Jacquetta M Trasler

Jacquetta M Trasler

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Jacquetta M Trasler

Jacquetta M Trasler

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Moderate maternal folic acid supplementation ameliorates adverse embryonic and epigenetic outcomes associated with assisted reproduction in a mouse model.

Hum Reprod 2019 May;34(5):851-862

Child Health and Human Development Program (CHHD), Research Institute of the McGill University Health Centre, 1001 Décarie Boulevard, Montréal QC, Canada.

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http://dx.doi.org/10.1093/humrep/dez036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505447PMC
May 2019

Compromised oocyte quality and assisted reproduction contribute to sex-specific effects on offspring outcomes and epigenetic patterning.

Hum Mol Genet 2016 11;25(21):4649-4660

Montreal Children's Hospital and Research Institute of the McGill University Health Centre, Montreal, QC, Canada.

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http://dx.doi.org/10.1093/hmg/ddw293DOI Listing
November 2016

Growing Mouse Oocytes Transiently Activate Folate Transport via Folate Receptors As They Approach Full Size.

Biol Reprod 2016 06 27;94(6):125. Epub 2016 Apr 27.

Ottawa Hospital Research Institute, Ottawa, Ontario, Canada Department of Obstetrics and Gynecology and Department of Cellular and Molecular Medicine, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada

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http://dx.doi.org/10.1095/biolreprod.115.137687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946804PMC
June 2016

Ovarian Stimulators, Intrauterine Insemination, and Assisted Reproductive Technologies Use and the Risk of Major Congenital Malformations-The AtRISK Study.

Birth Defects Res B Dev Reprod Toxicol 2016 Jun 13;107(3):136-47. Epub 2016 Jun 13.

Research Center, CHU Ste-Justine, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/bdrb.21178DOI Listing
June 2016

Association between ovarian stimulators with or without intrauterine insemination, and assisted reproductive technologies on multiple births.

Am J Obstet Gynecol 2015 Oct 14;213(4):511.e1-511.e14. Epub 2015 Jun 14.

Research Center and Department of Obstetrics and Gynecology, CHU Sainte-Justine, Montreal, Quebec, Canada; Faculties of Pharmacy, University of Montreal, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajog.2015.06.028DOI Listing
October 2015

Developmental windows of susceptibility for epigenetic inheritance through the male germline.

Semin Cell Dev Biol 2015 Jul 8;43:96-105. Epub 2015 Aug 8.

Departments of Pediatrics, Human Genetics and Pharmacology & Therapeutics, McGill University, Canada; Montreal Children's Hospital and Research Institute, McGill University Health Centre, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2015.07.006DOI Listing
July 2015

Both the folate cycle and betaine-homocysteine methyltransferase contribute methyl groups for DNA methylation in mouse blastocysts.

FASEB J 2015 Mar 2;29(3):1069-79. Epub 2014 Dec 2.

*Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Departments of Obstetrics and Gynecology, and Cellular and Molecular Medicine, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada; Department of Obstetrics and Gynecology, and Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Children's Health Research Institute, London, Ontario, Canada; Developmental Biology and Cancer Program, University College London Institute of Child Health, London, United Kingdom; Research Institute of the McGill University Health Centre, Montréal Children's Hospital, Montréal, Quebec, Canada; and Departments of Human Genetics, Pediatrics, and Pharmacology and Therapeutics, McGill University, Montréal, Quebec, Canada

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http://dx.doi.org/10.1096/fj.14-261131DOI Listing
March 2015

Transient DNMT1 suppression reveals hidden heritable marks in the genome.

Nucleic Acids Res 2015 Feb 10;43(3):1485-97. Epub 2015 Jan 10.

Departments of Pediatrics, Human Genetics and Pharmacology & Therapeutics, McGill University and the Research Institute of the McGill University Health Centre at the Montreal Children's Hospital, Montreal, QC H3Z 2Z3, Canada

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http://dx.doi.org/10.1093/nar/gku1386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330356PMC
February 2015

Modulation of imprinted gene expression following superovulation.

Mol Cell Endocrinol 2014 May 12;388(1-2):51-7. Epub 2014 Mar 12.

