Jacob M van Laar

Jacob M van Laar

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Jacob M van Laar

Jacob M van Laar

Publications by authors named "Jacob M van Laar"

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Is There a Place for Hematopoietic Stem Cell Transplantation in Rheumatology?

Rheum Dis Clin North Am 2019 Aug 27;45(3):399-416. Epub 2019 May 27.

Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584 CX, the Netherlands.

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http://dx.doi.org/10.1016/j.rdc.2019.04.003DOI Listing
August 2019

Second autologous haematopoietic stem cell transplantation in systemic sclerosis-a case report.

Rheumatology (Oxford) 2019 Jul;58(7):1305-1307

Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/kez010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587916PMC
July 2019

Resetting the T Cell Compartment in Autoimmune Diseases With Autologous Hematopoietic Stem Cell Transplantation: An Update.

Front Immunol 2018 20;9:767. Epub 2018 Apr 20.

Laboratory of Translational Immunology, Department of Pediatrics, University Medical Center Utrecht, Utrecht, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2018.00767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920130PMC
June 2019

Is prediction of clinical response to methotrexate in individual rheumatoid arthritis patients possible? A systematic literature review.

Joint Bone Spine 2019 Apr 11. Epub 2019 Apr 11.

Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.jbspin.2019.04.002DOI Listing
April 2019

Automated CT quantification methods for the assessment of interstitial lung disease in collagen vascular diseases: A systematic review.

Eur J Radiol 2019 Mar 24;112:200-206. Epub 2019 Jan 24.

Department of Radiology, Division of Imaging, University Medical Centre Utrecht and Utrecht University, Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.ejrad.2019.01.024DOI Listing
March 2019

Hematopoietic stem-cell transplantation in systemic sclerosis: an update.

Curr Opin Rheumatol 2018 11;30(6):541-547

Department of Rheumatology and Clinical Immunology.

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http://dx.doi.org/10.1097/BOR.0000000000000541DOI Listing
November 2018

Targeting the TLR4-MD2 axis in systemic sclerosis.

Nat Rev Rheumatol 2018 10;14(10):564-566

University Medical Centre Utrecht, Department of Rheumatology and Immunology, Utrecht, Netherlands.

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http://dx.doi.org/10.1038/s41584-018-0077-6DOI Listing
October 2018

RNA sequencing to predict response to TNF-α inhibitors reveals possible mechanism for nonresponse in smokers.

Expert Rev Clin Immunol 2018 07 6;14(7):623-633. Epub 2018 Jun 6.

a Rheumatology & Clinical Immunology , University Medical Center Utrecht , Utrecht , The Netherlands.

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http://dx.doi.org/10.1080/1744666X.2018.1480937DOI Listing
July 2018

Optical spectral transmission to assess inflammation in hand and wrist joints of rheumatoid arthritis patients.

Rheumatology (Oxford) 2018 05;57(5):865-872

Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/kex531DOI Listing
May 2018

Patterns and predictors of skin score change in early diffuse systemic sclerosis from the European Scleroderma Observational Study.

Ann Rheum Dis 2018 04 6;77(4):563-570. Epub 2018 Jan 6.

UCL Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK.

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http://dx.doi.org/10.1136/annrheumdis-2017-211912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890636PMC
April 2018

Autologous hematopoietic stem cell transplantation in systemic sclerosis: A reset to tolerance?

Immunol Lett 2018 03 16;195:88-96. Epub 2017 Nov 16.

Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2017.11.005DOI Listing
March 2018

Immunology and systemic sclerosis - Editorial.

Immunol Lett 2018 03;195

Department of Rheumatology and Clinical Immunology, UMC Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.imlet.2018.02.005DOI Listing
March 2018

Targeting of tolerogenic dendritic cells towards heat-shock proteins: a novel therapeutic strategy for autoimmune diseases?

Immunology 2018 01 18;153(1):51-59. Epub 2017 Sep 18.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/imm.12811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721256PMC
January 2018

Difficult-to-treat rheumatoid arthritis: an area of unmet clinical need.

Rheumatology (Oxford) 2017 Oct 4. Epub 2017 Oct 4.

Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1093/rheumatology/kex349DOI Listing
October 2017

Measurement of antinuclear antibodies and their fine specificities: time for a change in strategy?

Clin Exp Rheumatol 2017 May-Jun;35(3):462-470. Epub 2017 Feb 24.

Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands.

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August 2017

Necessity of TNF-alpha inhibitor discontinuation in rheumatoid arthritis is predicted by smoking and number of previously used biological DMARDs.

Clin Exp Rheumatol 2017 Mar-Apr;35(2):221-228. Epub 2016 Oct 7.

Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands.

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June 2017

Haematopoietic stem cell transplantation for autoimmune diseases.

