Dr Jacques Baudier, PhD - INSERM - Director

Dr Jacques Baudier

PhD

INSERM

Director

Marseille, france | france

Main Specialties: Biology

Additional Specialties: Neuroscience, biophysic,

ORCID logohttps://orcid.org/0000-0001-8427-4444

Dr Jacques Baudier, PhD - INSERM - Director

Dr Jacques Baudier

PhD

Introduction

Primary Affiliation: INSERM - Marseille, france , france

Specialties:

Additional Specialties:

Publications

28Publications

527Reads

12Profile Views

453PubMed Central Citations

ATAD3 proteins: brokers of a mitochondria-endoplasmic reticulum connection in mammalian cells.

Authors:
Jacques Baudier

Biol Rev Camb Philos Soc 2018 05 20;93(2):827-844. Epub 2017 Sep 20.

Aix Marseille Université, CNRS, IBDM, 13284, Marseille Cedex 07, France.

In yeast, a sequence of physical and genetic interactions termed the endoplasmic reticulum (ER)-mitochondria organizing network (ERMIONE) controls mitochondria-ER interactions and mitochondrial biogenesis. Several functions that characterize ERMIONE complexes are conserved in mammalian cells, suggesting that a similar tethering complex must exist in metazoans. Recent studies have identified a new family of nuclear-encoded ATPases associated with diverse cellular activities (AAA+-ATPase) mitochondrial membrane proteins specific to multicellular eukaryotes, called the ATPase family AAA domain-containing protein 3 (ATAD3) proteins (ATAD3A and ATAD3B). These proteins are crucial for normal mitochondrial-ER interactions and lie at the heart of processes underlying mitochondrial biogenesis. ATAD3A orthologues have been studied in flies, worms, and mammals, highlighting the widespread importance of this gene during embryonic development and in adulthood. ATAD3A is a downstream effector of target of rapamycin (TOR) signalling in Drosophila and exhibits typical features of proteins from the ERMIONE-like complex in metazoans. In humans, mutations in the ATAD3A gene represent a new link between altered mitochondrial-ER interaction and recognizable neurological syndromes. The primate-specific ATAD3B protein is a biomarker of pluripotent embryonic stem cells. Through negative regulation of ATAD3A function, ATAD3B supports mitochondrial stemness properties.

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http://dx.doi.org/10.1111/brv.12373DOI Listing
May 2018
143 Reads

The filamin-B-refilin axis - spatiotemporal regulators of the actin-cytoskeleton in development and disease.

J Cell Sci 2018 04 13;131(8). Epub 2018 Apr 13.

Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand

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http://dx.doi.org/10.1242/jcs.213959DOI Listing
April 2018
4 Reads
5.430 Impact Factor

Refilins are short-lived Actin-bundling proteins that regulate lamellipodium protrusion dynamics.

Biol Open 2016 Oct 15;5(10):1351-1361. Epub 2016 Oct 15.

INSERM U873 and INSERM Unité 1038, Grenoble F-38000, France CEA, BIG, BGE, Grenoble F-38000, France Université Grenoble Alpes, Grenoble F-38000, France

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http://dx.doi.org/10.1242/bio.019588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087682PMC
October 2016
10 Reads

COX assembly factor ccdc56 regulates mitochondrial morphology by affecting mitochondrial recruitment of Drp1.

FEBS Lett 2015 Oct 7;589(20 Pt B):3126-32. Epub 2015 Sep 7.

Department of Chemistry, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2015.08.039DOI Listing
October 2015
4 Reads
2 Citations
3.170 Impact Factor

S100A1 and S100B are dispensable for endochondral ossification during skeletal development.

Biomed Res 2014 ;35(4):243-50

Sensory & Motor System Medicine, Faculty of Medicine, University of Tokyo.

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May 2015
10 Reads
1 Citation
1.102 Impact Factor

Refilin holds the cap.

Commun Integr Biol 2011 Nov;4(6):791-5

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306362PMC
http://dx.doi.org/10.4161/cib.17911DOI Listing
November 2011
5 Reads
4 Citations

RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape.

Proc Natl Acad Sci U S A 2011 Jul 27;108(28):11464-9. Epub 2011 Jun 27.

Institut National de la Santé et de la Recherche Médicale, Unité 873, F-38054 Grenoble, France.

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http://dx.doi.org/10.1073/pnas.1104211108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136255PMC
July 2011
13 Reads
27 Citations
9.810 Impact Factor

S100P is a novel interaction partner and regulator of IQGAP1.

J Biol Chem 2011 Mar 22;286(9):7227-38. Epub 2010 Dec 22.

Institute of Medical Biochemistry, Centre for Molecular Biology of Inflammation, University of Muenster, Von-Esmarch-Strasse 56, D-48149 Muenster, Germany.

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http://dx.doi.org/10.1074/jbc.M110.135095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044979PMC
March 2011
8 Reads
22 Citations
4.573 Impact Factor

The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes.

Mol Cell Biol 2010 Apr 12;30(8):1984-96. Epub 2010 Feb 12.

INSERM Unité 873/TS-iRTSV, CEA Grenoble, 38054 Grenoble Cedex 9, France.

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http://dx.doi.org/10.1128/MCB.00007-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849464PMC
April 2010
8 Reads
25 Citations
4.780 Impact Factor

The Drosophila ubiquitin-specific protease dUSP36/Scny targets IMD to prevent constitutive immune signaling.

