Jacques Hugon

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital/Mölndal, SE-431 80, Mölndal, Sweden.

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December 2020

Copper and zinc isotopic excursions in the human brain affected by Alzheimer's disease.

Authors:

Frédéric Moynier Marie Le Borgne Esther Laoud Brandon Mahan Francois Mouton-Ligier Jacques Hugon Claire Paquet

Alzheimers Dement (Amst) 2020 19;12(1):e12112. Epub 2020 Oct 19.

Centre de Neurologie Cognitive Hopital Lariboisière Fernand-Widal GHU Nord APHP Université de Paris, and Inserm Paris France.

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October 2020

STAT3 inhibition protects against neuroinflammation and BACE1 upregulation induced by systemic inflammation.

Authors:

Périne Millot Carine San Evangeline Bennana Baptiste Porte Nicolas Vignal Jacques Hugon Claire Paquet Benoit Hosten François Mouton-Liger

Immunol Lett 2020 Dec 21;228:129-134. Epub 2020 Oct 21.

INSERM U1144 Optimisation Thérapeutique en Neuropsychopharmacologie, Université de Paris, Paris, France; Centre de Neurologie Cognitive/CMRR Paris Nord Ile de France, APHP Nord Université de Paris, Lariboisière Hospital, Paris, France. Electronic address:

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December 2020

Biomarker counseling, disclosure of diagnosis and follow-up in patients with mild cognitive impairment: A European Alzheimer's disease consortium survey.

Int J Geriatr Psychiatry 2021 Feb 16;36(2):324-333. Epub 2020 Sep 16.

Department of Neurology, Danish Dementia Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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February 2021

[Alzheimer's disease: preclinical and early aspects : 10 key messages].

Authors:

Jacques Hugon Joël Ménard

Rev Prat 2020 02;70(2):177

Faculté de médecine Paris- Descartes, université de Paris.

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February 2020

[Transcranial cerebral stimulation in Alzheimer's disease].

Authors:

Jacques Hugon Claire Paquet

Rev Prat 2020 02;70(2):173-174

Centre de neurologie cognitive, hôpital Lariboisière-Fernand- Widal, AP-HP, université de Paris, Inserm U 1144, Paris, France.

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February 2020

[Alzheimer's disease: a biological disorder?]

Authors:

Jacques Hugon

Rev Prat 2020 Feb;70(2):152-155

Centre de neurologie cognitive, hôpital Lariboisière-Fernand- Widal, AP-HP, université de Paris et Inserm 1144, Paris, France.

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February 2020

[Accumulating knowledge and one objective: to act early].

Authors:

Jacques Hugon Joël Ménard

Rev Prat 2020 02;70(2):147-148

Faculté de médecine Paris-Descartes, université de Paris.

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February 2020

Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study.

PLoS Med 2020 08 20;17(8):e1003289. Epub 2020 Aug 20.

Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France.

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August 2020

CSF levels of the BACE1 substrate NRG1 correlate with cognition in Alzheimer's disease.

Authors:

François Mouton-Liger Julien Dumurgier Emmanuel Cognat Claire Hourregue Henrik Zetterberg Hugo Vanderstichele Eugeen Vanmechelen Elodie Bouaziz-Amar Kaj Blennow Jacques Hugon Claire Paquet

Alzheimers Res Ther 2020 07 20;12(1):88. Epub 2020 Jul 20.

Inserm U 1144, University de Paris, Paris, France.

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July 2020

Dissection of synaptic pathways through the CSF biomarkers for predicting Alzheimer disease.

Authors:

Marion Tible Åsa Sandelius Kina Höglund Ann Brinkmalm Emmanuel Cognat Julien Dumurgier Henrik Zetterberg Jacques Hugon Claire Paquet Kaj Blennow

Neurology 2020 08 25;95(8):e953-e961. Epub 2020 Jun 25.