Research Institute at the Montreal Children's Hospital of the McGill University Health Centre and Department of Human Genetics, McGill University, Montreal, Quebec H3H 1P3, Canada; Research Institute at the Montreal Children's Hospital of the McGill University Health Centre and Department of Pediatrics, McGill University, Montreal, Quebec H3H 1P3, Canada; Research Institute at the Montreal Children's Hospital of the McGill University Health Centre and Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3H 1P3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2014.03.003DOI Listing
May 2014

Uptake of betaine into mouse cumulus-oocyte complexes via the SLC7A6 isoform of y+L transporter.

Biol Reprod 2014 Apr 17;90(4):81. Epub 2014 Apr 17.

Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1095/biolreprod.113.116939DOI Listing
April 2014

Stability of DNA methylation patterns in mouse spermatogonia under conditions of MTHFR deficiency and methionine supplementation.

Biol Reprod 2013 Nov 27;89(5):125. Epub 2013 Nov 27.

McGill University Health Centre Research Institute at the Montréal Children's Hospital, Montréal, Québec, Canada.

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http://dx.doi.org/10.1095/biolreprod.113.109066DOI Listing
November 2013

Loss of DNMT1o disrupts imprinted X chromosome inactivation and accentuates placental defects in females.

PLoS Genet 2013 Nov 21;9(11):e1003873. Epub 2013 Nov 21.

Departments of Pharmacology & Therapeutics, Pediatrics and Human Genetics, Research Institute at The Montreal Children's Hospital of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1003873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836718PMC
November 2013

Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos.

Biol Reprod 2013 Sep 19;89(3):63. Epub 2013 Sep 19.

Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1095/biolreprod.113.111146DOI Listing
September 2013

Selective induction of glutathione S-transferases in round spermatids from the Brown-Norway rat by the chemotherapeutic regimen for testicular cancer.

Reprod Toxicol 2013 Apr 29;36:24-32. Epub 2012 Nov 29.

Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada.

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http://dx.doi.org/10.1016/j.reprotox.2012.10.012DOI Listing
April 2013

Critical period of nonpromoter DNA methylation acquisition during prenatal male germ cell development.

PLoS One 2011 19;6(9):e24156. Epub 2011 Sep 19.

Department of Pharmacology and Therapeutics, McGill University and Research Institute at The Montreal Children's Hospital of the McGill University Health Centre, Montréal, Quebec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024156PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176233PMC
March 2012

Epigenetic alterations in sperm DNA associated with testicular cancer treatment.

Toxicol Sci 2012 Feb 10;125(2):532-43. Epub 2011 Nov 10.

Research Institute of the McGill University Health Centre at Montreal Children's Hospital, Montreal, Quebec H3Z 2Z3, Canada.

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http://dx.doi.org/10.1093/toxsci/kfr307DOI Listing
February 2012

Developmental expression of SRC-related tyrosine kinases in the mouse testis.

J Androl 2011 Jan-Feb;32(1):95-110. Epub 2010 Aug 26.

Ontogenie et Reproduction, Centre Hospitalier Universitaire de Québec-Centre Hospitalier de l'Université Laval (CHUQ-CHUL), 2705 Boul. Laurier, Ste-Foy, QC, Canada.

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http://dx.doi.org/10.2164/jandrol.110.010462DOI Listing
March 2011

Strain-specific defects in testicular development and sperm epigenetic patterns in 5,10-methylenetetrahydrofolate reductase-deficient mice.

Endocrinology 2010 Jul 5;151(7):3363-73. Epub 2010 May 5.

Montréal Children's Hospital Research Institute, 2300 Tupper Street, Montréal, Québec, Canada H3H 1P3.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2009-1340DOI Listing
July 2010

Epigenetics in spermatogenesis.

Mol Cell Endocrinol 2009 Jul 20;306(1-2):33-6. Epub 2009 Jan 20.

Departments of Pediatrics, McGill University, Montreal Children's Hospital, McGill University Health Centre Research Institute, Montreal, QC, Canada.

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http://dx.doi.org/10.1016/j.mce.2008.12.018DOI Listing
July 2009

Reproductive and epigenetic outcomes associated with aging mouse oocytes.

Hum Mol Genet 2009 Jun 17;18(11):2032-44. Epub 2009 Mar 17.

Department of Human Genetics, McGill University and Montreal Children's Hospital of the McGill University Health Centre Research Institute, Montreal, Quebec, Canada H3H 1P3.

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http://dx.doi.org/10.1093/hmg/ddp127DOI Listing
June 2009

Epigenetic modification of the gene for the vitamin B(12) chaperone MMACHC can result in increased tumorigenicity and methionine dependence.

