Jacqueline Boultwood

Jacqueline Boultwood

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Jacqueline Boultwood

Jacqueline Boultwood

Publications by authors named "Jacqueline Boultwood"

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Splicing factor mutant myelodysplastic syndromes: Recent advances.

Adv Biol Regul 2019 Sep 19:100655. Epub 2019 Sep 19.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford BRC Haematology Theme, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2019.100655DOI Listing
September 2019

Application of induced pluripotent stem cell technology for the investigation of hematological disorders.

Adv Biol Regul 2019 Jan 10;71:19-33. Epub 2018 Oct 10.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and Oxford BRC Haematology Theme, Oxford, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22124926183014
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http://dx.doi.org/10.1016/j.jbior.2018.10.001DOI Listing
January 2019

L-leucine increases translation of and in erythroblasts from del(5q) myelodysplastic syndrome patients.

Haematologica 2018 11 14;103(11):e496-e500. Epub 2018 Jun 14.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and Oxford BRC Haematology Theme, UK

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http://dx.doi.org/10.3324/haematol.2018.190447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278984PMC
November 2018

SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.

Cell Stem Cell 2018 09 23;23(3):355-369.e9. Epub 2018 Aug 23.

Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143172PMC
September 2018

Splicing factor mutations in the myelodysplastic syndromes: target genes and therapeutic approaches.

Adv Biol Regul 2018 01 22;67:13-29. Epub 2017 Sep 22.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and Oxford BRC Haematology Theme, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2017.09.008DOI Listing
January 2018

Impact of Splicing Factor Mutations on Pre-mRNA Splicing in the Myelodysplastic Syndromes.

Curr Pharm Des 2016 ;22(16):2333-44

Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

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http://dx.doi.org/10.2174/1381612822666160226132112DOI Listing
November 2017

The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.

J Clin Invest 2017 Jun 24;127(6):2206-2221. Epub 2017 Apr 24.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and BRC Blood Theme, National Institute for Health Research (NIHR) Oxford Biomedical Centre, Oxford University Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1172/JCI91363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451246PMC
June 2017

Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications.

Adv Biol Regul 2017 Jan 21;63:59-70. Epub 2016 Aug 21.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford; NIHR Biomedical Research Centre, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2016.08.001DOI Listing
January 2017

The Effects of Severe Hypoxia on Glycolytic Flux and Enzyme Activity in a Model of Solid Tumors.

J Cell Biochem 2016 08 2;117(8):1890-901. Epub 2016 Feb 2.

Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, The University of Oxford, Headington, UK.

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http://dx.doi.org/10.1002/jcb.25488DOI Listing
August 2016

Application of genome editing technologies to the study and treatment of hematological disease.

Adv Biol Regul 2016 Jan 26;60:122-134. Epub 2015 Sep 26.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and NIHR Biomedical Research Centre, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2015.09.005DOI Listing
January 2016

ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts.

Oncotarget 2015 Dec;6(42):44061-71

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford University Hospital, Oxford, UK.

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http://dx.doi.org/10.18632/oncotarget.6392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792541PMC
December 2015

CSNK1A1 mutations and gene expression analysis in myelodysplastic syndromes with del(5q).

Br J Haematol 2015 Oct 18;171(2):210-214. Epub 2015 Jun 18.

LLR Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/bjh.13563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744770PMC
October 2015

PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.

Blood 2015 Aug 13;126(9):1118-27. Epub 2015 Jul 13.

Departments of Cell Biology and of Medicine, Division of Hemato-Oncology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY;

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http://dx.doi.org/10.1182/blood-2014-12-618801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551362PMC
August 2015

The molecular pathogenesis of the myelodysplastic syndromes.

Eur J Haematol 2015 Jul 20;95(1):3-15. Epub 2015 Feb 20.

Leukaemia & Lymphoma Research Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/ejh.12515DOI Listing
July 2015

Application of CRISPR/Cas9 genome editing to the study and treatment of disease.

Arch Toxicol 2015 Jul 1;89(7):1023-34. Epub 2015 Apr 1.

Leukaemia and Lymphoma Research Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, and NIHR Biomedical Research Centre, Oxford University Hospitals, University of Oxford, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1007/s00204-015-1504-yDOI Listing
July 2015

Recent Advances in the 5q- Syndrome.

Mediterr J Hematol Infect Dis 2015 20;7(1):e2015037. Epub 2015 May 20.

Leukaemia & Lymphoma Research Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford University Hospitals, Oxford, United Kingdom.

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http://www.mjhid.org/index.php/mjhid/article/view/2015.037
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http://dx.doi.org/10.4084/MJHID.2015.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450650PMC
June 2015

Clinical associations of CSNK1A1 mutation in myelodysplastic syndrome.

Lancet Haematol 2015 May 6;2(5):e182-3. Epub 2015 May 6.

Leukaemia and Lymphoma Research Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1016/S2352-3026(15)00070-8DOI Listing
May 2015

Reduced translation of GATA1 in Diamond-Blackfan anemia.

Nat Med 2014 Jul;20(7):703-4

Leukaemia & Lymphoma Research Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/nm.3630DOI Listing
July 2014

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Cancer Cell 2014 Jun 15;25(6):794-808. Epub 2014 May 15.

Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.036DOI Listing
June 2014

The role of splicing factor mutations in the pathogenesis of the myelodysplastic syndromes.

Adv Biol Regul 2014 Jan 15;54:153-61. Epub 2013 Sep 15.

LLR Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

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http://dx.doi.org/10.1016/j.jbior.2013.09.005DOI Listing
January 2014

Identification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes.

J Clin Oncol 2013 Oct 3;31(28):3557-64. Epub 2013 Sep 3.

Andrea Pellagatti, Janet Perry, James S. Wainscoat, and Jacqueline Boultwood, University of Oxford, Oxford; Ken I. Mills, Queen's University Belfast, Belfast; Emma-Jane McDonald and Sally Killick, Royal Bournemouth Hospital, Bournemouth, United Kingdom; Axel Benner, German Cancer Research Center, Heidelberg; Aristoteles Giagounidis, St Johannes Hospital, Duisburg; Lars Bullinger, University Hospital of Ulm, Ulm, Germany; Mario Cazzola, Luca Malcovati, and Matteo G. Della Porta, Fondazione Istituto di Ricovera e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy; Martin Jädersten and Eva Hellström-Lindberg, Karolinska Institutet, Stockholm, Sweden; and Amit Verma, Albert Einstein College of Medicine, New York, NY.

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http://dx.doi.org/10.1200/JCO.2012.45.5626DOI Listing
October 2013

Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34⁺ progenitor cells.

Br J Haematol 2013 Mar 8;160(6):842-50. Epub 2013 Jan 8.

LLR Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1111/bjh.12217DOI Listing
March 2013

CUX1 in leukemia: dosage matters.

Blood 2013 Feb;121(6):869-71

University of Oxford.

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http://dx.doi.org/10.1182/blood-2012-12-473421DOI Listing
February 2013

Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q- syndrome and other ribosomopathies.

Adv Biol Regul 2013 Jan 13;53(1):8-17. Epub 2012 Sep 13.

LLR Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1016/j.jbior.2012.09.002DOI Listing
January 2013

5q- syndrome.

Curr Pharm Des 2012 ;18(22):3180-3

LLR Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.2174/1381612811209023180DOI Listing
October 2012

Haploinsufficiency of ribosomal proteins and p53 activation in anemia: Diamond-Blackfan anemia and the 5q- syndrome.

Adv Biol Regul 2012 Jan;52(1):196-203

LLR Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S00652571110005
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http://dx.doi.org/10.1016/j.advenzreg.2011.09.008DOI Listing
January 2012

Advances in the 5q- syndrome.

Blood 2010 Dec 23;116(26):5803-11. Epub 2010 Aug 23.

Leukaemia & Lymphoma Research Molecular Haematology Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

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http://dx.doi.org/10.1182/blood-2010-04-273771DOI Listing
December 2010

Molecular and clinical features of refractory anemia with ringed sideroblasts associated with marked thrombocytosis.

Blood 2009 Oct 19;114(17):3538-45. Epub 2009 Aug 19.

Department of Hematology Oncology, University of Pavia & Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS), Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1182/blood-2009-05-222331DOI Listing
October 2009

Genome-wide analysis of copy number changes and loss of heterozygosity in myelodysplastic syndrome with del(5q) using high-density single nucleotide polymorphism arrays.

Haematologica 2008 Jul 27;93(7):994-1000. Epub 2008 May 27.

LRF Molecular Haematology Unit, Nuffield Department of Clinical, Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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http://www.haematologica.org/cgi/doi/10.3324/haematol.12603
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http://dx.doi.org/10.3324/haematol.12603DOI Listing
July 2008

Gene silencing by DNA methylation in haematological malignancies.

Br J Haematol 2007 Jul 9;138(1):3-11. Epub 2007 May 9.

LRF Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford, UK.

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http://doi.wiley.com/10.1111/j.1365-2141.2007.06604.x
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http://dx.doi.org/10.1111/j.1365-2141.2007.06604.xDOI Listing
July 2007

Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients.

Proc Natl Acad Sci U S A 2007 Jul 18;104(27):11406-11. Epub 2007 Jun 18.

Leukaemia Research Fund Molecular Haematology Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0610477104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892786PMC
July 2007

Gene expression profiles of CD34+ cells in myelodysplastic syndromes: involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype.

Blood 2006 Jul 9;108(1):337-45. Epub 2006 Mar 9.

Leukaemia Research Fund (LRF) Molecular Haematology Unit, Nuffield Department of Clinical Laboratory Sciences (NDCLS), John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

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http://dx.doi.org/10.1182/blood-2005-12-4769DOI Listing
July 2006

Gene expression profiling in the myelodysplastic syndromes.

Hematology 2005 Aug;10(4):281-7

Leukaemia Research Fund Molecular Haematology Unit, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1080/10245330500065680DOI Listing
August 2005

Gene expression profiling in the myelodysplastic syndromes using cDNA microarray technology.

Br J Haematol 2004 Jun;125(5):576-83

Leukaemia Research Fund Molecular Haematology Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2004.04958.xDOI Listing
June 2004

Gene expression profiling in polycythemia vera using cDNA microarray technology.

Cancer Res 2003 Jul;63(14):3940-4

Leukaemia Research Fund, Molecular Haematology Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

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July 2003