From the Université de Paris INSERM U1144 (M.T., E.C., J.D., J.H., C.P.), France; Clinical Neurochemistry Laboratory (A.S., K.H., A.B., H.Z., K.B.), Sahlgrenska University Hospital; Institute of Neuroscience and Physiology (A.S., K.H., A.B., H.Z., K.B.), Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; and Center of Cognitive Neurology (E.C., J.D., J.H., C.P.), Lariboisière Fernand-Widal Hospital, APHP, Paris, France.

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August 2020

Are ketogenic diets promising for Alzheimer's disease? A translational review.

Authors:

Matthieu Lilamand Baptiste Porte Emmanuel Cognat Jacques Hugon François Mouton-Liger Claire Paquet

Alzheimers Res Ther 2020 04 14;12(1):42. Epub 2020 Apr 14.

INSERM U1144 Optimisation Thérapeutique en Neuropsychopharmacologie, Université de Paris, Paris, France.

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April 2020

Dose-dependent neuroprotective effect of the JNK inhibitor Brimapitide in 5xFAD transgenic mice.

Authors:

Baptiste Porte Gwendolyn Marguerit Sylvie Thomasseau Claire Paquet Jacques Hugon

Brain Res 2020 01 4;1727:146587. Epub 2019 Dec 4.

Université de Paris, INSERM UMR-S 1144, F-75006 Paris, France; Centre de Neurologie Cognitive, AP-HP, Hôpital Fernand-Widal, F-75475 Paris, France. Electronic address:

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January 2020

How many patients are eligible for disease-modifying treatment in Alzheimer's disease? A French national observational study over 5 years.

BMJ Open 2019 06 24;9(6):e029663. Epub 2019 Jun 24.

Neurology, CHU de la Pitiè Salpêtrière-AP-HP, Paris, France.

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June 2019

What is the clinical impact of cerebrospinal fluid biomarkers on final diagnosis and management in patients with mild cognitive impairment in clinical practice? Results from a nation-wide prospective survey in France.

BMJ Open 2019 05 30;9(5):e026380. Epub 2019 May 30.

Université de Paris, UMRS-1144, Inserm, F-75010 Paris, France.

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May 2019

Biomarker profiles of Alzheimer's disease and dynamic of the association between cerebrospinal fluid levels of β-amyloid peptide and tau.

Authors:

Aysha S Mohamed Lafirdeen Emmanuel Cognat Severine Sabia Claire Hourregue Matthieu Lilamand Aline Dugravot Elodie Bouaziz-Amar Jean-Louis Laplanche Jacques Hugon Archana Singh-Manoux Claire Paquet Julien Dumurgier

PLoS One 2019 14;14(5):e0217026. Epub 2019 May 14.

Cognitive Neurology Center, Saint Louis-Lariboisiere-Fernand Widal Hospital, AP-HP, Université de Paris, Paris, France.

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February 2020

CSF level of β-amyloid peptide predicts mortality in Alzheimer's disease.

Authors:

Adla Boumenir Emmanuel Cognat Severine Sabia Claire Hourregue Matthieu Lilamand Aline Dugravot Elodie Bouaziz-Amar Jean-Louis Laplanche Jacques Hugon Archana Singh-Manoux Claire Paquet Julien Dumurgier

Alzheimers Res Ther 2019 03 28;11(1):29. Epub 2019 Mar 28.

Cognitive Neurology Center, Saint Louis - Lariboisiere - Fernand Widal Hospital, AP-HP, Université Paris Diderot, Sorbonne Paris Cité, 200 rue du Faubourg Saint Denis, 75010, Paris, France.

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March 2019

[Biomarkers of Alzheimer's disease in older and oldest old patients].

Authors:

Matthieu Lilamand Emmanuel Cognat Stéphane Goutagny Claire Hourregue Jacques Hugon Julien Dumurgier Claire Paquet

Geriatr Psychol Neuropsychiatr Vieil 2019 03;17(1):65-72

Centre de neurologie cognitive Paris-Nord, Hôpital Lariboisière-Fernand Widal, AP-HP, Paris, France, Inserm U942 BioCanVas, Hôpital Lariboisière, Paris, France.

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March 2019

PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions.

