Publications


Defective regulation of autoreactive IL-6-producing transitional B lymphocytes is associated with disease in patients with systemic sclerosis.
Arthritis Rheumatol 2017 Nov 28. Epub 2017 Nov 28.
Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK.



Cell-specific epigenome-wide DNA methylation profile in long-term cultured minor salivary gland epithelial cells from patients with Sjögren's syndrome.
Ann Rheum Dis 2017 Mar 16;76(3):625-628. Epub 2017 Jan 16.
INSERM U1227 B lymphocytes and autoimmunity, Labex IGO, Réseau épigénétique et réseau canaux ioniques du cancéropole Grand Ouest, Université de Brest, Brest, France.



CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes.
Cell Mol Immunol 2016 Aug 8. Epub 2016 Aug 8.
Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.

Regulatory B lymphocyte functions should be considered in chronic lymphocytic leukemia.
Oncoimmunology 2016 May 16;5(5):e1132977. Epub 2016 Mar 16.
INSERM ESPRI ERI29/EA2216 Laboratory of Immunotherapies and Pathologies of B Lymphocytes, Université de Brest, Labex IGO "Immunotherapy Graft, Oncology," Reseau Epigenetique et Reseau Canaux Ioniques du Cancéropole Grand Ouest , Brest, France.

Blood and salivary-gland BAFF-driven B-cell hyperactivity is associated to rituximab inefficacy in primary Sjögren's syndrome.
J Autoimmun 2016 Feb 10;67:102-110. Epub 2015 Dec 10.
EA2216, INSERM ESPRI, ERI29, Laboratoire d'Immunothérapies et Pathologies lymphocytaires B, Université de Brest, and Labex "IGO", Brest, France. Electronic address:



ANCA-associated vasculitis in patients with primary Sjögren's syndrome: detailed analysis of 7 new cases and systematic literature review.
Autoimmun Rev 2015 Aug 24;14(8):742-50. Epub 2015 Apr 24.
Service de Rhumatologie, CHRU Brest, France; EA2216, INSERM ESPRI, ERI29, Laboratoire d'Immunothérapies et Pathologies lymphocytaires B, Université de Brest, Brest, France. Electronic address:

Reliability of histopathological salivary gland biopsy assessment in Sjögren's syndrome: a multicentre cohort study.
Rheumatology (Oxford) 2015 Jun 27;54(6):1056-64. Epub 2014 Nov 27.
Pathology Department, Brest University Hospital, Brest, France, Pathology Department, Vannes General Hospital, Vannes, Brest Occidental University, Rheumatology Unit, Hôpital de la Cavale Blanche, EA 2216, ESPRI 29, Brest University, Brest, Rheumatology Department, Hôtel Dieu University Hospital, Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and Brest Occidental University, Clinical Investigation Centre, Institut National de la Santé et de la Recherche Médicale, Brest, France Pathology Department, Brest University Hospital, Brest, France, Pathology Department, Vannes General Hospital, Vannes, Brest Occidental University, Rheumatology Unit, Hôpital de la Cavale Blanche, EA 2216, ESPRI 29, Brest University, Brest, Rheumatology Department, Hôtel Dieu University Hospital, Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and Brest Occidental University, Clinical Investigation Centre, Institut National de la Santé et de la Recherche Médicale, Brest, France

Salivary gland ultrasonography improves the diagnostic performance of the 2012 American College of Rheumatology classification criteria for Sjögren's syndrome.
Rheumatology (Oxford) 2014 Sep 4;53(9):1604-7. Epub 2014 Apr 4.
Department of Rheumatology, EA 2216 Immunology and Pathology, SFR ScinBios, Labex Immunotherapy, Graft, Oncology, Brest University, Department of Odontology and Laboratory of Immunology and Immunotherapy, Brest Teaching Hospital, Brest, France. Department of Rheumatology, EA 2216 Immunology and Pathology, SFR ScinBios, Labex Immunotherapy, Graft, Oncology, Brest University, Department of Odontology and Laboratory of Immunology and Immunotherapy, Brest Teaching Hospital, Brest, France.

TLR9 expressed on plasma membrane acts as a negative regulator of human B cell response.
J Autoimmun 2014 Jun 26;51:23-9. Epub 2014 Feb 26.
EA2216 Immunologie et Pathologie, LabEx IGO, SFR ScInBioS, Université de Brest et Université Européenne de Bretagne, Brest, France; Laboratory of Immunology and Immunotherapy, CHRU Brest, Brest, France. Electronic address:

B cells display an abnormal distribution and an impaired suppressive function in patients with chronic antibody-mediated rejection.
Kidney Int 2014 Mar 27;85(3):590-9. Epub 2013 Nov 27.
1] EA2216 'Immunology and Pathology' Université de Brest, SFR ScinBios, LabEx IGO 'Immunotherapy Graft, Oncology', Brest, France [2] Laboratory of Immunology, CHRU Morvan, Brest, France.



Ectopic germinal centers are rare in Sjogren's syndrome salivary glands and do not exclude autoreactive B cells.
J Immunol 2009 Mar;182(6):3540-7
Equipe d'Accueil 2216 and Institut Fédératif de Recherche 418, Science et Ingénierie en Biologie-Santé, Université de Brest, Brest, and Université Européenne de Bretagne, Brest, France.


The contribution of epigenetics in Sjögren's Syndrome.
Front Genet 2014 3;5:71. Epub 2014 Apr 3.
Research Unit EA2216 Immunology, Pathology and Immunotherapy, SFR ScinBios and Labex Igo "Immunotherapy Graft, Oncology", Réseau Épigénétique du Cancéropole Grand Ouest, European University of Brittany Brest France ; Laboratory of Immunology and Immunotherapy, Hôpital Morvan - Brest University Medical School Brest France.


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