Cell Host Microbe 2009 Oct;6(4):309-20

CEA, DSV, iRTSV, LTS, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire de Transduction du Signal, CEA Grenoble, 38054 Grenoble, France.

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http://dx.doi.org/10.1016/j.chom.2009.09.007DOI Listing
October 2009
71 Reads
24 Citations
12.330 Impact Factor

ATAD 3A and ATAD 3B are distal 1p-located genes differentially expressed in human glioma cell lines and present in vitro anti-oncogenic and chemoresistant properties.

Exp Cell Res 2008 Sep 1;314(15):2870-83. Epub 2008 Jul 1.

Laboratoire Transduction du Signal EMI104 INSERM/CEA/UJF DRDC Centre d'étude Nucléaire, 17 Ave des Martyrs, 38054 Grenoble cedex, France.

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http://dx.doi.org/10.1016/j.yexcr.2008.06.017DOI Listing
September 2008
3 Reads
13 Citations
3.250 Impact Factor

IQGAP1 regulates adult neural progenitors in vivo and vascular endothelial growth factor-triggered neural progenitor migration in vitro.

J Neurosci 2007 Apr;27(17):4716-24

Institut National de la Santé et de la Recherche Médicale, Unité 873, Laboratoire Transduction du Signal, F-38054 Grenoble, France.

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http://dx.doi.org/10.1523/JNEUROSCI.0830-07.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672986PMC
April 2007
8 Reads
17 Citations
6.344 Impact Factor

AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration.

FASEB J 2007 Mar 21;21(3):732-42. Epub 2006 Dec 21.

Center for Human and Clinical Genetics, Leiden Univesity Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1096/fj.06-6628comDOI Listing
March 2007
16 Reads
40 Citations
5.043 Impact Factor

Identification of an AHNAK binding motif specific for the Annexin2/S100A10 tetramer.

J Biol Chem 2006 Nov 19;281(46):35030-8. Epub 2006 Sep 19.

INSERM, EMI01-04, Grenoble, France.

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http://dx.doi.org/10.1074/jbc.M606545200DOI Listing
November 2006
3 Reads
14 Citations
4.573 Impact Factor

IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme.

Cancer Res 2006 Sep;66(18):9074-82

Institut National de la Santé et de la Recherche Médicale EMI 0104, Département de Réponse et Dynamique Cellulaires, CEA Grenoble, Grenoble, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0761DOI Listing
September 2006
18 Reads
15 Citations
9.330 Impact Factor

Specific AHNAK expression in brain endothelial cells with barrier properties.

J Cell Physiol 2005 May;203(2):362-71

Laboratoire de Transduction du Signal INSERM EMI-0104, Grenoble, France.

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http://dx.doi.org/10.1002/jcp.20232DOI Listing
May 2005
66 Reads
10 Citations
3.840 Impact Factor

Nuclear expression of S100B in oligodendrocyte progenitor cells correlates with differentiation toward the oligodendroglial lineage and modulates oligodendrocytes maturation.

Mol Cell Neurosci 2004 Dec;27(4):453-65

Laboratoire de Transduction du Signal, INSERM EMI-0104, DRDC CEA-Grenoble, 38054 Grenoble, France.

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http://dx.doi.org/10.1016/j.mcn.2004.07.008DOI Listing
December 2004
20 Reads
35 Citations
3.840 Impact Factor

AHNAK interaction with the annexin 2/S100A10 complex regulates cell membrane cytoarchitecture.

J Cell Biol 2004 Jan 29;164(1):133-44. Epub 2003 Dec 29.

INSERM EMI-0104, DRDC-TS, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.

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http://dx.doi.org/10.1083/jcb.200307098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171952PMC
January 2004
2 Reads
44 Citations
9.834 Impact Factor

Monitoring of S100 homodimerization and heterodimeric interactions by the yeast two-hybrid system.

Microsc Res Tech 2003 Apr;60(6):560-8

Département Réponse et Dynamique Cellulaires du CEA, INSERM, EMI 0104, CEA-Grenoble, 38054 Grenoble Cedex 9, France.

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http://dx.doi.org/10.1002/jemt.10298DOI Listing
April 2003
1 Read
9 Citations
1.170 Impact Factor

Expression of the giant protein AHNAK (desmoyokin) in muscle and lining epithelial cells.

J Histochem Cytochem 2003 Mar;51(3):339-48

Laboratoire de Transduction du Signal INSERM EMI-0104, Grenoble, France.

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http://dx.doi.org/10.1177/002215540305100309DOI Listing
March 2003
1 Read
10 Citations
1.960 Impact Factor

The zinc- and calcium-binding S100B interacts and co-localizes with IQGAP1 during dynamic rearrangement of cell membranes.

J Biol Chem 2002 Dec 10;277(51):49998-50007. Epub 2002 Oct 10.

Département Réponse et Différenciation Cellulaires du Commissariat à l'Energie Atomique (CEA), INSERM EMI-0104 DRDC-TS, Grenoble 38054, France.

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http://dx.doi.org/10.1074/jbc.M205363200DOI Listing
December 2002
2 Reads
24 Citations
4.573 Impact Factor

S100 proteins. From purification to functions.

Methods Mol Biol 2002 ;172:185-98

Departement de Biologie Moleculaire et Structurale du CEA, EMI-INSERM104, Grenoble, France.

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http://dx.doi.org/10.1385/1-59259-183-3:185DOI Listing
August 2002
3 Reads
5 Citations