclusions: In our experience, the incidence of ureteral obstruction was slightly higher than in previous reports. Our study identified no predictive risk factors for developing ureteral obstruction after endoscopic treatment. Although most of the ureteral obstructions resolved spontaneously within 1 month, some cases required drainage to relieve symptoms or to prevent renal function deterioration.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4111/kju.2015.56.7.533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500811PMC
July 2015

Primary androgen deprivation therapy for prostate cancer in koreans: a retrospective multicenter study.

World J Mens Health 2014 Dec 29;32(3):159-66. Epub 2014 Dec 29.

Department of Urology, Inje University College of Medicine, Busan, Korea.

Purpose: To evaluate the characteristics of patients who received primary androgen deprivation therapy (PADT) for prostate cancer and the clinical efficacy of this treatment.

Materials And Methods: Two hundred forty patients treated by PADT were reviewed. These patients could not receive definitive therapy owing to old age, patient need, and medical comorbidity. The patients were divided into three groups according to the extent of prostate cancer: localized, locally advanced, and metastatic. Then, prostate-specific antigen (PSA) progression in these groups was analyzed.

Results: The median age of the patients was 73.0 years, and the median pretreatment PSA level was 47.0 ng/mL. Of the patients, 91.7% were treated with combined androgen blockade, and 8.3% were treated with monotherapy. Clinical factors for PSA progression were a PSA nadir and a high clinical stage. Estimated PSA recurrence-free median survival time in each group was 57, 24, and 12 months, respectively. A PSA nadir of >0.2 ng/mL and metastatic stage were independent factors for expecting a poor response to PADT (hazard ratio 4.26, p<0.001; and 2.60, p<0.001).

Conclusions: Patients with localized or locally advanced prostate cancer who did not receive definitive therapy had lower PSA progression rates than those at metastatic stage during PADT. Further, a PSA nadir of ≤0.2 ng/mL showed better progression-free survival. Therefore, PADT can be another therapeutic option in well-selected patients with localized or locally advanced prostate cancer and PSA change should be checked carefully.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5534/wjmh.2014.32.3.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298819PMC
December 2014

Overview of pediatric testicular tumors in Korea.

Korean J Urol 2014 Dec 5;55(12):789-96. Epub 2014 Dec 5.

Department of Urology, Pusan National University School of Medicine, Yangsan, Korea.

Prepubertal testicular tumors are rare compared with postpubertal testicular tumors. The incidence of prepubertal testicular tumors peaks at 2 years of age, tapers off after 4 years of age, and then begins to rise again at puberty. Prepubertal and postpubertal testicular tumors show many differences, including the typical tumor histology, molecular biological differences, and the malignant potential of tumors at different ages. Pediatric testicular tumors are classified as benign or malignant on the basis of their clinical behavior and histologically are divided into germ cell and gonadal stromal (nongerm cell) tumors. Many histological and biological studies have further confirmed the distinct nature of prepubertal and postpubertal testicular tumors. These differences have led to various management strategies for prepubertal and postpubertal tumors. Because overall about 75% of prepubertal testicular tumors are benign, a testis-sparing approach is becoming more common in children. Orchiectomy and observation with very selective use of chemotherapy has become the standard approach when a malignant tumor is identified. Retroperitoneal lymph node dissection and radiation therapy play very limited roles.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4111/kju.2014.55.12.789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265712PMC
December 2014

Efficacy and tolerability of anticholinergics in Korean children with overactive bladder: a multicenter retrospective study.

J Korean Med Sci 2014 Nov 4;29(11):1550-4. Epub 2014 Nov 4.

Department of Urology, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea.

We investigated the efficacy and tolerability of various anticholinergics in Korean children with non-neurogenic overactive bladder (OAB). A total of 326 children (males:females= 157:169) aged under 18 yr (mean age 7.3±2.6 yr) who were diagnosed with OAB from 2008 to 2011 were retrospectively reviewed. The mean duration of OAB symptoms before anticholinergic treatment was 16.9±19.0 months. The mean duration of medication was 5.6±7.3 months. Urgency urinary incontinence episodes per week decreased from 1.9±3.1 to 0.4±1.5 times (P<0.001). The median voiding frequency during daytime was decreased from 9.2±5.4 to 6.3±4.2 times (P<0.001). According to 3-day voiding diaries, the maximum and average bladder capacity were increased from 145.5±66.9 to 196.8±80.3 mL and from 80.8±39.6 to 121.8±56.5 mL, respectively (P<0.001). On uroflowmetry, maximum flow rate was increased from 17.6±8.4 to 20.5±8.2 mL/sec (P<0.001). Adverse effects were reported in 14 (4.3%) children and six children (1.8%) discontinued medication due to adverse effects. Our results indicate that anticholinergics are effective to improve OAB symptoms and tolerability was acceptable without severe complications in children.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3346/jkms.2014.29.11.1550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234924PMC
November 2014

A prospective Korean multicenter study for infectious complications in patients undergoing prostate surgery: risk factors and efficacy of antibiotic prophylaxis.