Authors:

Marion Tible François Mouton Liger Julien Schmitt Albert Giralt Karim Farid Sylvie Thomasseau Sarah Gourmaud Claire Paquet Laure Rondi Reig Eliane Meurs Jean-Antoine Girault Jacques Hugon

Aging Cell 2019 06 1;18(3):e12887. Epub 2019 Mar 1.

Inserm U1144, Paris, France.

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June 2019

A Novel ELISA for the Measurement of Cerebrospinal Fluid SNAP-25 in Patients with Alzheimer's Disease.

Authors:

Annika Öhrfelt Ann Brinkmalm Julien Dumurgier Henrik Zetterberg Elodie Bouaziz-Amar Jacques Hugon Claire Paquet Kaj Blennow

Neuroscience 2019 11 5;420:136-144. Epub 2018 Dec 5.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden. Electronic address:

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November 2019

Blood-Based Kinase Assessments in Alzheimer's Disease.

Authors:

Jacques Hugon François Mouton-Liger Emmanuel Cognat Julien Dumurgier Claire Paquet

Front Aging Neurosci 2018 14;10:338. Epub 2018 Nov 14.

Center of Cognitive Neurology, Lariboisiere Fernand-Widal Hospital, APHP, University Paris Diderot, Paris, France.

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November 2018

Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts.

Authors:

Andrew S P Lim Chris Gaiteri Lei Yu Shahmir Sohail Walter Swardfager Shinya Tasaki Julie A Schneider Claire Paquet Donald T Stuss Mario Masellis Sandra E Black Jacques Hugon Aron S Buchman Lisa L Barnes David A Bennett Philip L De Jager

PLoS Med 2018 09 4;15(9):e1002647. Epub 2018 Sep 4.

Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York, United States of America.

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September 2018

Increased PKR level in human CADASIL brains.

Authors:

Emmanuel Cognat Marion Tible Ilyes Methnani Hugues Chabriat Homa Adle-Biassette Jacques Hugon Claire Paquet

Virchows Arch 2018 Dec 2;473(6):771-774. Epub 2018 Aug 2.

INSERM U942, Paris, France.

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December 2018

Distribution of Cerebrospinal Fluid Biomarker Profiles in Patients Explored for Cognitive Disorders.

Authors:

Claire Paquet Elodie Bouaziz-Amar Emmanuel Cognat Lisette Volpe-Gillot Victor Haddad Florence Mahieux Siham Dekimeche Benedicte Defontaines Hugues Chabriat Catherine Belin Antonio Texeira Stephane Goutagny Frank Questel Julien Azuar Pierre-Olivier Sellier Jean-Louis Laplanche Jacques Hugon Julien Dumurgier

J Alzheimers Dis 2018 ;64(3):889-897

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July 2019

Neural correlates of episodic memory in the Memento cohort.

Alzheimers Dement (N Y) 2018 22;4:224-233. Epub 2018 May 22.

Inserm, Bordeaux Population Health Research Center, UMR 1219, University Bordeaux, ISPED, CIC 1401-EC, Univ Bordeaux, Bordeaux, France.

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May 2018

PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease.

Authors:

Albert Giralt Benoit de Pins Carmen Cifuentes-Díaz Laura López-Molina Amel Thamila Farah Marion Tible Vincent Deramecourt Stefan T Arold Silvia Ginés Jacques Hugon Jean-Antoine Girault

Exp Neurol 2018 09 24;307:62-73. Epub 2018 May 24.

Inserm UMR-S 839, Paris, France; Sorbonne Université, Science and Engineering Faculty, Paris, France; Institut du Fer a Moulin, Paris, France. Electronic address:

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September 2018

PKR modulates abnormal brain signaling in experimental obesity.

Authors:

Mariko Taga François Mouton-Liger Malha Sadoune Sarah Gourmaud Jenny Norman Marion Tible Sylvie Thomasseau Claire Paquet James A R Nicoll Delphine Boche Jacques Hugon

PLoS One 2018 24;13(5):e0196983. Epub 2018 May 24.

INSERM Units U942, Paris, France.

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August 2018

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