Publications by authors named "Jacques Hamon"

16Publications

Multidimensional de novo design reveals 5-HT2B receptor-selective ligands.

Angew Chem Int Ed Engl 2015 Jan 4;54(5):1551-5. Epub 2014 Dec 4.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), Vladimir-Prelog-Weg 4, 8093 Zurich (Switzerland).

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January 2015

Efficient search of chemical space: navigating from fragments to structurally diverse chemotypes.

J Med Chem 2013 Nov 31;56(21):8879-91. Epub 2013 Oct 31.

Novartis Institutes for Biomedical Research Inc. , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

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November 2013

In vitro safety pharmacology profiling: what else beyond hERG?

Future Med Chem 2009 Jul;1(4):645-65

Center for Proteomic Chemistry, Novartis Pharma AG, Forum 1, 4002 Basel, Switzerland.

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July 2009

Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis.

J Chem Inf Model 2009 Feb;49(2):308-17

Lead Discovery Informatics and Preclinical Safety Profiling, CPC, Novartis Institutes for Biomedical Research, 250 Massachussetts Avenue, Cambridge, Massachusetts 02139, USA.

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February 2009

Mapping adverse drug reactions in chemical space.

J Med Chem 2009 May;52(9):3103-7

Lead Discovery Informatics, CPC, Novartis Institutes for Biomedical Research, 250 Massachussetts Avenue, Cambridge, Massachusetts 02139, USA.

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May 2009

Modeling promiscuity based on in vitro safety pharmacology profiling data.

ChemMedChem 2007 Jun;2(6):874-80

CPC/LFP/MLI, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Postfach, 4002 Basel, Switzerland.

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June 2007

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure.

ChemMedChem 2007 Jun;2(6):861-73

Lead Finding Platform, Novartis Institutes for BioMedical Research Inc. 250 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.

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June 2007

Clustering and rule-based classifications of chemical structures evaluated in the biological activity space.

J Chem Inf Model 2007 Mar-Apr;47(2):325-36. Epub 2007 Feb 8.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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May 2007

Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects.

J Biol Chem 2006 May 17;281(20):14192-206. Epub 2006 Mar 17.

Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich, Switzerland.

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May 2006

Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development.

Drug Discov Today 2005 Nov;10(21):1421-33

PreClinical Profiling, Lead Discovery Center, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

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November 2005

Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors.

Bioorg Med Chem Lett 2005 Aug;15(16):3787-90

Department of Chemistry, Pfizer Global Research and Development, Fresnes Laboratories, 3-9 rue de la Loge, BP 100, F-94265 Fresnes Cedex, France.

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August 2005