J Korean Med Sci 2014 Sep 2;29(9):1271-7. Epub 2014 Sep 2.

Department of Urology, Chung-Ang University, College of Medicine, Seoul, Korea. ; The Korean Association of Urogenital Tract Infection and Inflammation (KAUTII), Seoul, Korea.

This multicenter study was undertaken to determine the efficacy of antibiotic prophylaxis and identify the risk factors for infectious complications after prostate surgery in Korean patients. A total of 424 patients who underwent surgery of the prostate were reviewed. All patients underwent urinalysis and urine culture preoperatively and postoperatively. Efficacy of antibiotic prophylaxis and risk factors for infectious complications were investigated. Infectious complications were observed in 34.9% of all patients. Factors independently associated with infectious complications were diabetes mellitus (adjusted OR, 1.99; 95% CI, 1.09-3.65, P=0.025) and operation time (adjusted OR, 1.08; 95% CI, 1.03-1.13, P=0.004). Clinicians should be aware of the high risk of infectious complications in patients with diabetes and those who undergo a prolonged operation time. Neither the type nor duration of prophylactic antibiotics resulted in differences in infectious complications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3346/jkms.2014.29.9.1271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168182PMC
September 2014

Contrasting levels of clonal and within-population genetic diversity between the 2 ecologically different herbs Polygonatum stenophyllum and Polygonatum inflatum (Liliaceae).

J Hered 2014 Sep-Oct;105(5):690-701

From the Department of Biology and the Research Institute of Natural Science, Gyeongsang National University, Jinju 660-701, Republic of Korea (M. Y. Chung and M.G. Chung); the BioC-GReB, Botanic Institute of Barcelona (IBB-CSIC-ICUB), Barcelona 08038, Spain (López-Pujol); the Department of Plant Resources Conservation, Korea National Arboretum, Pocheon 487-821, Republic of Korea (J.M. Chung); and the School of Life Sciences, Korea University, Seoul 136-701, Republic of Korea (Kim). Mi Yoon Chung is now at the Department of Biology Education, Seowon University, Cheongju 361-742, Republic of Korea.

Comparative studies on clonal and genetic structure between ecologically contrasting congeners may provide valuable insights into the mechanisms promoting the maintenance of genetic diversity in clonal plant species. Polygonatum stenophyllum has long rhizomes (ca. 30-40 cm long) and largely occurs on sandy soils in open river banks, whereas its congener Polygonatum inflatum has short ones (ca. 5-10 cm long) and occurs on humic soils under deciduous forests. Using 21 allozyme loci, we comparatively assessed levels of clonal and genetic diversity in the 2 clonal species. Seven populations of P. stenophyllum consisted of single clones, and levels of within-population clonal and genetic variation were considerably lower than those of P. inflatum. However, when samples were pooled, P. stenophyllum harbored higher genetic variation than P. inflatum, which is due to higher among-population genetic differentiation in the former species compared with the latter (FST=0.636 vs. FST=0.165). Our data suggest that populations of P. stenophyllum have been mainly founded by a single seed or rhizome (through river water) or by a few seeds, whereas populations of P. inflatum would have been established through multiple, repeated seedling recruitment. Moderate levels of genetic diversity in a population of P. stenophyllum located at the foot of the Baekdudaegan Mountains and in all the populations of P. inflatum are consistent with the previous hypothesis that these mountains served as a glacial refugium for many boreal species of the Korean Peninsula.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/jhered/esu048DOI Listing
April 2015

Squamous cell carcinoma of the suprapubic cystostomy tract with bladder involvement.

Korean J Urol 2013 Sep 10;54(9):638-40. Epub 2013 Sep 10.

Department of Urology, Kosin University College of Medicine, Busan, Korea.

Herein we report a case of a squamous cell carcinoma of a well-healed suprapubic cystostomy tract scar involving the bladder mucosa in a 56-year-old man. He presented with a spontaneous suprapubic urinary leak from a suprapubic cystostomy tract scar. He had a history of urethral stricture and failed urethroplasty. Preoperative cystoscopy suggested a bladder mass. Transurethral biopsy of the bladder mass revealed a squamous cell carcinoma confined to the suprapubic cystostomy tract involving the bladder mucosa. The patient died 6 months after the start of radiation therapy after lung metastasis and pneumonia.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4111/kju.2013.54.9.638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773596PMC
September 2013

Genetic diversity in the Homosporous Fern Ophioglossum vulgatum (Ophioglossaceae) from South Korea: inference of mating system and population history.