Nat Rev Rheumatol 2017 Apr 23;13(4):244-256. Epub 2017 Feb 23.

Paediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, 3508 AB Utrecht, Netherlands.

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http://dx.doi.org/10.1038/nrrheum.2017.7DOI Listing
April 2017

Microbial Dysbiosis in Common Variable Immune Deficiencies: Evidence, Causes, and Consequences.

Trends Immunol 2017 03 22;38(3):206-216. Epub 2016 Dec 22.

Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14714906163020
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http://dx.doi.org/10.1016/j.it.2016.11.008DOI Listing
March 2017

Automated joint space width quantification of hand and wrist joints: a proof of concept study.

Clin Exp Rheumatol 2016 Sep-Oct;34(5 Suppl 101):S34-S39. Epub 2016 Oct 18.

Department of Rheumatology and Clinical Immunology, UMC Utrecht, The Netherlands.

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February 2017

Rheumatology post-Brexit.

Authors:
Jacob M van Laar

Rheumatology (Oxford) 2017 Jan;56(1):1-3

Editor Rheumatology, British Society for Rheumatology, London, UK

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http://dx.doi.org/10.1093/rheumatology/kew455DOI Listing
January 2017

Histone Demethylation and Toll-like Receptor 8-Dependent Cross-Talk in Monocytes Promotes Transdifferentiation of Fibroblasts in Systemic Sclerosis Via Fra-2.

Arthritis Rheumatol 2016 06;68(6):1493-504

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK, and University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/art.39602DOI Listing
June 2016

Stem cell transplantation and mesenchymal cells to treat autoimmune diseases.

Presse Med 2016 Jun 30;45(6 Pt 2):e159-69. Epub 2016 May 30.

University medical center Utrecht, department of rheumatology and clinical immunology, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.lpm.2016.05.002DOI Listing
June 2016

Personalized biological treatment for rheumatoid arthritis: a systematic review with a focus on clinical applicability.

Rheumatology (Oxford) 2016 May 29;55(5):826-39. Epub 2015 Dec 29.

Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/kev421DOI Listing
May 2016

IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics.

Sci Rep 2016 04 26;6:25066. Epub 2016 Apr 26.

Department of Rheumatology and Clinical Immunology University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/srep25066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844987PMC
April 2016

Connective tissue diseases: Nucleosomes and systemic sclerosis.

Nat Rev Rheumatol 2016 Mar 4;12(3):138-9. Epub 2016 Feb 4.

University Medical Centre (UMC) Utrecht, Department of Rheumatology and Immunology, Heidelberglaan 100, 3584 CX Utrecht, Netherlands.

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http://dx.doi.org/10.1038/nrrheum.2016.9DOI Listing
March 2016

Cellular Therapies in Systemic Sclerosis: Recent Progress.

Curr Rheumatol Rep 2016 Feb;18(2):12

Department of Rheumatology & Clinical Immunology, Division of Internal Medicine and Dermatology, University Medical Center Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s11926-015-0555-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779139PMC
February 2016

MiR-29a reduces TIMP-1 production by dermal fibroblasts via targeting TGF-β activated kinase 1 binding protein 1, implications for systemic sclerosis.

PLoS One 2014 30;9(12):e115596. Epub 2014 Dec 30.

Newcastle University, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom; University Medical Center Utrecht, Department of Rheumatology & Clinical Immunology, Utrecht, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115596PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280195PMC
January 2016

Does disease activity add to functional disability in estimation of utility for rheumatoid arthritis patients on biologic treatment?

Rheumatology (Oxford) 2016 Jan 27;55(1):94-102. Epub 2015 Aug 27.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht and National Institute of Public Health and the Environment, Bilthoven, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/kev291DOI Listing
January 2016

Haematopoietic stem cell transplantation for poor-prognosis systemic sclerosis.

Rheumatology (Oxford) 2015 Dec 6;54(12):2126-33. Epub 2015 May 6.

Department of Rheumatology, University Hospital, Basel, Switzerland.

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http://dx.doi.org/10.1093/rheumatology/kev117DOI Listing
December 2015

The immunopathology of systemic sclerosis.

Semin Immunopathol 2015 Sep 19;37(5):439-41. Epub 2015 Aug 19.

Feinberg School of Medicine, Northwestern University, Chicago, IL, 60657, USA,

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http://dx.doi.org/10.1007/s00281-015-0517-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554741PMC
September 2015

Effects and safety of rituximab in systemic sclerosis: an analysis from the European Scleroderma Trial and Research (EUSTAR) group.

Ann Rheum Dis 2015 Jun 17;74(6):1188-94. Epub 2014 Jan 17.

Divison of Rheumatology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1136/annrheumdis-2013-204522DOI Listing
June 2015

Monitoring of rheumatoid arthritis disease activity in individual patients: still a hurdle when implementing the treat-to-target principle in daily clinical practice.

