Jae Hoon Sul

Jae Hoon Sul

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Jae Hoon Sul

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Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.

Am J Psychiatry 2019 03;176(3):217-227

The Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Department of Psychiatry, Massachusetts General Hospital, Boston (Yu, Illmann, Osiecki, Smoller, Pauls, Neale, Scharf); the Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Mass. (Yu, Neale, Scharf); the Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles (Sul, Huang, Zelaya, Ophoff, Freimer, Coppola); the Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (Sul, Huang, Zelaya, Freimer, Coppola); the Department of Molecular Biology and Genetics, Democritus University of Thrace, Xanthi, Greece (Tsetsos); the Department of Biological Sciences, Purdue University, West Lafayette, Ind. (Tsetsos, Paschou); deCODE Genetics/Amgen, Reykjavik, Iceland (Nawaz, H. Stefansson, K. Stefansson); the Bioinformatics Interdepartmental Program, University of California, Los Angeles (Huang, Zelaya); the Department of Psychiatry, University of California, San Francisco (Darrow); the Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco (Hirschtritt, Willsey); the Department of Psychiatry, Massachusetts General Hospital, Boston (Greenberg, Roffman, Buckner); the Clinic of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School, Hannover, Germany (Muller-Vahl); the Institute of Human Genetics, Hannover Medical School, Hannover, Germany (Stuhrmann); McGill University Health Center, University of Montreal, McGill University Health Centre, Montreal (Dion); the Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal (Rouleau); the Department of Psychiatry and Psychotherapy, Medical University Vienna, Vienna (Aschauer, Stamenkovic); Biopsychosocial Corporation, Vienna (Aschauer, Schlögelhofer); University Health Network, Youthdale Treatment Centres, and University of Toronto, Toronto (Sandor); the Krembil Research Institute, University Health Network, Hospital for Sick Children, and University of Toronto, Toronto (Barr); Johns Hopkins University School of Medicine, Baltimore (Grados, Singer); the Institute of Human Genetics, University Hospital Bonn, University of Bonn Medical School, Bonn, Germany (Nöthen); the Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany (Hebebrand, Hinney); the Yale Child Study Center and the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. (King, Fernandez); the Institute of Medical Chemistry, Molecular Biology, and Pathobiochemistry, Semmelweis University, Budapest, Hungary (Barta); Vadaskert Child and Adolescent Psychiatric Hospital, Budapest, Hungary (Tarnok, Nagy); the Institute of Human Genetics, University Hospital Essen, University Duisburg-Essen, Essen, Germany (Depienne); Sorbonne Universités, UPMC Université Paris 06, UMR S 1127, CNRS UMR 7225, ICM, Paris (Depienne, Worbe, Hartmann); French Reference Centre for Gilles de la Tourette Syndrome, Groupe Hospitalier Pitié-Salpêtrière, Paris (Worbe, Hartmann); Assistance Publique-Hôpitaux de Paris, Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, Paris (Worbe, Hartmann); Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York (Budman); Child Neuropsychiatry, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy (Rizzo); the Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York (Lyon); the Department of Psychiatry, University of Utah, Salt Lake City (McMahon); Children's Mercy Hospital, Kansas City, Mo. (Batterson); the Department of Psychiatry, University Medical Center Groningen and Rijksuniversity Groningen, and Drenthe Mental Health Center, Groningen, the Netherlands (Cath); the Department of Neurology, Fixel Center for Neurological Diseases, McKnight Brain Institute, University of Florida, Gainesville (Malaty, Okun); Pennsylvania State University College of Medicine, Hershey (Berlin); Marquette University and University of Wisconsin-Milwaukee, Milwaukee (Woods); Tripler Army Medical Center and University of Hawaii John A. Burns School of Medicine, Honolulu (Lee); Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston (Jankovic); the Division of Psychiatry, Department of Neuropsychiatry, University College London (Robertson); the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati (Gilbert); Children's Hospital of Philadelphia, Philadelphia (Brown); the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami (Coffey); the Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (Dietrich, Hoekstra); University of Iowa Carver College of Medicine, Iowa City (Kuperman); the Department of Pediatrics, University of Washington, Seattle (Zinner); the Department of Pediatrics, Landspitalinn University Hospital, Reykjavik, Iceland (Luðvigsson, Thorarensen); the Faculty of Medicine, University of Iceland, Reykjavík, Iceland (Sæmundsen, Stefansson); the State Diagnostic and Counselling Centre, Kópavogur, Iceland (Sæmundsen); the Department of Genetics and the Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (Atzmon, Barzilai); the Department of Human Biology, Haifa University, Haifa, Israel (Atzmon); the Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany (Wagner); the Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany (Moessner); SUNY Downstate Medical Center Brooklyn, New York (C.M. Pato, M.T. Pato, Knowles); the Athinoula A. Martinos Center for Biomedical Research, Department of Radiology, Massachusetts General Hospital, Charlestown (Roffman, Buckner); the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (Smoller); the Center for Brain Science and Department of Psychology, Harvard University, Cambridge, Mass. (Buckner); the Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco (Willsey); the Department of Genetics and the Human Genetics Institute of New Jersey, Rutgers, the State University of New Jersey, Piscataway (Tischfield, Heiman); the Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam (Posthuma); the Division of Genetic Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tenn. (Cox, Davis); the Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston (Neale); the Department of Psychiatry, Genetics Institute, University of Florida, Gainesville (Mathews); and the Department of Neurology, Brigham and Women's Hospital, and the Department of Neurology, Massachusetts General Hospital, Boston (Scharf).