J Hered 2013 Mar 29;104(2):263-72. Epub 2012 Oct 29.

Department of Biology and the Research Institute of Natural Science, Gyeongsang National University, Jinju 660-701, Republic of Korea.

It is generally believed that the members of Ophioglossaceae have subterranean, potentially bisexual gametophytes, which favor intragametophytic selfing. In Ophioglossaceae, previous allozyme studies revealed substantial inbreeding within Botrychium species and Mankyua chejuense. However, little is known about the mating system in species of the genus Ophioglossum. Molecular marker analyses can provide insights into the relative occurrence of selfing versus cross-fertilization in the species of Ophioglossum. We investigated allozyme variation in 8 Korean populations of the homosporous fern Ophioglossum vulgatum to infer its mating system and to get some insight into the population-establishment history in South Korea. We detected homozygous genotypes for alternative alleles at several loci, which suggest the occurrence of intragametophytic self-fertilization. Populations harbor low within-population variation (% P = 7.2, A = 1.08, and H (e) = 0.026) and a high among-population differentiation (F (ST) = 0.733). This, together with the finding that alternative alleles were fixed at several loci, suggests that the number and size of populations of O. vulgatum might have been severely reduced during the last glaciation (i.e., due to its in situ persistence in small, isolated refugia). The combined effects of severe random genetic drift and high rates of intragametophytic selfing are likely responsible for the genetic structure displayed by this homosporous fern. Its low levels of genetic diversity in South Korea justify the implementation of some conservation measures to ensure its long-term preservation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/jhered/ess087DOI Listing
March 2013

Malignant inflammatory myofibroblastic tumor of the bladder with rapid progression.

Korean J Urol 2012 Sep 19;53(9):657-61. Epub 2012 Sep 19.

Department of Urology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

A 71-year-old man was referred for painless hematuria and a bladder tumor. Cystoscopy and computed tomography revealed a 3-cm oval nodular mass on the left lateral side of the bladder. The patient underwent a complete transurethral resection of the lesion and histology showed a proliferation of atypical spindle cells with inflammation consistent with a myofibroblastic tumor. After 4 and 7 months, follow-up cystoscopy demonstrated nodular mass lesions and transurethral resection of bladder tumor was done, which showed chronic cystitis and a recurred myofibroblastic tumor, respectively. Five months later, multiple lymph node, bone, and soft tissue metastases were found by positron emission tomography. The patient was treated first with palliative chemotherapy, including doxorubicin and cisplatin. After that, radiologic studies showed disease progression but the patient refused further treatment and died 6 months later.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4111/kju.2012.53.9.657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460011PMC
September 2012

Safety and efficacy of once daily administration of 50 mg mirodenafil in patients with erectile dysfunction: a multicenter, double-blind, placebo controlled trial.

J Urol 2013 Mar 24;189(3):1006-13. Epub 2012 Sep 24.

Department of Urology, Hanyang University College of Medicine, Seoul, Korea.

Purpose: We evaluated the improvement in erectile dysfunction and lower urinary tract symptoms as well as the safety of once daily administration of 50 mg mirodenafil in men with erectile dysfunction.

Materials And Methods: A total of 226 patients visited for treatment of erectile dysfunction and were recruited for the study. Of these men 180 met the study inclusion criteria after completing a 2-week screening period (visit [V]1). The patients were randomly allocated into 2 groups. Group 1 (90 patients) received 50 mg mirodenafil once daily and group 2 (90 patients) received a placebo daily. Blood pressure, heart rate, IIEF-5 (5-item version of the International Index of Erectile Function), and SEP (Sexual Encounter Profile) questions 2 and 3 were assessed at 4 (V2), 8 (V3) and 12 weeks after the start of treatment (V4). I-PSS (International Prostate Symptom Score), maximal flow rate and post-void residual volume were also assessed for the evaluation of lower urinary tract symptoms.

Results: Of the 180 patients 71 in group 1 and 63 in group 2 completed the 12-week clinical trial. IIEF-5 and I-PSS significantly improved in group 1 (p <0.001 for both). Facial flushing was the most common adverse effect, followed by headaches. Notably there were no statistically significant differences in either of the variables related to the cardiovascular system.

Conclusions: Once daily administration of 50 mg mirodenafil was efficacious and safe for the treatment of erectile dysfunction and lower urinary tract symptoms.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.juro.2012.08.243DOI Listing
March 2013