Jacques Gilloteaux, PhD - St George's School of Medicine - Professor Emeritus

Jacques Gilloteaux

PhD

St George's School of Medicine

Professor Emeritus

Newcastle | United Kingdom

Main Specialties: Biology

Additional Specialties: Anatomy


Top Author

Jacques Gilloteaux, PhD - St George's School of Medicine - Professor Emeritus

Jacques Gilloteaux

PhD

Introduction

Scientific Collaborator, Unit of Research in Molecular Physiology, Fac of Medicine, University of Namur, Namur, Belgium (10-2016- current)

Emeritus Professor of Anatomical Sciences, Cell Biology/Histology and Part-time Professor Saint George’s University International School of Medicine, KB Taylor Global Scholars’ Programme at Northumbria University Campus, Newcastle upon Tyne, United Kingdom, Grenada WI et New York, USA (2015-current).

Past- Co Director of course ANAT 531 Cell Biology and Histology (Jan. 2008- July 2015)
Advanced Course SCSK 526 ‘Applied Cell Biology and Histology’ on Introduction in Cell Pathology and Cancer biology

Senior Scientist - Departments of Obstetrics and Gynecology, and Urology, Summa Health System University Hospital Research on Cancer Biology (co-discoverer of new cancer cell death and antiviral therapy) and with Department of Surgery on Biliary tract pathology, Akron OH, and Summa Research Foundation, Akron OH, USA 983 -2014).

HONORS in TEACHING HISTOLOGY COURSES IN MEDICAL SCHOOLS:

* Outstanding Teacher of the Year 1998 et 2001, Sophomore class of LECollege of Medicine, May 2001 as Professor of Cell Biology, Histology and Cell Pathology (Core and Integrated Systems).

*** Elected Alpha Omega Alpha Professor, National Medical Honor Society of United States
with citation for "efforts in teaching, research (and clinical skill) as well as integrity and
compassion for those with whom you work" and "enthusiasm for the education of future
physicians is deserving commendation." Inducted April 28, 1994 by members (honor
medical students and alumni physicians) of the Zeta Chapter of Ohio at Northeastern Ohio
Universities College of Medicine.

ACADEMIC Career

1. Professor of Anatomy: Course director of Cell Biology and Histology (2002- Dec 2007) at the American University of the Caribbean School of Medicine, Campus St Maarten and Director of the S. L. Gaffin Research Laboratory (2007-2008).

2. Professor of Anatomy, Course Director of Cell Biology and Histology – LECOM, Erie PA, USA. Course Director (1995-2001) year I (histology) and year II (organ systems, integrated teaching) Medical Students (LECOM);and Cell Pathology in General Pathology course.

3. Assistant and Associate Professor of Anatomical Sciences, NorthEastern Ohio Universities College of Medicine, (Now NEOUMed), Rootstown Ohio, USA (1979-1995).

4. Professor of Anatomy, Physiology and Human Biology, Cuyahoga Community College, Highland Highs-Cleveland, Summer and Fall 2001.

5. Assistant Professor of Physiology (7-1977-6-79) and Research Associate (6-77), State University of New York, Upstate Medical Center, Syracuse, NY, USA.

6. Research Associate and Lecturer in Cell Biology/Histology (non-tenure track), Department
of Anatomical Sciences, State University of New York, Stony Brook, NY Long Island (1976-1977), USA.

Special Courses

1. Biology of Aging. Coordinator and team-teaching as basic Scientist to the Course of Geriatric and Gerontology for 2nd year Medical Students: 1984-1995.

2. Preparation for Medical National Board (part I and part II) tests.

3. Facilitator, Problem Based Learning, Medical School Curriculum, trained with Ohio State University Program at LECOM, Erie PA, 1999-2000.

4. Embryology and Human Development: team-taught course (1995-2001), Medical
students .

Clinical Basic Science Associate:

1. Associate Professor of Urology (joint appointment, 1994-1995), Department of Urology,
Summa Health System, Akron, Ohio (currently [i.e.1995- 2013] collaborating in research on
Cancer biology with the Department of Urology.

2. Assistant Professor et Associate Professor, Anatomy, Northeastern Ohio Universities
College of Medicine, Rootstown, Ohio, Full Member of the Cell and Molecular Biology and
Neurobiology Committees of the Graduate College, Biomedical Sciences, Kent State
University, Kent OH, USA 1979-1995.