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http://dx.doi.org/10.1176/appi.ajp.2018.18070857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677250PMC
March 2019

Population structure in genetic studies: Confounding factors and mixed models.

PLoS Genet 2018 12 27;14(12):e1007309. Epub 2018 Dec 27.

Department of Computer Science, University of California, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307707PMC
December 2018

Understanding the Hidden Complexity of Latin American Population Isolates.

Am J Hum Genet 2018 11 25;103(5):707-726. Epub 2018 Oct 25.

Department of Human Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Ecology & Evolutionary Biology, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183035
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http://dx.doi.org/10.1016/j.ajhg.2018.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218714PMC
November 2018

Colocalization of GWAS and eQTL Signals Detects Target Genes.

Am J Hum Genet 2016 Dec 17;99(6):1245-1260. Epub 2016 Nov 17.

Department of Computer Science, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://www.cell.com/ajhg/pdf/S0002-9297(16)30439-6.pdf
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http://biorxiv.org/content/biorxiv/early/2016/08/29/065037.f
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http://dx.doi.org/10.1016/j.ajhg.2016.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142122PMC
December 2016

A genome-wide association analysis of chromosomal aberrations and Hirschsprung disease.

Transl Res 2016 11 14;177:31-40.e6. Epub 2016 Jun 14.

Research Institute for Basic Science, Sogang University, Seoul, Republic of Korea; Department of Life Science, Sogang University, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2016.06.001DOI Listing
November 2016

Increasing Generality and Power of Rare-Variant Tests by Utilizing Extended Pedigrees.

Am J Hum Genet 2016 Oct 22;99(4):846-859. Epub 2016 Sep 22.

Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065687PMC
October 2016

Using genomic annotations increases statistical power to detect eGenes.

Bioinformatics 2016 06;32(12):i156-i163

Department of Computer Science Department of Human Genetics, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1093/bioinformatics/btw272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908356PMC
June 2016

A general framework for meta-analyzing dependent studies with overlapping subjects in association mapping.

Hum Mol Genet 2016 05 21;25(9):1857-66. Epub 2016 Feb 21.

Division of Genetics, Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA, Partners Center for Personalized Genetic Medicine, Boston, MA 02115, USA and Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PL, UK.