Mol Genet Metab 2009 Apr 5;96(4):261-7. Epub 2009 Feb 5.

Department of Human Genetics, McGill University, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Ave, Room L3.319, Montreal, Que., Canada H3G 1A4.

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http://dx.doi.org/10.1016/j.ymgme.2008.12.011DOI Listing
April 2009

Restriction digestion and real-time PCR (qAMP).

Methods Mol Biol 2009 ;507:271-80

Department of Pharmacology and Therapeutics and The Montreal Children's Hospital Research Institute, McGill University, Quebec, Montreal, Canada.

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http://dx.doi.org/10.1007/978-1-59745-522-0_20DOI Listing
March 2009

Impact of the chemotherapy cocktail used to treat testicular cancer on the gene expression profile of germ cells from male Brown-Norway rats.

Biol Reprod 2009 Feb 5;80(2):320-7. Epub 2008 Nov 5.

Department of Pharmacology and Therapeutics, McGill University, Montreal Children's Hospital Research Institute, Montréal, Québec, Canada H3G 1Y6.

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https://academic.oup.com/biolreprod/article-lookup/doi/10.10
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http://dx.doi.org/10.1095/biolreprod.108.072108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848733PMC
February 2009

Superovulation alters the expression of imprinted genes in the midgestation mouse placenta.

Hum Mol Genet 2008 Jun 20;17(11):1653-65. Epub 2008 Feb 20.

Department of Human Genetics, McGill University, Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1093/hmg/ddn055DOI Listing
June 2008

Profound phenotypic variation among mice deficient in the maintenance of genomic imprints.

Hum Reprod 2008 Apr 13;23(4):807-18. Epub 2008 Feb 13.

McGill University-Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada H3H 1P3.

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http://dx.doi.org/10.1093/humrep/den009DOI Listing
April 2008

Evaluation of a quantitative DNA methylation analysis technique using methylation-sensitive/dependent restriction enzymes and real-time PCR.

Epigenetics 2006 Jul-Sep;1(3):146-52. Epub 2006 Sep 8.

Department of Pharmacology and Therapeutics, The Montreal Children's Hospital Research Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.4161/epi.1.3.3392DOI Listing
December 2007

Adverse effects of 5-aza-2'-deoxycytidine on spermatogenesis include reduced sperm function and selective inhibition of de novo DNA methylation.

J Pharmacol Exp Ther 2007 Sep 20;322(3):1171-80. Epub 2007 Jun 20.

Department of Pharmacology and Therapeutics, McGill University-Montreal Children's Hospital Research Institute, 2300 Tupper St., Montreal, QC, Canada.

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http://dx.doi.org/10.1124/jpet.107.121699DOI Listing
September 2007

Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L.

BMC Dev Biol 2007 Sep 18;7:104. Epub 2007 Sep 18.

Department of Pharmacology & Therapeutics, McGill University and The Montreal Children's Hospital Research Institute, Montréal, QC H3H 1P3, Canada.

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http://www.springerlink.com/index/d7236422118l0374.pdf
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http://bmcdevbiol.biomedcentral.com/articles/10.1186/1471-21
Publisher Site
http://dx.doi.org/10.1186/1471-213X-7-104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212652PMC
September 2007

Coordinate regulation of DNA methyltransferase expression during oogenesis.

BMC Dev Biol 2007 Apr 19;7:36. Epub 2007 Apr 19.

Montreal Children's Hospital Research Institute and Department of Pediatrics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1186/1471-213X-7-36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1878483PMC
April 2007

Bovine SNRPN methylation imprint in oocytes and day 17 in vitro-produced and somatic cell nuclear transfer embryos.

Biol Reprod 2006 Oct 21;75(4):531-8. Epub 2006 Jun 21.

McGill University and Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1095/biolreprod.106.051722DOI Listing
October 2006

Dynamic expression of DNMT3a and DNMT3b isoforms during male germ cell development in the mouse.

Dev Biol 2006 Aug 21;296(1):71-82. Epub 2006 Apr 21.

Department of Pharmacology and Therapeutics, and Montreal Children's Hospital Research Institute, McGill University, Montreal, QC, Canada H3H 1P3.

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http://linkinghub.elsevier.com/retrieve/pii/S001216060600716
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http://dx.doi.org/10.1016/j.ydbio.2006.04.436DOI Listing
August 2006

Gamete imprinting: setting epigenetic patterns for the next generation.