3. Research Associate - Postdoctoral Scientist: Institut National de la Santé et de la
Recherche Médicale (INSERM) U 124, Lille, Cytobiologie du Cancer and Protéines and
Université des Sciences et Techniques de Lille I (France); support by the European
Molecular Biology Organization (EMBO), the Ministry of Education and the
Fondation Universitaire de Belgique (1st laureate after National competition). 10/74-1/75

4. Collaborateur scientifique Hamot Heart Institute, Hamot Medical Center of Hershey
Medical School, Erie, PA. (Dir. J.D. Maloney, M.D. Cardiologist) [Morphology and discovery
of cardiac pacemaker cells in pulmonary veins walls] (2000-2003) on description of
myocardial sleeves in human and their implementation on pacemaker and cardiac
electrophysiology.

Primary Affiliation: St George's School of Medicine - Newcastle , United Kingdom

Specialties:

Additional Specialties:

Research Interests:


View Jacques Gilloteaux’s Resume / CV

Education

Oct 1974
Universite Catholique de Louvain
Dr Sc

Experience

Dec 1994
Alpha Omega Alpha Honor Professor

Publications

30Publications

320Reads

90Profile Views

Ultrastructural Analysis of Thalamus Damages in a Mouse Model of Osmotic-Induced Demyelination.

Neurotox Res 2019 Jul 2;36(1):144-162. Epub 2019 May 2.

Unité de Recherche en Physiologie Moléculaire (URPhyM) - NARILIS, Faculté de Médecine, Université de Namur, Rue de Bruxelles 61, B-5000, Namur, Belgium.

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http://dx.doi.org/10.1007/s12640-019-00041-xDOI Listing
July 2019
4 Reads
3.538 Impact Factor

Osmotic Demyelination: From an Oligodendrocyte to an Astrocyte Perspective.

Int J Mol Sci 2019 Mar 5;20(5). Epub 2019 Mar 5.

URPhyM-NARILIS, Université de Namur, 5000 Namur, Belgium.

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https://www.mdpi.com/1422-0067/20/5/1124
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http://dx.doi.org/10.3390/ijms20051124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429405PMC
March 2019
20 Reads
2.862 Impact Factor

The leptin receptor mutation of the obese Zucker rat causes sciatic nerve demyelination with a centripetal pattern defect.

Ultrastruct Pathol 2018 Sep-Oct;42(5):377-408. Epub 2018 Oct 19.

b Unité de Recherche en Physiologie Moléculaire (URPhyM), Laboratoire de Neurodégénérescence et Régénération, Département de Médecine , Université de Namur , Namur , Belgium.

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http://dx.doi.org/10.1080/01913123.2018.1522405DOI Listing
December 2018
4 Reads
1.133 Impact Factor

Formation of intracellular lumina in human prostate carcinoma (DU145) cells, maturation into signet cells, and the cribriform morphology of tumors.

Ultrastruct Pathol 2016 Jul-Aug;40(4):189-99. Epub 2016 Apr 4.

c The Apatone Development Center , St. Thomas Hospital, Summa Research Foundation , Akron , OH , USA.

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http://dx.doi.org/10.3109/01913123.2016.1155684DOI Listing
March 2017
19 Reads
1.133 Impact Factor

Calcitonin: Survey of New Anatomy Data to Pathology and Therapeutic Aspects.

Translational Research in Anatomy

Since the discovery of calcitonin (CT) reports have questioned the physiological role of human CT in regulating calcemia. This peptide is produced out of the CT/CGRP gene splicing along with other factors or hormones, including somatostatin by synonymously called parafollicular cells, C thyrocytes or C cells located in the thyroid glands. The C cells have recently been proven to originate out of the ultimobranchial anlage of the pharyngeal endoderm instead of the neural crest cells as indicated in all textbooks. Both blood and urine CT and procalcitonin (proCT) found in human and other mammals can also be secreted by cells located outside the thyroid glands. Taking account of dietetic calcium intake, CT assists in the homeostasis of bone mineral mass during growth, lactation, and pregnancy, hypo- and hyper gravity along with other paracrine thyroid secretions. Excess CT level in tissue fluids, needle aspirations and, now proCT, can diagnose sepsis, medullary thyroid or other carcinomas; caution to be taken with ectopic CT and gender-difference levels. Salmon CT as diurnal oral delivery seems, if proven not toxic, best suited to continue preventing or treating several defects, especially osteoporosis, orthopedic-related pains, perinatal or acute, fatal hypercalcemia. Contemplating old with recent physiological clinical results, human longitudinal morphologic and molecular data dealing with C cells and their paracrine interactions are few while only animal studies make us know much about CT. Human samples out of biopsies or cadavers should be further endeavored from development to aging to fully correlate normal with extreme or peculiar pathologies.

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February 2017
86 Reads

Crinophagy in Thyroid Follicular and Parafollicular Cells of Male Obese Zucker Rat.

Ultrastruct Pathol 2015 13;39(4):255-69. Epub 2015 Apr 13.

Department of Anatomical Sciences, St George's University School of Medicine, KB Taylor Global Scholar's Programme at Northumbria University , Newcastle upon Tyne , UK.