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http://dx.doi.org/10.1093/hmg/ddw049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986332PMC
May 2016

Accounting for Population Structure in Gene-by-Environment Interactions in Genome-Wide Association Studies Using Mixed Models.

PLoS Genet 2016 Mar 4;12(3):e1005849. Epub 2016 Mar 4.

Computer Science Department, University of California, Los Angeles, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778803PMC
March 2016

Characterization of genome-methylome interactions in 22 nuclear pedigrees.

PLoS One 2014 14;9(7):e99313. Epub 2014 Jul 14.

Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099313PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096397PMC
November 2015

A genome-wide association study identifies potential susceptibility loci for Hirschsprung disease.

PLoS One 2014 13;9(10):e110292. Epub 2014 Oct 13.

Research Institute for Basic Science, Sogang University, Seoul, Republic of Korea; Department of Life Science, Sogang University, Seoul, Republic of Korea; Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Republic of Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110292PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195606PMC
September 2015

Gene-Gene Interactions Detection Using a Two-stage Model.

J Comput Biol 2015 Jun 14;22(6):563-76. Epub 2015 Apr 14.

1Computer Science Department, University of California Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1089/cmb.2014.0163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449719PMC
June 2015

Accurate and fast multiple-testing correction in eQTL studies.

Am J Hum Genet 2015 Jun 28;96(6):857-68. Epub 2015 May 28.

Asan Institute for Life Sciences, Asan Medical Center, Seoul 138-736, Republic of Korea; Department of Medicine, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457958PMC
June 2015

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.

Authors:
Cornelius A Rietveld Sarah E Medland Jaime Derringer Jian Yang Tõnu Esko Nicolas W Martin Harm-Jan Westra Konstantin Shakhbazov Abdel Abdellaoui Arpana Agrawal Eva Albrecht Behrooz Z Alizadeh Najaf Amin John Barnard Sebastian E Baumeister Kelly S Benke Lawrence F Bielak Jeffrey A Boatman Patricia A Boyle Gail Davies Christiaan de Leeuw Niina Eklund Daniel S Evans Rudolf Ferhmann Krista Fischer Christian Gieger Håkon K Gjessing Sara Hägg Jennifer R Harris Caroline Hayward Christina Holzapfel Carla A Ibrahim-Verbaas Erik Ingelsson Bo Jacobsson Peter K Joshi Astanand Jugessur Marika Kaakinen Stavroula Kanoni Juha Karjalainen Ivana Kolcic Kati Kristiansson Zoltán Kutalik Jari Lahti Sang H Lee Peng Lin Penelope A Lind Yongmei Liu Kurt Lohman Marisa Loitfelder George McMahon Pedro Marques Vidal Osorio Meirelles Lili Milani Ronny Myhre Marja-Liisa Nuotio Christopher J Oldmeadow Katja E Petrovic Wouter J Peyrot Ozren Polasek Lydia Quaye Eva Reinmaa John P Rice Thais S Rizzi Helena Schmidt Reinhold Schmidt Albert V Smith Jennifer A Smith Toshiko Tanaka Antonio Terracciano Matthijs J H M van der Loos Veronique Vitart Henry Völzke Jürgen Wellmann Lei Yu Wei Zhao Jüri Allik John R Attia Stefania Bandinelli François Bastardot Jonathan Beauchamp David A Bennett Klaus Berger Laura J Bierut Dorret I Boomsma Ute Bültmann Harry Campbell Christopher F Chabris Lynn Cherkas Mina K Chung Francesco Cucca Mariza de Andrade Philip L De Jager Jan-Emmanuel De Neve Ian J Deary George V Dedoussis Panos Deloukas Maria Dimitriou Guðny Eiríksdóttir Martin F Elderson Johan G Eriksson David M Evans Jessica D Faul Luigi Ferrucci Melissa E Garcia Henrik Grönberg Vilmundur Guðnason Per Hall Juliette M Harris Tamara B Harris Nicholas D Hastie Andrew C Heath Dena G Hernandez Wolfgang Hoffmann Adriaan Hofman Rolf Holle Elizabeth G Holliday Jouke-Jan Hottenga William G Iacono Thomas Illig Marjo-Riitta Järvelin Mika Kähönen Jaakko Kaprio Robert M Kirkpatrick Matthew Kowgier Antti Latvala Lenore J Launer Debbie A Lawlor Terho Lehtimäki Jingmei Li Paul Lichtenstein Peter Lichtner David C Liewald Pamela A Madden Patrik K E Magnusson Tomi E Mäkinen Marco Masala Matt McGue Andres Metspalu Andreas Mielck Michael B Miller Grant W Montgomery Sutapa Mukherjee Dale R Nyholt Ben A Oostra Lyle J Palmer Aarno Palotie Brenda W J H Penninx Markus Perola Patricia A Peyser Martin Preisig Katri Räikkönen Olli T Raitakari Anu Realo Susan M Ring Samuli Ripatti Fernando Rivadeneira Igor Rudan Aldo Rustichini Veikko Salomaa Antti-Pekka Sarin David Schlessinger Rodney J Scott Harold Snieder Beate St Pourcain John M Starr Jae Hoon Sul Ida Surakka Rauli Svento Alexander Teumer Henning Tiemeier Frank J A van Rooij David R Van Wagoner Erkki Vartiainen Jorma Viikari Peter Vollenweider Judith M Vonk Gérard Waeber David R Weir H-Erich Wichmann Elisabeth Widen Gonneke Willemsen James F Wilson Alan F Wright Dalton Conley George Davey-Smith Lude Franke Patrick J F Groenen Albert Hofman Magnus Johannesson Sharon L R Kardia Robert F Krueger David Laibson Nicholas G Martin Michelle N Meyer Danielle Posthuma A Roy Thurik Nicholas J Timpson André G Uitterlinden Cornelia M van Duijn Peter M Visscher Daniel J Benjamin David Cesarini Philipp D Koellinger