Reprod Fertil Dev 2006 ;18(1-2):63-9

McGill University-Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada.

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March 2006

Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation.

Biol Reprod 2005 Mar 17;72(3):667-77. Epub 2004 Nov 17.

Department of Pediatrics, McGill University and the Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada.

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https://academic.oup.com/biolreprod/article-lookup/doi/10.10
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http://dx.doi.org/10.1095/biolreprod.104.035238DOI Listing
March 2005

Potential significance of genomic imprinting defects for reproduction and assisted reproductive technology.

Hum Reprod Update 2004 Jan-Feb;10(1):3-18

McGill University-Montreal Children's Hospital Research Institute and Department of Paediatrics, McGill University, Montreal, Quebec, H3H 1P3, Canada.

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http://dx.doi.org/10.1093/humupd/dmh002DOI Listing
September 2004

Postnatal development and regulation of beta-hexosaminidase in epithelial cells of the rat epididymis.

J Androl 2004 Jan-Feb;25(1):69-81

Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.

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August 2004

Gene-specific timing and epigenetic memory in oocyte imprinting.

Hum Mol Genet 2004 Apr 3;13(8):839-49. Epub 2004 Mar 3.

McGill University, Montreal Children's Hospital Research Institute and Departments of Pediatrics, Human Genetics and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3H 1P3.

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http://dx.doi.org/10.1093/hmg/ddh104DOI Listing
April 2004

Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells.

Dev Biol 2004 Apr;268(2):403-15

Department of Pharmacology and Therapeutics and the Montreal Children's Hospital Research Institute, McGill University, Montreal, QC, Canada H3H 1P3.

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http://linkinghub.elsevier.com/retrieve/pii/S001216060400028
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http://dx.doi.org/10.1016/j.ydbio.2003.12.031DOI Listing
April 2004

Translational research in male mediated developmental toxicity.

Adv Exp Med Biol 2003 ;518:279-84

Department of Pediatrics, McGill University and The McGill University-Montreal Children's Hospital, Research Institute, 2300 Tupper Street, Montreal, Quebec, Canada H3H 1P3.

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http://dx.doi.org/10.1007/978-1-4419-9190-4_26DOI Listing
January 2004

5-aza-2'-deoxycytidine induces alterations in murine spermatogenesis and pregnancy outcome.

J Androl 2003 Nov-Dec;24(6):822-30

Departments of Pediatrics, McGill University, and McGill University-Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada.

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January 2004

Gamete imprinting: implications for assisted reproductive technologies.

J Assist Reprod Genet 2003 Dec;20(12):483-4

Department of Pediatrics, McGill University and Montreal Children's Hospital Research Institute, Quebec, Canada.

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http://dx.doi.org/10.1023/b:jarg.0000013647.64239.adDOI Listing
December 2003

Effects of in utero tributyltin chloride exposure in the rat on pregnancy outcome.

Toxicol Sci 2003 Aug 28;74(2):407-15. Epub 2003 May 28.

Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada H3G 1Y6.

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http://dx.doi.org/10.1093/toxsci/kfg131DOI Listing
August 2003

Gestational exposure to persistent organic pollutants: maternal liver residues, pregnancy outcome, and effects on hepatic gene expression profiles in the dam and fetus.

Toxicol Sci 2003 Apr 7;72(2):242-52. Epub 2003 Mar 7.

Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec H3G 1Y6, Canada.

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http://dx.doi.org/10.1093/toxsci/kfg023DOI Listing
April 2003

Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats.

Proc Natl Acad Sci U S A 2003 Feb 6;100(4):1775-80. Epub 2003 Feb 6.

Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada H3H 1P3.

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http://dx.doi.org/10.1073/pnas.0437971100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149909PMC
February 2003

Buthionine sulfoximine embryotoxicity is associated with prolonged AP-1 activation.

Teratology 2002 Oct;66(4):192-200

Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada H3G 1Y6.

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http://dx.doi.org/10.1002/tera.10084DOI Listing
October 2002

Methylation dynamics of imprinted genes in mouse germ cells.

Genomics 2002 Apr;79(4):530-8

McGill University-Montreal Children's Hospital Research Institute and Departments of Pediatrics, Human Genetics, and Pharmacology & Therapeutics, McGill University, Montreal, Quebec, H3H 1P3, Canada.

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http://dx.doi.org/10.1006/geno.2002.6732DOI Listing
April 2002