Rheumatology (Oxford) 2015 Jun 28;54(6):959-61. Epub 2014 Aug 28.

Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht and Department of Rheumatology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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https://academic.oup.com/rheumatology/article-lookup/doi/10.
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http://dx.doi.org/10.1093/rheumatology/keu334DOI Listing
June 2015

Glucocorticoids in early rheumatoid arthritis: are the benefits of joint-sparing effects offset by the adverse effect of osteoporosis? the effects on bone in the utrecht study and the CAMERA-II study.

Neuroimmunomodulation 2015 12;22(1-2):66-71. Epub 2014 Sep 12.

Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1159/000362729DOI Listing
June 2015

Is serum procalcitonin measurement a useful addition to a rheumatologist's repertoire? A review of its diagnostic role in systemic inflammatory diseases and joint infections.

Rheumatology (Oxford) 2015 Feb 27;54(2):231-40. Epub 2014 Oct 27.

Department of Rheumatology, James Cook University Hospital, Middlesbrough, UK and Department of Rheumatology & Clinical Immunology, University Medical Center, Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/keu416DOI Listing
February 2015

Cardiac assessment before stem cell transplantation for systemic sclerosis--reply.

JAMA 2014 Nov;312(17):1803-4

Department of Rheumatology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1001/jama.2014.12572DOI Listing
November 2014

Concepts of pathogenesis and emerging treatments for inflammatory arthritis.

Best Pract Res Clin Rheumatol 2014 Aug;28(4):537-8

San Diego, USA.

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http://dx.doi.org/10.1016/j.berh.2014.11.001DOI Listing
August 2014

Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-β (TGF-β) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.

J Biol Chem 2014 Apr 18;289(14):9952-60. Epub 2014 Feb 18.

From the Musculoskeletal Research Group, Institute of Cellular Medicine, 4th Floor Cookson Building, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M113.545822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975039PMC
April 2014

Doctor who?

Rheumatology (Oxford) 2014 Mar;53(3):385-6

British Society for Rheumatology, Bride House, 18-20 Bride Lane, London EC4Y 8EE, UK.

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http://dx.doi.org/10.1093/rheumatology/keu017DOI Listing
March 2014

Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.

Am J Hum Genet 2014 Jan;94(1):47-61

Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada 18016, Spain.

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http://eprints.gla.ac.uk/104672/1/104672.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S000292971300571
Publisher Site
http://dx.doi.org/10.1016/j.ajhg.2013.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882906PMC
January 2014

Stem cell transplantation in systemic sclerosis.

Curr Opin Rheumatol 2013 Nov;25(6):719-25

aInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK bDivision of Cellular Therapy, Duke University Medical Center, Durham, North Carolina, USA.

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http://dx.doi.org/10.1097/01.bor.0000434669.32150.acDOI Listing
November 2013

The clinical utility of bone marker measurements in osteoporosis.

J Transl Med 2013 Aug 29;11:201. Epub 2013 Aug 29.

Department of Biochemistry, The James Cook University Hospital, Middlesbrough TS4 3BW, UK.

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http://dx.doi.org/10.1186/1479-5876-11-201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765909PMC
August 2013

Role of toll-like receptors in systemic sclerosis.

Expert Rev Mol Med 2013 Aug 28;15:e9. Epub 2013 Aug 28.

Musculoskeletal Research Group, Institute of Cellular Medicine, 4th Floor Cookson Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1017/erm.2013.10DOI Listing
August 2013

Update on stem cell transplantation for systemic sclerosis: recent trial results.

Curr Rheumatol Rep 2013 May;15(5):326

Department of Rheumatology, The James Cook University Hospital, Middlesbrough, UK.

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http://link.springer.com/10.1007/s11926-013-0326-2
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http://dx.doi.org/10.1007/s11926-013-0326-2DOI Listing
May 2013

Interleukin-6: a new therapeutic target in systemic sclerosis?

Clin Transl Immunology 2013 Apr 12;2(4):e4. Epub 2013 Apr 12.

Musculoskeletal Research Group, Institute of Cellular Medicine , Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1038/cti.2013.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232056PMC
April 2013

T cells in systemic sclerosis: a reappraisal.

Rheumatology (Oxford) 2012 Sep 9;51(9):1540-9. Epub 2012 May 9.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1093/rheumatology/kes090DOI Listing
September 2012

Interleukin-6, its role in fibrosing conditions.

Cytokine Growth Factor Rev 2012 Jun 5;23(3):99-107. Epub 2012 May 5.

Musculoskeletal Research Group, Institute of Cellular Medicine, 4(th) Floor Cookson Building, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1016/j.cytogfr.2012.04.003DOI Listing
June 2012