Science 2013 Jun 30;340(6139):1467-71. Epub 2013 May 30.

Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, Netherlands.

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http://dx.doi.org/10.1126/science.1235488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751588PMC
June 2013

Effectively identifying eQTLs from multiple tissues by combining mixed model and meta-analytic approaches.

PLoS Genet 2013 Jun 13;9(6):e1003491. Epub 2013 Jun 13.

Computer Science Department, University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1371/journal.pgen.1003491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681686PMC
June 2013

Mixed models can correct for population structure for genomic regions under selection.

Nat Rev Genet 2013 Apr 26;14(4):300. Epub 2013 Feb 26.

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http://dx.doi.org/10.1038/nrg2813-c1DOI Listing
April 2013

Increasing power of groupwise association test with likelihood ratio test.

J Comput Biol 2011 Nov 15;18(11):1611-24. Epub 2011 Sep 15.

Department of Computer Science, University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1089/cmb.2011.0161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216097PMC
November 2011

An optimal weighted aggregated association test for identification of rare variants involved in common diseases.

Genetics 2011 May 2;188(1):181-8. Epub 2011 Mar 2.

Computer Science Department, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1534/genetics.110.125070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120154PMC
May 2011

Variance component model to account for sample structure in genome-wide association studies.

Nat Genet 2010 Apr 7;42(4):348-54. Epub 2010 Mar 7.

Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.

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http://www.nature.com/articles/ng.548
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http://dx.doi.org/10.1038/ng.548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092069PMC
April 2010

Mapping subsets of scholarly information.

Proc Natl Acad Sci U S A 2004 Apr 6;101 Suppl 1:5236-40. Epub 2004 Feb 6.

Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1073/pnas.0308253100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC387301PMC
April 2004