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http://dx.doi.org/10.3109/01913123.2015.1014611DOI Listing
June 2016
1.133 Impact Factor

Pro-oxidant treatment of human prostate carcinoma (DU145) induces autoschizis cell death: autophagosomes build up out of injured endomembranes and mitochondria.

Ultrastruct Pathol 2014 Oct 23;38(5):315-28. Epub 2014 Jun 23.

Department of Anatomical Sciences, St Georges' University School of Medicine, KB Taylor Global Scholar's Programme , Newcastle upon Tyne , United Kingdom and.

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http://dx.doi.org/10.3109/01913123.2014.927404DOI Listing
October 2014
21 Reads
1.133 Impact Factor

Clarification of the terminology of the major human salivary glands: acinus and alveolus are not synonymous.

Anat Rec (Hoboken) 2014 Aug 6;297(8):1354-63. Epub 2014 Jun 6.

Department of Anatomical Sciences, St George's University International School of Medicine, K B. Taylor Global Scholar's Programme, Newcastle upon, Tyne, UK.

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http://dx.doi.org/10.1002/ar.22950DOI Listing
August 2014
1 Read
1.530 Impact Factor

Synergistic antitumor cytotoxic actions of ascorbate and menadione on human prostate (DU145) cancer cells in vitro: nucleus and other injuries preceding cell death by autoschizis.

Ultrastruct Pathol 2014 Apr 24;38(2):116-40. Epub 2014 Jan 24.

Department of Anatomical Sciences, St Georges' University International School of Medicine, K B Taylor Scholar's Programme , Newcastle upon Tyne , UK and.

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http://dx.doi.org/10.3109/01913123.2013.852645DOI Listing
April 2014
19 Reads
1.133 Impact Factor

A rare, human prostate oncocyte cell originates from the prostatic carcinoma (DU145) cell line.

Ultrastruct Pathol 2013 Dec 19;37(6):440-8. Epub 2013 Aug 19.

Department of Anatomical Sciences, St Georges' University International School of Medicine, K. B. Taylor Global Scholar's Programme , Newcastle upon Tyne , UK .

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http://dx.doi.org/10.3109/01913123.2013.814739DOI Listing
December 2013
25 Reads
1.133 Impact Factor

Human prostate DU145 carcinoma cells implanted in nude mice remove the peritoneal mesothelium to invade and grow as carcinomas.

Anat Rec (Hoboken) 2013 Jan 25;296(1):40-55. Epub 2012 Oct 25.

Department of Anatomical Sciences, St Georges' University International School of Medicine, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/ar.22607DOI Listing
January 2013
7 Reads
1.530 Impact Factor

Xenotransplanted human prostate carcinoma (DU145) cells develop into carcinomas and cribriform carcinomas: ultrastructural aspects.

Ultrastruct Pathol 2012 Oct;36(5):294-311

Department of Anatomical Sciences, St George's University International School of Medicine, at Northumbria University-School of Life Sciences, Drill Hall 013, Newcastle upon Tyne NE1 8ST, UK.

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http://dx.doi.org/10.3109/01913123.2012.708472DOI Listing
October 2012
17 Reads
1.133 Impact Factor

Cell damage and death by autoschizis in human bladder (RT4) carcinoma cells resulting from treatment with ascorbate and menadione.

Ultrastruct Pathol 2010 May;34(3):140-60

Department of Anatomical Sciences, St. Georges' University School of Medicine, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.3109/01913121003662304DOI Listing
May 2010
21 Reads
1.133 Impact Factor

Cocaine causes atrial Purkinje fiber damage.

Ultrastruct Pathol 2010 Apr;34(2):90-8

Department of Anatomical Sciences, St Georges' University School of Medicine, K B Taylor Global Scholar's Programme, Newcastle upon Tyne, UK.

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http://www.tandfonline.com/doi/full/10.3109/0191312100362666
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http://dx.doi.org/10.3109/01913121003626663DOI Listing
April 2010
3 Reads
1.133 Impact Factor

The perinuclear space of pancreatic acinar cells and the synthetic pathway of zymogen in Scorpaena scrofa L.: ultrastructural aspects.

Tissue Cell 2008 Feb 24;40(1):7-20. Epub 2007 Oct 24.

Department of Anatomy, American University of the Caribbean School of Medicine, Coral Gables, FL 33134, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S004081660700079
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http://dx.doi.org/10.1016/j.tice.2007.08.004DOI Listing
February 2008
5 Reads
1.049 Impact Factor

Morphology and DNA degeneration during autoschizic cell death in bladder carcinoma T24 cells induced by ascorbate and menadione treatment.

Anat Rec A Discov Mol Cell Evol Biol 2006 Jan;288(1):58-83

Department of Anatomy, American University of the Caribbean, School of Medicine, Coral Gables, Florida 33134, USA.

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http://dx.doi.org/10.1002/ar.a.20276DOI Listing
January 2006
1 Read

Cell death by autoschizis in TRAMP prostate carcinoma cells as a result of treatment by ascorbate: menadione combination.

Ultrastruct Pathol 2005 May-Aug;29(3-4):221-35

American University of the Caribbean School of Medicine, Campus St. Maarten, M.E.I.O., Inc, Coral Gables, Florida 33134, USA.

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http://dx.doi.org/10.1080/01913120590951239DOI Listing
August 2005
13 Reads
1.133 Impact Factor

Carcinoma in situ of the cystic duct.

Ultrastruct Pathol 2005 Mar-Apr;29(2):79-84

Department of Surgery, Summa Health System, Summa Research Foundation, Akron, Ohio, USA.

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http://dx.doi.org/10.1080/01913120590916814DOI Listing
August 2005
2 Reads
1.133 Impact Factor

Intracellular liposomes and cholesterol deposits in chronic cholecystitis and biliary sludge.

Ultrastruct Pathol 2004 May-Jun;28(3):123-36

Departments of Pathology and Surgery, Summa Health System, Summa Research Foundation, Akron, Ohio, USA.

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http://dx.doi.org/10.1080/01913120490475888DOI Listing
December 2004
10 Reads
1.133 Impact Factor

Inhibition of the development of metastases by dietary vitamin C:K3 combination.

Life Sci 2004 Jul;75(8):955-67

Unité de Pharmacocinétique, Métabolisme, Nutrition, et Toxicologie, Université Catholique de Louvain, Avenue E. Mounier, 73, B-1200 Bruxelles, Belgium.

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http://dx.doi.org/10.1016/j.lfs.2004.02.011DOI Listing
July 2004
7 Reads
2.702 Impact Factor

Autoschizis: a new form of cell death for human ovarian carcinoma cells following ascorbate:menadione treatment. Nuclear and DNA degradation.

Tissue Cell 2004 Jun;36(3):197-209

Department of Anatomy, American University of the Caribbean, School of Medicine, Campus St. Maarten, M.E.I.O. Inc., Ponce de Leon Boulevard 901, Suite #401, Coral Gables, FL 33135, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S004081660400017
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http://dx.doi.org/10.1016/j.tice.2004.01.006DOI Listing
June 2004
32 Reads
1.049 Impact Factor

Lipid deposits and lipo-mucosomes in human cholecystitis and epithelial metaplasia in chronic cholecystitis.

Ultrastruct Pathol 2003 Sep-Oct;27(5):313-21

Department of Anatomy, American University of the Caribbean, School of Medicine, Cupecoy-Lowlands, St. Maarten, NA, West Indies.

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May 2004
3 Reads
1.133 Impact Factor

Cell cycle arrest and autoschizis in a human bladder carcinoma cell line following Vitamin C and Vitamin K3 treatment.

Biochem Pharmacol 2004 Jan;67(2):337-51

Department of Urology, College of Medicine, Northeastern Ohio Universities, Summa Health System/NEOUCOM, Akron, OH 44304, USA.

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http://dx.doi.org/10.1016/j.bcp.2003.08.040DOI Listing
January 2004
2 Reads
5.009 Impact Factor

The in vitro antitumor activity of vitamins C and K3 against ovarian carcinoma.

Anticancer Res 2003 Jul-Aug;23(4):3279-87

Department of Obstetrics and Gynecology, SUMMA Health System, 525 E. Market Street, Akron, OH 44309, USA.

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September 2003
2 Reads
1.872 Impact Factor

Microscopic aspects of autoschizic cell death in human ovarian carcinoma (2774) cells following vitamin C, vitamin K3 or vitamin C:K3 treatment.

Microsc Microanal 2003 Aug;9(4):311-29

Department of Urology, Summa Health System, Akron, OH 44304, USA.

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http://dx.doi.org/10.1017/S1431927603030125DOI Listing
August 2003
9 Reads
1.877 Impact Factor

The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy.

Eur J Med Chem 2003 May;38(5):451-7

Unité de Pharmacocinétique, Métabolisme, Nutrition et Toxicologie, Département des sciences pharmaceutiques, Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1016/s0223-5234(03)00082-5DOI Listing
May 2003
10 Reads
3.447 Impact Factor

Autoschizis: a novel cell death.

Biochem Pharmacol 2002 May;63(10):1773-83

Department of Urology, Summa Health System/Northeastern Ohio Universities College of Medicine, 2209 State Route 44, PO Box 95, Rootstown, OH 44272-0095, USA.

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http://dx.doi.org/10.1016/s0006-2952(02)00904-8DOI Listing
May 2002
21 Reads
5.009 Impact Factor